WO1989007441A1 - Procede et agent anti-oncogene contenant de la 6-amino-1, 2-benzopyrone - Google Patents

Procede et agent anti-oncogene contenant de la 6-amino-1, 2-benzopyrone Download PDF

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Publication number
WO1989007441A1
WO1989007441A1 PCT/US1989/000516 US8900516W WO8907441A1 WO 1989007441 A1 WO1989007441 A1 WO 1989007441A1 US 8900516 W US8900516 W US 8900516W WO 8907441 A1 WO8907441 A1 WO 8907441A1
Authority
WO
WIPO (PCT)
Prior art keywords
benzopyrone
amino
cells
compound
dex
Prior art date
Application number
PCT/US1989/000516
Other languages
English (en)
Inventor
Alexander Tseng, Jr.
Jerome Mclick
Hakam Alaeddin
Original Assignee
The Regents Of The University Of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Regents Of The University Of California filed Critical The Regents Of The University Of California
Publication of WO1989007441A1 publication Critical patent/WO1989007441A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen

Abstract

On administre à un mammifère hôte 6-amino-1, 2-benzopyrone en tant qu'agent chimiopréventif ou anti-oncogène afin d'inhiber la formation de tumeurs. De préférence, l'administration se fait par une dose orale quotidienne d'environ 100 mg par jour.
PCT/US1989/000516 1988-02-10 1989-02-09 Procede et agent anti-oncogene contenant de la 6-amino-1, 2-benzopyrone WO1989007441A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US15485388A 1988-02-10 1988-02-10
US154,853 1988-02-10

Publications (1)

Publication Number Publication Date
WO1989007441A1 true WO1989007441A1 (fr) 1989-08-24

Family

ID=22553082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1989/000516 WO1989007441A1 (fr) 1988-02-10 1989-02-09 Procede et agent anti-oncogene contenant de la 6-amino-1, 2-benzopyrone

Country Status (1)

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WO (1) WO1989007441A1 (fr)

Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991004663A1 (fr) 1989-09-26 1991-04-18 The Regents Of The University Of California 6-amino-1,2-benzopyrones utiles dans le traitement de maladies virales
WO1992018123A2 (fr) * 1991-04-10 1992-10-29 Octamer, Inc. Procede d'inhibition de la replication retrovirale
US5262564A (en) * 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
US5482975A (en) * 1991-10-22 1996-01-09 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5484951A (en) * 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
US5516941A (en) * 1991-10-22 1996-05-14 Octamer, Inc. Specific inactivators of "retroviral" (asymmetric) zinc fingers
WO1996022791A1 (fr) * 1995-01-13 1996-08-01 Octamer, Inc. Nouvelles compositions synergiques antitumorales et antiretrovirales
US5652260A (en) * 1991-10-22 1997-07-29 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compound useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5783599A (en) * 1993-02-24 1998-07-21 Octamer Inc Methods of treating cancer and viral infections with 5-iodo-6-amino-and 5-iodo-6-nitroso-1 2-benzopyrones
WO2001016108A2 (fr) * 1999-08-27 2001-03-08 Ligand Pharmaceuticals Incorporated Composes de modulateur de recepteur de progesterone et d'androgene bicyclique et procedes correspondants
US6462038B1 (en) 1999-08-27 2002-10-08 Ligand Pharmaceuticals, Inc. Androgen receptor modulator compounds and methods
US6593493B1 (en) 1999-09-14 2003-07-15 Ligand Pharmaceuticals, Inc. RXR modulators with improved pharmacologic profile
US6667313B1 (en) 1999-08-27 2003-12-23 Ligand Pharmaceuticals Inc. 8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators
US7727980B2 (en) 2001-02-23 2010-06-01 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
US7816372B2 (en) 2003-08-22 2010-10-19 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Volume 60, Abstract No. 15017c (KITAGAWA et al.), "Coumarin derivatives for medical purposes", (1964). *

Cited By (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0494231A1 (fr) * 1989-09-26 1992-07-15 The Regents Of The University Of California 6-amino-1,2-benzopyrones utiles dans le traitement de maladies virales
EP0494231A4 (en) * 1989-09-26 1992-09-16 The Regents Of The University Of California 6-amino-1,2-benzopyrones useful for treatment of viral diseases
WO1991004663A1 (fr) 1989-09-26 1991-04-18 The Regents Of The University Of California 6-amino-1,2-benzopyrones utiles dans le traitement de maladies virales
US5583155A (en) * 1989-09-26 1996-12-10 Octamer, Inc. 6-amino-1,2-benzopyrones useful for treatment of viral diseases
US5519053A (en) * 1990-10-19 1996-05-21 Octamer, Inc. 5-Iodo-6-amino-1,2-Benzopyrones and their metabolites useful as cytostatic agents
US5484951A (en) * 1990-10-19 1996-01-16 Octamer, Incorporated 5-iodo-6-amino-6-nitroso-1,2-benzopyrones useful as cytostatic and antiviral agents
WO1992018123A2 (fr) * 1991-04-10 1992-10-29 Octamer, Inc. Procede d'inhibition de la replication retrovirale
WO1992018123A3 (fr) * 1991-04-10 1993-03-04 Octamer Inc Procede d'inhibition de la replication retrovirale
US5652260A (en) * 1991-10-22 1997-07-29 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compound useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5516941A (en) * 1991-10-22 1996-05-14 Octamer, Inc. Specific inactivators of "retroviral" (asymmetric) zinc fingers
US5482975A (en) * 1991-10-22 1996-01-09 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents and anti-tumor agents
US5753674A (en) * 1991-10-22 1998-05-19 Octamer, Inc. Adenosine diphosphoribose polymerase binding nitroso aromatic compounds useful as retroviral inactivating agents, anti-retroviral agents, anti-retroviral agents and anti-tumor agents
US5877185A (en) * 1991-10-22 1999-03-02 Octamer, Inc. Synergistic compositions useful as anti-tumor agents
US5262564A (en) * 1992-10-30 1993-11-16 Octamer, Inc. Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents
US5783599A (en) * 1993-02-24 1998-07-21 Octamer Inc Methods of treating cancer and viral infections with 5-iodo-6-amino-and 5-iodo-6-nitroso-1 2-benzopyrones
WO1996022791A1 (fr) * 1995-01-13 1996-08-01 Octamer, Inc. Nouvelles compositions synergiques antitumorales et antiretrovirales
WO2001016108A3 (fr) * 1999-08-27 2001-12-20 Ligand Pharm Inc Composes de modulateur de recepteur de progesterone et d'androgene bicyclique et procedes correspondants
WO2001016108A2 (fr) * 1999-08-27 2001-03-08 Ligand Pharmaceuticals Incorporated Composes de modulateur de recepteur de progesterone et d'androgene bicyclique et procedes correspondants
US6462038B1 (en) 1999-08-27 2002-10-08 Ligand Pharmaceuticals, Inc. Androgen receptor modulator compounds and methods
US6566372B1 (en) 1999-08-27 2003-05-20 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
US6667313B1 (en) 1999-08-27 2003-12-23 Ligand Pharmaceuticals Inc. 8-substituted-6-triflouromethyl-9-pyrido [3,2-G] quinoline compounds as androgen receptor modulators
US7696246B2 (en) 1999-08-27 2010-04-13 Ligand Pharmaceuticals Incorporated Bicyclic androgen and progesterone receptor modulator compounds and methods
US6593493B1 (en) 1999-09-14 2003-07-15 Ligand Pharmaceuticals, Inc. RXR modulators with improved pharmacologic profile
US7727980B2 (en) 2001-02-23 2010-06-01 Ligand Pharmaceuticals Incorporated Tricyclic androgen receptor modulator compounds and methods
US7816372B2 (en) 2003-08-22 2010-10-19 Ligand Pharmaceuticals Incorporated 6-cycloamino-2-quinolinone derivatives as androgen receptor modulator compounds

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