HK1039903B - Using glycosaminoglycans to treat senile dementia - Google Patents

Using glycosaminoglycans to treat senile dementia Download PDF

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Publication number
HK1039903B
HK1039903B HK02101550.8A HK02101550A HK1039903B HK 1039903 B HK1039903 B HK 1039903B HK 02101550 A HK02101550 A HK 02101550A HK 1039903 B HK1039903 B HK 1039903B
Authority
HK
Hong Kong
Prior art keywords
glycosaminoglycans
molecular weight
treatment
heparin
average molecular
Prior art date
Application number
HK02101550.8A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1039903A1 (en
Inventor
De Ambrosi Luigi
Hanin Israel
Fareed Jawed
Lee John
Lorens Stanley
F. Mervis Ronald
Cornelli Umberto
Original Assignee
Cornelli Umberto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cornelli Umberto filed Critical Cornelli Umberto
Publication of HK1039903A1 publication Critical patent/HK1039903A1/en
Publication of HK1039903B publication Critical patent/HK1039903B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials Engineering (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Polymers & Plastics (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
HK02101550.8A 1999-05-14 2000-05-12 Using glycosaminoglycans to treat senile dementia HK1039903B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999MI001066A IT1312107B1 (it) 1999-05-14 1999-05-14 Glicosaminoglicani aventi peso molecolare medio di 2400 d atti altrattamento della demenza senile
ITMI99A001066 1999-05-14
PCT/EP2000/004311 WO2000069444A1 (en) 1999-05-14 2000-05-12 Glycosaminoglycans having an average molecular weight equal to 2400 d suitable for the treatment of senile dementia

Publications (2)

Publication Number Publication Date
HK1039903A1 HK1039903A1 (en) 2002-05-17
HK1039903B true HK1039903B (en) 2005-08-26

Family

ID=11382970

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02101550.8A HK1039903B (en) 1999-05-14 2000-05-12 Using glycosaminoglycans to treat senile dementia

Country Status (22)

Country Link
US (1) US6979680B1 (https=)
EP (1) EP1181024B1 (https=)
JP (1) JP2002544233A (https=)
KR (1) KR100711142B1 (https=)
CN (1) CN1178667C (https=)
AT (1) ATE288761T1 (https=)
AU (1) AU764743C (https=)
CA (1) CA2373975A1 (https=)
CZ (1) CZ20014092A3 (https=)
DE (1) DE60018061T2 (https=)
DK (1) DK1181024T3 (https=)
ES (1) ES2237425T3 (https=)
HK (1) HK1039903B (https=)
HU (1) HUP0201100A3 (https=)
IL (1) IL146458A0 (https=)
IT (1) IT1312107B1 (https=)
NO (1) NO328902B1 (https=)
PL (1) PL198016B1 (https=)
PT (1) PT1181024E (https=)
RU (1) RU2248800C2 (https=)
WO (1) WO2000069444A1 (https=)
ZA (1) ZA200109331B (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1344781A1 (en) * 2002-03-12 2003-09-17 Laboratori Derivati Organici S.P.A. Process for the depolymerization of glycosaminoglycanes and products obtained therefrom
ITMI20031023A1 (it) 2003-05-21 2004-11-22 Umberto Cornelli Glicosaminoglicani aventi peso molecolare medio 2400 d atti al trattamento delle disfunzioni emozionali.
EP1524276A1 (en) * 2003-10-16 2005-04-20 Laboratori Derivati Organici S.P.A. Multistep process for the physical depolymerization of heparin and products obtained therefrom
US7939512B2 (en) 2004-10-13 2011-05-10 Laboratori Derivati Organici Spa Multistep process for the physical depolymerization of heparin and products obtained therefrom
EP1968561B8 (en) 2005-12-22 2010-10-20 Kiacta Sàrl Treatment of diabetic nephropathy
WO2009007224A1 (en) * 2007-07-10 2009-01-15 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Low molecular weight heparin derivatives having neuroprotective activity
EP2283711B1 (en) 2008-05-22 2018-07-11 Vladimir Yegorovich Balakin Charged particle beam acceleration apparatus as part of a charged particle cancer therapy system
WO2010101489A1 (en) 2009-03-04 2010-09-10 Zakrytoe Aktsionernoe Obshchestvo Protom Multi-field charged particle cancer therapy method and apparatus
EP2283705B1 (en) 2008-05-22 2017-12-13 Vladimir Yegorovich Balakin Charged particle beam extraction apparatus used in conjunction with a charged particle cancer therapy system
US8896239B2 (en) 2008-05-22 2014-11-25 Vladimir Yegorovich Balakin Charged particle beam injection method and apparatus used in conjunction with a charged particle cancer therapy system
WO2009142549A2 (en) 2008-05-22 2009-11-26 Vladimir Yegorovich Balakin Multi-axis charged particle cancer therapy method and apparatus
WO2009142546A2 (en) 2008-05-22 2009-11-26 Vladimir Yegorovich Balakin Multi-field charged particle cancer therapy method and apparatus
US8609097B2 (en) * 2009-06-10 2013-12-17 Hoffmann-La Roche Inc. Use of an anti-Tau pS422 antibody for the treatment of brain diseases
CA2851761C (en) * 2011-10-14 2021-06-15 Centre National De La Recherche Scientifique Method of diagnosis, prognostic or treatment of neurodegenerative diseases
CN112426434A (zh) * 2020-11-04 2021-03-02 山东大学 硫酸乙酰肝素在防治阿尔兹海默症中的应用
CN114478816A (zh) * 2022-02-11 2022-05-13 上海兴糖生物技术有限公司 一种白玉蜗牛多糖及其制备方法和用途

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351938A (en) * 1980-05-19 1982-09-28 Riker Laboratories, Inc. Anticoagulant substance
US4847338A (en) * 1985-03-28 1989-07-11 University Of Iowa Research Foundation Low molecular weight heparin fragments as inhibitors of complement activation
EP0243974B1 (en) * 1986-05-01 1994-03-02 Toppan Printing Co., Ltd. Scanner set-up simulation apparatus
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
IT1205042B (it) * 1987-05-28 1989-03-10 Crinos Industria Farmaco Composizione farmaceutica ad attivita' terapeutica per il trattamento della demenza senile di tipo alzheimer
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
IT1240615B (it) 1990-04-03 1993-12-17 Mediolanum Farmaceutici Spa Impiego del dermatan solfato nella prevenzione e terapia dell'invecchiamento cerebrale e degli stati di deficit funzionale del sistema nervoso centrale
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
CA2067614C (en) * 1991-05-02 2002-07-30 Eiichi Otomo Agent for improving dementia
RU2106864C1 (ru) * 1995-10-23 1998-03-20 Николай Серафимович Зефиров Средство для лечения болезни альцгеймера

Also Published As

Publication number Publication date
IT1312107B1 (it) 2002-04-04
DK1181024T3 (da) 2005-06-13
DE60018061D1 (de) 2005-03-17
HUP0201100A2 (hu) 2002-07-29
JP2002544233A (ja) 2002-12-24
HK1039903A1 (en) 2002-05-17
NO20015544L (no) 2002-01-14
EP1181024A1 (en) 2002-02-27
AU764743C (en) 2004-03-18
KR20020005033A (ko) 2002-01-16
DE60018061T2 (de) 2006-04-13
CZ20014092A3 (cs) 2002-04-17
PL352070A1 (en) 2003-07-28
US6979680B1 (en) 2005-12-27
ZA200109331B (en) 2002-08-28
IL146458A0 (en) 2002-07-25
NO20015544D0 (no) 2001-11-13
WO2000069444A1 (en) 2000-11-23
KR100711142B1 (ko) 2007-04-24
CN1350459A (zh) 2002-05-22
ES2237425T3 (es) 2005-08-01
ATE288761T1 (de) 2005-02-15
EP1181024B1 (en) 2005-02-09
HUP0201100A3 (en) 2003-03-28
AU4405200A (en) 2000-12-05
PL198016B1 (pl) 2008-05-30
CN1178667C (zh) 2004-12-08
AU764743B2 (en) 2003-08-28
PT1181024E (pt) 2005-06-30
ITMI991066A1 (it) 2000-11-14
NO328902B1 (no) 2010-06-14
RU2248800C2 (ru) 2005-03-27
CA2373975A1 (en) 2000-11-23

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100512