HK1071136A1 - Quinoline derivative and quinazoline derivative and medicinal composition containing the same - Google Patents
Quinoline derivative and quinazoline derivative and medicinal composition containing the sameInfo
- Publication number
- HK1071136A1 HK1071136A1 HK05103925.9A HK05103925A HK1071136A1 HK 1071136 A1 HK1071136 A1 HK 1071136A1 HK 05103925 A HK05103925 A HK 05103925A HK 1071136 A1 HK1071136 A1 HK 1071136A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cyc
- optionally substituted
- halo
- alkyl
- quinoline
- Prior art date
Links
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract 3
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 101100062121 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cyc-1 gene Proteins 0.000 abstract 4
- 125000001475 halogen functional group Chemical group 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- BCOSVBKPHCKEII-UHFFFAOYSA-N 2-phenylsulfanylquinoline Chemical compound C=1C=C2C=CC=CC2=NC=1SC1=CC=CC=C1 BCOSVBKPHCKEII-UHFFFAOYSA-N 0.000 abstract 2
- -1 S-A Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 241000699660 Mus musculus Species 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004966 cyanoalkyl group Chemical group 0.000 abstract 1
- 239000000824 cytostatic agent Substances 0.000 abstract 1
- 230000001085 cytostatic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000010534 mechanism of action Effects 0.000 abstract 1
- 238000011580 nude mouse model Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/40—Nitrogen atoms attached in position 8
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2001190238 | 2001-06-22 | ||
PCT/JP2002/006239 WO2003000660A1 (fr) | 2001-06-22 | 2002-06-21 | Derive de quinoleine et derive de quinoleine permettant d'inhiber l'auto-phosphorylation du recepteur des proliferateurs des hepatocytes, ainsi que des compositions medicinales contenant ce derive |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1071136A1 true HK1071136A1 (en) | 2005-07-08 |
Family
ID=19029043
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05103925.9A HK1071136A1 (en) | 2001-06-22 | 2005-05-10 | Quinoline derivative and quinazoline derivative and medicinal composition containing the same |
Country Status (11)
Country | Link |
---|---|
US (3) | US7425564B2 (fr) |
EP (3) | EP1411046B1 (fr) |
JP (1) | JP4342935B2 (fr) |
KR (1) | KR100883731B1 (fr) |
CN (1) | CN100415720C (fr) |
AT (1) | ATE443047T1 (fr) |
AU (1) | AU2002313249B2 (fr) |
CA (1) | CA2454538A1 (fr) |
DE (1) | DE60233736D1 (fr) |
HK (1) | HK1071136A1 (fr) |
WO (1) | WO2003000660A1 (fr) |
Families Citing this family (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7135466B2 (en) * | 1999-12-24 | 2006-11-14 | Kirin Beer Kabushiki Kaisha | Quinoline and quinazoline derivatives and drugs containing the same |
KR100589032B1 (ko) | 2000-10-20 | 2006-06-14 | 에자이 가부시키가이샤 | 질소 함유 방향환 유도체 |
CA2491191C (fr) | 2002-07-15 | 2014-02-04 | Exelixis, Inc. | Modulateurs de kinase de type recepteur et procedes d'utilisation |
EP1566379A4 (fr) * | 2002-10-29 | 2005-11-09 | Kirin Brewery | DERIVES DE QUINOLINE ET DE QUINAZOLINE INHIBANT L'AUTOPHOSPHORYLATION DE Flt3 ET COMPOSITIONS MEDICALES LES CONTENANT |
WO2005005389A2 (fr) | 2003-07-07 | 2005-01-20 | Merck Patent Gmbh | Derives de malonamide |
GB0317268D0 (en) * | 2003-07-23 | 2003-08-27 | Viral Asa A | Compounds |
AU2013204031B2 (en) * | 2003-09-26 | 2016-10-27 | Exelixis, Inc. | c-Met modulators and methods of use |
DK2210607T3 (da) * | 2003-09-26 | 2011-12-12 | Exelixis Inc | N-[3-fluor-4-({6-(methyloxy)-7-[(3-morpholin-4-ylpropyl)oxy]quinolin-4-yl}oxy)phenyl]-N'-(4-fluorphenyl)cyclopropan-1,1-dicarboxamid til behandling af kræft |
EP1683785B1 (fr) | 2003-11-11 | 2013-10-16 | Eisai R&D Management Co., Ltd. | Derive d'uree et son procede de production |
US7435823B2 (en) * | 2004-01-23 | 2008-10-14 | Amgen Inc. | Compounds and methods of use |
WO2005073224A2 (fr) | 2004-01-23 | 2005-08-11 | Amgen Inc | Composes et methodes d'utilisation de ces derniers |
TW200538097A (en) * | 2004-02-27 | 2005-12-01 | Eisai Co Ltd | Novel pyridine derivative and pyrimidine derivative |
US7459562B2 (en) | 2004-04-23 | 2008-12-02 | Bristol-Myers Squibb Company | Monocyclic heterocycles as kinase inhibitors |
CN101128199B (zh) * | 2004-04-23 | 2013-07-24 | 布里斯托尔-迈尔斯斯奎布公司 | 作为激酶抑制剂的单环杂环 |
TW200538453A (en) * | 2004-04-26 | 2005-12-01 | Bristol Myers Squibb Co | Bicyclic heterocycles as kinase inhibitors |
JP5097539B2 (ja) | 2004-05-07 | 2012-12-12 | アムジエン・インコーポレーテツド | タンパク質キナーゼ調節剤および使用方法 |
WO2005121125A1 (fr) * | 2004-06-09 | 2005-12-22 | Pfizer Inc. | Composes heteroaryle a liaison ether |
US7439246B2 (en) | 2004-06-28 | 2008-10-21 | Bristol-Myers Squibb Company | Fused heterocyclic kinase inhibitors |
US7432373B2 (en) | 2004-06-28 | 2008-10-07 | Bristol-Meyers Squibb Company | Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors |
US7173031B2 (en) * | 2004-06-28 | 2007-02-06 | Bristol-Myers Squibb Company | Pyrrolotriazine kinase inhibitors |
WO2006014325A2 (fr) * | 2004-07-02 | 2006-02-09 | Exelixis, Inc. | Modulateurs de c-met et leur methode d'utilisation |
RU2007107167A (ru) * | 2004-07-30 | 2008-09-10 | Метилджин, Инк. (Ca) | Ингибиторы передачи сигнала рецептора vegf и рецептора hgf |
KR20070053205A (ko) | 2004-09-17 | 2007-05-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 의약 조성물 |
MX2007006230A (es) * | 2004-11-30 | 2007-07-25 | Amgen Inc | Quinolinas y analogos de quinazolinas y su uso como medicamentos para tratar cancer. |
AU2006229343A1 (en) * | 2005-03-28 | 2006-10-05 | Kirin Pharma Kabushiki Kaisha | Thienopyridine derivative, or quinoline derivative, or quinazoline derivative, having c-Met autophosphorylation inhibiting potency |
WO2006108059A1 (fr) * | 2005-04-06 | 2006-10-12 | Exelixis, Inc. | Modulateurs c-met modulators et procedes d’utilisation |
JO2787B1 (en) * | 2005-04-27 | 2014-03-15 | امجين إنك, | Alternative amide derivatives and methods of use |
MX2007014617A (es) * | 2005-05-20 | 2008-02-11 | Methylgene Inc | Inhibidores de senalizacion de receptor de factor de crecimiento endotelial bascular y receptor de factor de crecimiento de hepatocitos. |
WO2008041053A2 (fr) * | 2005-05-20 | 2008-04-10 | Methylgene, Inc. | Inhibiteurs de la signalisation du récepteur vegf et du récepteur hgf |
AU2006265835B2 (en) | 2005-06-30 | 2012-05-03 | Amgen Inc. | Bis-aryl kinase inhibitors and their use in the treatment of inflammation, angiogenesis and cancer |
EP1925676A4 (fr) | 2005-08-02 | 2010-11-10 | Eisai R&D Man Co Ltd | Procédé d'analyse de l' effet d 'un inhibiteur de vascularisation |
SI1889836T1 (sl) * | 2005-08-24 | 2013-10-30 | Eisai R&D Management Co., Ltd. | Nov derivat piridina in derivat piridina (3) |
AU2006309551B2 (en) | 2005-11-07 | 2012-04-19 | Eisai R & D Management Co., Ltd. | Use of combination of anti-angiogenic substance and c-kit kinase inhibitor |
WO2008063202A2 (fr) * | 2006-01-30 | 2008-05-29 | Array Biopharma Inc. | Composés hétérobicycliques de thiophène et leurs méthodes d'utilisation |
US7868177B2 (en) | 2006-02-24 | 2011-01-11 | Amgen Inc. | Multi-cyclic compounds and method of use |
BRPI0708615A2 (pt) | 2006-03-07 | 2011-06-07 | Array Biopharma Inc | compostos de pirazol heterobicìclicos e métodos de uso |
CA2652442C (fr) | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Agent antitumoral destine au cancer de la thyroide |
US20080004273A1 (en) * | 2006-05-30 | 2008-01-03 | Stephane Raeppel | Inhibitors of protein tyrosine kinase activity |
WO2007146824A2 (fr) * | 2006-06-08 | 2007-12-21 | Array Biopharma Inc. | Quinolines et méthodes d'utilisation |
JP4948913B2 (ja) * | 2006-06-16 | 2012-06-06 | 上野製薬株式会社 | ナフタレンカルボン酸アミドの製造方法 |
CN101454311B (zh) * | 2006-08-23 | 2013-03-27 | 卫材R&D管理有限公司 | 苯氧基吡啶衍生物的盐和其结晶及其制备方法 |
US8865737B2 (en) | 2006-08-28 | 2014-10-21 | Eisai R&D Management Co., Ltd. | Antitumor agent for undifferentiated gastric cancer |
US7790885B2 (en) | 2006-08-31 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Process for preparing phenoxypyridine derivatives |
AU2007338793B2 (en) | 2006-12-20 | 2012-05-03 | Amgen Inc. | Heterocyclic compounds and their use in treating inflammation, angiogenesis and cancer |
CA2676796C (fr) | 2007-01-29 | 2016-02-23 | Eisai R & D Management Co., Ltd. | Composition destinee au traitement d'un cancer de l'estomac de type indifferencie |
DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
DK2183254T3 (en) | 2007-08-29 | 2017-09-11 | Methylgene Inc | INHIBITORS OF PROTEINTYROSINKINASE ACTIVITY |
US7795254B2 (en) * | 2007-10-29 | 2010-09-14 | Amgen Inc. | Benzomorpholine derivatives and methods of use |
CA2704000C (fr) | 2007-11-09 | 2016-12-13 | Eisai R&D Management Co., Ltd. | Combinaison d'une substance antiangiogenique et d'un complexe de platine antitumoral |
JP2009132660A (ja) | 2007-11-30 | 2009-06-18 | Eisai R & D Management Co Ltd | 食道癌治療用組成物 |
JP2009203226A (ja) * | 2008-01-31 | 2009-09-10 | Eisai R & D Management Co Ltd | ピリジン誘導体およびピリミジン誘導体を含有するレセプターチロシンキナーゼ阻害剤 |
US20100311972A1 (en) * | 2008-02-18 | 2010-12-09 | Mitsuo Nagai | Method for producing phenoxypyridine derivative |
SG10201608813PA (en) | 2008-03-17 | 2016-12-29 | Ambit Biosciences Corp | Quinazoline derivatives as raf kinase modulators and methods of use thereof |
BRPI0911679B8 (pt) * | 2008-04-10 | 2021-05-25 | Taiho Pharmaceutical Co Ltd | composto aciltioureia ou um sal do mesmo, uso do dito composto para tratar câncer, bem como agente farmacêutico, agente antitumoral e composição farmacêutica compreendendo dito composto |
AR073231A1 (es) * | 2008-08-29 | 2010-10-20 | Genentech Inc | Metodos diagnosticos y tratamientos para los tumores independientes del vegf (factor de crecimiento endotelial vascular) |
RU2011119478A (ru) * | 2008-10-14 | 2012-11-27 | Нин Си | Соединения и способы применения |
EP2365752B1 (fr) * | 2008-10-29 | 2014-09-24 | Deciphera Pharmaceuticals, Llc | Amides de cyclopropane et analogues présentant des activités anticancéreuses et antiprolifératives |
KR20110084455A (ko) * | 2008-11-13 | 2011-07-22 | 엑셀리시스, 인코포레이티드 | 퀴놀린 유도체를 제조하는 방법 |
DE102009003975A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Benzothiazolonderivate |
NZ618004A (en) | 2009-01-16 | 2015-06-26 | Exelixis Inc | Malate salt of n-(4-{ [6,7-bis(methyloxy)quinolin-4-yl]oxy} phenyl)-n’-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer |
EP2408300B1 (fr) * | 2009-03-21 | 2016-05-11 | Sunshine Lake Pharma Co., Ltd. | Dérivés d'ester d'amino, sels de ceux-ci et procédés d'utilisation |
KR101106050B1 (ko) * | 2009-03-25 | 2012-01-18 | 한국과학기술연구원 | 아미노퀴놀린 화합물, 이의 제조 방법 및 이를 함유하는 의약 조성물 |
EP2435444A1 (fr) * | 2009-05-28 | 2012-04-04 | Vertex Pharmaceuticals Incorporated | Inhibiteurs à base de pyrazole substitué de la protéine kinase c-met |
MX2012000809A (es) | 2009-07-17 | 2012-03-14 | Exelixis Inc | Formas cristalinas de n-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin- 4-ilpropil)oxi]-quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclop ropan-1,1-dicarboxamida. |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
CA2802644C (fr) | 2010-06-25 | 2017-02-21 | Eisai R & D Management Co., Ltd. | Agent anticancereux utilisant des composes ayant un effet inhibiteur de kinase en combinaison |
EP2594566A4 (fr) | 2010-07-16 | 2014-10-01 | Kyowa Hakko Kirin Co Ltd | Dérivé de cycle hétérocyclique aromatique azoté |
JP2013537918A (ja) | 2010-09-27 | 2013-10-07 | エクセリクシス, インク. | 去勢抵抗性前立腺癌および骨芽細胞骨転移の治療のためのmetおよびvegfの二元阻害薬 |
BR112013021941B1 (pt) | 2011-04-18 | 2022-11-16 | Eisai R & D Management Co., Ltd | Agente terapêutico para tumor |
US9945862B2 (en) | 2011-06-03 | 2018-04-17 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
CN102643268B (zh) * | 2011-12-30 | 2014-05-21 | 沈阳药科大学 | 喹啉类及噌啉类化合物及其应用 |
WO2013143376A1 (fr) * | 2012-03-26 | 2013-10-03 | 武汉盛云生物医药科技有限责任公司 | Composés quinoline contenant la 1,2,4-triazine-3,5-dione et leur utilisation |
WO2013152252A1 (fr) | 2012-04-06 | 2013-10-10 | OSI Pharmaceuticals, LLC | Polythérapie antinéoplasique |
WO2013180128A1 (fr) * | 2012-05-28 | 2013-12-05 | 協和発酵キリン株式会社 | Dérivé de 4-[4-(hétérocyclique aromatique à 5 chaînons carbonyl uréide)phényloxy]quinoléine |
EP2864291B1 (fr) | 2012-06-26 | 2016-10-05 | Bayer Pharma Aktiengesellschaft | N-[4-(quinolin-4-yloxy)cyclohexyl(méthyl)](hétéro)arylcarboxamides utilisables en tant qu'antagonistes des récepteurs aux androgènes, leur production et leur utilisation en tant que médicaments |
WO2014038881A2 (fr) * | 2012-09-06 | 2014-03-13 | 씨제이제일제당 (주) | Inhibiteur de protéine kinase comprenant des dérivés de pyridine |
AU2013364953A1 (en) | 2012-12-21 | 2015-04-30 | Eisai R&D Management Co., Ltd. | Amorphous form of quinoline derivative, and method for producing same |
JP6669499B2 (ja) * | 2013-02-15 | 2020-03-18 | カラ ファーマシューティカルズ インコーポレイテッド | 治療用化合物 |
US9695184B2 (en) | 2013-02-15 | 2017-07-04 | Kala Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
US9382228B2 (en) * | 2013-03-15 | 2016-07-05 | Deciphera Pharmaceuticals, Llc | N-acyl-N′-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities |
NZ714049A (en) | 2013-05-14 | 2020-05-29 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
MX2016012285A (es) | 2014-03-24 | 2017-01-23 | Genentech Inc | Tratamiento de cáncer con antagonista de c-met y correlación de estos con la expresión de hgf. |
EP2974729A1 (fr) | 2014-07-17 | 2016-01-20 | Abivax | Dérivés de quinoléine utilisés dans le traitement de maladies inflammatoires |
KR102329681B1 (ko) | 2014-08-28 | 2021-11-23 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 고순도의 퀴놀린 유도체 및 이를 제조하는 방법 |
PT3263106T (pt) | 2015-02-25 | 2024-01-12 | Eisai R&D Man Co Ltd | Método para suprimir o amargor do derivado de quinolina |
AU2015384801B2 (en) | 2015-03-04 | 2022-01-06 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer |
AU2016279474B2 (en) | 2015-06-16 | 2021-09-09 | Eisai R&D Management Co., Ltd. | Anticancer agent |
MX2018004109A (es) | 2015-10-05 | 2018-09-27 | Univ Columbia | Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías. |
EP3246028A1 (fr) * | 2016-05-18 | 2017-11-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Composés de quinoléine pour augmenter la libération d'insuline |
JP7105774B2 (ja) | 2016-12-01 | 2022-07-25 | イグナイタ インコーポレイテッド | がん治療のための方法 |
CA3053739C (fr) | 2017-02-15 | 2023-02-14 | Taiho Pharmaceutical Co., Ltd. | Composition pharmaceutique |
KR102584306B1 (ko) * | 2017-09-08 | 2023-10-04 | 다이호야쿠힌고교 가부시키가이샤 | 항종양제 및 항종양 효과 증강제 |
CN109824587A (zh) * | 2017-11-23 | 2019-05-31 | 上海翔锦生物科技有限公司 | 酪氨酸激酶抑制剂xjf007及其中间体的制备方法 |
CA3090876C (fr) | 2018-02-11 | 2022-12-06 | Beijing Scitech-Mq Pharmaceuticals Limited | Compose de dioxazoline, son procede de preparation et ses applications |
US11702425B2 (en) | 2018-08-01 | 2023-07-18 | Agency For Science, Technology And Research | Bicyclic compounds as kinase modulators, methods and uses thereof |
EP3669873A1 (fr) | 2018-12-20 | 2020-06-24 | Abivax | Dérivés de quinoline destinés à être utilisés dans le traitement de maladies inflammatoires |
PL3902547T3 (pl) | 2018-12-28 | 2024-02-26 | Deciphera Pharmaceuticals, Llc | Inhibitory CSF1R do stosowania w leczeniu nowotworu złośliwego |
CN111848580B (zh) * | 2019-04-30 | 2021-09-14 | 武汉盛云生物医药科技有限责任公司 | 含1,2,4-三嗪-3,5-二酮的喹啉类化合物的晶型及其制备方法和应用 |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5772968A (en) | 1980-10-24 | 1982-05-07 | Nissan Chem Ind Ltd | Aniline derivative and its preparation |
US4425343A (en) | 1980-10-24 | 1984-01-10 | Nissan Chemical Industries, Ltd. | Benzoazine ether or thioether linkage containing urea compounds, process for producing same and insecticides containing said compounds |
IL83488A (en) | 1986-08-15 | 1991-12-15 | Ciba Geigy Ag | Heterocyclic substituted thioureas,isothioureas and carbodiimides,process for their preparation and insecticidal and acaricidal compositions containing them |
US5624937A (en) | 1995-03-02 | 1997-04-29 | Eli Lilly And Company | Chemical compounds as inhibitors of amyloid beta protein production |
WO1997017329A1 (fr) | 1995-11-07 | 1997-05-15 | Kirin Beer Kabushiki Kaisha | Derives de quinoline et derives de quinazoline inhibant l'autophosphorylation d'un recepteur de facteur de croissance originaire de plaquettes, et compositions pharmaceutiques les contenant |
JPH09328782A (ja) | 1996-06-12 | 1997-12-22 | Shin Caterpillar Mitsubishi Ltd | 建設機械の作業機制御装置 |
US6069151A (en) * | 1996-11-06 | 2000-05-30 | Darwin Discovery, Ltd. | Quinolines and their therapeutic use |
JP4303792B2 (ja) | 1997-04-18 | 2009-07-29 | 協和発酵キリン株式会社 | キノロン誘導体の製造方法 |
JP4194678B2 (ja) | 1997-11-28 | 2008-12-10 | キリンファーマ株式会社 | キノリン誘導体およびそれを含む医薬組成物 |
US7143764B1 (en) * | 1998-03-13 | 2006-12-05 | Astrazeneca Ab | Inhalation device |
FR2788768B1 (fr) | 1999-01-21 | 2001-02-16 | Oreal | Nouveaux 2-acylaminophenols cationiques, leur utilisation a titre de coupleur pour la teinture d'oxydation, compositions les comprenant, et procedes de teinture |
BR0007656A (pt) * | 1999-01-22 | 2001-10-30 | Kirin Brewery | Composto,composição farmacêutica, uso docomposto, e, métodos para tratar uma doençaselecionada do grupo que consiste de tumor,retinopatia diabética, reumatismo crÈnico,psorìase, aterosclerose, e sarcoma de kaposi epara inibir a angiogênese de vasossanguineos-alvo |
GB9922173D0 (en) * | 1999-09-21 | 1999-11-17 | Zeneca Ltd | Chemical compounds |
JP4592856B2 (ja) | 1999-12-24 | 2010-12-08 | 東京エレクトロン株式会社 | バッフル板及びガス処理装置 |
US7135466B2 (en) | 1999-12-24 | 2006-11-14 | Kirin Beer Kabushiki Kaisha | Quinoline and quinazoline derivatives and drugs containing the same |
KR100589032B1 (ko) | 2000-10-20 | 2006-06-14 | 에자이 가부시키가이샤 | 질소 함유 방향환 유도체 |
DE60226912D1 (de) * | 2001-04-27 | 2008-07-10 | Kirin Pharma K K | Chinolin- und Chianzolinderivate zur Behandlung von Tumoren |
EP1447405A4 (fr) * | 2001-10-17 | 2005-01-12 | Kirin Brewery | Derives de quinoline ou de quinazoline inhibant l'autophosphorylation de recepteurs du facteur de croissance des fibroblastes |
-
2002
- 2002-06-21 KR KR1020037016646A patent/KR100883731B1/ko not_active IP Right Cessation
- 2002-06-21 EP EP02738777A patent/EP1411046B1/fr not_active Expired - Lifetime
- 2002-06-21 CN CNB028161211A patent/CN100415720C/zh not_active Expired - Fee Related
- 2002-06-21 AT AT02738777T patent/ATE443047T1/de not_active IP Right Cessation
- 2002-06-21 EP EP10179308A patent/EP2258366B1/fr not_active Expired - Lifetime
- 2002-06-21 US US10/480,632 patent/US7425564B2/en not_active Expired - Fee Related
- 2002-06-21 DE DE60233736T patent/DE60233736D1/de not_active Expired - Lifetime
- 2002-06-21 CA CA002454538A patent/CA2454538A1/fr not_active Abandoned
- 2002-06-21 AU AU2002313249A patent/AU2002313249B2/en not_active Ceased
- 2002-06-21 EP EP09160115A patent/EP2088141A3/fr not_active Withdrawn
- 2002-06-21 JP JP2003507066A patent/JP4342935B2/ja not_active Expired - Fee Related
- 2002-06-21 WO PCT/JP2002/006239 patent/WO2003000660A1/fr active Application Filing
-
2005
- 2005-05-10 HK HK05103925.9A patent/HK1071136A1/xx not_active IP Right Cessation
-
2008
- 2008-07-17 US US12/175,361 patent/US20080312221A1/en not_active Abandoned
-
2011
- 2011-01-10 US US12/987,610 patent/US8324245B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPWO2003000660A1 (ja) | 2004-10-07 |
CN1553899A (zh) | 2004-12-08 |
AU2002313249B2 (en) | 2008-08-21 |
EP2258366B1 (fr) | 2013-04-03 |
JP4342935B2 (ja) | 2009-10-14 |
US8324245B2 (en) | 2012-12-04 |
EP2258366A2 (fr) | 2010-12-08 |
EP1411046A1 (fr) | 2004-04-21 |
DE60233736D1 (de) | 2009-10-29 |
EP2258366A3 (fr) | 2012-01-18 |
US20040242603A1 (en) | 2004-12-02 |
EP1411046A4 (fr) | 2005-08-31 |
EP1411046B1 (fr) | 2009-09-16 |
US7425564B2 (en) | 2008-09-16 |
CA2454538A1 (fr) | 2003-01-03 |
EP2088141A2 (fr) | 2009-08-12 |
WO2003000660A1 (fr) | 2003-01-03 |
EP2088141A3 (fr) | 2009-11-18 |
US20080312221A1 (en) | 2008-12-18 |
CN100415720C (zh) | 2008-09-03 |
ATE443047T1 (de) | 2009-10-15 |
KR20040030690A (ko) | 2004-04-09 |
US20110105747A1 (en) | 2011-05-05 |
KR100883731B1 (ko) | 2009-02-12 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1071136A1 (en) | Quinoline derivative and quinazoline derivative and medicinal composition containing the same | |
CA2107014A1 (fr) | Agent therapeutique pour la maladie de parkinson | |
IE46167L (en) | Alkaloid-containing nasal pharmaceutical compositions | |
HUT64336A (en) | Methods for producing new thiazole-benzofurane derivatives and pharmaceutical preparatives containing them | |
IL104024A (en) | 4-pyrimidinyl and pyridinyl derivatives of indol-3-yl- alkyl piperazines and antimigraine pharmaceutical compositions containing them | |
MY127718A (en) | Dolastatin 10 derivatives. | |
YU86383A (en) | Process for obtaining ethanolamine derivatives | |
EP0092391A3 (fr) | Dérivés de la pipéridine et les compositions pharmaceutiques les contenant | |
ES8107201A1 (es) | Un procedimiento para la preparacion de derivados de morfo- lina | |
MXPA03005822A (es) | Compuestos heterociclicos que tienen actividad antibacteriana, proceso para su preparacion y composiciones farmaceuticas que los contienen. | |
MXPA02004448A (es) | Derivados de imidazopiridina como inhibidores de la fosfodiesterasa vii. | |
ES8302001A1 (es) | Un procedimiento para la preparacion de nuevos derivados de cefalospirina. | |
DE60105610D1 (en) | Pyrazinonderivate | |
WO1989007441A1 (fr) | Procede et agent anti-oncogene contenant de la 6-amino-1, 2-benzopyrone | |
EP0123962A3 (en) | Novel benzimidazole derivative, process for the preparation thereof and pharmaceutical composition | |
ES476385A1 (es) | Un procedimiento para preparar derivados de transpirindina | |
NZ225528A (en) | Benzimidazoles substituted in the 2 position by n(4-n-guanidyl) piperidinyl radicals; preparations thereof; pharmaceutical compositions | |
ES8600224A1 (es) | Procedimiento de preparacion de nuevos derivados carbamiloxibenzoles | |
AP2002002494A0 (en) | Hygromycin derivatives. | |
AU2002222225A1 (en) | Substituted-4-quinolones | |
EP0017352A3 (fr) | Dérivés de chromanone, procédé pour leur préparation, compositions les contenant | |
IL147307A0 (en) | Indolocarbazole alkaloid derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof | |
IL115085A0 (en) | Bicyclic carboxamide derivatives their preparation and pharmaceutical compositions containing them | |
ES8801652A1 (es) | Un procedimiento para la preparacion de un derivado de tiazolidina. | |
ES8308332A1 (es) | Un procedimiento para la preparacion de nuevos derivados de fosfolipidos. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20130621 |