HK1050370A1 - Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives. - Google Patents

Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives.

Info

Publication number
HK1050370A1
HK1050370A1 HK03102597A HK03102597A HK1050370A1 HK 1050370 A1 HK1050370 A1 HK 1050370A1 HK 03102597 A HK03102597 A HK 03102597A HK 03102597 A HK03102597 A HK 03102597A HK 1050370 A1 HK1050370 A1 HK 1050370A1
Authority
HK
Hong Kong
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
HK03102597A
Other languages
English (en)
Inventor
Constantine Sklavounos
John Lloyd Tucker
Lulin Wei
Kerry Peter Mahon Jr
Philip Dietrich Hammen
Joanna Teresa Negri
Richard Shelton Lehner
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of HK1050370A1 publication Critical patent/HK1050370A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK03102597A 2001-04-27 2003-04-10 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives. HK1050370A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28720301P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
HK1050370A1 true HK1050370A1 (en) 2003-06-20

Family

ID=23101880

Family Applications (2)

Application Number Title Priority Date Filing Date
HK03102597A HK1050370A1 (en) 2001-04-27 2003-04-10 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives.
HK04108627A HK1065803A1 (en) 2001-04-27 2004-11-03 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK04108627A HK1065803A1 (en) 2001-04-27 2004-11-03 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Country Status (23)

Country Link
US (1) US6825327B2 (es)
EP (2) EP1383780A1 (es)
JP (3) JP4104463B2 (es)
KR (1) KR100474225B1 (es)
CN (4) CN100413879C (es)
AR (1) AR035871A1 (es)
AU (1) AU784362B2 (es)
BR (2) BR0209241A (es)
CA (2) CA2445306C (es)
CZ (1) CZ303716B6 (es)
DK (1) DK1253153T3 (es)
ES (1) ES2608848T3 (es)
HK (2) HK1050370A1 (es)
HU (1) HU230717B1 (es)
IL (3) IL158059A0 (es)
MX (2) MXPA03009786A (es)
PL (2) PL371766A1 (es)
PT (1) PT1253153T (es)
RU (2) RU2263117C2 (es)
SG (1) SG100789A1 (es)
WO (1) WO2002088158A1 (es)
YU (1) YU29502A (es)
ZA (2) ZA200203252B (es)

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US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
PE20060489A1 (es) 2004-08-13 2006-06-19 Schering Plough Ltd Formulacion farmaceutica que comprende un antibiotico, un triazol y un corticosteroide
MX2007003378A (es) 2004-09-23 2007-05-10 Schering Plough Ltd Control de parasitos en animales mediante el uso de nuevos derivados de trifluorometansulfonanilida oxima eter.
DE602005017419D1 (de) 2004-11-19 2009-12-10 Schering Plough Ltd Kontrolle von parasiten bei tieren mittels verwendung von parasitiziden 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitril-derivaten
ES2326002T3 (es) * 2005-01-14 2009-09-28 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9a-carbamoil y tiocarbamoil azalidos con actividad antipaludica.
US20060281695A1 (en) * 2005-06-09 2006-12-14 Schering-Plough Animal Health Corporation Control of parasites in animals by N-[(phenyloxy)phenyl]-1,1,1-trifluoromethanesulfonamide and N-[(phenylsulfanyl)phenyl]-1,1,1-trifluoromethanesulfonamide derivatives
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
CN101600686A (zh) * 2006-12-13 2009-12-09 先灵-普劳有限公司 氯霉素、甲砜霉素及其类似物的水溶性前药
EP2091909A1 (en) * 2006-12-13 2009-08-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX368680B (es) 2007-06-27 2019-10-11 Du Pont Administración subcutánea de un derivado de isoxazol-benzamida para usarse en un método para proteger un mamífero de una pulga.
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
CN102131772B (zh) * 2008-07-30 2015-03-11 英特威国际有限公司 用作氟苯尼考的中间体的*唑啉-保护的氨基二醇化合物的制备方法
WO2010086351A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
AU2010279587A1 (en) 2009-08-05 2012-02-09 E. I. Du Pont De Nemours And Company Mesoionic pesticides
KR20120050467A (ko) 2009-08-05 2012-05-18 이 아이 듀폰 디 네모아 앤드 캄파니 메소이온성 살충제
MA34247B1 (fr) 2010-05-27 2013-05-02 Du Pont Forme cristalline du 4-[5-[3-chloro-5-(trifluorométhyl) phényl] -4,5-dihydro-5-(trifluorométhyl)-3-isoxazolyl]-n-[2-oxo-2-[(2, 2,2-trifluoroéthyl) amino] éthyl]-1-naphtalènecarboxamide
US20130102551A1 (en) * 2010-07-01 2013-04-25 Andreas Hotte Antibiotic compositions
US8940880B2 (en) 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) * 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
EP3406619B1 (en) * 2016-01-18 2020-11-25 Zhejiang Hisun Pharmaceutical Co., Ltd. Method and intermediate for preparing tulathromycin
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN106434797A (zh) * 2016-08-25 2017-02-22 艾美科健（中国）生物医药有限公司 一种酶法合成泰拉霉素的工艺
CN106939029B (zh) * 2017-04-28 2020-10-13 艾美科健（中国）生物医药有限公司 一种泰拉霉素的制备方法
CN107400152B (zh) * 2017-08-29 2019-10-15 博瑞生物医药（苏州）股份有限公司 泰拉菌素草酸盐
CN107556351B (zh) * 2017-08-29 2019-10-18 博瑞生物医药（苏州）股份有限公司 一种泰拉菌素的制备方法
CN109535210A (zh) * 2018-12-19 2019-03-29 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
EP3955937A4 (en) 2019-04-18 2023-01-18 Azura Ophthalmics Ltd. COMPOUNDS AND METHODS FOR TREATING EYE DISORDERS
CN111072730B (zh) * 2019-12-16 2021-01-12 浙江国邦药业有限公司 一种泰拉霉素中间体盐的制备方法及应用
CN112225769A (zh) * 2020-09-21 2021-01-15 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
CN113493483A (zh) * 2021-07-05 2021-10-12 上海应用技术大学 一种泰拉霉素的合成方法

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Also Published As

Publication number Publication date
RU2003131351A (ru) 2005-02-27
AR035871A1 (es) 2004-07-21
ZA200203252B (en) 2003-10-24
IL149226A (en) 2008-06-05
JP2004528353A (ja) 2004-09-16
EP1253153B1 (en) 2016-11-02
CN1295240C (zh) 2007-01-17
CZ20021417A3 (cs) 2003-05-14
CN1715289A (zh) 2006-01-04
MXPA03009786A (es) 2004-01-29
RU2263117C2 (ru) 2005-10-27
RU2233287C2 (ru) 2004-07-27
CZ303716B6 (cs) 2013-04-03
MXPA02004231A (es) 2002-11-13
HU230717B1 (hu) 2017-11-28
SG100789A1 (en) 2003-12-26
IL182418A0 (en) 2008-01-06
JP2007091754A (ja) 2007-04-12
CN100413879C (zh) 2008-08-27
CA2383409C (en) 2007-01-02
IL182418A (en) 2012-07-31
BR0201437A (pt) 2003-06-10
PL213731B1 (pl) 2013-04-30
US6825327B2 (en) 2004-11-30
HK1065803A1 (en) 2005-03-04
IL149226A0 (en) 2002-11-10
BRPI0201437B8 (pt) 2021-05-25
HU0201385D0 (es) 2002-06-29
DK1253153T3 (da) 2017-01-02
ES2608848T3 (es) 2017-04-17
PT1253153T (pt) 2016-12-29
EP1383780A1 (en) 2004-01-28
CN1167708C (zh) 2004-09-22
IL158059A0 (en) 2004-03-28
CN1530370A (zh) 2004-09-22
YU29502A (sh) 2005-03-15
CA2445306C (en) 2008-02-12
AU3563002A (en) 2002-10-31
ZA200307506B (en) 2005-01-26
WO2002088158A1 (en) 2002-11-07
US20030064939A1 (en) 2003-04-03
KR20020083474A (ko) 2002-11-02
PL371766A1 (en) 2005-06-27
CN1384108A (zh) 2002-12-11
CN1297564C (zh) 2007-01-31
CN1503804A (zh) 2004-06-09
PL353633A1 (en) 2002-11-04
CA2383409A1 (en) 2002-10-27
JP4104463B2 (ja) 2008-06-18
JP4100955B2 (ja) 2008-06-11
CA2445306A1 (en) 2002-11-07
AU784362B2 (en) 2006-03-16
EP1253153A1 (en) 2002-10-30
HUP0201385A2 (hu) 2003-12-29
KR100474225B1 (ko) 2005-03-08
BR0209241A (pt) 2004-06-15
BRPI0201437B1 (pt) 2017-11-28
JP2002326998A (ja) 2002-11-15

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