DE60038363D1 - Detektion von kleinen molekülen mit piezo-elektrischem sensor - Google Patents

Detektion von kleinen molekülen mit piezo-elektrischem sensor

Info

Publication number
DE60038363D1
DE60038363D1 DE60038363T DE60038363T DE60038363D1 DE 60038363 D1 DE60038363 D1 DE 60038363D1 DE 60038363 T DE60038363 T DE 60038363T DE 60038363 T DE60038363 T DE 60038363T DE 60038363 D1 DE60038363 D1 DE 60038363D1
Authority
DE
Germany
Prior art keywords
antigen
binding portion
altered
protein
detection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60038363T
Other languages
English (en)
Other versions
DE60038363T2 (de
Inventor
Itamar Willner
Zelig Eshhar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yeda Research and Development Co Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Biosensor Applications Sweden AB
Original Assignee
Yeda Research and Development Co Ltd
Yissum Research Development Co of Hebrew University of Jerusalem
Biosensor Applications Sweden AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research and Development Co Ltd, Yissum Research Development Co of Hebrew University of Jerusalem, Biosensor Applications Sweden AB filed Critical Yeda Research and Development Co Ltd
Publication of DE60038363D1 publication Critical patent/DE60038363D1/de
Application granted granted Critical
Publication of DE60038363T2 publication Critical patent/DE60038363T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings

Landscapes

  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Measurement Of Length, Angles, Or The Like Using Electric Or Magnetic Means (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Piezo-Electric Transducers For Audible Bands (AREA)
  • Measuring Fluid Pressure (AREA)
  • Investigating Or Analyzing Materials By The Use Of Fluid Adsorption Or Reactions (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60038363T 1999-01-25 2000-01-25 Detektion von kleinen molekülen mit piezo-elektrischem sensor Expired - Lifetime DE60038363T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IL12821299A IL128212A (en) 1999-01-25 1999-01-25 Detection of small molecules by use of a piezoelectric sensor
IL12821299 1999-01-25
PCT/IL2000/000048 WO2000043774A2 (en) 1999-01-25 2000-01-25 Detection of small molecules by use of a piezoelectric sensor

Publications (2)

Publication Number Publication Date
DE60038363D1 true DE60038363D1 (de) 2008-04-30
DE60038363T2 DE60038363T2 (de) 2009-04-23

Family

ID=11072413

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60038363T Expired - Lifetime DE60038363T2 (de) 1999-01-25 2000-01-25 Detektion von kleinen molekülen mit piezo-elektrischem sensor

Country Status (7)

Country Link
US (1) US7135295B1 (de)
EP (1) EP1145006B1 (de)
AT (1) ATE389881T1 (de)
AU (1) AU2126400A (de)
DE (1) DE60038363T2 (de)
IL (1) IL128212A (de)
WO (1) WO2000043774A2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1514109B1 (de) 2002-06-19 2011-03-02 Biosensor Applications Sweden AB (Publ) Beschichtete metalloberfläche auf einem festträger mit nützlichkeit bei der analytedetektion durch verschiebung
WO2004001417A1 (en) * 2002-06-19 2003-12-31 Biosensor Applications Sweden Ab (Publ) Coated metal surface on solid support for displacement reactions
FI20030615A0 (fi) * 2003-04-24 2003-04-24 Marko Virta Nanopartikkeli bioaffiniteettimäärityksiin
WO2005050209A1 (en) * 2003-11-20 2005-06-02 Biosensor Applications Sweden (Publ) Mixture of at least two different antibodies specific for predetermined antigens and use of the mixture
US8349604B2 (en) * 2006-06-15 2013-01-08 University Of South Florida Nano-based device for detection of disease biomarkers and other target molecules
US20080100279A1 (en) * 2006-06-15 2008-05-01 University Of South Florida Nano-Based Device for Detection of Disease Biomarkers and Other Target Molecules
EP2102659B1 (de) * 2006-12-13 2012-10-31 Biosensor Applications Sweden AB (Publ) Ständig wiederholbares verfahren zum nachweis von antigenen in einem testvolumen
CN101595387B (zh) * 2006-12-13 2014-01-29 生物传感器应用国际有限公司 在测试体积中测试抗原的连续可重复方法
WO2012054758A2 (en) 2010-10-20 2012-04-26 Rapid Diagnostek, Inc. Apparatus and method for measuring binding kinetics with a resonating sensor
US8771402B2 (en) * 2011-06-14 2014-07-08 Ut-Battelle, Llc Membrane based apparatus for measurement of volatile particles
CA2846448C (en) * 2011-08-26 2022-09-27 Aviana Molecular Technologies, Llc Biocoated piezoelectric biosensor platform for point-of-care diagnostic use
CN107003302B (zh) 2014-09-15 2021-11-05 Qorvo美国公司 通过氧化还原耦合的质量检测
CN104407150B (zh) * 2014-11-12 2016-03-30 浙江大学 用于2,4,6-tnt检测的生物纳米传感器制备方法
FR3032792B1 (fr) * 2015-02-13 2017-03-24 Inst De Rech Pour Le Dev (Ird) Dispositif de captage d'au moins une espece chimique comprenant un capteur chimique et procede de fabrication d'un tel capteur chimique
CA3029332A1 (en) 2016-07-01 2018-01-04 Ludwig Institute For Cancer Research Ltd Methods and compositions for pdgf-cc inhibition

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4242096A (en) 1977-11-14 1980-12-30 Minnesota Mining And Manufacturing Company Immunoassay for antigens
US4236893A (en) 1979-04-09 1980-12-02 Minnesota Mining And Manufacturing Company Method for the assay of classes of antigen-specific antibodies
US4314821A (en) * 1979-04-09 1982-02-09 Minnesota Mining And Manufacturing Company Sandwich immunoassay using piezoelectric oscillator
US4735906A (en) 1984-11-28 1988-04-05 Texas A&M University Sensor having piezoelectric crystal for microgravimetric immunoassays
US4999284A (en) 1988-04-06 1991-03-12 E. I. Du Pont De Nemours And Company Enzymatically amplified piezoelectric specific binding assay
JPH01269485A (ja) * 1988-04-20 1989-10-26 Matsushita Electric Ind Co Ltd モノクローナル抗体産生細胞ラインおよびモノクローナル抗体
JPH01269488A (ja) * 1988-04-20 1989-10-26 Matsushita Electric Ind Co Ltd モノクローナル抗体産生細胞ラインおよびモノクローナル抗体
JPH05500715A (ja) * 1989-10-04 1993-02-12 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー バイオセンサーの表面上の生物学的標的複合体のアツセイ方法
US5179028A (en) 1990-04-20 1993-01-12 Hughes Aircraft Company Antibody coated crystal chemical sensor
IL114692A (en) 1995-07-21 1999-10-28 Yissum Res Dev Co Determination of an analyte in a liquid medium
JP3992114B2 (ja) 1997-06-12 2007-10-17 バイオセンサー、アプリケーションズ、スエーデン、アクチボラグ 空気中の検体の検出のための装置、システムおよび方法

Also Published As

Publication number Publication date
WO2000043774A3 (en) 2001-03-01
ATE389881T1 (de) 2008-04-15
AU2126400A (en) 2000-08-07
EP1145006B1 (de) 2008-03-19
US7135295B1 (en) 2006-11-14
EP1145006A2 (de) 2001-10-17
WO2000043774A2 (en) 2000-07-27
IL128212A0 (en) 1999-11-30
IL128212A (en) 2004-06-20
DE60038363T2 (de) 2009-04-23

Similar Documents

Publication Publication Date Title
DE60038363D1 (de) Detektion von kleinen molekülen mit piezo-elektrischem sensor
WO2001061053A3 (en) Protein and peptide sensors using electrical detection methods
ATE329267T1 (de) Nachweis von autoantikörpern von patienten mit rheumatischer arthritis
EP0621284A4 (de) PEPTIDE BESTEHEND AUS AMINOSÄURESEQUENZEN AUS ENTWEDER LIPOPROTEIN(a) ODER APOLIPOPROTEIN(a), ANTIKÖRPER, DIE DIESE AMINOSÄURESEQUENZEN ERKENNEN UND MESSVERFAHREN MIT DIESEN ANTIKÖRPERN.
NZ527053A (en) Modified amyloid precursor protein polynucleotides and polypeptides
AU3625999A (en) Detection of a target in a sample
NZ520659A (en) Xylanase variants having altered sensitivity to xylanase inhibitors caused by mutations in the lid region
EP0960939A3 (de) Doppeletikettierte Proteine und ihre Verwendungen
FI962247A (fi) Uudet apoptoosia muuntavat proteiinit, niitä koodaava DNA ja näiden käyttömenetelmät
DE69937835D1 (de) Antikörper für apoptosemarker und anwendungsverfahren
BR9812783A (pt) "sistemas de detecção para o registro de interações e as relações funcionais de proteìnas"
DK0532587T3 (da) Fremgangsmåder til trans-destabilisering af specifikke proteiner in vivo
DK1336109T3 (da) Kit og fremgangsmåde til at påvise proteinet EMS-1
DE60123755D1 (de) Komplementierungsassay für den nachweis von protein-löslichkeit und -faltung
ATE513040T1 (de) Zinkfingerdomänenbibliotheken
DE60025704D1 (de) Das goodpasture-antigen bindende protein
DK1400589T3 (da) Fremgangsmåde til påvisning af prokaryotisk DNA
DE69932834D1 (de) Chi-Conotoxinpeptide als Inhibitoren neuronaler Amintransporter
WO2003002730A3 (fr) Methode de detection de l'activite de la calpaine 3 dans un echantillon biologique et peptides pour la mise en oeuvre de ladite methode
DK450187D0 (da) Fremgangsmaade til fremstilling af proteiner
DE69121861D1 (de) Peptide von sm-d-antigen, deren benützung zum nachweis von disseminierten lupus-erythemateux
WO2002102847A1 (fr) Nouveau ligand et son adn
HUP9800782A2 (hu) Új antitest, az azt tartalmazó renin-aktív anyag és a prorenin vizsgálatára szolgáló reagens
DE69817338D1 (de) Verfahren zum nachweis von autoimmun-pathologien
DK0994187T3 (da) Renin-aktivt stof omfattende humant prorenin og antistoffer mod prorenin-profragmentet

Legal Events

Date Code Title Description
8364 No opposition during term of opposition