HK1047938A1 - 作为抗肿瘤剂的c7酯取代的紫杉烷 - Google Patents
作为抗肿瘤剂的c7酯取代的紫杉烷 Download PDFInfo
- Publication number
- HK1047938A1 HK1047938A1 HK03100173.6A HK03100173A HK1047938A1 HK 1047938 A1 HK1047938 A1 HK 1047938A1 HK 03100173 A HK03100173 A HK 03100173A HK 1047938 A1 HK1047938 A1 HK 1047938A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyridyl
- furyl
- thienyl
- taxane
- coox
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17979400P | 2000-02-02 | 2000-02-02 | |
| US60/179,794 | 2000-02-02 | ||
| PCT/US2001/003385 WO2001057027A1 (en) | 2000-02-02 | 2001-02-02 | C7 ester substituted taxanes as antitumor agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1047938A1 true HK1047938A1 (zh) | 2003-03-14 |
Family
ID=22658029
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK03100173.6A HK1047938A1 (zh) | 2000-02-02 | 2001-02-02 | 作为抗肿瘤剂的c7酯取代的紫杉烷 |
Country Status (35)
| Country | Link |
|---|---|
| US (3) | US6610860B2 (https=) |
| EP (1) | EP1183253B8 (https=) |
| JP (1) | JP2003522167A (https=) |
| KR (1) | KR100784161B1 (https=) |
| CN (1) | CN1362955A (https=) |
| AR (1) | AR030188A1 (https=) |
| AT (1) | ATE396188T1 (https=) |
| AU (1) | AU776051B2 (https=) |
| BG (1) | BG65279B1 (https=) |
| BR (1) | BR0104749A (https=) |
| CA (1) | CA2368993C (https=) |
| CO (1) | CO5280224A1 (https=) |
| CZ (1) | CZ298484B6 (https=) |
| DE (1) | DE60134094D1 (https=) |
| DK (1) | DK1183253T3 (https=) |
| ES (1) | ES2307588T3 (https=) |
| GE (1) | GEP20043322B (https=) |
| HK (1) | HK1047938A1 (https=) |
| HU (1) | HUP0200917A3 (https=) |
| IL (1) | IL145641A0 (https=) |
| MX (1) | MXPA01009901A (https=) |
| MY (1) | MY137637A (https=) |
| NO (1) | NO327982B1 (https=) |
| NZ (1) | NZ514409A (https=) |
| PL (1) | PL202668B1 (https=) |
| PT (1) | PT1183253E (https=) |
| RO (1) | RO121777B1 (https=) |
| RU (1) | RU2265017C2 (https=) |
| SA (1) | SA01220045B1 (https=) |
| SK (1) | SK13712001A3 (https=) |
| TR (1) | TR200102856T1 (https=) |
| TW (1) | TWI291873B (https=) |
| UA (1) | UA75573C2 (https=) |
| WO (1) | WO2001057027A1 (https=) |
| ZA (1) | ZA200108060B (https=) |
Families Citing this family (41)
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| MXPA01009900A (es) * | 2000-02-02 | 2003-08-20 | Univ Florida State Res Found | Formulaciones de taxano que tienen solubilidad mejorada. |
| CO5280224A1 (es) * | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| CA2354486A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C7 ester substituted taxanes |
| SG125889A1 (en) * | 2001-08-01 | 2006-10-30 | Univ Florida State Res Found | C7 ester subsituted taxanes |
| KR100819578B1 (ko) * | 2001-08-01 | 2008-04-04 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | Ｃ７ 에스테르 치환된 탁산 |
| US20030082229A1 (en) * | 2001-11-01 | 2003-05-01 | Board Of Regents, The University Of Texas Systems | Parenteral chlorambucil for treatment of malignant and autoimmune disease and methods of use |
| US8012950B2 (en) * | 2003-08-29 | 2011-09-06 | Wisconsin Alumni Research Foundation | Method to diagnose and treat degenerative joint disease |
| CA2539975C (en) | 2003-09-25 | 2012-11-20 | Tapestry Pharmaceuticals, Inc. | 9,10-.alpha.,.alpha.-oh-taxane analogs and methods for production thereof |
| EP1894921A3 (en) * | 2003-09-25 | 2008-03-12 | Tapestry Pharmaceuticals, Inc. | 9, 10-Alpha, Alpha-Oh-Taxane analogs and methods for production thereof |
| PE20060014A1 (es) * | 2004-03-05 | 2006-02-18 | Univ Florida State Res Found | Taxanos con sustituyentes lactiloxilo en el c7 |
| TW200533339A (en) * | 2004-03-16 | 2005-10-16 | Bristol Myers Squibb Co | Therapeutic synergy of anti-cancer compounds |
| AU2005294214A1 (en) * | 2004-10-07 | 2006-04-20 | Emory University | Multifunctional nanoparticles conjugates and their use |
| ES2565929T3 (es) | 2004-10-25 | 2016-04-07 | Dekk-Tec, Inc. | Sales de mostaza de isofosforamida y análogos de las mismas como agentes antitumorales |
| US20060216767A1 (en) * | 2005-03-22 | 2006-09-28 | Saladax Biomedical Inc. | Docetaxel immunoassay |
| PL217731B1 (pl) | 2006-06-01 | 2014-08-29 | Tomasz Byrski | Sposób wykrywania genetycznie uwarunkowanej obniżonej odpowiedzi na chemioterapię cytostatykiem taksanowym, zastosowanie mutacji założycielskiej oraz zestawu do wykrywania takiej odpowiedzi |
| EP1913958B1 (en) * | 2006-08-03 | 2009-12-23 | Sanofi-Aventis | Antitumor compositions containing acetylcyclopropyl docetaxel and trastuzumab |
| US11786504B2 (en) | 2006-09-28 | 2023-10-17 | Tapestry Pharmaceuticals, Inc. | Taxane analogs for the treatment of brain cancer |
| WO2008121476A1 (en) | 2007-03-28 | 2008-10-09 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US11873308B2 (en) | 2006-11-06 | 2024-01-16 | Tapestry Pharmaceuticals, Inc. | Biologically active taxane analogs and methods of treatment by oral administration |
| US20120128657A1 (en) | 2007-02-07 | 2012-05-24 | Bewley Carole A | Synthetic macrocyclic compounds and methods for treating cancer |
| WO2008109360A1 (en) | 2007-02-28 | 2008-09-12 | Tapestry Pharmaceuticals, Inc | Taxane analogs for the treatment of brain cancer |
| ES2547302T3 (es) | 2007-04-06 | 2015-10-05 | Ziopharm Oncology, Inc. | Sales de mostaza de isofosforamida y análogos de las mismas |
| CA2732290A1 (en) | 2008-07-31 | 2010-02-04 | Ziopharm Oncology, Inc. | Synthesis and formulations of salts of isophosphoramide mustard and analogs thereof |
| JP5779106B2 (ja) | 2009-02-24 | 2015-09-16 | デック−テック， インコーポレイテッド | 抗腫瘍剤としての４−ヒドロペルオキシイホスファミドの錯体 |
| WO2010138686A1 (en) | 2009-05-29 | 2010-12-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mdri-inverse agents |
| CA2791702C (en) | 2010-03-10 | 2018-05-29 | Sri International | The use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas |
| WO2012033601A1 (en) | 2010-08-20 | 2012-03-15 | The United States Of America, As Represented By The Secretary, Department Of Health & Human Services | Thiosemicarbazones with mdr1 - inverse activity |
| CN103781495A (zh) | 2011-07-11 | 2014-05-07 | 美国政府(由卫生和人类服务部的部长所代表) | 光敏抗体-荧光团缀合物 |
| AU2013266235B2 (en) | 2012-05-25 | 2017-06-08 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods of regulating cannabinoid receptor activity-related disorders and diseases |
| CN105813654B (zh) | 2013-10-11 | 2019-05-31 | 美国政府(由卫生和人类服务部的部长所代表) | Tem8抗体及其用途 |
| SG11201610052TA (en) | 2014-08-08 | 2017-02-27 | Us Health | Photo-controlled removal of targets in vitro and in vivo |
| EP3973973A1 (en) | 2017-10-31 | 2022-03-30 | KaliVir Immunotherapeutics, Inc. | Platform oncolytic vector for systemic delivery |
| WO2019099615A1 (en) | 2017-11-17 | 2019-05-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Use of copeptin to modulate the immune response and hematopoiesis, and stimulate bone growth |
| CA3096305A1 (en) | 2018-04-10 | 2019-10-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Combination of near infrared photoimmunotherapy targeting cancer cells and host-immune activation |
| WO2021003297A1 (en) | 2019-07-02 | 2021-01-07 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Monoclonal antibodies that bind egfrviii and their use |
| WO2021154705A1 (en) | 2020-01-27 | 2021-08-05 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Rab13 and net1 antisense oligonucleotides to treat metastatic cancer |
| CA3197371A1 (en) | 2020-11-19 | 2022-05-27 | Kalivir Immunotherapeutics, Inc. | Oncolytic immunotherapy by tumor micro-environment remodeling |
| WO2022165277A1 (en) | 2021-01-29 | 2022-08-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Near infrared photoimmunotherapy (nir-pit) combination therapy to treat cancer |
| EP4329786A4 (en) | 2021-04-30 | 2024-12-11 | KaliVir Immunotherapeutics, Inc. | Oncolytic viruses for modified mhc expression |
| CA3260932A1 (en) | 2022-06-30 | 2024-01-04 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | CD25-SPECIFIC ANTIBODIES AND THEIR USES |
| WO2025014896A1 (en) | 2023-07-07 | 2025-01-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Humanized 40h3 antibody |
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| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5321128A (en) * | 1988-09-06 | 1994-06-14 | Kabi Pharmacia Ab | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| US4960790A (en) | 1989-03-09 | 1990-10-02 | University Of Kansas | Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof |
| SE463189B (sv) | 1989-03-13 | 1990-10-22 | Eston Joensson | Preparat avsett att tillfoeras amalgamfyllningar i taender foer att daerigenom hindra eller minska avgaang av kvicksilver eller kvicksilveraanga |
| US5175315A (en) | 1989-05-31 | 1992-12-29 | Florida State University | Method for preparation of taxol using β-lactam |
| FR2679230B1 (fr) | 1991-07-16 | 1993-11-19 | Rhone Poulenc Rorer Sa | Nouveaux derives d'analogues du taxol, leur preparation et les compositions qui les contiennent. |
| US5283253A (en) | 1991-09-23 | 1994-02-01 | Florida State University | Furyl or thienyl carbonyl substituted taxanes and pharmaceutical compositions containing them |
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| US5489601A (en) * | 1991-09-23 | 1996-02-06 | Florida State University | Taxanes having a pyridyl substituted side-chain and pharmaceutical compositions containing them |
| US5227400A (en) | 1991-09-23 | 1993-07-13 | Florida State University | Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them |
| US5714513A (en) | 1991-09-23 | 1998-02-03 | Florida State University | C10 taxane derivatives and pharmaceutical compositions |
| US5430160A (en) | 1991-09-23 | 1995-07-04 | Florida State University | Preparation of substituted isoserine esters using β-lactams and metal or ammonium alkoxides |
| US5243045A (en) | 1991-09-23 | 1993-09-07 | Florida State University | Certain alkoxy substituted taxanes and pharmaceutical compositions containing them |
| US5721268A (en) | 1991-09-23 | 1998-02-24 | Florida State University | C7 taxane derivatives and pharmaceutical compositions containing them |
| RU2059631C1 (ru) * | 1991-11-29 | 1996-05-10 | Дзе Юниверсити оф Канзас | Производные таксола и фармацевтическая композиция, обладающая противоопухолевой активностью |
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| US5200534A (en) | 1992-03-13 | 1993-04-06 | University Of Florida | Process for the preparation of taxol and 10-deacetyltaxol |
| JPH07505887A (ja) | 1992-04-17 | 1995-06-29 | アボツト・ラボラトリーズ | タキソール誘導体 |
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| WO2001025223A1 (en) | 1999-10-06 | 2001-04-12 | The Research Foundation Of State University Of New York | Stabilization of taxane-containing dispersed systems |
| CO5280224A1 (es) | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| KR20010111580A (ko) | 2000-02-02 | 2001-12-19 | 플로리다 스테이트 유니버시티 리서치 파운데이션, 인크 | 개선된 용해도를 갖는 탁산 제형물 |
| MXPA01009900A (es) * | 2000-02-02 | 2003-08-20 | Univ Florida State Res Found | Formulaciones de taxano que tienen solubilidad mejorada. |
| IT1319168B1 (it) | 2000-03-17 | 2003-09-26 | Indena Spa | Derivati di condensazione ad attivita' antitumorale, loro metodo dipreparazione e formulazioni che li contengono. |
-
2001
- 2001-01-31 CO CO01007075A patent/CO5280224A1/es not_active Application Discontinuation
- 2001-01-31 AR ARP010100463A patent/AR030188A1/es not_active Application Discontinuation
- 2001-02-02 PT PT01905349T patent/PT1183253E/pt unknown
- 2001-02-02 CZ CZ20013503A patent/CZ298484B6/cs not_active IP Right Cessation
- 2001-02-02 NZ NZ514409A patent/NZ514409A/xx unknown
- 2001-02-02 JP JP2001557859A patent/JP2003522167A/ja active Pending
- 2001-02-02 CA CA002368993A patent/CA2368993C/en not_active Expired - Fee Related
- 2001-02-02 MX MXPA01009901A patent/MXPA01009901A/es active IP Right Grant
- 2001-02-02 PL PL350026A patent/PL202668B1/pl not_active IP Right Cessation
- 2001-02-02 IL IL14564101A patent/IL145641A0/xx unknown
- 2001-02-02 WO PCT/US2001/003385 patent/WO2001057027A1/en not_active Ceased
- 2001-02-02 ES ES01905349T patent/ES2307588T3/es not_active Expired - Lifetime
- 2001-02-02 CN CN01800306A patent/CN1362955A/zh active Pending
- 2001-02-02 MY MYPI20010481A patent/MY137637A/en unknown
- 2001-02-02 RU RU2001129507/04A patent/RU2265017C2/ru not_active IP Right Cessation
- 2001-02-02 UA UA2001106734A patent/UA75573C2/uk unknown
- 2001-02-02 HK HK03100173.6A patent/HK1047938A1/zh unknown
- 2001-02-02 SK SK1371-2001A patent/SK13712001A3/sk unknown
- 2001-02-02 HU HU0200917A patent/HUP0200917A3/hu unknown
- 2001-02-02 GE GE4514A patent/GEP20043322B/en unknown
- 2001-02-02 DK DK01905349T patent/DK1183253T3/da active
- 2001-02-02 US US09/775,851 patent/US6610860B2/en not_active Expired - Fee Related
- 2001-02-02 EP EP01905349A patent/EP1183253B8/en not_active Expired - Lifetime
- 2001-02-02 DE DE60134094T patent/DE60134094D1/de not_active Expired - Fee Related
- 2001-02-02 RO ROA200101085A patent/RO121777B1/ro unknown
- 2001-02-02 TR TR2001/02856T patent/TR200102856T1/xx unknown
- 2001-02-02 AT AT01905349T patent/ATE396188T1/de not_active IP Right Cessation
- 2001-02-02 AU AU33239/01A patent/AU776051B2/en not_active Ceased
- 2001-02-02 BR BR0104749-3A patent/BR0104749A/pt not_active IP Right Cessation
- 2001-02-02 KR KR1020017012600A patent/KR100784161B1/ko not_active Expired - Fee Related
- 2001-03-06 TW TW090102237A patent/TWI291873B/zh active
- 2001-04-11 SA SA1220045A patent/SA01220045B1/ar unknown
- 2001-10-01 ZA ZA200108060A patent/ZA200108060B/en unknown
- 2001-10-01 NO NO20014759A patent/NO327982B1/no not_active IP Right Cessation
- 2001-10-01 BG BG105967A patent/BG65279B1/bg unknown
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2003
- 2003-06-25 US US10/606,027 patent/US7186849B2/en not_active Expired - Fee Related
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2007
- 2007-01-09 US US11/621,321 patent/US20070249708A1/en not_active Abandoned
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