HK1063012A1 - Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders - Google Patents

Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders

Info

Publication number
HK1063012A1
HK1063012A1 HK04105484A HK04105484A HK1063012A1 HK 1063012 A1 HK1063012 A1 HK 1063012A1 HK 04105484 A HK04105484 A HK 04105484A HK 04105484 A HK04105484 A HK 04105484A HK 1063012 A1 HK1063012 A1 HK 1063012A1
Authority
HK
Hong Kong
Prior art keywords
alzheimer
treatment
inhibitors
napthoquinone
neurodegenerative disorders
Prior art date
Application number
HK04105484A
Other languages
English (en)
Inventor
Claude Michel Wischik
David Horsley
Janet Elizabeth Rickard
Charles Robert Harrington
Original Assignee
Wista Lab Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wista Lab Ltd filed Critical Wista Lab Ltd
Publication of HK1063012A1 publication Critical patent/HK1063012A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK04105484A 2001-07-16 2004-07-24 Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders HK1063012A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0117326.9A GB0117326D0 (en) 2001-07-16 2001-07-16 Napthoquinone-type inhibitors of protein aggregation
PCT/GB2002/003269 WO2003007933A1 (en) 2001-07-16 2002-07-16 Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders

Publications (1)

Publication Number Publication Date
HK1063012A1 true HK1063012A1 (en) 2004-12-10

Family

ID=9918593

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04105484A HK1063012A1 (en) 2001-07-16 2004-07-24 Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders

Country Status (13)

Country Link
US (1) US7605179B2 (de)
EP (1) EP1408952B1 (de)
JP (1) JP5147157B2 (de)
CN (1) CN1313088C (de)
AT (1) ATE361067T1 (de)
AU (1) AU2002317354B2 (de)
CA (1) CA2451422C (de)
DE (1) DE60219917T2 (de)
ES (1) ES2287292T3 (de)
GB (1) GB0117326D0 (de)
HK (1) HK1063012A1 (de)
SG (1) SG148846A1 (de)
WO (1) WO2003007933A1 (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9506197D0 (en) 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
GB0100119D0 (en) 2001-01-03 2001-02-14 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
AU2004251511A1 (en) * 2003-06-23 2005-01-06 Neurochem (International) Limited Treatment of protein aggregation disorders
WO2005053609A2 (en) * 2003-11-26 2005-06-16 Guilford Pharmaceuticals Inc. Methods of nad+-dependent deacetylase inhibitors
WO2006007864A1 (en) * 2004-07-17 2006-01-26 Max Planck Geselllschaft Zur Förderung Der Wissenschaft Treating neurodegenerative conditions
FR2874923B1 (fr) * 2004-09-07 2006-10-27 Trophos Sa Application a titre de medicaments de derives du 3, 5-seco-4-nor-cholestane, compositions pharmaceutiques les renfermant, nouveaux derives et leur procede de preparation
CN101084204B (zh) 2004-09-23 2012-12-05 卫思道制药有限公司 包括亚甲蓝(mtc)在内的二氨基吩噻嗪鎓化合物的化学合成和纯化方法
JP4734602B2 (ja) 2004-12-21 2011-07-27 Ｄｏｗａエレクトロニクス株式会社 保存安定性に優れた窒化鉄系磁性粉末
JP4822312B2 (ja) * 2005-05-13 2011-11-24 学校法人慶應義塾 ナフトキノン誘導体化合物
KR100699945B1 (ko) * 2005-11-24 2007-03-26 (주) 디지탈바이오텍 나프토퀴논계 화합물을 함유하는 인지기능 장애의 예방 및 치료용 조성물
ES2349322T7 (es) 2006-03-29 2019-10-17 Wista Lab Ltd Sales de 3,7-diamino-10H-fenotiazina y su utilización
US8263589B2 (en) 2006-03-29 2012-09-11 Wista Laboratories Ltd. Inhibitors of protein aggregation
US20110201686A1 (en) * 2006-06-23 2011-08-18 Yousef Al-Abed Inhibitors of ASS and Synuclein Aggregation
KR20090127260A (ko) * 2007-04-05 2009-12-10 제이-오일 밀스, 인코포레이티드 신경 안정제 및 기능성 식품
JP2010538611A (ja) * 2007-09-07 2010-12-16 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク タウタンパク質スクリーニングアッセイ
EP2060256A1 (de) * 2007-11-16 2009-05-20 Gnosis S.p.A. Auf Menaquinolen basierende pharmazeutische und nutrazeutische Zusammensetzungen
GB0816269D0 (en) * 2008-09-05 2008-10-15 Univ Ramot Naphthoquinone derivatives useful for prevention of amyloid deposits and treatment of alzheimers disease
JP2013529181A (ja) 2010-03-25 2013-07-18 ザ ジェイ． デヴィッド グラッドストーン インスティテューツ 神経障害を治療するための組成物および方法
US9320793B2 (en) * 2010-07-14 2016-04-26 Acumen Pharmaceuticals, Inc. Method for treating a disease associated with soluble, oligomeric species of amyloid beta 1-42
EA201300215A1 (ru) * 2010-08-06 2013-07-30 Эдисон Фармасьютикалз, Инк. Лечение митохондриальных болезней нафтохинонами
US20120244174A1 (en) 2011-01-31 2012-09-27 Intellect Neurosciences Inc. Treatment of tauopathies
KR101888713B1 (ko) 2011-02-11 2018-08-14 위스타 레보레이토리스 리미티드 페노티아진 디아미늄 염 및 이의 용도
JP6038122B2 (ja) 2011-04-21 2016-12-07 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 機能性磁性ナノ粒子、ならびにアミロイド沈着物および神経原繊維濃縮体の画像処理における使用
WO2012170773A1 (en) * 2011-06-08 2012-12-13 Edison Pharmaceuticals, Inc. Adjunctive therapy for the treatment of mitochondrial disorders with quinones and naphthoquinones
WO2013051266A1 (ja) 2011-10-03 2013-04-11 独立行政法人国立長寿医療研究センター タウ凝集阻害剤
US9938560B2 (en) 2012-02-05 2018-04-10 Biodesy, Inc. Methods for identifying modulators of Ras using nonlinear techniques
HUE048780T2 (hu) 2012-08-16 2020-09-28 Ipierian Inc Tauopátia kezelésére szolgáló módszerek
WO2014039917A1 (en) 2012-09-07 2014-03-13 Edison Pharmaceuticals, Inc. Benzoquinone derivatives for treating oxidative stress disorders
WO2014066744A2 (en) 2012-10-25 2014-05-01 True North Therapeutics, Inc. Anti-complement c1s antibodies and uses thereof
US8945562B2 (en) 2012-11-02 2015-02-03 True North Therapeutics, Inc. Anti-complement C1s antibodies
US9907799B2 (en) 2013-04-02 2018-03-06 The Doshisha Tau aggregation inhibitor
EA039554B1 (ru) 2013-06-10 2022-02-09 АйПИЕРИАН, ИНК. Способ снижения уровней a40 и/или a42 в нервной клетке и/или во внеклеточной жидкости
CN105659087B (zh) * 2013-06-13 2019-09-17 比奥德赛公司 筛选靶向靶生物实体的候选生物实体的方法
US20150166476A1 (en) * 2013-12-17 2015-06-18 Yi-Cheng Chen Methods for treating neurodegenerative diseases associated with aggregation of amyloid-beta
EP3237906B8 (de) 2014-12-23 2020-10-28 Bluelight Therapeutics, Inc. Befestigung von proteinen an schnittstellen zur verwendung in nicht-linearer optischer detektion
WO2019191773A1 (en) 2018-03-30 2019-10-03 Kaydence Pharma As Rapidly improving vascular conditions by administering vitamin k
CN113874078A (zh) 2019-04-05 2021-12-31 Tauc3生物制品有限公司 抗tauc3抗体及其应用
CN110025624B (zh) * 2019-05-29 2021-04-02 济宁医学院附属医院 萘醌苷类化合物在老年痴呆中的应用及其药物制备
CN112778092B (zh) * 2020-12-31 2023-03-24 玉溪健坤生物药业有限公司 一种还原型维生素k2的制备方法及其用途

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59175449A (ja) * 1983-03-26 1984-10-04 Kyushu Kogyo Daigaku シコニンの製造法
JPS61143334A (ja) * 1984-12-18 1986-07-01 Mitsui Petrochem Ind Ltd ５，８−ジヒドロキシ−１，４−ナフトキノン誘導体
US4897388A (en) * 1988-12-20 1990-01-30 Geriatric Research Institute, Inc. Method of treating Alzheimer's disease
DE69231222T2 (de) * 1991-02-04 2001-03-01 Ks Biomedix Ltd., Esher Naphtochinonderivate zur Behandlung von chronischen Entzündungen
ATE438716T1 (de) 1991-12-06 2009-08-15 Max Planck Gesellschaft Verwendung von protein-kinasen zur diagnose und behandlung der alzheimer-krankheit
AU708682B2 (en) 1994-08-08 1999-08-12 Albert Einstein College Of Medicine Of Yeshiva University Methods for treating and/or preventing Alzheimer's disease using phenothiazines and/or thioxanthenes
JPH08193026A (ja) * 1995-01-12 1996-07-30 Teijin Ltd アミロイドβ蛋白凝集・沈着阻害剤
DE19504003A1 (de) * 1995-02-08 1996-08-14 Martin Dr Kohlmeier Verwendungen eines Vitamins der K-Gruppe
GB9506197D0 (en) * 1995-03-27 1995-05-17 Hoffmann La Roche Inhibition of tau-tau association.
US5804601A (en) 1995-04-10 1998-09-08 Takeda Chemical Industries, Ltd. Aromatic hydroxamic acid compounds, their production and use
KR0180791B1 (ko) * 1995-07-24 1999-05-15 김용옥 6-치환-5,8-디옥시-1,4-나프토퀴논 유도체, 그의 제조방법 및 그의 항암제로서의 용도
JP3809014B2 (ja) * 1998-05-22 2006-08-16 花王株式会社 養毛・育毛剤
US20020040011A1 (en) 2000-06-01 2002-04-04 Brown Dennis M. Naphthoquinone compositions and uses thereof
US20020016372A1 (en) 2000-07-31 2002-02-07 Allison Anthony Clifford Method for preventing and treating alzheimer's disease and brain damage associated with cardiov ascular disease and head injury
GB0100119D0 (en) 2001-01-03 2001-02-14 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0101049D0 (en) 2001-01-15 2001-02-28 Univ Aberdeen Materials and methods relating to protein aggregation in neurodegenerative disease
GB0106953D0 (en) 2001-03-20 2001-05-09 Univ Aberdeen Neufofibrillary labels
US6953974B2 (en) * 2003-08-26 2005-10-11 Texas Instruments Incorporated EEPROM device and method for providing lower programming voltage
GB0322756D0 (en) 2003-09-29 2003-10-29 Univ Aberdeen Methods of chemical synthesis
ES2736160T3 (es) 2004-09-23 2019-12-26 Wista Lab Ltd Procedimientos de síntesis química y purificación de compuestos de diaminofenotiazinio que incluyen cloruro de metiltioninio (CMT)

Also Published As

Publication number Publication date
ES2287292T3 (es) 2007-12-16
AU2002317354B2 (en) 2007-07-19
EP1408952A1 (de) 2004-04-21
DE60219917T2 (de) 2008-01-17
WO2003007933A1 (en) 2003-01-30
CA2451422C (en) 2010-10-19
ATE361067T1 (de) 2007-05-15
CN1313088C (zh) 2007-05-02
EP1408952B1 (de) 2007-05-02
GB0117326D0 (en) 2001-09-05
US7605179B2 (en) 2009-10-20
DE60219917D1 (de) 2007-06-14
SG148846A1 (en) 2009-01-29
CA2451422A1 (en) 2003-01-30
JP2004534854A (ja) 2004-11-18
US20050107472A1 (en) 2005-05-19
JP5147157B2 (ja) 2013-02-20
CN1553800A (zh) 2004-12-08

Similar Documents

Publication Publication Date Title
HK1063012A1 (en) Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders
NO20053855L (no) 1-fenylalkankarboksylsyrederivater til behandling av neurodegenerative sykdommer.
ES2170104T3 (es) Inhibidores de la produccion de proteinas de beta-amiloide.
DK1465626T3 (da) Farmaceutiske præparater (kit) der omfatter dihydropyridinonforbindelser og et immunregulatorisk (eller et antiinflammatorisk) middel samt anvendelser deraf
GB2364059A (en) Beta-Secretase enzyme compositions and methods
NO20034056D0 (no) Proliferative sykdommer
EP2213684A3 (de) Nogo-A-Antikörper für die Behandlung von Alzheimer-Krankheit
WO2005004803A3 (en) Phenylcarboxylate beta-secretase inhibitors for the treatment of alzheimer's disease
NO20035474D0 (no) Prodrugs av GABA-analoger, sammensetninger og anvendelse derav
WO2004014953A3 (en) Anti-myelin associated glycoprotein (mag) antibodies
IL169889A0 (en) Methods for diagnosis and monitoring of neurological disease by detection of an encephalotoxin
NO20015247L (no) Glysinspaltingssysteminhibitorer som potensielle antipsykotika
ATE522230T1 (de) Biphenyle als bilderzeugungsmittel bei der alzheimerschen krankheit
NO20044530L (no) Fremgangsmate for behandling av kognitive forstyrrelser
BR0314541A (pt) Tratamento de demência e doença de parkinson
MY135225A (en) Napthoquinone derivatives as inhibitors of tau aggregation for the treatment of alzheimer's and related neurodegenerative disorders
WO2004096199A3 (en) Regulation of guanine nucleotide exchange factor
WO2004047854A3 (en) Methods for the treatment of alzheimers disease and compositions therefore

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20220715