DE60123755D1 - Komplementierungsassay für den nachweis von protein-löslichkeit und -faltung - Google Patents
Komplementierungsassay für den nachweis von protein-löslichkeit und -faltungInfo
- Publication number
- DE60123755D1 DE60123755D1 DE60123755T DE60123755T DE60123755D1 DE 60123755 D1 DE60123755 D1 DE 60123755D1 DE 60123755 T DE60123755 T DE 60123755T DE 60123755 T DE60123755 T DE 60123755T DE 60123755 D1 DE60123755 D1 DE 60123755D1
- Authority
- DE
- Germany
- Prior art keywords
- protein
- folding
- improper
- marker protein
- detecting protein
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 6
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 238000003556 assay Methods 0.000 title 1
- 239000003550 marker Substances 0.000 abstract 3
- 108020001507 fusion proteins Proteins 0.000 abstract 2
- 102000037865 fusion proteins Human genes 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000001594 aberrant effect Effects 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 230000007547 defect Effects 0.000 abstract 1
- 238000001514 detection method Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000035118 modified proteins Human genes 0.000 abstract 1
- 108091005573 modified proteins Proteins 0.000 abstract 1
- 230000012846 protein folding Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Toxicology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18228300P | 2000-02-14 | 2000-02-14 | |
| US182283P | 2000-02-14 | ||
| US775051 | 2001-01-31 | ||
| US09/775,051 US6727070B2 (en) | 2000-02-14 | 2001-01-31 | Protein/solubility folding assessed by structural complementation |
| PCT/US2001/005097 WO2001060840A2 (en) | 2000-02-14 | 2001-02-14 | Complementation assay assessing protein solubility and folding |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60123755D1 true DE60123755D1 (de) | 2006-11-23 |
| DE60123755T2 DE60123755T2 (de) | 2007-10-18 |
Family
ID=56290109
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60123755T Expired - Lifetime DE60123755T2 (de) | 2000-02-14 | 2001-02-14 | Komplementierungsassay für den nachweis von protein-löslichkeit und -faltung |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6727070B2 (de) |
| EP (1) | EP1257829B1 (de) |
| JP (1) | JP4772247B2 (de) |
| AT (1) | ATE342510T1 (de) |
| AU (2) | AU2001237055B2 (de) |
| CA (1) | CA2398834C (de) |
| DE (1) | DE60123755T2 (de) |
| DK (1) | DK1257829T3 (de) |
| ES (1) | ES2273809T3 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6727070B2 (en) * | 2000-02-14 | 2004-04-27 | The Board Of Regents, The University Of Texas System | Protein/solubility folding assessed by structural complementation |
| US8609436B2 (en) * | 2000-03-17 | 2013-12-17 | Guy's & St Thomas' Hospital NHS Trust (“GST”) | Method |
| US8088586B2 (en) * | 2000-03-17 | 2012-01-03 | Oxford Radcliffe Hospital Nhs Trust | Method of producing a body fluid sample depleted of anti-MHC antibodies |
| US20060105377A1 (en) * | 2001-08-30 | 2006-05-18 | Eglen Richard M | Screening to optimize RNAi |
| US20040137480A1 (en) * | 2001-08-30 | 2004-07-15 | Eglen Richard M. | Monitoring intracellular proteins |
| EP2400030B1 (de) * | 2004-05-18 | 2016-01-20 | The Board of Trustees of the Leland Stanford Junior University | Detektion von Proteintranslokation durch Beta-Galactosidase-Reporter-Fragmentkomplementierung |
| CA2638888A1 (en) * | 2004-12-04 | 2006-06-15 | The Regents Of The University Of California | Protein subcellular localization assays using split fluorescent proteins |
| EP1683868A1 (de) * | 2005-01-21 | 2006-07-26 | Medizinische Universität Graz | Kringle Domäne in einem Calcium-sensitiven Fusionsprotein |
| US7390640B2 (en) * | 2005-02-22 | 2008-06-24 | Los Alamos National Security, Llc | Circular permutant GFP insertion folding reporters |
| US7355920B2 (en) * | 2006-02-16 | 2008-04-08 | Micron Technology, Inc. | Write latency tracking using a delay lock loop in a synchronous DRAM |
| JP5758801B2 (ja) * | 2008-07-22 | 2015-08-05 | トラスティーズ・オブ・ダートマス・カレッジＴｒｕｓｔｅｅｓ ｏｆ Ｄａｒｔｍｏｕｔｈ Ｃｏｌｌｅｇｅ | 単環式シアノエノンおよびその使用方法説明 |
| DE102008048036A1 (de) * | 2008-09-19 | 2010-03-25 | Meurer, Heinrich, Dr. | Verfahren zur Detektion ionisierender Strahlung |
| US8892184B2 (en) | 2010-10-18 | 2014-11-18 | Siemens Medical Solutions Usa, Inc. | Systems and methods for reducing interference in a dual modality imaging system |
| EP3233087B1 (de) | 2014-12-16 | 2019-10-02 | Axovant Sciences GmbH | Geminale substituierte chinuklidinamidverbindungen als agonisten von alpha-7-nikotinischen acetylcholinrezeptoren |
| US10370370B2 (en) | 2015-06-10 | 2019-08-06 | Axovant Sciences Gmbh | Aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
| US10428062B2 (en) | 2015-08-12 | 2019-10-01 | Axovant Sciences Gmbh | Geminal substituted aminobenzisoxazole compounds as agonists of α7-nicotinic acetylcholine receptors |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120653A (en) | 1985-04-08 | 1992-06-09 | Microgenics Corporation | Vector comprising DNA sequence coding for enzyme-donor polypeptide |
| CA2196496A1 (en) | 1997-01-31 | 1998-07-31 | Stephen William Watson Michnick | Protein fragment complementation assay for the detection of protein-protein interactions |
| US6294330B1 (en) * | 1997-01-31 | 2001-09-25 | Odyssey Pharmaceuticals Inc. | Protein fragment complementation assays for the detection of biological or drug interactions |
| US6342345B1 (en) | 1997-04-02 | 2002-01-29 | The Board Of Trustees Of The Leland Stanford Junior University | Detection of molecular interactions by reporter subunit complementation |
| US6727070B2 (en) * | 2000-02-14 | 2004-04-27 | The Board Of Regents, The University Of Texas System | Protein/solubility folding assessed by structural complementation |
-
2001
- 2001-01-31 US US09/775,051 patent/US6727070B2/en not_active Expired - Lifetime
- 2001-02-14 AT AT01909281T patent/ATE342510T1/de active
- 2001-02-14 AU AU2001237055A patent/AU2001237055B2/en not_active Expired
- 2001-02-14 AU AU3705501A patent/AU3705501A/xx active Pending
- 2001-02-14 DK DK01909281T patent/DK1257829T3/da active
- 2001-02-14 EP EP01909281A patent/EP1257829B1/de not_active Expired - Lifetime
- 2001-02-14 JP JP2001560224A patent/JP4772247B2/ja not_active Expired - Lifetime
- 2001-02-14 ES ES01909281T patent/ES2273809T3/es not_active Expired - Lifetime
- 2001-02-14 CA CA2398834A patent/CA2398834C/en not_active Expired - Lifetime
- 2001-02-14 DE DE60123755T patent/DE60123755T2/de not_active Expired - Lifetime
-
2003
- 2003-12-30 US US10/748,720 patent/US7455978B2/en not_active Expired - Lifetime
-
2006
- 2006-12-28 US US11/617,191 patent/US7635569B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US6727070B2 (en) | 2004-04-27 |
| US7635569B2 (en) | 2009-12-22 |
| CA2398834C (en) | 2010-08-10 |
| US20070178498A1 (en) | 2007-08-02 |
| EP1257829B1 (de) | 2006-10-11 |
| AU3705501A (en) | 2001-08-27 |
| EP1257829A2 (de) | 2002-11-20 |
| JP4772247B2 (ja) | 2011-09-14 |
| US20050019829A1 (en) | 2005-01-27 |
| ATE342510T1 (de) | 2006-11-15 |
| DE60123755T2 (de) | 2007-10-18 |
| DK1257829T3 (da) | 2007-02-12 |
| US20040002065A1 (en) | 2004-01-01 |
| ES2273809T3 (es) | 2007-05-16 |
| CA2398834A1 (en) | 2001-08-23 |
| AU2001237055B2 (en) | 2006-09-14 |
| US7455978B2 (en) | 2008-11-25 |
| JP2004500092A (ja) | 2004-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |