ATE207205T1 - Verfahren zumm assay von endotoxin-konzentration - Google Patents

Verfahren zumm assay von endotoxin-konzentration

Info

Publication number
ATE207205T1
ATE207205T1 AT95201582T AT95201582T ATE207205T1 AT E207205 T1 ATE207205 T1 AT E207205T1 AT 95201582 T AT95201582 T AT 95201582T AT 95201582 T AT95201582 T AT 95201582T AT E207205 T1 ATE207205 T1 AT E207205T1
Authority
AT
Austria
Prior art keywords
proteins
endotoxin concentration
endotoxin
assaying endotoxin
binding
Prior art date
Application number
AT95201582T
Other languages
English (en)
Inventor
Norman R Wainwright
Thomas J Novitsky
Original Assignee
Ass Cape Cod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ass Cape Cod Inc filed Critical Ass Cape Cod Inc
Application granted granted Critical
Publication of ATE207205T1 publication Critical patent/ATE207205T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43509—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from crustaceans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/579—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving limulus lysate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
    • B01D15/125—Pre-filtration

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
AT95201582T 1988-06-23 1989-06-21 Verfahren zumm assay von endotoxin-konzentration ATE207205T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21057588A 1988-06-23 1988-06-23

Publications (1)

Publication Number Publication Date
ATE207205T1 true ATE207205T1 (de) 2001-11-15

Family

ID=22783435

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95201582T ATE207205T1 (de) 1988-06-23 1989-06-21 Verfahren zumm assay von endotoxin-konzentration

Country Status (7)

Country Link
EP (2) EP0379549B1 (de)
JP (1) JP2774343B2 (de)
AT (1) ATE207205T1 (de)
AU (1) AU3772289A (de)
CA (1) CA1338836C (de)
DE (2) DE68929334T2 (de)
WO (1) WO1989012644A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK255887D0 (da) * 1987-05-20 1987-05-20 Claus Koch Immunoassay
US5594113A (en) * 1988-06-23 1997-01-14 Associates Of Cape Cod, Inc. Endotoxin binding and neutralizing protein and uses thereof
JP3117985B2 (ja) 1990-07-24 2000-12-18 マルハ株式会社 細菌性ショック治療剤
EP0572541A1 (de) * 1991-02-22 1993-12-08 Massachusetts Institute Of Technology Behandlung des endotoxinschocks
WO1992019745A1 (en) * 1991-05-08 1992-11-12 Vertex Pharmaceuticals Incorporated Rfkbp: a novel prolyl isomerase and rapamycin/fk506 binding protein
AU2006892A (en) * 1991-05-16 1992-12-30 Associates Of Cape Cod, Inc. Endotoxin binding and neutralizing protein and uses thereof
AU669723B2 (en) * 1992-05-19 1996-06-20 Xoma Corporation Improved methods for the preparation of endotoxin-binding proteins
US6274348B1 (en) 1992-05-19 2001-08-14 Xoma Corporation Methods for the preparation of positively charged proteins
JP3402476B2 (ja) * 1992-08-24 2003-05-06 生化学工業株式会社 リポ多糖結合性タンパク質及びその製造法
CA2146667A1 (en) * 1993-08-18 1995-02-23 Adolf Hoess Lipopolysaccharide-binding and neutralizing peptides
NZ275205A (en) * 1993-09-22 1998-03-25 Xoma Corp Use of bactericidal/permeability-increasing protein in treating gram-negative bacterial infection
US5624904A (en) * 1993-11-17 1997-04-29 Massachusetts Institute Of Technology Method for treating gram positive septicemia
US5578568A (en) 1994-04-22 1996-11-26 Xoma Corporation Method of treating conditions associated with intestinal ischemia/reperfusion
US5932536A (en) * 1994-06-14 1999-08-03 The Rockefeller University Compositions for neutralization of lipopolysaccharides
FR2739448B1 (fr) * 1995-09-29 1997-10-24 Thomson Csf Dispositif de detection et de controle de biofilms
US5780429A (en) * 1995-12-22 1998-07-14 Marine Biological Laboratory Anti-LPS factor from horseshoe crabs and methods of use
CN1293383C (zh) * 2005-01-13 2007-01-03 丁友玲 一种临床检测试剂的制备方法
JP7327096B2 (ja) * 2019-11-13 2023-08-16 株式会社島津製作所 分子の分離方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4107077A (en) 1975-07-14 1978-08-15 Associates Of Cape Cod, Inc. Limulus lysate of improved sensitivity and preparing the same
US4201865A (en) 1976-01-15 1980-05-06 Gruppo Lepetit S.P.A. Novel prostaglandin analogues
US4038147A (en) 1976-06-15 1977-07-26 Becton, Dickinson And Company Method for detecting endotoxins
US4221866A (en) 1978-10-06 1980-09-09 Baxter Travenol Laboratories, Inc. Method for determining endotoxin concentration
US4276050A (en) 1980-01-10 1981-06-30 Abbott Laboratories Method for systemic endotoxin detection
US4273557A (en) 1980-03-31 1981-06-16 Mallinckrodt, Inc. Limulus lysate procedure for determining endotoxins
FR2497798A1 (fr) * 1981-01-09 1982-07-16 Pharmindustrie Nouveaux peptides portant un fluorophore, procede pour leur preparation et leur application au dosage fluorimetrique des endotoxines
US4614714A (en) 1982-08-21 1986-09-30 Yamasa Shoyu Kabushiki Kaisha Use of novel L-glutamic acid oxidase
US4758655A (en) * 1983-01-03 1988-07-19 Scripps Clinic And Research Foundation Synthetic polypeptide corresponding to a portion of the heat-labile enterotoxin of escherichia coli, compositions and methods of therewith
US4713347A (en) * 1985-01-14 1987-12-15 Sensor Diagnostics, Inc. Measurement of ligand/anti-ligand interactions using bulk conductance
US4677194A (en) 1985-08-09 1987-06-30 Biotech Research Laboratories, Inc. Isolation of an endotoxin inactivator from human plasma
US4780529A (en) * 1985-08-09 1988-10-25 Biotech Research Laboratories, Inc. Isolation of an endotoxin inactivator from human plasma, and methods of use
USH201H (en) 1985-08-23 1987-01-06 United States Of America Biosensors from membrane proteins reconstituted in polymerized lipid bilayers
US4680268A (en) 1985-09-18 1987-07-14 Children's Hospital Medical Center Implantable gas-containing biosensor and method for measuring an analyte such as glucose
US4717658A (en) * 1985-12-03 1988-01-05 Miles Inc. Gram negative bacteria screening method with horseshoe crab amebocyte lysate (LAL)

Also Published As

Publication number Publication date
EP0379549A1 (de) 1990-08-01
EP0687911B1 (de) 2001-10-17
EP0379549B1 (de) 1995-12-27
EP0379549A4 (en) 1992-04-01
JPH03501733A (ja) 1991-04-18
EP0687911A3 (de) 1996-08-21
DE68929334D1 (de) 2001-11-22
JP2774343B2 (ja) 1998-07-09
DE68925275D1 (de) 1996-02-08
EP0687911A2 (de) 1995-12-20
CA1338836C (en) 1997-01-07
DE68925275T2 (de) 1996-08-22
AU3772289A (en) 1990-01-12
WO1989012644A1 (en) 1989-12-28
DE68929334T2 (de) 2005-08-18

Similar Documents

Publication Publication Date Title
ATE207205T1 (de) Verfahren zumm assay von endotoxin-konzentration
EP2141243A3 (de) Proteingerüste für Antikörpermimetika und andere Bindungsproteine
DE69434942D1 (de) Mehrzweckreagenzsystem zur schnellen lysierung von vollblutproben
FI883708L (fi) Menetelmä emäksisten proteiinien eristämiseksi proteiiniseoksista, jotka sisältävät tällaisia emäksisiä proteiineja
DK0557350T3 (da) Assay for glycerede blodproteiner
DE69422687D1 (de) Biosensor zur hämatokritbestimmung
DE3585147D1 (de) Verfahren zur reinigung von proteinen.
DE68901632D1 (de) Reaktionsgefaess zur durchfuehrung von aufeinanderfolgenden analytischen testen.
NO961115D0 (no) Humane metabotrope glutamatreseptorsubtyper (HMR4, HMR6, HMR7) og relaterte DNA forbindelser
DE69012636D1 (de) Verfahren zur Trennung von Makromolekülen.
DK0770876T3 (da) En screening-fremgangsmåde til at identificere ligander for målproteiner
ATE258598T1 (de) Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht
DE69902796D1 (de) Verfahren zur reinigung von biomolekül- oder proteinkomplexen
FI885312L (fi) Menetelmä spesifisesti sitovan proteiinin ja vastaavan sidottavan aineen välisen reaktion yhden tai useamman komponentin määrittämiseksi koenäytteestä käyttäen ainakin yhtä leimattua komponenttia, menetelmä leimatun komponentin valmistamiseksi sekä koepakkaus.......
ATE285474T1 (de) Haemophilus adhäsionsproteinen
DE68902666D1 (de) Verfahren zur abtrennung von halogenierten benzolabkoemmlingen.
FI904087A7 (fi) Monoklonaalisia vasta-aineita aktivoituja ras-proteiineja vastaan, joi lla on aminohappomutaatioita proteiinin kohdassa 13
SE9602822D0 (sv) New receptor
DK0972781T3 (da) Protein S-polypeptider og anvendelser deraf
DE69327167D1 (de) Nukleotidsequenzen die fur proteine von cryptosporidium kodieren, polypeptide, welche durch diese sequenzen kodiert werden, und kits fur deren benutzung
FI884470L (fi) Biologiskt diagnostiskt analyseringssystem.
DE59004279D1 (de) Verfahren zur C-terminalen Modifizierung von Proteinen.
ATE182215T1 (de) Verfahren zur bestimmung von rheumafaktoren und mittel zur durchführung des verfahrens
ATE115630T1 (de) Trennung von antikörpern gegen metallchelate.
FI865253A7 (fi) IgE-sidosproteiinin määrittäminen molekyylikloonauksen avulla.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties