HK1042300B - 多環的噻唑體系和它們作為減食慾劑的用途 - Google Patents

多環的噻唑體系和它們作為減食慾劑的用途 Download PDF

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Publication number
HK1042300B
HK1042300B HK02104057.0A HK02104057A HK1042300B HK 1042300 B HK1042300 B HK 1042300B HK 02104057 A HK02104057 A HK 02104057A HK 1042300 B HK1042300 B HK 1042300B
Authority
HK
Hong Kong
Prior art keywords
alkyl
acid
compounds
compound
phenyl
Prior art date
Application number
HK02104057.0A
Other languages
English (en)
Chinese (zh)
Other versions
HK1042300A1 (en
Inventor
G‧杰恩
G‧傑恩
K‧盖森
H-J‧兰格
K‧蓋森
M‧毕克尔
H-J‧蘭格
M‧畢克爾
Original Assignee
阿文蒂斯药物德国有限公司
阿文蒂斯藥物德國有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 阿文蒂斯药物德国有限公司, 阿文蒂斯藥物德國有限公司 filed Critical 阿文蒂斯药物德国有限公司
Publication of HK1042300A1 publication Critical patent/HK1042300A1/xx
Publication of HK1042300B publication Critical patent/HK1042300B/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/84—Naphthothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK02104057.0A 1999-02-26 2000-02-05 多環的噻唑體系和它們作為減食慾劑的用途 HK1042300B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19908533.1 1999-02-26
DE19908533A DE19908533A1 (de) 1999-02-26 1999-02-26 Polycyclische Thiazol-Systeme, Verfahren zu ihrer Herstellung und Arzneimittel enthaltend diese Verbindungen
PCT/EP2000/000927 WO2000051997A1 (de) 1999-02-26 2000-02-05 Polycyclische thiazol-systeme und ihre verwendung als anorektika

Publications (2)

Publication Number Publication Date
HK1042300A1 HK1042300A1 (en) 2002-08-09
HK1042300B true HK1042300B (zh) 2004-12-10

Family

ID=7899078

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02104057.0A HK1042300B (zh) 1999-02-26 2000-02-05 多環的噻唑體系和它們作為減食慾劑的用途

Country Status (19)

Country Link
US (1) US6187801B1 (https=)
EP (1) EP1183247B1 (https=)
JP (1) JP4728485B2 (https=)
KR (1) KR20020000545A (https=)
CN (1) CN1149205C (https=)
AT (1) ATE296295T1 (https=)
AU (1) AU762802B2 (https=)
BR (1) BR0008511A (https=)
CA (1) CA2364903A1 (https=)
CO (1) CO5180595A1 (https=)
DE (2) DE19908533A1 (https=)
DK (1) DK1183247T3 (https=)
ES (1) ES2241574T3 (https=)
HK (1) HK1042300B (https=)
MY (1) MY133195A (https=)
PT (1) PT1183247E (https=)
TW (1) TW593294B (https=)
WO (1) WO2000051997A1 (https=)
ZA (1) ZA200106440B (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19908535A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Verwendung von polycyclischen Thiazol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
KR100763214B1 (ko) * 2000-02-26 2007-10-08 사노피-아벤티스 도이칠란트 게엠베하 2 위치에서 설폰아미도 또는 설포노 치환체를 갖는 8,8ａ-디하이드로-인데노[1,2-ｄ]티아졸 유도체, 이의 제조방법 및 이를 포함하는 약제
DE10142663B4 (de) 2001-08-31 2004-08-19 Aventis Pharma Deutschland Gmbh C2-Disubstituierte Indan-1-ol-Systeme
KR100712171B1 (ko) * 2004-09-17 2007-05-02 김진우 폐타이어를 이용한 조립식 배관블록
ES2480994T3 (es) 2008-03-31 2014-07-29 Genentech, Inc. Compuestos de tipo benzopirano y benzoxepina inhibidores de PI3K y métodos de uso
ES2558742T3 (es) 2009-09-28 2016-02-08 F. Hoffmann-La Roche Ag Compuestos inhibidores de PI3K de benzoxepina y métodos de uso
ES2570569T3 (es) 2009-09-28 2016-05-19 Hoffmann La Roche Compuestos de benzoxazepina como inhibidores de la PI3K y métodos de uso
WO2012126901A1 (en) 2011-03-21 2012-09-27 F. Hoffmann-La Roche Ag Benzoxazepin compounds selective for pi3k p110 delta and methods of use

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2640358A1 (de) * 1976-09-08 1978-03-16 Hoechst Ag Thiazolidinderivate und verfahren zu ihrer herstellung
NZ281718A (en) * 1994-03-11 1997-08-22 Yamanouchi Pharma Co Ltd Heterocyclically-substituted (condensed) thiazoles
JPH1179993A (ja) * 1997-09-05 1999-03-23 Sumitomo Pharmaceut Co Ltd 免疫抑制剤
DE19831878C2 (de) * 1998-07-17 2001-05-17 Aventis Pharma Gmbh Polycyclische Thiazolidin-2-yliden Amine, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE19908535A1 (de) * 1999-02-26 2000-08-31 Aventis Pharma Gmbh Verwendung von polycyclischen Thiazol-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas

Also Published As

Publication number Publication date
JP2002538150A (ja) 2002-11-12
BR0008511A (pt) 2002-04-02
EP1183247B1 (de) 2005-05-25
DE50010403D1 (de) 2005-06-30
AU2441600A (en) 2000-09-21
ES2241574T3 (es) 2005-11-01
HK1042300A1 (en) 2002-08-09
KR20020000545A (ko) 2002-01-05
CA2364903A1 (en) 2000-09-08
DE19908533A1 (de) 2000-08-31
CN1341108A (zh) 2002-03-20
PT1183247E (pt) 2005-07-29
AU762802B2 (en) 2003-07-03
MY133195A (en) 2007-10-31
ATE296295T1 (de) 2005-06-15
JP4728485B2 (ja) 2011-07-20
ZA200106440B (en) 2002-03-06
WO2000051997A1 (de) 2000-09-08
TW593294B (en) 2004-06-21
DK1183247T3 (da) 2005-09-19
CN1149205C (zh) 2004-05-12
CO5180595A1 (es) 2002-07-30
EP1183247A1 (de) 2002-03-06
US6187801B1 (en) 2001-02-13

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20080205