HK1065801A1 - Quinazoline derivatives as antitumor agents - Google Patents
Quinazoline derivatives as antitumor agentsInfo
- Publication number
- HK1065801A1 HK1065801A1 HK04108771.4A HK04108771A HK1065801A1 HK 1065801 A1 HK1065801 A1 HK 1065801A1 HK 04108771 A HK04108771 A HK 04108771A HK 1065801 A1 HK1065801 A1 HK 1065801A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antitumor agents
- quinazoline derivatives
- quinazoline
- derivatives
- antitumor
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C04—CEMENTS; CONCRETE; ARTIFICIAL STONE; CERAMICS; REFRACTORIES
- C04B—LIME, MAGNESIA; SLAG; CEMENTS; COMPOSITIONS THEREOF, e.g. MORTARS, CONCRETE OR LIKE BUILDING MATERIALS; ARTIFICIAL STONE; CERAMICS; REFRACTORIES; TREATMENT OF NATURAL STONE
- C04B35/00—Shaped ceramic products characterised by their composition; Ceramics compositions; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/622—Forming processes; Processing powders of inorganic compounds preparatory to the manufacturing of ceramic products
- C04B35/626—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B
- C04B35/63—Preparing or treating the powders individually or as batches ; preparing or treating macroscopic reinforcing agents for ceramic products, e.g. fibres; mechanical aspects section B using additives specially adapted for forming the products, e.g.. binder binders
- C04B35/632—Organic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Manufacturing & Machinery (AREA)
- Ceramic Engineering (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Structural Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0126433.2A GB0126433D0 (en) | 2001-11-03 | 2001-11-03 | Compounds |
PCT/GB2002/004932 WO2003040109A2 (en) | 2001-11-03 | 2002-10-31 | Quinazoline derivatives as antitumor agents |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1065801A1 true HK1065801A1 (en) | 2005-03-04 |
Family
ID=9925096
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK04108771.4A HK1065801A1 (en) | 2001-11-03 | 2004-11-08 | Quinazoline derivatives as antitumor agents |
Country Status (25)
Country | Link |
---|---|
US (2) | US20050054662A1 (ko) |
EP (1) | EP1444211B1 (ko) |
JP (1) | JP2005511603A (ko) |
KR (1) | KR20050042058A (ko) |
CN (1) | CN1764651A (ko) |
AR (1) | AR037193A1 (ko) |
AT (1) | ATE421507T1 (ko) |
BR (1) | BR0213843A (ko) |
CA (1) | CA2465100A1 (ko) |
CO (1) | CO5580775A2 (ko) |
DE (1) | DE60230995D1 (ko) |
ES (1) | ES2319880T3 (ko) |
GB (1) | GB0126433D0 (ko) |
HK (1) | HK1065801A1 (ko) |
HU (1) | HUP0401994A2 (ko) |
IL (1) | IL161620A0 (ko) |
IS (1) | IS7241A (ko) |
MX (1) | MXPA04004220A (ko) |
NO (1) | NO20042288L (ko) |
NZ (1) | NZ532523A (ko) |
PL (1) | PL369833A1 (ko) |
RU (1) | RU2004116908A (ko) |
TW (1) | TW200302221A (ko) |
WO (1) | WO2003040109A2 (ko) |
ZA (2) | ZA200403203B (ko) |
Families Citing this family (71)
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CA2441492C (en) * | 2001-03-23 | 2011-08-09 | Bayer Corporation | Rho-kinase inhibitors |
DK1370552T3 (da) * | 2001-03-23 | 2007-05-07 | Bayer Pharmaceuticals Corp | Rho-kinase-inhibitorer |
KR20050042055A (ko) * | 2001-11-03 | 2005-05-04 | 아스트라제네카 아베 | 항종양제로서의 퀴나졸린 유도체 |
RU2362774C1 (ru) * | 2002-02-01 | 2009-07-27 | Астразенека Аб | Хиназолиновые соединения |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
ES2400339T3 (es) | 2002-07-15 | 2013-04-09 | Symphony Evolution, Inc. | Compuestos, composiciones farmacéuticas de los mismos y su uso en el tratamiento del cáncer |
GB0309009D0 (en) * | 2003-04-22 | 2003-05-28 | Astrazeneca Ab | Quinazoline derivatives |
GB0309850D0 (en) * | 2003-04-30 | 2003-06-04 | Astrazeneca Ab | Quinazoline derivatives |
US8309562B2 (en) | 2003-07-03 | 2012-11-13 | Myrexis, Inc. | Compounds and therapeutical use thereof |
GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
EP1667996B1 (en) * | 2003-09-16 | 2009-07-22 | Astrazeneca AB | Quinazoline derivatives |
WO2005026151A1 (en) * | 2003-09-16 | 2005-03-24 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
ATE395346T1 (de) * | 2003-09-16 | 2008-05-15 | Astrazeneca Ab | Chinazolinderivate als tyrosinkinaseinhibitoren |
GB0321648D0 (en) * | 2003-09-16 | 2003-10-15 | Astrazeneca Ab | Quinazoline derivatives |
AU2004272345A1 (en) * | 2003-09-16 | 2005-03-24 | Astrazeneca Ab | Quinazoline derivatives |
GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
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DE10345875A1 (de) * | 2003-09-30 | 2005-04-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Vewendung und Verfahren zu ihrer Herstellung |
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WO2019196622A1 (zh) * | 2018-04-09 | 2019-10-17 | 威尚(上海)生物医药有限公司 | 具有穿过血脑屏障能力的5取代二氟哌啶化合物 |
CN110357858B (zh) | 2018-04-09 | 2022-02-18 | 威尚(上海)生物医药有限公司 | 具有穿过血脑屏障能力的5取代二氟哌啶化合物 |
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CN115894383A (zh) * | 2021-09-30 | 2023-04-04 | 北京赛特明强医药科技有限公司 | 一种喹唑啉类化合物、组合物及其应用 |
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US20020082270A1 (en) * | 2000-08-26 | 2002-06-27 | Frank Himmelsbach | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
US6562319B2 (en) * | 2001-03-12 | 2003-05-13 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Radiolabeled irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and their use in radioimaging and radiotherapy |
EP1396488A1 (en) * | 2001-05-23 | 2004-03-10 | Mitsubishi Pharma Corporation | Fused heterocyclic compound and medicinal use thereof |
US7176312B2 (en) * | 2001-10-12 | 2007-02-13 | The Scripps Research Institute | Kinase inhibitor scaffolds and methods for their preparation |
KR20050042055A (ko) * | 2001-11-03 | 2005-05-04 | 아스트라제네카 아베 | 항종양제로서의 퀴나졸린 유도체 |
TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
US6924285B2 (en) * | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
GB0309009D0 (en) * | 2003-04-22 | 2003-05-28 | Astrazeneca Ab | Quinazoline derivatives |
GB0309850D0 (en) * | 2003-04-30 | 2003-06-04 | Astrazeneca Ab | Quinazoline derivatives |
UY28441A1 (es) * | 2003-07-29 | 2005-02-28 | Astrazeneca Ab | Derivados de quinazolina |
GB0317665D0 (en) * | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
ATE395346T1 (de) * | 2003-09-16 | 2008-05-15 | Astrazeneca Ab | Chinazolinderivate als tyrosinkinaseinhibitoren |
WO2005026151A1 (en) * | 2003-09-16 | 2005-03-24 | Astrazeneca Ab | Quinazoline derivatives as tyrosine kinase inhibitors |
EP1667996B1 (en) * | 2003-09-16 | 2009-07-22 | Astrazeneca AB | Quinazoline derivatives |
GB0321648D0 (en) * | 2003-09-16 | 2003-10-15 | Astrazeneca Ab | Quinazoline derivatives |
US20070037837A1 (en) * | 2003-09-19 | 2007-02-15 | Hennequin Laurent Francois A | Quinazoline derivatives |
JP2007506716A (ja) * | 2003-09-25 | 2007-03-22 | アストラゼネカ アクチボラグ | キナゾリン誘導体 |
GB0322409D0 (en) * | 2003-09-25 | 2003-10-29 | Astrazeneca Ab | Quinazoline derivatives |
GB0326459D0 (en) * | 2003-11-13 | 2003-12-17 | Astrazeneca Ab | Quinazoline derivatives |
CN1914182B (zh) * | 2004-02-03 | 2011-09-07 | 阿斯利康(瑞典)有限公司 | 喹唑啉衍生物 |
US20070232607A1 (en) * | 2004-06-04 | 2007-10-04 | Bradbury Robert H | Quinazoline Derivatives as Erbb Receptor Tyrosine kinases |
-
2001
- 2001-11-03 GB GBGB0126433.2A patent/GB0126433D0/en not_active Ceased
-
2002
- 2002-10-31 AT AT02774961T patent/ATE421507T1/de not_active IP Right Cessation
- 2002-10-31 NZ NZ532523A patent/NZ532523A/en unknown
- 2002-10-31 RU RU2004116908/04A patent/RU2004116908A/ru not_active Application Discontinuation
- 2002-10-31 EP EP02774961A patent/EP1444211B1/en not_active Expired - Lifetime
- 2002-10-31 CA CA002465100A patent/CA2465100A1/en not_active Abandoned
- 2002-10-31 US US10/494,388 patent/US20050054662A1/en not_active Abandoned
- 2002-10-31 DE DE60230995T patent/DE60230995D1/de not_active Expired - Lifetime
- 2002-10-31 WO PCT/GB2002/004932 patent/WO2003040109A2/en active Application Filing
- 2002-10-31 BR BR0213843-3A patent/BR0213843A/pt not_active IP Right Cessation
- 2002-10-31 HU HU0401994A patent/HUP0401994A2/hu unknown
- 2002-10-31 MX MXPA04004220A patent/MXPA04004220A/es unknown
- 2002-10-31 JP JP2003542155A patent/JP2005511603A/ja not_active Ceased
- 2002-10-31 KR KR1020047006735A patent/KR20050042058A/ko not_active Application Discontinuation
- 2002-10-31 CN CNA028262824A patent/CN1764651A/zh active Pending
- 2002-10-31 ES ES02774961T patent/ES2319880T3/es not_active Expired - Lifetime
- 2002-10-31 PL PL02369833A patent/PL369833A1/xx not_active Application Discontinuation
- 2002-10-31 IL IL16162002A patent/IL161620A0/xx unknown
- 2002-11-01 TW TW091132368A patent/TW200302221A/zh unknown
- 2002-11-01 AR ARP020104182A patent/AR037193A1/es not_active Application Discontinuation
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2004
- 2004-04-28 ZA ZA200403203A patent/ZA200403203B/en unknown
- 2004-04-28 ZA ZA200403200A patent/ZA200403200B/en unknown
- 2004-04-30 IS IS7241A patent/IS7241A/is unknown
- 2004-06-02 CO CO04051630A patent/CO5580775A2/es not_active Application Discontinuation
- 2004-06-03 NO NO20042288A patent/NO20042288L/no not_active Application Discontinuation
- 2004-11-08 HK HK04108771.4A patent/HK1065801A1/xx not_active IP Right Cessation
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2006
- 2006-05-31 US US11/443,395 patent/US20070088044A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
TW200302221A (en) | 2003-08-01 |
ZA200403200B (en) | 2005-07-28 |
CN1764651A (zh) | 2006-04-26 |
US20070088044A1 (en) | 2007-04-19 |
IS7241A (is) | 2004-04-30 |
CO5580775A2 (es) | 2005-11-30 |
US20050054662A1 (en) | 2005-03-10 |
ATE421507T1 (de) | 2009-02-15 |
ZA200403203B (en) | 2005-07-28 |
NO20042288L (no) | 2004-06-03 |
DE60230995D1 (de) | 2009-03-12 |
WO2003040109A2 (en) | 2003-05-15 |
EP1444211B1 (en) | 2009-01-21 |
AR037193A1 (es) | 2004-10-27 |
MXPA04004220A (es) | 2004-09-10 |
CA2465100A1 (en) | 2003-05-15 |
GB0126433D0 (en) | 2002-01-02 |
PL369833A1 (en) | 2005-05-02 |
BR0213843A (pt) | 2004-08-31 |
IL161620A0 (en) | 2004-09-27 |
NZ532523A (en) | 2007-02-23 |
HUP0401994A2 (hu) | 2005-01-28 |
RU2004116908A (ru) | 2005-11-10 |
ES2319880T3 (es) | 2009-05-14 |
JP2005511603A (ja) | 2005-04-28 |
WO2003040109A3 (en) | 2003-06-26 |
KR20050042058A (ko) | 2005-05-04 |
EP1444211A2 (en) | 2004-08-11 |
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Effective date: 20121031 |