SE9803891D0 - Protein Variants - Google Patents

Protein Variants

Info

Publication number
SE9803891D0
SE9803891D0 SE9803891A SE9803891A SE9803891D0 SE 9803891 D0 SE9803891 D0 SE 9803891D0 SE 9803891 A SE9803891 A SE 9803891A SE 9803891 A SE9803891 A SE 9803891A SE 9803891 D0 SE9803891 D0 SE 9803891D0
Authority
SE
Sweden
Prior art keywords
alpha
human hif
essentially
domain
amino acids
Prior art date
Application number
SE9803891A
Other languages
English (en)
Swedish (sv)
Inventor
Anders Berkenstam
Lorenz Poellinger
Original Assignee
Pharmacia & Upjohn Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Ab filed Critical Pharmacia & Upjohn Ab
Priority to SE9803891A priority Critical patent/SE9803891D0/xx
Publication of SE9803891D0 publication Critical patent/SE9803891D0/xx
Priority to TR2001/01345T priority patent/TR200101345T2/xx
Priority to AU15931/00A priority patent/AU761594B2/en
Priority to NZ511450A priority patent/NZ511450A/en
Priority to PCT/SE1999/002053 priority patent/WO2000029437A1/en
Priority to HK02105080.8A priority patent/HK1043372B/zh
Priority to KR1020017005928A priority patent/KR100648761B1/ko
Priority to JP2000582422A priority patent/JP2002530063A/ja
Priority to AT99958594T priority patent/ATE374210T1/de
Priority to EP99958594A priority patent/EP1141005B1/en
Priority to BR9915263-0A priority patent/BR9915263A/pt
Priority to CNB99814388XA priority patent/CN1330666C/zh
Priority to CA002350830A priority patent/CA2350830A1/en
Priority to DE69937199T priority patent/DE69937199D1/de
Priority to US09/438,833 priority patent/US6436654B1/en
Priority to ZA200103669A priority patent/ZA200103669B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Amplifiers (AREA)
  • Semiconductor Lasers (AREA)
  • Radar Systems Or Details Thereof (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Testing, Inspecting, Measuring Of Stereoscopic Televisions And Televisions (AREA)
SE9803891A 1998-11-13 1998-11-13 Protein Variants SE9803891D0 (sv)

Priority Applications (16)

Application Number Priority Date Filing Date Title
SE9803891A SE9803891D0 (sv) 1998-11-13 1998-11-13 Protein Variants
DE69937199T DE69937199D1 (de) 1998-11-13 1999-11-11 Verfahren zur identifikation von modulatoren von hif-1-alpha
KR1020017005928A KR100648761B1 (ko) 1998-11-13 1999-11-11 저산소증-유도성 인자 1α ＨＩＦ-1α 변이체 및ＨＩＦ-1α 조절제의 동정 방법
AT99958594T ATE374210T1 (de) 1998-11-13 1999-11-11 Verfahren zur identifikation von modulatoren von hif-1-alpha
NZ511450A NZ511450A (en) 1998-11-13 1999-11-11 Method of identifying compounds that modulate the function of the human hypoxia-inducible factor 1-alpha (HIF-1alpha) functional domain
PCT/SE1999/002053 WO2000029437A1 (en) 1998-11-13 1999-11-11 HYPOXIA-INDUCIBLE FACTOR 1α HIF-1α VARIANTS AND METHODS FOR IDENTIFYING HIF-1α MODULATORS
HK02105080.8A HK1043372B (zh) 1998-11-13 1999-11-11 低氧-诱导因子1αHIF-1α变体和鉴定HIF-1α调节剂的方法
TR2001/01345T TR200101345T2 (tr) 1998-11-13 1999-11-11 Hipoksiya'nın oluşturabildiği faktör 1alfa HIF-1alfa'nın değişik biçimleri için yöntemler.
JP2000582422A JP2002530063A (ja) 1998-11-13 1999-11-11 低酸素誘導性因子１α（ＨＩＦ−１α）変異体およびＨＩＦ−１α調整因子の同定法
AU15931/00A AU761594B2 (en) 1998-11-13 1999-11-11 Hypoxia-inducible factor 1alpha HIF-1alpha variants and methods for identifying HIF-1alpha modulators
EP99958594A EP1141005B1 (en) 1998-11-13 1999-11-11 Method for identifying hif-1alpha modulators
BR9915263-0A BR9915263A (pt) 1998-11-13 1999-11-11 Variantes do fator hif-1 "alfa" que induz à hipoxiahumana e métodos para identificação dosmoduladores de hif-1 "alfa"
CNB99814388XA CN1330666C (zh) 1998-11-13 1999-11-11 低氧－诱导因子1αHIF－1α变体和鉴定HIF－1α调节剂的方法
CA002350830A CA2350830A1 (en) 1998-11-13 1999-11-11 Hypoxia-inducible factor 1.alpha. hif-1.alpha. variants and methods for identifying hif-1.alpha. modulators
US09/438,833 US6436654B1 (en) 1998-11-13 1999-11-12 Methods for identifying compounds that modulate HIF-1α
ZA200103669A ZA200103669B (en) 1998-11-13 2001-05-07 Hypoxia-inducible factor 1a HIF-1α variants and methods for identifying HIF-1α modulators.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9803891A SE9803891D0 (sv) 1998-11-13 1998-11-13 Protein Variants

Publications (1)

Publication Number Publication Date
SE9803891D0 true SE9803891D0 (sv) 1998-11-13

Family

ID=20413284

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9803891A SE9803891D0 (sv) 1998-11-13 1998-11-13 Protein Variants

Country Status (15)

Country Link
EP (1) EP1141005B1 (https=)
JP (1) JP2002530063A (https=)
KR (1) KR100648761B1 (https=)
CN (1) CN1330666C (https=)
AT (1) ATE374210T1 (https=)
AU (1) AU761594B2 (https=)
BR (1) BR9915263A (https=)
CA (1) CA2350830A1 (https=)
DE (1) DE69937199D1 (https=)
HK (1) HK1043372B (https=)
NZ (1) NZ511450A (https=)
SE (1) SE9803891D0 (https=)
TR (1) TR200101345T2 (https=)
WO (1) WO2000029437A1 (https=)
ZA (1) ZA200103669B (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9911047D0 (en) 1999-05-12 1999-07-14 Isis Innovation Assay method and means
ATE383877T1 (de) * 1999-06-04 2008-02-15 Dana Farber Cancer Inst Inc Identifikation von stoffen, die transkriptionelle antworten auf hypoxia modifizieren
WO2001092578A2 (en) * 2000-05-26 2001-12-06 Board Of Trustees Of The University Of Illinois Reagents and methods for identifying and modulating expression of genes regulated by retinoids
AU9017901A (en) * 2000-08-07 2002-02-18 Angiogenetics Sweden Ab Mechanism of conditional regulation of the hypoxia-inducible factor-1 by the vonhippel-lindau tumor suppressor protein
US20030045830A1 (en) * 2001-04-17 2003-03-06 De Bizemont Therese Gene therapy with chimeric oligonucleotides delivered by a method comprising a step of iontophoresis
AU2002302252A1 (en) 2001-05-23 2002-12-03 Angiogene Inc. Hypoxia inducible factors and uses thereof for inducing angiogenesis and improving muscular functions
EP1842856A3 (en) * 2001-05-23 2007-12-12 Angiogene Inc. Hypoxia inducing factors and uses thereof for inducing angiogenesis and improving muscular functions
AU2003201798A1 (en) * 2002-01-11 2003-09-02 Angio Genetics Sweden Ab Hif-1 alpha proteins mutated in the c-terminal transactivation domain
CN100366747C (zh) * 2005-03-08 2008-02-06 上海第二医科大学附属仁济医院 低氧诱导因子小干扰rna质粒
CN100418574C (zh) * 2005-10-26 2008-09-17 王成球 一类封闭人类HIF-1α基因和调控网络中下游相关基因的染色质肽
CN102127161B (zh) * 2010-12-16 2013-03-27 何明忠 抗肿瘤多肽及其用途
CN106366173A (zh) * 2015-07-24 2017-02-01 北京京爱康科技有限公司 一种通过结合低氧反应元件控制缺氧反应基因表达的染色质肽

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5882914A (en) * 1995-06-06 1999-03-16 The Johns Hopkins University School Of Medicine Nucleic acids encoding the hypoxia inducible factor-1

Also Published As

Publication number Publication date
ZA200103669B (en) 2002-05-07
BR9915263A (pt) 2001-10-30
EP1141005A1 (en) 2001-10-10
HK1043372A1 (en) 2002-09-13
KR20010080411A (ko) 2001-08-22
CN1330666C (zh) 2007-08-08
AU761594B2 (en) 2003-06-05
KR100648761B1 (ko) 2006-11-23
WO2000029437A1 (en) 2000-05-25
CA2350830A1 (en) 2000-05-25
JP2002530063A (ja) 2002-09-17
HK1043372B (zh) 2008-05-09
DE69937199D1 (de) 2007-11-08
NZ511450A (en) 2003-08-29
ATE374210T1 (de) 2007-10-15
CN1330663A (zh) 2002-01-09
EP1141005B1 (en) 2007-09-26
TR200101345T2 (tr) 2001-10-22
AU1593100A (en) 2000-06-05

Similar Documents

Publication Publication Date Title
Franke et al. Differences of expression of cytoskeletal proteins in cultured rat hepatocytes and hepatoma cells
Wu et al. Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.
ATE352617T1 (de) Lösliche polypeptidfraktionen des lag-3-proteins; verfahren zur herstellung; therapeutische zusamensetzung; antiidiotypischer antikörper
SE9803891D0 (sv) Protein Variants
IL130036A0 (en) Survivin a protein that inhibits cellular apoptosis and its modulation
BR9912545A (pt) ácidos nucleicos codificando um receptorcopulado a proteìna g envolvido em transduçãosensorial
AU6162999A (en) Apoptosis marker antibodies and methods of use
ATE292801T1 (de) Verfahren zum screening von inhibitoren von asp2
DE69534252D1 (de) Enzyme zur spaltung der verankerungsregion von oberflächenproteinen aus gram-positiven bakterien
DE3587875D1 (de) Rekombinantverfahren zur herstellung von serinproteaseinhibitoren, sowie dns-sequenzen dazu.
DE69926627D1 (de) Insulinartigen wachstumsfaktor bindendes protein -3 variante
DE69628449D1 (de) Verfahren zur identifizierung unbekannter allele
DE60038363D1 (de) Detektion von kleinen molekülen mit piezo-elektrischem sensor
BR9510067A (pt) Peptídio capaz de interagir com o domínio sh3 da proteína gap anticorpo ou fragmento de anticorpo dirigido contra um polipeptídeo sequência nucleotídica codificando para um polipeptídio ácido nucléico anti-sentido capaz de inibir ao menos parcialmente a produção de polipeptídeos sua utilização composição farmacêutica e utilização de um anticorpo ou fragmento de anticorpo
KR930023469A (ko) 베타 아밀로이드 전구 단백질 프로세싱 효소의 검출 방법
ATE432287T1 (de) Peptidfragmente mit den zelltod verhindernder aktivität
DE69607034D1 (de) Pcna bindende substanz
ATE290088T1 (de) Verfahren zur spaltung eines chimeren proteins mittels eines 'processing'-enzyms
ATE405649T1 (de) Hemmstoff zur diagnose und behandlung von haemophilia a patienten
AR007279A1 (es) Composicion para la tincion y tonalizacion de cabellos
ATE121421T1 (de) Hemmung von migration von zellen mit hilfe von synthetischen peptiden.
WO1999001567A3 (en) Methods and compositions for a deubiquitinating enzyme and variants thereof
GB2289125A (en) Methods of assaying data-repairing enzymes and their alkylated derivatives
DE69023710D1 (de) Verfahren zur bestimmung von enzymatischer wirksamkeit.
DE60221698D1 (de) Nukleares protein "shoca" - eine komponente des wnt signaltransduktionsweges