CL2020003143A1 - Compuestos de ácido ascórbico y quinona en combinación con un agente antiparasitario para el tratamiento de una enfermedad parasitaria - Google Patents
Compuestos de ácido ascórbico y quinona en combinación con un agente antiparasitario para el tratamiento de una enfermedad parasitariaInfo
- Publication number
- CL2020003143A1 CL2020003143A1 CL2020003143A CL2020003143A CL2020003143A1 CL 2020003143 A1 CL2020003143 A1 CL 2020003143A1 CL 2020003143 A CL2020003143 A CL 2020003143A CL 2020003143 A CL2020003143 A CL 2020003143A CL 2020003143 A1 CL2020003143 A1 CL 2020003143A1
- Authority
- CL
- Chile
- Prior art keywords
- ascorbic acid
- treatment
- combination
- antiparasitic agent
- quinone compounds
- Prior art date
Links
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title abstract 4
- 239000003096 antiparasitic agent Substances 0.000 title abstract 2
- 229940125687 antiparasitic agent Drugs 0.000 title abstract 2
- 229960005070 ascorbic acid Drugs 0.000 title abstract 2
- 235000010323 ascorbic acid Nutrition 0.000 title abstract 2
- 239000011668 ascorbic acid Substances 0.000 title abstract 2
- 208000030852 Parasitic disease Diseases 0.000 title 1
- 150000004053 quinones Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 206010001935 American trypanosomiasis Diseases 0.000 abstract 1
- 208000024699 Chagas disease Diseases 0.000 abstract 1
- 241000223109 Trypanosoma cruzi Species 0.000 abstract 1
- AZQWKYJCGOJGHM-UHFFFAOYSA-N para-benzoquinone Natural products O=C1C=CC(=O)C=C1 AZQWKYJCGOJGHM-UHFFFAOYSA-N 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- -1 quinone compound Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000024891 symptom Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/345—Nitrofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4168—1,3-Diazoles having a nitrogen attached in position 2, e.g. clonidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Nutrition Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Zoology (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
La presente proporciona un método para tratar, prevenir o aliviar uno o más síntomas de la enfermedad de Chagas que comprende administrar: (i) ácido ascórbico; (ii) un compuesto de quinona, un enantiómero simple, una mezcla de enantiómeros, o una mezcla de diastereómeros de (i) y de (ii), o una sal, solvato, hidrato o profármaco farmacéuticamente aceptable de (i) y de (ii); y (iii) un agente antiparasitario.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862681500P | 2018-06-06 | 2018-06-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020003143A1 true CL2020003143A1 (es) | 2021-06-11 |
Family
ID=68769906
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020003143A CL2020003143A1 (es) | 2018-06-06 | 2020-12-03 | Compuestos de ácido ascórbico y quinona en combinación con un agente antiparasitario para el tratamiento de una enfermedad parasitaria |
Country Status (11)
Country | Link |
---|---|
US (2) | US11872233B2 (es) |
AR (1) | AR115493A1 (es) |
AU (1) | AU2019282657A1 (es) |
BR (1) | BR112020024807A2 (es) |
CA (1) | CA3101331C (es) |
CL (1) | CL2020003143A1 (es) |
CR (1) | CR20200636A (es) |
ES (1) | ES2811674B2 (es) |
MX (1) | MX2020013076A (es) |
PE (1) | PE20212333A1 (es) |
WO (1) | WO2019236656A1 (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112020024807A2 (pt) | 2018-06-06 | 2021-03-02 | IC-MedTech Corp. | ácido ascórbico e compostos de quinona em combinação com um agente antiparasítico para tratar uma doença parasítica |
US20230130144A1 (en) * | 2020-03-31 | 2023-04-27 | Natural Medicine Institute Of Zhejiang Yangshengtang Co., Ltd. | Pharmaceutical combination and use thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6468414B1 (en) | 2001-02-16 | 2002-10-22 | Hydro-Quebec | Method of purification of a redox mediator before electrolytic regeneration thereof |
US7091241B2 (en) | 2001-06-01 | 2006-08-15 | Summa Health System | Nontoxic potentiation/sensitization of cancer therapy by supplementary treatment with combined vitamins C and K3 |
EP2034835B1 (en) | 2006-06-16 | 2019-05-15 | Summa Health System | Non-toxic anti-cancer drug combining ascorbate, magnesium and a naphthoquinone |
WO2009035908A1 (en) | 2007-09-11 | 2009-03-19 | Wyeth | Compositions and their use for the treatment of protozoal infections comprising metaflumi zone |
WO2009063044A1 (en) | 2007-11-16 | 2009-05-22 | Pharmaq As | Treatment of parasite diseases using vitamin k3 |
CN105232533A (zh) | 2009-07-20 | 2016-01-13 | 萨马保健系统公司 | 维生素c和维生素k的组合及其用途 |
EP2595615A1 (en) | 2010-07-19 | 2013-05-29 | Summa Health System | Vitamin c and chromium-free vitamin k, and compositions thereof for treating an nfkb-mediated condition or disease |
EP2600855A2 (en) | 2010-08-04 | 2013-06-12 | Pellficure Pharmaceuticals, Inc. | Combination therapy for the treatment of prostate carcinoma |
WO2014110305A1 (en) | 2013-01-11 | 2014-07-17 | Mayo Foundation For Medical Education And Research | Vitamins c and k for treating polycystic diseases |
CA3031979A1 (en) | 2016-08-01 | 2018-02-08 | IC-MedTech Corp. | Ascorbic acid, quinone compound, and sodium glucose cotransporter inhibitor for treating cancer |
BR112020024807A2 (pt) | 2018-06-06 | 2021-03-02 | IC-MedTech Corp. | ácido ascórbico e compostos de quinona em combinação com um agente antiparasítico para tratar uma doença parasítica |
-
2019
- 2019-06-05 BR BR112020024807-0A patent/BR112020024807A2/pt unknown
- 2019-06-05 CA CA3101331A patent/CA3101331C/en active Active
- 2019-06-05 ES ES202090057A patent/ES2811674B2/es active Active
- 2019-06-05 AU AU2019282657A patent/AU2019282657A1/en active Pending
- 2019-06-05 PE PE2020001962A patent/PE20212333A1/es unknown
- 2019-06-05 CR CR20200636A patent/CR20200636A/es unknown
- 2019-06-05 US US16/972,004 patent/US11872233B2/en active Active
- 2019-06-05 WO PCT/US2019/035501 patent/WO2019236656A1/en active Application Filing
- 2019-06-05 MX MX2020013076A patent/MX2020013076A/es unknown
- 2019-06-05 AR ARP190101544A patent/AR115493A1/es unknown
-
2020
- 2020-12-03 CL CL2020003143A patent/CL2020003143A1/es unknown
-
2024
- 2024-01-15 US US18/412,805 patent/US20240165084A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US20210361666A1 (en) | 2021-11-25 |
WO2019236656A1 (en) | 2019-12-12 |
MX2020013076A (es) | 2021-03-02 |
CA3101331C (en) | 2023-12-19 |
US20240165084A1 (en) | 2024-05-23 |
ES2811674B2 (es) | 2024-02-07 |
PE20212333A1 (es) | 2021-12-14 |
ES2811674A2 (es) | 2021-03-12 |
US11872233B2 (en) | 2024-01-16 |
AR115493A1 (es) | 2021-01-27 |
ES2811674R1 (es) | 2021-09-20 |
CA3101331A1 (en) | 2019-12-12 |
AU2019282657A1 (en) | 2020-12-10 |
BR112020024807A2 (pt) | 2021-03-02 |
CR20200636A (es) | 2021-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CL2021001292A1 (es) | Terapia de combinación que incluye un inhibidor de krasg12c y uno o más agentes farmacéuticamente activos adicionales para el tratamiento de cánceres | |
CO2019015090A2 (es) | Métodos de tratamiento para la fibrosis cística | |
DOP2022000124A (es) | Derivados de pirazolilo útiles como agentes anticancerígenos | |
PE20190338A1 (es) | Metodos de tratamiento de trastornos del desarrollo con gaboxadol | |
AR096892A1 (es) | Una combinación farmacéutica para el tratamiento del melanoma | |
ECSP22019360A (es) | Piperidinil-metil-purinaminas como inhibidores de nsd2 y antineoplásicos | |
AR119158A1 (es) | Tratamientos de angioedema hereditario | |
MX2021009806A (es) | Ésteres de ácidos grasos de cadena media de beta-hidroxibutirato y butanodiol y composiciones y métodos para usar los mismos. | |
CL2020003143A1 (es) | Compuestos de ácido ascórbico y quinona en combinación con un agente antiparasitario para el tratamiento de una enfermedad parasitaria | |
BR112019007576A2 (pt) | compostos de bifenil sulfonamida para o tratamento de doenças ou transtornos renais | |
PH12021550713A1 (en) | Medicament for the treatment of chronic cough | |
AR119159A1 (es) | Tratamientos de angioedema | |
BR112015023761A2 (pt) | moduladores de molécula pequena de pcsk9 e seus métodos e usos | |
CO2019004004A2 (es) | Composición farmacéutica y método para el tratamiento de la enfermedad del hígado graso no alcohólico | |
BR112021006318A2 (pt) | terapia de combinação para o tratamento de câncer | |
UY39150A (es) | Pirrolopirimidinaminas como inhibidores del sistema del complemento | |
BR112017023164A2 (pt) | composto, e, método de prevenir e/ou tratar a esteato-hepatite não alcoólica em um indivíduo em necessidade do mesmo | |
CL2022000875A1 (es) | Inhibidores del factor d del complemento para administración oral | |
CL2016002318A1 (es) | Composición farmacéutica en forma de solución que comprende un portador líquido que comprende agua y entre 20% y 95% de uno o mas alcoholes y citrato de sildenafil disuelto en dicho portador líquido a una concentración de entre 7 y 125 mg/ml; métodos para obtenerla; forma de dosificación oral; forma de dosificación bucal; kits. | |
BR112019008698A2 (pt) | método para tratar câncer num sujeito que precisa do mesmo e composição farmacêutica | |
BR112018073556A2 (pt) | medicamento e composição farmacêutica para a prevenção ou o tratamento da neuralgia trigeminal, método para prevenir ou tratar neuralgia trigeminal em um indivíduo, e, uso de um composto de carbamato . | |
ECSP19048402A (es) | Compuestos de ácido ascórbico y quinona para el tratamiento de la enfermedad de chagas | |
CL2021001397A1 (es) | Vibegrón para el tratamiento de los síntomas de la vejiga hiperactiva | |
ECSP16095557A (es) | Métodos para tratar infecciones | |
BR112017017608A2 (pt) | métodos para tratamento de esquizofrenia ou um sintoma de esquizofrenia, para prevenir uma recaída esquizofrênica e para manter o efeito de iloperidona para esquizofrenia. |