HK1048114A1 - 藥劑排出泵抑制藥 - Google Patents

藥劑排出泵抑制藥

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Publication number
HK1048114A1
HK1048114A1 HK03100234.3A HK03100234A HK1048114A1 HK 1048114 A1 HK1048114 A1 HK 1048114A1 HK 03100234 A HK03100234 A HK 03100234A HK 1048114 A1 HK1048114 A1 HK 1048114A1
Authority
HK
Hong Kong
Prior art keywords
group
integer
furandiyl
discharge pump
pump inhibitors
Prior art date
Application number
HK03100234.3A
Other languages
English (en)
Inventor
Leger Roger
John Watkins William
Zhijia Zhang Jason
Eric Renau Thomas
Jack Lee Ving
Ohta Toshiharu
Nakayama Kiyoshi
Ishida Yohhei
Ohtsuka Masami
Kawato Haruko
Original Assignee
基本治療公司
第一制藥株式會社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 基本治療公司, 第一制藥株式會社 filed Critical 基本治療公司
Publication of HK1048114A1 publication Critical patent/HK1048114A1/zh

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    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4738Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • GPHYSICS
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
CA2445697A1 (en) * 2001-04-26 2002-11-07 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
JP2002322054A (ja) * 2001-04-26 2002-11-08 Dai Ichi Seiyaku Co Ltd 薬剤排出ポンプ阻害薬
US7056917B2 (en) 2001-04-26 2006-06-06 Daiichi Pharmaceutical Co., Ltd. Drug efflux pump inhibitor
US6596723B1 (en) 2001-07-16 2003-07-22 Essential Therapeutics, Inc. Fungal efflux pump inhibitors
JP2005512975A (ja) 2001-10-25 2005-05-12 アストラゼネカ アクチボラグ 抗菌薬として有用なイソキサゾリン誘導体
CA2509138A1 (en) * 2002-12-23 2004-07-08 4Sc Ag Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents
JP2006518738A (ja) * 2003-02-12 2006-08-17 トランス テック ファーマ,インコーポレイテッド 治療薬としての置換アゾール誘導体
CA2527779A1 (en) 2003-06-05 2004-12-16 Warner-Lambert Company Llc 3-substituted indoles and derivatives thereof as therapeutic agents
JP4898458B2 (ja) * 2004-02-12 2012-03-14 トランス テック ファーマ,インコーポレイテッド 置換アゾール誘導体、組成物及び使用方法
CA2571828A1 (en) 2004-05-21 2005-12-01 Mpex Pharmaceuticals, Inc. Bacterial efflux pump inhibitors and methods of treating bacterial infections
US7879795B2 (en) 2004-05-21 2011-02-01 Mpex Pharmaceuticals, Inc. Enhancement of tigecycline potency using efflux pump inhibitors
CN101006076B (zh) * 2004-06-24 2010-09-29 沃泰克斯药物股份有限公司 Atp-结合弹夹转运蛋白的调控剂
RU2556984C2 (ru) * 2004-06-24 2015-07-20 Вертекс Фармасьютикалз Инкорпорейтед Модуляторы транспортеров атф-связывающей кассеты
EP2502913A3 (en) * 2004-06-24 2013-11-27 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
JP5409010B2 (ja) 2005-12-28 2014-02-05 バーテックス ファーマシューティカルズ インコーポレイテッド N−[2,4−ビス(1,1−ジメチルエチル)−5−ヒドロキシフェニル]−1,4−ジヒドロ−4−オキソキノリン−3−カルボキサミドの固体形態
EP1991544B1 (en) 2006-01-30 2018-08-15 vTv Therapeutics LLC Substituted imidazole derivatives and their use as ptpase inhibitors
US8178490B2 (en) 2007-05-11 2012-05-15 Rempex Pharmaceuticals, Inc. Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof
EP2821400B1 (en) 2009-03-20 2017-09-27 Vertex Pharmaceuticals Incorporated Process for making modulators of cystic fibrosis transmembrane conductance regulator
AR079451A1 (es) 2009-12-18 2012-01-25 Nycomed Gmbh Compuestos 3,4,4a,10b-tetrahidro-1h-tiopirano[4,3-c]isoquinolina
US9301753B2 (en) 2010-09-30 2016-04-05 Ethicon Endo-Surgery, Llc Expandable tissue thickness compensator
US8802700B2 (en) 2010-12-10 2014-08-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
KR102137087B1 (ko) 2012-02-10 2020-07-24 피티씨 테라퓨틱스, 인크. 척수성 근위축증을 치료하기 위한 화합물
MX2014010253A (es) 2012-02-27 2014-11-12 Vertex Pharma Composicion farmaceutica y administraciones de la misma.
JP5881837B2 (ja) * 2012-09-26 2016-03-09 株式会社エーピーアイ コーポレーション テトラゾール化合物の脱保護方法
US10195202B2 (en) 2013-12-19 2019-02-05 Ptc Therapeutics, Inc. Methods for modulating the amount of RNA transcripts
WO2016057730A1 (en) 2014-10-07 2016-04-14 Strohmeier Mark Co-crystals of modulators of cystic fibrosis transmembrane conductance regulator
WO2016196386A1 (en) 2015-05-30 2016-12-08 Ptc Therapeutics, Inc. Methods for modulating rna splicing
US10464896B2 (en) 2015-06-11 2019-11-05 Basilea Pharmaceutica International AG Efflux-pump inhibitors and therapeutic uses thereof
WO2017042099A1 (en) 2015-09-09 2017-03-16 Basilea Pharmaceutica Ag Efflux-pump inhibitors and therapeutic uses thereof
WO2017093157A1 (en) 2015-11-30 2017-06-08 Basilea Pharmaceutica Ag Piperidine, pyrrolidine and 2-oxo-1,3-oxazinane derivatives as inhibitors of bacterial efflux-pumps for the treatment of microbial infections
MX2021001091A (es) 2015-12-10 2022-04-26 Ptc Therapeutics Inc Compuestos para usarse en el tratamiento o mejoramiento de la enfermedad de huntington.
CA3043755A1 (en) 2016-11-28 2018-05-31 Ptc Therapeutics, Inc. Methods for modulating rna splicing
US11407753B2 (en) 2017-06-05 2022-08-09 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
CA3065547A1 (en) 2017-06-14 2018-12-20 Ptc Therapeutics, Inc. Methods for modifying rna splicing
US11382918B2 (en) 2017-06-28 2022-07-12 Ptc Therapeutics, Inc. Methods for treating Huntington's Disease
BR112019027719A2 (pt) 2017-06-28 2020-07-28 Ptc Therapeutics, Inc. métodos para tratar a doença de huntington
JP7399870B2 (ja) 2018-03-27 2023-12-18 ピーティーシー セラピューティクス, インコーポレイテッド ハンチントン病を処置するための化合物
EP3814360A1 (en) 2018-06-27 2021-05-05 PTC Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
JP7421507B2 (ja) 2018-06-27 2024-01-24 ピーティーシー セラピューティクス, インコーポレイテッド ハンチントン病を処置するためのヘテロ環式およびヘテロアリール化合物

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1458066A (fr) * 1963-03-20 1966-03-04 Boehringer & Soehne Gmbh Procédé pour la préparation de nouveaux dérivés du nitrofurane
JPS442219B1 (zh) * 1965-04-09 1969-01-30
JPS4413952B1 (zh) * 1966-07-22 1969-06-21
US3567716A (en) * 1966-06-14 1971-03-02 Daiichi Seiyaku Co 1,8-naphthyridine derivatives and intermediates thereof
GB1305820A (zh) * 1970-09-28 1973-02-07
US3907808A (en) * 1971-05-17 1975-09-23 Sterling Drug Inc 1,4-Dihydro-4-oxo-7-pyridyl-3-quinolinecarboxylic acid derivatives
US3870712A (en) * 1972-03-17 1975-03-11 Lilly Co Eli Cinchoninic acid derivatives
US4013647A (en) * 1976-03-23 1977-03-22 American Home Products Corporation Morpholine containing tetrazole-5-carboxamide derivatives
US4404207A (en) * 1981-11-06 1983-09-13 Riker Laboratories, Inc. Antimicrobial 8-substituted benzo [IJ]quinolizines
US4665079A (en) * 1984-02-17 1987-05-12 Warner-Lambert Company Antibacterial agents
DE3417840A1 (de) * 1983-05-17 1984-11-22 Ciba-Geigy Ag, Basel Tetrazolverbindungen
HUT43322A (en) * 1985-09-24 1987-10-28 Schering Ag Compositions with herbicidal effect comprising imidazolinyl derivatives as active substance and process for preparing the active substances
DE3875750D1 (de) * 1987-01-30 1992-12-17 Ciba Geigy Ag Mikrobizide mittel.
JPH02219892A (ja) * 1989-02-22 1990-09-03 Dainippon Ink & Chem Inc 強誘電性液晶組成物
JPH03207789A (ja) * 1990-01-09 1991-09-11 Dainippon Ink & Chem Inc 強誘電性液晶組成物
DE69132006T2 (de) * 1990-11-30 2000-08-03 Otsuka Pharma Co Ltd Thiazolederivate als inhibitoren von aktivem sauerstoff
US5206235A (en) * 1991-03-20 1993-04-27 Merck & Co., Inc. Benzo-fused lactams that promote the release of growth hormone
JPH0543878A (ja) * 1991-08-15 1993-02-23 Dainippon Ink & Chem Inc 減粘性液晶を含有する強誘電性液晶組成物
DE69224836T2 (de) * 1991-12-26 1998-10-15 Kashima Oil Co Optisch aktive tetrahydropyran derivate, flüssigkristallzusammensetzungen und diese enthaltende flüssigkristallelemente
JPH07506369A (ja) * 1992-04-29 1995-07-13 エス・アール・アイ・インターナシヨナル 炎症を処置するためのデアザアミノプテリン
WO1993022315A1 (en) * 1992-04-29 1993-11-11 Sri International Heteroaroyl-10-deazaaminopterins for treatment of inflammation
US5512581A (en) * 1994-07-18 1996-04-30 Abbott Laboratories Iminoxycarboxylates and derivatives as inhibitors of leukotriene biosynthesis
HUT77609A (hu) * 1994-10-14 1998-06-29 Yamanouchi Pharmaceutical Co. Ltd. Azolszármazékok, az ezeket tartalmazó gyógyszerkészítmények és a vegyületek intermedierjei
US5989832A (en) * 1995-04-21 1999-11-23 Microcide Pharmaceuticals, Inc. Method for screening for non-tetracycline efflux pump inhibitors
WO1997003967A1 (en) * 1995-07-22 1997-02-06 Rhone-Poulenc Rorer Limited Substituted aromatic compounds and their pharmaceutical use
US5908858A (en) * 1996-04-05 1999-06-01 Sankyo Company, Limited 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses
WO1998002430A1 (en) * 1996-07-11 1998-01-22 Pfizer Pharmaceuticals Inc. Pyridylpyrrole compounds useful as interleukin- and tnf antagonists
US5935977A (en) * 1996-09-25 1999-08-10 Ss Pharmaceutical Co., Ltd. Substituted vinyl pyridine derivative and drugs containing the same
WO1998017625A1 (fr) * 1996-10-22 1998-04-30 Daiichi Pharmaceutical Co., Ltd. Nouveaux remedes pour des maladies infectieuses
JPH10310578A (ja) * 1996-11-13 1998-11-24 Yoshitomi Pharmaceut Ind Ltd 3−フェニルピラゾール化合物
AU8033598A (en) * 1997-06-18 1999-01-04 Nissan Chemical Industries Ltd. Pyridine compounds and herbicides
US5936977A (en) * 1997-09-17 1999-08-10 Cypress Semiconductor Corp. Scan path circuitry including a programmable delay circuit
EP1047692B1 (en) * 1998-01-14 2004-07-21 The Uab Research Foundation Methods of synthesizing and screening inhibitors of bacterial nad synthetase enzyme, compounds thereof and methods of treating bacterial and microbial infections with these inhibitors
WO1999036442A1 (en) * 1998-01-20 1999-07-22 Grain Processing Corporation Reduced malto-oligosaccharides
WO1999037667A1 (en) * 1998-01-23 1999-07-29 Microcide Pharmaceuticals, Inc. Efflux pump inhibitors
DE19814137A1 (de) * 1998-03-30 1999-10-14 Rhodia Acetow Ag Verfahren zum Austreiben von Ammoniak aus einem aktivierten Polysaccharid
DE19817459A1 (de) * 1998-04-20 1999-10-21 Basf Ag Neue heterozyklische substituierte Amide, Herstellung und Anwendung

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