AU761594B2 - Hypoxia-inducible factor 1alpha HIF-1alpha variants and methods for identifying HIF-1alpha modulators - Google Patents

Hypoxia-inducible factor 1alpha HIF-1alpha variants and methods for identifying HIF-1alpha modulators Download PDF

Info

Publication number
AU761594B2
AU761594B2 AU15931/00A AU1593100A AU761594B2 AU 761594 B2 AU761594 B2 AU 761594B2 AU 15931/00 A AU15931/00 A AU 15931/00A AU 1593100 A AU1593100 A AU 1593100A AU 761594 B2 AU761594 B2 AU 761594B2
Authority
AU
Australia
Prior art keywords
hif
leu
ser
thr
asp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU15931/00A
Other languages
English (en)
Other versions
AU1593100A (en
Inventor
Anders Berkenstam
Lorenz Poellinger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Angiogenetics Sweden AB
Original Assignee
Angiogenetics Sweden AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Angiogenetics Sweden AB filed Critical Angiogenetics Sweden AB
Publication of AU1593100A publication Critical patent/AU1593100A/en
Assigned to BIOVITRUM AB reassignment BIOVITRUM AB Alteration of Name(s) of Applicant(s) under S113 Assignors: PHARMACIA AB
Assigned to ANGIOGENETICS SWEDEN AB reassignment ANGIOGENETICS SWEDEN AB Alteration of Name(s) of Applicant(s) under S113 Assignors: BIOVITRUM AB
Application granted granted Critical
Publication of AU761594B2 publication Critical patent/AU761594B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Amplifiers (AREA)
  • Semiconductor Lasers (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)
AU15931/00A 1998-11-13 1999-11-11 Hypoxia-inducible factor 1alpha HIF-1alpha variants and methods for identifying HIF-1alpha modulators Ceased AU761594B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9803891A SE9803891D0 (sv) 1998-11-13 1998-11-13 Protein Variants
SE9803891 1998-11-13
PCT/SE1999/002053 WO2000029437A1 (en) 1998-11-13 1999-11-11 HYPOXIA-INDUCIBLE FACTOR 1α HIF-1α VARIANTS AND METHODS FOR IDENTIFYING HIF-1α MODULATORS

Publications (2)

Publication Number Publication Date
AU1593100A AU1593100A (en) 2000-06-05
AU761594B2 true AU761594B2 (en) 2003-06-05

Family

ID=20413284

Family Applications (1)

Application Number Title Priority Date Filing Date
AU15931/00A Ceased AU761594B2 (en) 1998-11-13 1999-11-11 Hypoxia-inducible factor 1alpha HIF-1alpha variants and methods for identifying HIF-1alpha modulators

Country Status (15)

Country Link
EP (1) EP1141005B1 (https=)
JP (1) JP2002530063A (https=)
KR (1) KR100648761B1 (https=)
CN (1) CN1330666C (https=)
AT (1) ATE374210T1 (https=)
AU (1) AU761594B2 (https=)
BR (1) BR9915263A (https=)
CA (1) CA2350830A1 (https=)
DE (1) DE69937199D1 (https=)
HK (1) HK1043372B (https=)
NZ (1) NZ511450A (https=)
SE (1) SE9803891D0 (https=)
TR (1) TR200101345T2 (https=)
WO (1) WO2000029437A1 (https=)
ZA (1) ZA200103669B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911047D0 (en) 1999-05-12 1999-07-14 Isis Innovation Assay method and means
ATE383877T1 (de) * 1999-06-04 2008-02-15 Dana Farber Cancer Inst Inc Identifikation von stoffen, die transkriptionelle antworten auf hypoxia modifizieren
WO2001092578A2 (en) * 2000-05-26 2001-12-06 Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
AU9017901A (en) * 2000-08-07 2002-02-18 Angiogenetics Sweden Ab Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the vonhippel-lindau tumor suppressor protein
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
AU2002302252A1 (en) 2001-05-23 2002-12-03 Angiogene Inc. Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
EP1842856A3 (en) * 2001-05-23 2007-12-12 Angiogene Inc. Hypoxia inducing factors and uses thereof for inducing angiogenesis and improving muscular functions
AU2003201798A1 (en) * 2002-01-11 2003-09-02 Angio Genetics Sweden Ab Hif-1 alpha proteins mutated in the c-terminal transactivation domain
CN100366747C (zh) * 2005-03-08 2008-02-06 上海第二医科大学附属仁济医院 低氧诱导因子小干扰rna质粒
CN100418574C (zh) * 2005-10-26 2008-09-17 王成球 一类封闭人类HIF-1α基因和调控网络中下游相关基因的染色质肽
CN102127161B (zh) * 2010-12-16 2013-03-27 何明忠 抗肿瘤多肽及其用途
CN106366173A (zh) * 2015-07-24 2017-02-01 北京京爱康科技有限公司 一种通过结合低氧反应元件控制缺氧反应基因表达的染色质肽

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1

Also Published As

Publication number Publication date
ZA200103669B (en) 2002-05-07
SE9803891D0 (sv) 1998-11-13
BR9915263A (pt) 2001-10-30
EP1141005A1 (en) 2001-10-10
HK1043372A1 (en) 2002-09-13
KR20010080411A (ko) 2001-08-22
CN1330666C (zh) 2007-08-08
KR100648761B1 (ko) 2006-11-23
WO2000029437A1 (en) 2000-05-25
CA2350830A1 (en) 2000-05-25
JP2002530063A (ja) 2002-09-17
HK1043372B (zh) 2008-05-09
DE69937199D1 (de) 2007-11-08
NZ511450A (en) 2003-08-29
ATE374210T1 (de) 2007-10-15
CN1330663A (zh) 2002-01-09
EP1141005B1 (en) 2007-09-26
TR200101345T2 (tr) 2001-10-22
AU1593100A (en) 2000-06-05

Similar Documents

Publication Publication Date Title
Boccuni et al. The human L (3) MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6)
Morris et al. Myosin VI binds to and localises with Dab2, potentially linking receptor‐mediated endocytosis and the actin cytoskeleton
Lai et al. A human importin-β family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins
Zhang et al. Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization
Gupta et al. Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1
AU761594B2 (en) Hypoxia-inducible factor 1alpha HIF-1alpha variants and methods for identifying HIF-1alpha modulators
Dorval et al. Transcriptional activity of the paired-like homeodomain proteins CHX10 and VSX1
US6436654B1 (en) Methods for identifying compounds that modulate HIF-1α
Perry et al. Direct interaction between myocyte enhancer factor 2 (MEF2) and protein phosphatase 1α represses MEF2-dependent gene expression
Piluso et al. Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1
Chen et al. Cubitus interruptus requires Drosophila CREB-binding protein to activate wingless expression in the Drosophila embryo
Hardivillé et al. O-GlcNAcylation/phosphorylation cycling at Ser10 controls both transcriptional activity and stability of Δ-lactoferrin
AU2001290179B2 (en) Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the von hippel-lindau tumor suppressor protein
Meloni et al. DAXX is a new AIRE-interacting protein
Clements et al. Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila
US5876972A (en) Nucleic acid molecules coding for tumor suppressor proteins and methods for their isolation
WO2001068846A2 (en) Transcription activator of the cited family
US7081343B2 (en) Methods for identifying modulators of NF-KB activity
AU2416600A (en) Exocytosis pathway proteins and methods of use
MXPA01004787A (en) HYPOXIA-INDUCIBLE FACTOR 1&agr;HIF-1&agr;VARIANTS AND METHODS FOR IDENTIFYING HIF-1&agr;MODULATORS
EP1637540A1 (en) Hyperactive Stat molecules and their use in assays employing gene activation
Zhang Regulation of the activity of Erythroid Krüppel-like Factor (EKLF) by histone acetyltransferases
US6812336B1 (en) Transcription factor coactivator protein, p/CIP
Herzig Jr NRF-1 regulation of respiratory function: Involvement of phosphorylation and protein-protein interactions
WO2003074560A2 (en) Critical hypoxia-inducible factor-1alpha residues, products and methods related thereto

Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: BIOVITRUM AB

Free format text: THE FORMER OWNER WAS: PHARMACIA AB

PC1 Assignment before grant (sect. 113)

Owner name: ANGIOGENETICS SWEDEN AB

Free format text: THE FORMER OWNER WAS: BIOVITRUM AB

FGA Letters patent sealed or granted (standard patent)