HK1043372B - 低氧-诱导因子1αHIF-1α变体和鉴定HIF-1α调节剂的方法 - Google Patents

低氧-诱导因子1αHIF-1α变体和鉴定HIF-1α调节剂的方法 Download PDF

Info

Publication number
HK1043372B
HK1043372B HK02105080.8A HK02105080A HK1043372B HK 1043372 B HK1043372 B HK 1043372B HK 02105080 A HK02105080 A HK 02105080A HK 1043372 B HK1043372 B HK 1043372B
Authority
HK
Hong Kong
Prior art keywords
hif
leu
ser
thr
glu
Prior art date
Application number
HK02105080.8A
Other languages
English (en)
Chinese (zh)
Other versions
HK1043372A1 (en
Inventor
A‧伯肯斯塔姆
L‧波尔林格
L‧波爾林格
Original Assignee
血管遗传瑞典股份公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 血管遗传瑞典股份公司 filed Critical 血管遗传瑞典股份公司
Publication of HK1043372A1 publication Critical patent/HK1043372A1/xx
Publication of HK1043372B publication Critical patent/HK1043372B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Amplifiers (AREA)
  • Semiconductor Lasers (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)
HK02105080.8A 1998-11-13 1999-11-11 低氧-诱导因子1αHIF-1α变体和鉴定HIF-1α调节剂的方法 HK1043372B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9803891A SE9803891D0 (sv) 1998-11-13 1998-11-13 Protein Variants
SE9803891-2 1998-11-13
PCT/SE1999/002053 WO2000029437A1 (en) 1998-11-13 1999-11-11 HYPOXIA-INDUCIBLE FACTOR 1α HIF-1α VARIANTS AND METHODS FOR IDENTIFYING HIF-1α MODULATORS

Publications (2)

Publication Number Publication Date
HK1043372A1 HK1043372A1 (en) 2002-09-13
HK1043372B true HK1043372B (zh) 2008-05-09

Family

ID=20413284

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02105080.8A HK1043372B (zh) 1998-11-13 1999-11-11 低氧-诱导因子1αHIF-1α变体和鉴定HIF-1α调节剂的方法

Country Status (15)

Country Link
EP (1) EP1141005B1 (https=)
JP (1) JP2002530063A (https=)
KR (1) KR100648761B1 (https=)
CN (1) CN1330666C (https=)
AT (1) ATE374210T1 (https=)
AU (1) AU761594B2 (https=)
BR (1) BR9915263A (https=)
CA (1) CA2350830A1 (https=)
DE (1) DE69937199D1 (https=)
HK (1) HK1043372B (https=)
NZ (1) NZ511450A (https=)
SE (1) SE9803891D0 (https=)
TR (1) TR200101345T2 (https=)
WO (1) WO2000029437A1 (https=)
ZA (1) ZA200103669B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911047D0 (en) 1999-05-12 1999-07-14 Isis Innovation Assay method and means
ATE383877T1 (de) * 1999-06-04 2008-02-15 Dana Farber Cancer Inst Inc Identifikation von stoffen, die transkriptionelle antworten auf hypoxia modifizieren
WO2001092578A2 (en) * 2000-05-26 2001-12-06 Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
AU9017901A (en) * 2000-08-07 2002-02-18 Angiogenetics Sweden Ab Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the vonhippel-lindau tumor suppressor protein
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
AU2002302252A1 (en) 2001-05-23 2002-12-03 Angiogene Inc. Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
EP1842856A3 (en) * 2001-05-23 2007-12-12 Angiogene Inc. Hypoxia inducing factors and uses thereof for inducing angiogenesis and improving muscular functions
AU2003201798A1 (en) * 2002-01-11 2003-09-02 Angio Genetics Sweden Ab Hif-1 alpha proteins mutated in the c-terminal transactivation domain
CN100366747C (zh) * 2005-03-08 2008-02-06 上海第二医科大学附属仁济医院 低氧诱导因子小干扰rna质粒
CN100418574C (zh) * 2005-10-26 2008-09-17 王成球 一类封闭人类HIF-1α基因和调控网络中下游相关基因的染色质肽
CN102127161B (zh) * 2010-12-16 2013-03-27 何明忠 抗肿瘤多肽及其用途
CN106366173A (zh) * 2015-07-24 2017-02-01 北京京爱康科技有限公司 一种通过结合低氧反应元件控制缺氧反应基因表达的染色质肽

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1

Also Published As

Publication number Publication date
ZA200103669B (en) 2002-05-07
SE9803891D0 (sv) 1998-11-13
BR9915263A (pt) 2001-10-30
EP1141005A1 (en) 2001-10-10
HK1043372A1 (en) 2002-09-13
KR20010080411A (ko) 2001-08-22
CN1330666C (zh) 2007-08-08
AU761594B2 (en) 2003-06-05
KR100648761B1 (ko) 2006-11-23
WO2000029437A1 (en) 2000-05-25
CA2350830A1 (en) 2000-05-25
JP2002530063A (ja) 2002-09-17
DE69937199D1 (de) 2007-11-08
NZ511450A (en) 2003-08-29
ATE374210T1 (de) 2007-10-15
CN1330663A (zh) 2002-01-09
EP1141005B1 (en) 2007-09-26
TR200101345T2 (tr) 2001-10-22
AU1593100A (en) 2000-06-05

Similar Documents

Publication Publication Date Title
CN1330666C (zh) 低氧－诱导因子1αHIF－1α变体和鉴定HIF－1α调节剂的方法
WO2018062866A2 (en) CELL-PERMEABLE (CP)-Cas9 RECOMBINANT PROTEIN AND USES THEREOF
WO2019009682A2 (ko) 표적 특이적 crispr 변이체
Mimura et al. Functional role of AhR in the expression of toxic effects by TCDD
WO2017116204A1 (ko) 글루카곤, glp-1 및 gip 수용체 모두에 활성을 갖는 삼중 활성체
WO2017030292A1 (ko) P62 zz 도메인에 결합하는 리간드 또는 아르기닌화된 bip에 의해 매개되는 오토파지 활성을 통한 신경변성 질환 예방 및 치료
WO2017026779A1 (en) Improved cell-permeable cre (icp-cre) recombinant protein and use thereof
WO2017026776A1 (en) Improved cell-permeable reprogramming factor (icp-rf) recombinant protein and use thereof
WO2020256444A1 (ko) p62 리간드 화합물 및 이의 ER-파지 촉진 용도
WO2018038352A2 (ko) 치매진단용 자가항체 바이오마커 및 이를 이용한 치매진단 방법
WO2016122058A1 (ko) 세포성점균을 이용한 인간 페닐알라닌 수산화효소의 활성분석 방법
WO2020218657A1 (ko) 표적 특이적 crispr 변이체
WO2013100273A1 (ko) 방사선 피폭 진단용 마커 ｉｇｆｂｐ-5, 그 마커의 발현수준을 측정하는 방사선 피폭 진단용 조성물, 그 조성물을 포함하는 방사선 피폭 진단용 키트, 및 그 마커를 이용한 방사선 피폭을 진단하는 방법
WO2022139493A1 (ko) TGF-β 신호전달을 억제할 수 있는 신규한 펩타이드 및 이의 용도
WO2016178511A1 (ko) Kai1 폴리펩타이드 또는 이를 코딩하는 유전자를 포함하는 혈관신생 억제용 조성물 및 이의 용도
WO2017010790A1 (ko) 나노입자-유리체 기반 단백질 복합체를 유효성분으로 포함하는 혈관신생억제용 조성물 및 이의 용도
WO2024144330A1 (ko) 레베르 유전성 시신경병증의 미토콘드리아 염기 변이 교정 시스템
WO2016117949A1 (ko) 포스파티딜이노시톨포스페이트 결합 물질의 세포 사멸 검출 용도
WO2024167317A1 (ko) 신규 CRISPR/Cas12a 조성물 및 이의 표적 핵산 검출 용도
WO2011155643A1 (ko) 포그 ２ 다섯 번째 징크 핑거 도메인을 포함하는 포스파티딜이노시톨３키나아제 활성 조절제
WO2023140694A1 (ko) 스트렙토코커스 피오게네스 유래 cas9 변이체
WO2009145488A2 (ko) 지방세포로의 분화 조절 기능을 갖는 지방세포 분화 표지자로서의 xbp1(s) 단백질 및 그 용도
WO2025174135A1 (ko) 샤르코-마리-투스 질환 치료를 위한 징크 핑거 단백질 및 이를 발현시키는 방법
US20240368571A1 (en) Eubacterium rectale cas12a mutants
WO2022215843A1 (ko) 암 환자에 대하여 자연살해세포를 이용한 면역 항암 치료의 치료 반응성을 예측하는 방법

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20111111