ATE258598T1 - Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht - Google Patents

Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht

Info

Publication number
ATE258598T1
ATE258598T1 AT98943346T AT98943346T ATE258598T1 AT E258598 T1 ATE258598 T1 AT E258598T1 AT 98943346 T AT98943346 T AT 98943346T AT 98943346 T AT98943346 T AT 98943346T AT E258598 T1 ATE258598 T1 AT E258598T1
Authority
AT
Austria
Prior art keywords
molecular weight
low molecular
protein refolding
refolding method
zwitterionic agents
Prior art date
Application number
AT98943346T
Other languages
English (en)
Inventor
Steven M Vicik
Original Assignee
Inst Genetics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Genetics Llc filed Critical Inst Genetics Llc
Application granted granted Critical
Publication of ATE258598T1 publication Critical patent/ATE258598T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98943346T 1997-10-08 1998-08-24 Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht ATE258598T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/946,839 US20020052026A1 (en) 1997-10-08 1997-10-08 Methods of refolding proteins
PCT/US1998/017499 WO1999018196A1 (en) 1997-10-08 1998-08-24 Methods of refolding proteins by use of zwitterionic low molecular weight agents

Publications (1)

Publication Number Publication Date
ATE258598T1 true ATE258598T1 (de) 2004-02-15

Family

ID=25485053

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98943346T ATE258598T1 (de) 1997-10-08 1998-08-24 Verfahren zur proteinrückfaltung durch verwendung zwitterionischer wirkstoffe von niedrigem molekulargewicht

Country Status (8)

Country Link
US (5) US20020052026A1 (de)
EP (1) EP1021528B1 (de)
JP (1) JP2001519149A (de)
AT (1) ATE258598T1 (de)
AU (1) AU757692B2 (de)
CA (1) CA2305559A1 (de)
DE (1) DE69821376D1 (de)
WO (1) WO1999018196A1 (de)

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ES2361993T5 (es) 2002-02-14 2014-12-09 The Board Of Trustees Of The Leland Stanford Junior University Tratamiento con enzimas de productos alimenticios para celiaquía
US8143210B2 (en) 2002-02-14 2012-03-27 The Board Of Trustees Of The Leland Stanford Junior University Enzyme treatment of foodstuffs for celiac sprue
JP4401618B2 (ja) 2002-04-15 2010-01-20 キヤノン株式会社 記録装置、及び、バッファ管理方法
WO2004045392A2 (en) 2002-11-20 2004-06-03 The Board Of Trustees Of The Leland Stanford Junior University Diagnostic method for celiac sprue
SI21273A (sl) * 2002-07-31 2004-02-29 LEK farmacevtska dru�ba d.d. Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
EP1449848A1 (de) * 2003-02-20 2004-08-25 GBF German Research Centre for Biotechnology Verfahren zur Herstellung von Proteinen aus der Cystine-Knoten-Familie
US7579313B2 (en) 2003-11-18 2009-08-25 The Board Of Trustees Of The Leland Stanford Junior University Transglutaminase inhibitors and methods of use thereof
GB0604964D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
EP2136833B1 (de) * 2007-03-16 2019-05-01 The Board of Trustees of the Leland Stanford Junior University Kombinationsenzymtherapie zum aufschluss von gluten in der nahrung
WO2008115428A2 (en) * 2007-03-16 2008-09-25 The Board Of Trustees Of The Leland Stanford Junior University A scaleable manufacturing process for cysteine endoprotease b, isoform 2
AU2008272762B2 (en) * 2007-07-03 2014-06-19 Amgen Inc. Measurement of protein using inclusion body dry weight
KR101741859B1 (ko) 2009-06-22 2017-06-15 암젠 인크 화학적으로 조절된 산화환원 상태를 사용한 단백질의 재폴딩
SI3660032T1 (sl) 2009-06-25 2026-02-27 Amgen Inc. Postopki zajemanja in čiščenja beljakovin, izraženih v nesesalskem sistemu
WO2012029148A1 (ja) 2010-09-01 2012-03-08 株式会社オステオファーマ 組換えヒト骨形成タンパク質－２凍結乾燥製剤
GB201315321D0 (en) * 2013-08-28 2013-10-09 Koninklijke Nederlandse Akademie Van Wetenschappen Transduction Buffer
US9630916B2 (en) 2014-08-19 2017-04-25 Wisconsin Alumni Research Foundation Organocatalysts of oxidative protein folding
EP3344651B1 (de) 2015-09-02 2022-03-02 Merck Sharp & Dohme Corp. Verfahren zur gewinnung von insulin mit korrekt geformten disulfidbindungen
WO2020138389A1 (ja) * 2018-12-27 2020-07-02 アステラス製薬株式会社 ナノ粒子、これを含む磁気共鳴イメージング用造影剤及び双性イオンリガンド化合物
US20220340630A1 (en) * 2019-09-13 2022-10-27 National Science And Technology Development Agency Composition of renaturation buffer solution for dimeric proteins and method of renaturation dimeric proteins using the composition thereof
CN119684427A (zh) * 2024-12-25 2025-03-25 无锡傲锐东源生物科技有限公司 一种重组bmp4蛋白复性液及重组bmp4蛋白的制备方法

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WO1996001845A1 (en) 1994-07-08 1996-01-25 The Johns Hopkins University School Of Medicine Growth differentiation factor-11
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US5635372A (en) 1995-05-18 1997-06-03 Genetics Institute, Inc. BMP-15 compositions

Also Published As

Publication number Publication date
AU757692B2 (en) 2003-03-06
US6593106B1 (en) 2003-07-15
CA2305559A1 (en) 1999-04-15
US6632635B1 (en) 2003-10-14
DE69821376D1 (de) 2004-03-04
AU9116798A (en) 1999-04-27
EP1021528A1 (de) 2000-07-26
US6593107B1 (en) 2003-07-15
US6596511B1 (en) 2003-07-22
US20020052026A1 (en) 2002-05-02
JP2001519149A (ja) 2001-10-23
EP1021528B1 (de) 2004-01-28
WO1999018196A1 (en) 1999-04-15

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