CN1330666C - 低氧－诱导因子1αHIF－1α变体和鉴定HIF－1α调节剂的方法 - Google Patents

低氧－诱导因子1αHIF－1α变体和鉴定HIF－1α调节剂的方法 Download PDF

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CN1330666C
CN1330666C CNB99814388XA CN99814388A CN1330666C CN 1330666 C CN1330666 C CN 1330666C CN B99814388X A CNB99814388X A CN B99814388XA CN 99814388 A CN99814388 A CN 99814388A CN 1330666 C CN1330666 C CN 1330666C
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glu
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CN1330663A (zh
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A·伯肯斯塔姆
L·波尔林格
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Angiogenetics Sweden AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Amplifiers (AREA)
  • Semiconductor Lasers (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)
CNB99814388XA 1998-11-13 1999-11-11 低氧－诱导因子1αHIF－1α变体和鉴定HIF－1α调节剂的方法 Expired - Fee Related CN1330666C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9803891A SE9803891D0 (sv) 1998-11-13 1998-11-13 Protein Variants
SE98038912 1998-11-13

Publications (2)

Publication Number Publication Date
CN1330663A CN1330663A (zh) 2002-01-09
CN1330666C true CN1330666C (zh) 2007-08-08

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CNB99814388XA Expired - Fee Related CN1330666C (zh) 1998-11-13 1999-11-11 低氧－诱导因子1αHIF－1α变体和鉴定HIF－1α调节剂的方法

Country Status (15)

Country Link
EP (1) EP1141005B1 (https=)
JP (1) JP2002530063A (https=)
KR (1) KR100648761B1 (https=)
CN (1) CN1330666C (https=)
AT (1) ATE374210T1 (https=)
AU (1) AU761594B2 (https=)
BR (1) BR9915263A (https=)
CA (1) CA2350830A1 (https=)
DE (1) DE69937199D1 (https=)
HK (1) HK1043372B (https=)
NZ (1) NZ511450A (https=)
SE (1) SE9803891D0 (https=)
TR (1) TR200101345T2 (https=)
WO (1) WO2000029437A1 (https=)
ZA (1) ZA200103669B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911047D0 (en) 1999-05-12 1999-07-14 Isis Innovation Assay method and means
ATE383877T1 (de) * 1999-06-04 2008-02-15 Dana Farber Cancer Inst Inc Identifikation von stoffen, die transkriptionelle antworten auf hypoxia modifizieren
WO2001092578A2 (en) * 2000-05-26 2001-12-06 Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
AU9017901A (en) * 2000-08-07 2002-02-18 Angiogenetics Sweden Ab Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the vonhippel-lindau tumor suppressor protein
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
AU2002302252A1 (en) 2001-05-23 2002-12-03 Angiogene Inc. Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
EP1842856A3 (en) * 2001-05-23 2007-12-12 Angiogene Inc. Hypoxia inducing factors and uses thereof for inducing angiogenesis and improving muscular functions
AU2003201798A1 (en) * 2002-01-11 2003-09-02 Angio Genetics Sweden Ab Hif-1 alpha proteins mutated in the c-terminal transactivation domain
CN100366747C (zh) * 2005-03-08 2008-02-06 上海第二医科大学附属仁济医院 低氧诱导因子小干扰rna质粒
CN100418574C (zh) * 2005-10-26 2008-09-17 王成球 一类封闭人类HIF-1α基因和调控网络中下游相关基因的染色质肽
CN102127161B (zh) * 2010-12-16 2013-03-27 何明忠 抗肿瘤多肽及其用途
CN106366173A (zh) * 2015-07-24 2017-02-01 北京京爱康科技有限公司 一种通过结合低氧反应元件控制缺氧反应基因表达的染色质肽

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039426A1 (en) * 1995-06-06 1996-12-12 The Johns Hopkins University School Of Medicine Hypoxia inducible factor-1 and method of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996039426A1 (en) * 1995-06-06 1996-12-12 The Johns Hopkins University School Of Medicine Hypoxia inducible factor-1 and method of use

Also Published As

Publication number Publication date
ZA200103669B (en) 2002-05-07
SE9803891D0 (sv) 1998-11-13
BR9915263A (pt) 2001-10-30
EP1141005A1 (en) 2001-10-10
HK1043372A1 (en) 2002-09-13
KR20010080411A (ko) 2001-08-22
AU761594B2 (en) 2003-06-05
KR100648761B1 (ko) 2006-11-23
WO2000029437A1 (en) 2000-05-25
CA2350830A1 (en) 2000-05-25
JP2002530063A (ja) 2002-09-17
HK1043372B (zh) 2008-05-09
DE69937199D1 (de) 2007-11-08
NZ511450A (en) 2003-08-29
ATE374210T1 (de) 2007-10-15
CN1330663A (zh) 2002-01-09
EP1141005B1 (en) 2007-09-26
TR200101345T2 (tr) 2001-10-22
AU1593100A (en) 2000-06-05

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