BR9915263A - Variantes do fator hif-1 "alfa" que induz à hipoxiahumana e métodos para identificação dosmoduladores de hif-1 "alfa" - Google Patents

Variantes do fator hif-1 "alfa" que induz à hipoxiahumana e métodos para identificação dosmoduladores de hif-1 "alfa"

Info

Publication number
BR9915263A
BR9915263A BR9915263-0A BR9915263A BR9915263A BR 9915263 A BR9915263 A BR 9915263A BR 9915263 A BR9915263 A BR 9915263A BR 9915263 A BR9915263 A BR 9915263A
Authority
BR
Brazil
Prior art keywords
alpha
hif
human hif
essentially
domain
Prior art date
Application number
BR9915263-0A
Other languages
English (en)
Inventor
Anders Berkenstam
Lorenz Poellinger
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of BR9915263A publication Critical patent/BR9915263A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Semiconductor Lasers (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Amplifiers (AREA)
  • Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)

Abstract

"VARIANTES DO FATOR HIF-1<244> QUE INDUZ à HIPOXIAHUMANA E MéTODOS PARA IDENTIFICAçãO DOSMODULADORES DE HIF-1<244>". A presente invenção se referea um método para identificação de compostos capazes de modulara função de um domínio funcional do fator HIF-<244> humano, ditométodo compreendendo: (i) contatar um composto candidato comuma variante de HIF1<244> a humano, dita variante omitindoessencialmente pelo menos um domínio funcional do fatorHIF-1<244> humano ou tendo uma mutação que torna pelo menosum domínio funcional do fator HIF-1<244> essencialmente inativo,dito domínio funcional ou domínios funcionais sendo selecionadosdo grupo que consiste de: (a) domínio de PAS-B localizado no fatorHIF-1<244> humano, entre os aminoácidos 178 e 390; (b)seq³ência de localização nuclear (NLS) do terminal C localizada nofator HIF-1<244> humano, essencialmente nos aminoácidos 718 a721; (c) domínio de transativação/co-ativação (N-TAD) localizadono fator HIF-1<244> humano, essencialmente entre osaminoácidos 531 a 584; e (d) domínio detransativação/co-ativação (C-TAD) localizado no fator HIF-1<244>humano, essencialmente entre os aminoácidos 813 e 826; e (ii)determinar o efeito do composto candidato na dita variante.
BR9915263-0A 1998-11-13 1999-11-11 Variantes do fator hif-1 "alfa" que induz à hipoxiahumana e métodos para identificação dosmoduladores de hif-1 "alfa" BR9915263A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9803891A SE9803891D0 (sv) 1998-11-13 1998-11-13 Protein Variants
PCT/SE1999/002053 WO2000029437A1 (en) 1998-11-13 1999-11-11 HYPOXIA-INDUCIBLE FACTOR 1α HIF-1α VARIANTS AND METHODS FOR IDENTIFYING HIF-1α MODULATORS

Publications (1)

Publication Number Publication Date
BR9915263A true BR9915263A (pt) 2001-10-30

Family

ID=20413284

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9915263-0A BR9915263A (pt) 1998-11-13 1999-11-11 Variantes do fator hif-1 "alfa" que induz à hipoxiahumana e métodos para identificação dosmoduladores de hif-1 "alfa"

Country Status (15)

Country Link
EP (1) EP1141005B1 (pt)
JP (1) JP2002530063A (pt)
KR (1) KR100648761B1 (pt)
CN (1) CN1330666C (pt)
AT (1) ATE374210T1 (pt)
AU (1) AU761594B2 (pt)
BR (1) BR9915263A (pt)
CA (1) CA2350830A1 (pt)
DE (1) DE69937199D1 (pt)
HK (1) HK1043372B (pt)
NZ (1) NZ511450A (pt)
SE (1) SE9803891D0 (pt)
TR (1) TR200101345T2 (pt)
WO (1) WO2000029437A1 (pt)
ZA (1) ZA200103669B (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911047D0 (en) 1999-05-12 1999-07-14 Isis Innovation Assay method and means
ES2299427T3 (es) * 1999-06-04 2008-06-01 Dana-Farber Cancer Institute, Inc. Identificacion de compuestos que modifiquen respuestas transcripcionales a la hipoxia.
EP1348033A2 (en) * 2000-05-26 2003-10-01 Board of Trustees of the University of Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
CN1835969A (zh) * 2000-08-07 2006-09-20 血管基因瑞典有限公司 冯希普尔－林道肿瘤抑制蛋白对低氧诱导因子－1的条件调节机制
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
WO2002094862A2 (en) 2001-05-23 2002-11-28 Angiogene Inc. Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
EP1842856A3 (en) * 2001-05-23 2007-12-12 Angiogene Inc. Hypoxia inducing factors and uses thereof for inducing angiogenesis and improving muscular functions
AU2003201798A1 (en) * 2002-01-11 2003-09-02 Angio Genetics Sweden Ab Hif-1 alpha proteins mutated in the c-terminal transactivation domain
CN100366747C (zh) * 2005-03-08 2008-02-06 上海第二医科大学附属仁济医院 低氧诱导因子小干扰rna质粒
CN100418574C (zh) * 2005-10-26 2008-09-17 王成球 一类封闭人类HIF-1α基因和调控网络中下游相关基因的染色质肽
CN102127161B (zh) * 2010-12-16 2013-03-27 何明忠 抗肿瘤多肽及其用途
CN106366173A (zh) * 2015-07-24 2017-02-01 北京京爱康科技有限公司 一种通过结合低氧反应元件控制缺氧反应基因表达的染色质肽

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1

Also Published As

Publication number Publication date
HK1043372B (zh) 2008-05-09
SE9803891D0 (sv) 1998-11-13
CA2350830A1 (en) 2000-05-25
JP2002530063A (ja) 2002-09-17
NZ511450A (en) 2003-08-29
AU1593100A (en) 2000-06-05
HK1043372A1 (en) 2002-09-13
CN1330666C (zh) 2007-08-08
CN1330663A (zh) 2002-01-09
TR200101345T2 (tr) 2001-10-22
EP1141005A1 (en) 2001-10-10
ZA200103669B (en) 2002-05-07
EP1141005B1 (en) 2007-09-26
AU761594B2 (en) 2003-06-05
KR100648761B1 (ko) 2006-11-23
WO2000029437A1 (en) 2000-05-25
DE69937199D1 (de) 2007-11-08
KR20010080411A (ko) 2001-08-22
ATE374210T1 (de) 2007-10-15

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