ES476385A1 - Un procedimiento para preparar derivados de transpirindina - Google Patents
Un procedimiento para preparar derivados de transpirindinaInfo
- Publication number
- ES476385A1 ES476385A1 ES476385A ES476385A ES476385A1 ES 476385 A1 ES476385 A1 ES 476385A1 ES 476385 A ES476385 A ES 476385A ES 476385 A ES476385 A ES 476385A ES 476385 A1 ES476385 A1 ES 476385A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- pyrindines
- chem
- alkyl
- except
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un procedimiento para preparar derivados de transpirindina de fórmula general **fórmula** en donde R''1 es hidrógeno, alquilo de 1 a 8 átomos de carbono, CH2R''3¿o --(CH2)n-(X)m **fórmula**; en la cual : R3 es alquenilo de 2 a 7 átomos de carabono, cicloalquilo de 3 a 6 átomos de carbono, furilo o tetrahidrofurilo; R4 y R5 independientemente son hidrógenos, alquilo de 1 a 3 átomos de carbono, o halógeno ; n es 0, 1, 2 ó 3; m es 0 ó 1, excepto que cuando m es 0, n es diferente de O; X CO, CHOH, CH=CH; SA u O, excepto que cuando n es O, X es diferente de S u O; R2 es hidrógeno , hidroxi, alcoxi de 1 a 3 átomos de carbono o alcanoiloxi de 1 a 3 átomos de carbono ; y sus sales de adición de ácido farmacéuticamente aceptables; cuyo procedimiento comprende: a)hacer reaccionar un compuesto de fórmula general ** fórmula** en donde : R1 es hidrógeno , alquilo de 1 a 8 átomos de carbono, **Fórmulas** R''3 es cicloalquilo de 3 a 6 átomos de carbono, furilo o tetrahidrofurilo; R4 y R5 independientemete son hidrógeno , alquilo de 1 a 3 átomos de carbono, o halógeno; n es , 1, 2 ó 3; m es ó 1 excepto que cuando m es , es diferente a , X es CO, CHOH, CH=CH, S u O, excepto que cuando n es , X es diferente de S u O; R2 es hidrógeno , hidroxi, alcoxi de 1 a 3 átomos de carbono o alcanoliloxi de 1 a 3 átomos de carbono; con hidrógeno y óxido de platino; B) si se desea y cuando R1 es hidrógeno, someter a reacción de alquilación el producto de la etapa anterior; c) opcionalmente , convertir los grupos R2 en otros grupos R2 comprendididos dentro de las definiciones y, si se desea, formar las sales de ácidos farmacéuticamente aceptables de los compuestos obtenidos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US86489977A | 1977-12-27 | 1977-12-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES476385A1 true ES476385A1 (es) | 1979-11-16 |
Family
ID=25344312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES476385A Expired ES476385A1 (es) | 1977-12-27 | 1978-12-27 | Un procedimiento para preparar derivados de transpirindina |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP0002937A1 (es) |
JP (1) | JPS5498770A (es) |
AR (1) | AR221352A1 (es) |
AU (1) | AU4286678A (es) |
BE (1) | BE872990A (es) |
BG (1) | BG30927A3 (es) |
CA (1) | CA1105026A (es) |
CS (1) | CS203940B2 (es) |
DD (1) | DD141156A5 (es) |
DK (1) | DK577078A (es) |
ES (1) | ES476385A1 (es) |
FI (1) | FI783992A (es) |
FR (1) | FR2413370A1 (es) |
GB (1) | GB2010806A (es) |
GR (1) | GR70349B (es) |
IL (1) | IL56268A0 (es) |
IT (1) | IT1101682B (es) |
LU (1) | LU80719A1 (es) |
NZ (1) | NZ189230A (es) |
PL (1) | PL117572B1 (es) |
PT (1) | PT68934A (es) |
RO (1) | RO75805A (es) |
SU (1) | SU841586A3 (es) |
ZA (1) | ZA787156B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4415736A (en) * | 1981-12-28 | 1983-11-15 | E. I. Du Pont De Nemours & Co. | Certain tetrahydropyridine intermediates |
US4579952A (en) * | 1981-12-28 | 1986-04-01 | E. I. Du Pont De Nemours And Company | Intermediates for octahydrobenzofuro[3,2-e]isoquinolines |
US4537963A (en) * | 1981-12-28 | 1985-08-27 | E. I. Du Pont De Nemours And Company | Intermediates for octahydrobenzofuro[3,2-E]isoquinolines |
FR2617481B1 (fr) * | 1987-07-03 | 1989-11-10 | Roussel Uclaf | Nouveaux derives de la tetrahydropyridine, leur procede de preparation et les intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
WO2011140425A1 (en) | 2010-05-06 | 2011-11-10 | Vertex Pharmaceuticals Incorporated | Heterocyclic chromene-spirocyclic piperidine amides as modulators of ion channels |
AR085893A1 (es) | 2011-02-02 | 2013-11-06 | Vertex Pharma | Pirrolopirazina-amidas de piperidina espirociclica como moduladores de los canales ionicos |
CA2827311A1 (en) | 2011-02-18 | 2012-08-23 | Vertex Pharmaceuticals Incorporated | Chroman-spirocyclic piperidine amides as modulators of ion channels |
EP2686325B1 (en) | 2011-03-14 | 2016-12-14 | Vertex Pharmaceuticals Incorporated | Morpholine-spirocyclic piperidine amides as modulators of ion channels |
ES2780699T3 (es) * | 2013-07-10 | 2020-08-26 | Vertex Pharma | Amidas de piperidina fusionadas útiles como moduladores de canales iónicos |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1024149A (en) * | 1972-07-20 | 1978-01-10 | E.I. Du Pont De Nemours And Company | 4.alpha.-ARYL-TRANS-DECAHYDROISOQUINOLINES |
ZA734895B (en) * | 1972-07-20 | 1974-06-26 | Du Pont | Analgesigs and/or narcotic antagonists |
PT67194B (en) * | 1976-11-02 | 1979-03-23 | Lilly Co Eli | Process for preparing 4a-aryl-octahydro-1h-2-pyrindines |
-
1978
- 1978-12-19 PL PL1978211919A patent/PL117572B1/pl unknown
- 1978-12-19 NZ NZ189230A patent/NZ189230A/xx unknown
- 1978-12-19 PT PT68934A patent/PT68934A/pt unknown
- 1978-12-19 BG BG041785A patent/BG30927A3/xx unknown
- 1978-12-20 GR GR57949A patent/GR70349B/el unknown
- 1978-12-20 ZA ZA787156A patent/ZA787156B/xx unknown
- 1978-12-20 AR AR274886A patent/AR221352A1/es active
- 1978-12-20 RO RO7895989A patent/RO75805A/ro unknown
- 1978-12-20 CA CA318,284A patent/CA1105026A/en not_active Expired
- 1978-12-21 FR FR7835977A patent/FR2413370A1/fr not_active Withdrawn
- 1978-12-21 GB GB7849437A patent/GB2010806A/en not_active Withdrawn
- 1978-12-21 IL IL56268A patent/IL56268A0/xx unknown
- 1978-12-21 EP EP78300879A patent/EP0002937A1/en not_active Withdrawn
- 1978-12-22 DK DK577078A patent/DK577078A/da not_active Application Discontinuation
- 1978-12-22 AU AU42866/78A patent/AU4286678A/en active Pending
- 1978-12-22 BE BE1009211A patent/BE872990A/xx unknown
- 1978-12-22 LU LU80719A patent/LU80719A1/xx unknown
- 1978-12-22 IT IT31268/78A patent/IT1101682B/it active
- 1978-12-22 CS CS788854A patent/CS203940B2/cs unknown
- 1978-12-25 JP JP16448778A patent/JPS5498770A/ja active Pending
- 1978-12-26 SU SU782701053A patent/SU841586A3/ru active
- 1978-12-27 ES ES476385A patent/ES476385A1/es not_active Expired
- 1978-12-27 DD DD78210204A patent/DD141156A5/de unknown
- 1978-12-27 FI FI783992A patent/FI783992A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
JPS5498770A (en) | 1979-08-03 |
NZ189230A (en) | 1981-05-15 |
BG30927A3 (en) | 1981-09-15 |
AR221352A1 (es) | 1981-01-30 |
FI783992A (fi) | 1979-06-28 |
IL56268A0 (en) | 1979-03-12 |
PL211919A1 (pl) | 1979-09-10 |
AU4286678A (en) | 1979-07-05 |
CA1105026A (en) | 1981-07-14 |
GB2010806A (en) | 1979-07-04 |
ZA787156B (en) | 1980-08-27 |
BE872990A (fr) | 1979-06-22 |
GR70349B (es) | 1982-09-23 |
PT68934A (en) | 1979-01-01 |
DD141156A5 (de) | 1980-04-16 |
IT1101682B (it) | 1985-10-07 |
CS203940B2 (en) | 1981-03-31 |
RO75805A (ro) | 1981-02-28 |
EP0002937A1 (en) | 1979-07-11 |
SU841586A3 (ru) | 1981-06-23 |
LU80719A1 (fr) | 1979-04-13 |
DK577078A (da) | 1979-06-28 |
IT7831268A0 (it) | 1978-12-22 |
PL117572B1 (en) | 1981-08-31 |
FR2413370A1 (fr) | 1979-07-27 |
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