DK1368336T3 - Thiophensubstituerede aminderivater som GlyT-1-inhibitorer - Google Patents
Thiophensubstituerede aminderivater som GlyT-1-inhibitorerInfo
- Publication number
- DK1368336T3 DK1368336T3 DK02702186T DK02702186T DK1368336T3 DK 1368336 T3 DK1368336 T3 DK 1368336T3 DK 02702186 T DK02702186 T DK 02702186T DK 02702186 T DK02702186 T DK 02702186T DK 1368336 T3 DK1368336 T3 DK 1368336T3
- Authority
- DK
- Denmark
- Prior art keywords
- glyt
- thiophene
- inhibitors
- substituted amine
- amine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Epoxy Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26924101P | 2001-02-16 | 2001-02-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1368336T3 true DK1368336T3 (da) | 2006-10-02 |
Family
ID=23026417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02702186T DK1368336T3 (da) | 2001-02-16 | 2002-02-15 | Thiophensubstituerede aminderivater som GlyT-1-inhibitorer |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US6667336B2 (da) |
| EP (1) | EP1368336B9 (da) |
| JP (2) | JP2004523548A (da) |
| KR (1) | KR100900020B1 (da) |
| CN (1) | CN1219776C (da) |
| AT (1) | ATE327986T1 (da) |
| AU (1) | AU2002235682C1 (da) |
| BG (1) | BG108164A (da) |
| BR (1) | BR0207307A (da) |
| CA (1) | CA2438367A1 (da) |
| CY (1) | CY1105529T1 (da) |
| CZ (1) | CZ20032503A3 (da) |
| DE (1) | DE60211866T2 (da) |
| DK (1) | DK1368336T3 (da) |
| EA (1) | EA006636B1 (da) |
| EE (1) | EE05329B1 (da) |
| ES (1) | ES2266446T3 (da) |
| HK (1) | HK1061025A1 (da) |
| HR (1) | HRP20030696A2 (da) |
| HU (1) | HUP0303185A3 (da) |
| IL (1) | IL157194A (da) |
| MX (1) | MXPA03007309A (da) |
| NO (1) | NO329038B1 (da) |
| NZ (1) | NZ527695A (da) |
| PL (1) | PL365024A1 (da) |
| PT (1) | PT1368336E (da) |
| SI (1) | SI1368336T1 (da) |
| SK (1) | SK287304B6 (da) |
| UA (1) | UA75114C2 (da) |
| WO (1) | WO2002066456A2 (da) |
| ZA (1) | ZA200307201B (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6191165B1 (en) * | 1996-05-31 | 2001-02-20 | Allelix Neuroscience Inc. | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
| EP1830833B1 (en) * | 2004-12-16 | 2010-01-27 | Janssen Pharmaceutica N.V. | Combination of a glycine transporter (glyt1) inhibitor and an antipsychotic for the treatment of symptoms of schizophrenia as well as its preparation and use thereof |
| WO2008040669A2 (en) * | 2006-10-02 | 2008-04-10 | Janssen Pharmaceutica N.V. | Novel intermediates for the preparation of a glyt1 inhibitor |
| WO2008065500A2 (en) * | 2006-11-30 | 2008-06-05 | Pfizer Products Inc. | Heteroaryl amides as type i glycine transport inhibitors |
| CN103374057B (zh) * | 2012-04-16 | 2015-08-19 | 中国医药集团总公司四川抗菌素工业研究所 | 一种对甘氨酸转运子具有抑制活性的化合物 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3010599A1 (de) | 1979-03-22 | 1980-10-09 | Continental Pharma | Derivate von glycinamid, deren herstellung und verwendung |
| BE885303A (fr) | 1980-09-19 | 1981-03-19 | Continental Pharma | Glycinamides |
| AU552050B2 (en) | 1981-05-26 | 1986-05-22 | Smithkline Beckman Corporation | N-substituted azeheterocyclic carboxylic acids and their esters |
| US4383999A (en) | 1981-05-26 | 1983-05-17 | Smithkline Beckman Corporation | Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters |
| US4514414A (en) | 1982-10-25 | 1985-04-30 | Smithkline Beckman Corporation | N-Substituted pyrrolidineacetic acids and their esters |
| DK288385D0 (da) | 1985-06-26 | 1985-06-26 | Novo Industri As | Aminosyrederivater |
| FI864246A (fi) | 1985-11-08 | 1987-05-09 | Warner Lambert Co | N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat. |
| US4772615A (en) | 1985-11-08 | 1988-09-20 | Warner-Lambert Company | Various N-substituted 3-piperidine carboxylic acids or N-substituted 3-pyridinecarboxylic acids and derivatives thereof |
| EP0231996B1 (en) | 1986-01-07 | 1993-10-06 | Novo Nordisk A/S | Novel amino acid derivatives |
| JPH02129158A (ja) | 1988-11-07 | 1990-05-17 | Nippon Steel Corp | 光学活性なグリシン誘導体及びその製造方法 |
| IE913279A1 (en) * | 1990-09-26 | 1992-04-08 | Astra Ab | (2-Thienyl)alkylamine Derivatives Having Neuroprotective¹Properties |
| ES2036926B1 (es) | 1991-08-08 | 1994-01-16 | Uriach & Cia Sa J | "procedimiento para la obtencion de derivados de la (2-alquil-3-piridil)metilpiperazina". |
| WO1997020553A1 (en) | 1995-12-07 | 1997-06-12 | Javitt Daniel C | Treatment of negative and cognitive symptoms of schizophrenia with glycine uptake antagonists |
| WO1997045115A1 (en) * | 1996-05-31 | 1997-12-04 | Trophix Pharmaceuticals, Inc. | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
| US6191165B1 (en) | 1996-05-31 | 2001-02-20 | Allelix Neuroscience Inc. | Pharmaceutical for treatment of neurological and neuropsychiatric disorders |
| US5922770A (en) * | 1996-07-22 | 1999-07-13 | Novo Nordisk A/S | Compounds with growth hormone releasing properties |
| CN1284942A (zh) * | 1998-01-09 | 2001-02-21 | 辉瑞大药厂 | 基质金属蛋白酶抑制剂 |
| US6103743A (en) * | 1999-08-06 | 2000-08-15 | Allelix Neuroscience, Inc. | Unsaturated amino acid derivatives |
-
2002
- 2002-02-15 KR KR1020037010609A patent/KR100900020B1/ko not_active IP Right Cessation
- 2002-02-15 DE DE60211866T patent/DE60211866T2/de not_active Expired - Lifetime
- 2002-02-15 MX MXPA03007309A patent/MXPA03007309A/es active IP Right Grant
- 2002-02-15 EA EA200300900A patent/EA006636B1/ru not_active IP Right Cessation
- 2002-02-15 ES ES02702186T patent/ES2266446T3/es not_active Expired - Lifetime
- 2002-02-15 PT PT02702186T patent/PT1368336E/pt unknown
- 2002-02-15 CN CNB028050819A patent/CN1219776C/zh not_active Expired - Fee Related
- 2002-02-15 AT AT02702186T patent/ATE327986T1/de not_active IP Right Cessation
- 2002-02-15 HU HU0303185A patent/HUP0303185A3/hu unknown
- 2002-02-15 CA CA002438367A patent/CA2438367A1/en not_active Abandoned
- 2002-02-15 DK DK02702186T patent/DK1368336T3/da active
- 2002-02-15 SI SI200230381T patent/SI1368336T1/sl unknown
- 2002-02-15 US US10/077,579 patent/US6667336B2/en not_active Expired - Fee Related
- 2002-02-15 EP EP02702186A patent/EP1368336B9/en not_active Expired - Lifetime
- 2002-02-15 BR BR0207307-2A patent/BR0207307A/pt not_active IP Right Cessation
- 2002-02-15 JP JP2002565971A patent/JP2004523548A/ja active Pending
- 2002-02-15 WO PCT/CA2002/000176 patent/WO2002066456A2/en active IP Right Grant
- 2002-02-15 AU AU2002235682A patent/AU2002235682C1/en not_active Ceased
- 2002-02-15 NZ NZ527695A patent/NZ527695A/en unknown
- 2002-02-15 EE EEP200300394A patent/EE05329B1/xx not_active IP Right Cessation
- 2002-02-15 UA UA2003087630A patent/UA75114C2/uk unknown
- 2002-02-15 CZ CZ20032503A patent/CZ20032503A3/cs unknown
- 2002-02-15 SK SK1144-2003A patent/SK287304B6/sk not_active IP Right Cessation
- 2002-02-15 PL PL02365024A patent/PL365024A1/xx unknown
-
2003
- 2003-07-31 IL IL157194A patent/IL157194A/en not_active IP Right Cessation
- 2003-08-15 NO NO20033634A patent/NO329038B1/no not_active IP Right Cessation
- 2003-09-01 HR HR20030696A patent/HRP20030696A2/xx not_active Application Discontinuation
- 2003-09-09 BG BG108164A patent/BG108164A/xx unknown
- 2003-09-15 ZA ZA200307201A patent/ZA200307201B/en unknown
-
2004
- 2004-06-08 HK HK04104072A patent/HK1061025A1/xx not_active IP Right Cessation
-
2006
- 2006-08-22 CY CY20061101160T patent/CY1105529T1/el unknown
-
2009
- 2009-11-09 JP JP2009255663A patent/JP2010059182A/ja active Pending
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