HK1061025A1 - Thiophene substituted amine derivatives as glyt-1 inhibitors - Google Patents

Thiophene substituted amine derivatives as glyt-1 inhibitors

Info

Publication number
HK1061025A1
HK1061025A1 HK04104072A HK04104072A HK1061025A1 HK 1061025 A1 HK1061025 A1 HK 1061025A1 HK 04104072 A HK04104072 A HK 04104072A HK 04104072 A HK04104072 A HK 04104072A HK 1061025 A1 HK1061025 A1 HK 1061025A1
Authority
HK
Hong Kong
Prior art keywords
glyt
inhibitors
substituted amine
amine derivatives
thiophene substituted
Prior art date
Application number
HK04104072A
Other languages
English (en)
Inventor
Ian Egle
William Delaney
Zhao-Qing Wang
Richard Shumacer
Allen T Hopper
Ashok Thim
Shawn Maddaford
Original Assignee
Allelix Neuroscience Inc
Nps Allelix Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23026417&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1061025(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Allelix Neuroscience Inc, Nps Allelix Corp filed Critical Allelix Neuroscience Inc
Publication of HK1061025A1 publication Critical patent/HK1061025A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
HK04104072A 2001-02-16 2004-06-08 Thiophene substituted amine derivatives as glyt-1 inhibitors HK1061025A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26924101P 2001-02-16 2001-02-16
PCT/CA2002/000176 WO2002066456A2 (en) 2001-02-16 2002-02-15 Thiophene substituted amine derivatives as glyt-1 inhibitors

Publications (1)

Publication Number Publication Date
HK1061025A1 true HK1061025A1 (en) 2004-09-03

Family

ID=23026417

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04104072A HK1061025A1 (en) 2001-02-16 2004-06-08 Thiophene substituted amine derivatives as glyt-1 inhibitors

Country Status (31)

Country Link
US (1) US6667336B2 (pt)
EP (1) EP1368336B9 (pt)
JP (2) JP2004523548A (pt)
KR (1) KR100900020B1 (pt)
CN (1) CN1219776C (pt)
AT (1) ATE327986T1 (pt)
AU (1) AU2002235682C1 (pt)
BG (1) BG108164A (pt)
BR (1) BR0207307A (pt)
CA (1) CA2438367A1 (pt)
CY (1) CY1105529T1 (pt)
CZ (1) CZ20032503A3 (pt)
DE (1) DE60211866T2 (pt)
DK (1) DK1368336T3 (pt)
EA (1) EA006636B1 (pt)
EE (1) EE05329B1 (pt)
ES (1) ES2266446T3 (pt)
HK (1) HK1061025A1 (pt)
HR (1) HRP20030696A2 (pt)
HU (1) HUP0303185A3 (pt)
IL (1) IL157194A (pt)
MX (1) MXPA03007309A (pt)
NO (1) NO329038B1 (pt)
NZ (1) NZ527695A (pt)
PL (1) PL365024A1 (pt)
PT (1) PT1368336E (pt)
SI (1) SI1368336T1 (pt)
SK (1) SK287304B6 (pt)
UA (1) UA75114C2 (pt)
WO (1) WO2002066456A2 (pt)
ZA (1) ZA200307201B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191165B1 (en) * 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
PT1830833E (pt) * 2004-12-16 2010-03-12 Janssen Pharmaceutica Nv Combinação de um inibidor do transportador da glicina (glyt1) e um antipsicótico para o tratamento de sintomas de esquizofrenia, bem como a sua preparação e sua utilização
US20090253918A1 (en) * 2006-10-02 2009-10-08 Janssen Pharmaceuticals, N.V. Novel intermediate for glyt1 inhibitor
WO2008065500A2 (en) * 2006-11-30 2008-06-05 Pfizer Products Inc. Heteroaryl amides as type i glycine transport inhibitors
CN103374057B (zh) * 2012-04-16 2015-08-19 中国医药集团总公司四川抗菌素工业研究所 一种对甘氨酸转运子具有抑制活性的化合物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010599A1 (de) 1979-03-22 1980-10-09 Continental Pharma Derivate von glycinamid, deren herstellung und verwendung
BE885303A (fr) 1980-09-19 1981-03-19 Continental Pharma Glycinamides
US4383999A (en) 1981-05-26 1983-05-17 Smithkline Beckman Corporation Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
AU552050B2 (en) 1981-05-26 1986-05-22 Smithkline Beckman Corporation N-substituted azeheterocyclic carboxylic acids and their esters
US4514414A (en) 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
DK288385D0 (da) 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
US4772615A (en) 1985-11-08 1988-09-20 Warner-Lambert Company Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof
FI864246A (fi) 1985-11-08 1987-05-09 Warner Lambert Co N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
PT84064B (pt) 1986-01-07 1989-07-31 Novo Industri As Processo para a preparacao de novos derivados de aminoacidos e de composicoes farmaceuticas que os contem
JPH02129158A (ja) 1988-11-07 1990-05-17 Nippon Steel Corp 光学活性なグリシン誘導体及びその製造方法
IE913279A1 (en) * 1990-09-26 1992-04-08 Astra Ab (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties
ES2036926B1 (es) 1991-08-08 1994-01-16 Uriach & Cia Sa J "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina".
IL124536A (en) 1995-12-07 2001-03-19 Daniel C Javitt Pharmaceutical compositions containing a glycine uptake antagonist
NZ332780A (en) * 1996-05-31 2000-07-28 Allelix Neuroscience Inc Substituted amines for the treatment of neurological and neuropsychiatric disorders
US6191165B1 (en) 1996-05-31 2001-02-20 Allelix Neuroscience Inc. Pharmaceutical for treatment of neurological and neuropsychiatric disorders
EP0923539B1 (en) * 1996-07-22 2002-06-05 Novo Nordisk A/S Compounds with growth hormone releasing properties
CZ20002459A3 (cs) * 1998-01-09 2001-12-12 Pfizer, Inc. Inhibitory matričních metaloproteinas, způsoby jejich výroby, farmaceutické kompozice a způsoby léčení na jejich bázi
US6103743A (en) * 1999-08-06 2000-08-15 Allelix Neuroscience, Inc. Unsaturated amino acid derivatives

Also Published As

Publication number Publication date
EE200300394A (et) 2003-12-15
NO20033634L (no) 2003-10-08
CN1219776C (zh) 2005-09-21
ES2266446T3 (es) 2007-03-01
EP1368336A2 (en) 2003-12-10
NO329038B1 (no) 2010-08-02
SK11442003A3 (sk) 2004-03-02
JP2004523548A (ja) 2004-08-05
EP1368336B9 (en) 2007-02-14
SI1368336T1 (sl) 2006-10-31
CZ20032503A3 (cs) 2004-02-18
HRP20030696A2 (en) 2005-04-30
WO2002066456A3 (en) 2002-10-17
DK1368336T3 (da) 2006-10-02
AU2002235682C1 (en) 2008-12-11
DE60211866D1 (de) 2006-07-06
UA75114C2 (en) 2006-03-15
HUP0303185A2 (hu) 2003-12-29
HUP0303185A3 (en) 2008-12-29
KR100900020B1 (ko) 2009-06-01
NO20033634D0 (no) 2003-08-15
WO2002066456A2 (en) 2002-08-29
MXPA03007309A (es) 2004-06-30
BG108164A (en) 2004-07-30
IL157194A (en) 2006-12-31
NZ527695A (en) 2005-05-27
PL365024A1 (en) 2004-12-27
US6667336B2 (en) 2003-12-23
BR0207307A (pt) 2004-08-17
CN1491221A (zh) 2004-04-21
ZA200307201B (en) 2004-07-28
EE05329B1 (et) 2010-08-16
EA200300900A1 (ru) 2004-02-26
EP1368336B1 (en) 2006-05-31
ATE327986T1 (de) 2006-06-15
JP2010059182A (ja) 2010-03-18
CA2438367A1 (en) 2002-08-29
KR20040028719A (ko) 2004-04-03
EA006636B1 (ru) 2006-02-24
SK287304B6 (sk) 2010-06-07
PT1368336E (pt) 2006-10-31
CY1105529T1 (el) 2010-07-28
AU2002235682B2 (en) 2007-04-26
US20030176489A1 (en) 2003-09-18
DE60211866T2 (de) 2007-06-14

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110215