HK1046912B - 取代的皂苷酸基及它們的用途 - Google Patents

取代的皂苷酸基及它們的用途

Info

Publication number
HK1046912B
HK1046912B HK02108205.2A HK02108205A HK1046912B HK 1046912 B HK1046912 B HK 1046912B HK 02108205 A HK02108205 A HK 02108205A HK 1046912 B HK1046912 B HK 1046912B
Authority
HK
Hong Kong
Prior art keywords
substituted sapogenins
sapogenins
treatment
substituted
disclosed
Prior art date
Application number
HK02108205.2A
Other languages
English (en)
Other versions
HK1046912A1 (en
Inventor
Paul Barraclough
Jim Hanson
Phil Gunning
Daryl Rees
Zongqin Xia
Yaer Hu
Original Assignee
Phytopharm Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phytopharm Plc filed Critical Phytopharm Plc
Publication of HK1046912A1 publication Critical patent/HK1046912A1/xx
Publication of HK1046912B publication Critical patent/HK1046912B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Catalysts (AREA)
  • Polyesters Or Polycarbonates (AREA)
HK02108205.2A 2000-01-06 2002-11-13 取代的皂苷酸基及它們的用途 HK1046912B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0000228.7A GB0000228D0 (en) 2000-01-06 2000-01-06 Fluoro substituted sapogenins and their use
PCT/GB2001/000048 WO2001049703A2 (en) 2000-01-06 2001-01-08 Substituted sapogenins and their use

Publications (2)

Publication Number Publication Date
HK1046912A1 HK1046912A1 (en) 2003-01-30
HK1046912B true HK1046912B (zh) 2009-07-31

Family

ID=9883260

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02108205.2A HK1046912B (zh) 2000-01-06 2002-11-13 取代的皂苷酸基及它們的用途

Country Status (15)

Country Link
US (3) US20030158161A1 (zh)
EP (1) EP1246835B9 (zh)
JP (1) JP2003519624A (zh)
CN (1) CN1215080C (zh)
AT (1) ATE420097T1 (zh)
AU (1) AU2386201A (zh)
BR (1) BR0107691A (zh)
CA (1) CA2395100C (zh)
DE (1) DE60137307D1 (zh)
ES (1) ES2323671T3 (zh)
GB (1) GB0000228D0 (zh)
HK (1) HK1046912B (zh)
MX (1) MXPA02006720A (zh)
PT (1) PT1246835E (zh)
WO (1) WO2001049703A2 (zh)

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GB9923076D0 (en) 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB9923078D0 (en) * 1999-09-29 1999-12-01 Phytopharm Plc Sapogenin derivatives and their use
GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
ATE424211T1 (de) * 2002-03-27 2009-03-15 Phytopharm Plc Therapeutische verwendung von sapogeninen
EP1490071B1 (en) * 2002-03-27 2009-03-04 Phytopharm Plc Therapeutic uses of sapogenins
EP2111864A3 (en) * 2002-03-27 2009-12-30 Phytopharm Plc Therapeutic methods and uses of sapogenins and their derivatives
KR101130212B1 (ko) * 2002-03-27 2012-04-13 파이토팜 피엘씨 사포게닌 및 그 유도체의 치료 방법 및 사용법
US7718792B2 (en) 2002-10-28 2010-05-18 Phytopharm Plc Stereospecific reduction of sapogen-3-ones
GB0409567D0 (en) 2004-04-28 2004-06-02 Phytopharm Plc Chemical compounds
GB0424528D0 (en) 2004-11-05 2004-12-08 Phytopharm Plc Chemical compounds
CA2750510A1 (en) 2009-01-24 2010-07-29 Phytopharm Plc Treatment of neurotrophic factor mediated disorders
CA2805693A1 (en) 2010-07-20 2012-01-26 Phytopharm Plc Treatment of l-dopa, dopamine agonist and/or dopamine enhancer induced disorders
CN113956315A (zh) 2011-09-08 2022-01-21 萨奇治疗股份有限公司 神经活性类固醇、组合物、及其用途
WO2013149580A1 (en) 2012-04-03 2013-10-10 Chiming Che Timosaponin compounds
ES2886506T3 (es) 2013-03-13 2021-12-20 Sage Therapeutics Inc Esteroides neuroactivos
EP4306114A1 (en) 2014-06-18 2024-01-17 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
CN106905407B (zh) * 2015-01-27 2019-08-13 华东理工大学 知母皂苷元结构修饰的衍生物、其药物组合物及其应用
CA2991311A1 (en) 2015-07-06 2017-01-12 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
HUE053778T2 (hu) 2015-07-06 2021-07-28 Sage Therapeutics Inc Oxiszterinek és ezek alkalmazása
MA54851A (fr) 2015-07-06 2021-12-08 Sage Therapeutics Inc Oxystérols et leurs procédés d'utilisation
KR101777920B1 (ko) * 2015-07-27 2017-09-14 재단법인 지능형 바이오 시스템 설계 및 합성 연구단 진세노사이드 f1을 포함하는 아밀로이드 플라크 제거용 조성물
PT3436022T (pt) 2016-04-01 2022-07-04 Sage Therapeutics Inc Oxisteróis e métodos de utilização dos mesmos
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
EP3481846B1 (en) 2016-07-07 2021-05-12 Sage Therapeutics, Inc. 11-substituted 24-hydroxysterols for use in the treatment of nmda related conditions
BR112019006365A2 (pt) 2016-09-30 2019-08-06 Sage Therapeutics Inc oxisteróis substituídos c7 e métodos de utilização dos mesmos
EP3529257B1 (en) 2016-10-18 2023-05-10 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
JP2019532079A (ja) 2016-10-18 2019-11-07 セージ セラピューティクス， インコーポレイテッド オキシステロールおよびその使用方法
CN108117580A (zh) * 2016-11-30 2018-06-05 沈阳药科大学 菝葜皂苷元衍生物及其制备方法和用途
CN108264535A (zh) 2016-12-30 2018-07-10 中国科学院上海药物研究所 一种抗抑郁化合物及其制备方法和应用
CN109206472A (zh) * 2018-09-27 2019-01-15 华东理工大学 薯蓣皂苷元衍生物、其药物组合物及其应用

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GB0000228D0 (en) * 2000-01-06 2000-03-01 Phytopharm Plc Fluoro substituted sapogenins and their use
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Also Published As

Publication number Publication date
BR0107691A (pt) 2005-03-22
GB0000228D0 (en) 2000-03-01
EP1246835A2 (en) 2002-10-09
US20030158161A1 (en) 2003-08-21
AU2386201A (en) 2001-07-16
CA2395100C (en) 2010-12-21
EP1246835B9 (en) 2010-02-17
MXPA02006720A (es) 2002-09-30
HK1046912A1 (en) 2003-01-30
WO2001049703A3 (en) 2002-02-21
ATE420097T1 (de) 2009-01-15
CA2395100A1 (en) 2001-07-12
CN1215080C (zh) 2005-08-17
ES2323671T3 (es) 2009-07-23
US20100087411A1 (en) 2010-04-08
DE60137307D1 (de) 2009-02-26
EP1246835B1 (en) 2009-01-07
US20080207576A1 (en) 2008-08-28
WO2001049703A2 (en) 2001-07-12
JP2003519624A (ja) 2003-06-24
PT1246835E (pt) 2009-04-15
CN1452630A (zh) 2003-10-29

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Legal Events

Date Code Title Description
CHPA Change of a particular in the register (except of change of ownership)
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130108