HK1039328B - 用於治療陽痿的吡唑並嘧啶酮衍生物 - Google Patents

用於治療陽痿的吡唑並嘧啶酮衍生物

Info

Publication number
HK1039328B
HK1039328B HK02100595.7A HK02100595A HK1039328B HK 1039328 B HK1039328 B HK 1039328B HK 02100595 A HK02100595 A HK 02100595A HK 1039328 B HK1039328 B HK 1039328B
Authority
HK
Hong Kong
Prior art keywords
impotence
treatment
derivatives
pyrazolopyrimidinone derivatives
pyrazolopyrimidinone
Prior art date
Application number
HK02100595.7A
Other languages
English (en)
Other versions
HK1039328A1 (en
Inventor
劉武熙
金源培
張民善
林重仁
金東成
金翼淵
林泰均
安秉玉
姜慶求
孫美苑
都賢美
金舜會
沈賢珠
吳泰寧
金與渽
金東九
Original Assignee
Dong A Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27349839&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1039328(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dong A Pharm Co Ltd filed Critical Dong A Pharm Co Ltd
Publication of HK1039328A1 publication Critical patent/HK1039328A1/xx
Publication of HK1039328B publication Critical patent/HK1039328B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK02100595.7A 1998-11-11 2002-01-25 用於治療陽痿的吡唑並嘧啶酮衍生物 HK1039328B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR19980048100 1998-11-11
KR19990014972 1999-04-27
KR19990049384A KR100353014B1 (ko) 1998-11-11 1999-11-09 발기부전 치료에 효과를 갖는 피라졸로피리미디논 화합물
PCT/KR1999/000675 WO2000027848A1 (en) 1998-11-11 1999-11-10 Pyrazolopyrimidinone derivatives for the treatment of impotence

Publications (2)

Publication Number Publication Date
HK1039328A1 HK1039328A1 (en) 2002-04-19
HK1039328B true HK1039328B (zh) 2004-06-25

Family

ID=27349839

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02100595.7A HK1039328B (zh) 1998-11-11 2002-01-25 用於治療陽痿的吡唑並嘧啶酮衍生物

Country Status (17)

Country Link
US (1) US6583147B1 (zh)
EP (1) EP1129093B1 (zh)
JP (1) JP3577630B2 (zh)
KR (1) KR100353014B1 (zh)
CN (1) CN1136219C (zh)
AT (1) ATE245650T1 (zh)
AU (1) AU760422B2 (zh)
BR (1) BRPI9915822B8 (zh)
CA (1) CA2350538C (zh)
DE (1) DE69909818T2 (zh)
DK (1) DK1129093T3 (zh)
ES (1) ES2204169T3 (zh)
HK (1) HK1039328B (zh)
NZ (1) NZ511015A (zh)
PT (1) PT1129093E (zh)
TR (1) TR200101335T2 (zh)
WO (1) WO2000027848A1 (zh)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1185294T3 (da) * 1999-06-23 2005-08-01 Centre Nat Rech Scient Peptider til behandling af svækkede interpersonelle og adfærdsmæssige lidelser
YU59100A (sh) * 1999-10-11 2003-10-31 Pfizer Inc. Postupak za dobijanje pirazolo (4,3-d) pirimidin-7-ona-3-piridilsulfonil jedinjenja i njihova intermedijera
KR100377782B1 (ko) 2000-06-23 2003-03-29 동아제약 주식회사 발기부전 치료에 효과를 갖는 피라졸로피리미디논화합물의 제조방법
BRPI0207215B8 (pt) * 2001-12-13 2022-11-01 Daiichi Suntory Biomedical Res Limited Derivados de pirazolopirimidinona tendo ação de inibição de pde7
DE60332387D1 (de) 2002-12-13 2010-06-10 Warner Lambert Co Alpha-2-delta-ligand zur behandlung vonsymptomen der unteren harnwege
CA2519357A1 (en) * 2003-03-17 2004-09-30 Pfizer Products Inc. Treatment of type 1 diabetes with pde5 inhibitors
CN100374441C (zh) 2003-06-06 2008-03-12 天津倍方科技发展有限公司 二氢吡咯[2，3-d]嘧啶-4-酮衍生物，其制备方法及其制药用途
US7449462B2 (en) 2004-01-22 2008-11-11 Pfizer, Inc. Triazole derivatives which inhibit vasopressin antagonistic activity
US7649002B2 (en) 2004-02-04 2010-01-19 Pfizer Inc (3,5-dimethylpiperidin-1yl)(4-phenylpyrrolidin-3-yl)methanone derivatives as MCR4 agonists
CN102351862A (zh) * 2005-02-18 2012-02-15 表面线段公司 药动学改善的化合物
EP1848437A4 (en) * 2005-02-18 2012-04-25 Surface Logix Inc METHOD FOR PRODUCING PHARMACOKINETIC IMPROVED COMPOUNDS WITH FUNCTIONAL RESTORATIONS OR GROUPS AND PHARMACEUTICAL COMPOSITIONS WITH THESE COMPOUNDS
US8648100B2 (en) 2005-04-19 2014-02-11 Takeda Gmbh Roflumilast for the treatment of pulmonary hypertension
UA86528C2 (uk) * 2005-06-10 2009-04-27 Донг-А Фармацевтікал.Ко., Лтд. Засіб для попередження та лікування хвороб печінки, що містить похідну піразолопіримідинону
CN1966506A (zh) * 2005-11-17 2007-05-23 上海特化医药科技有限公司 吡唑并嘧啶酮衍生物及其制备方法和用途
AU2006341342B2 (en) * 2006-04-04 2010-05-20 Dong-A Pharmaceutical.Co., Ltd. Agent for the prevention and treatment of prostatic hyperplasia comprising pyrazolopyrimidinone compound
WO2007141805A2 (en) * 2006-06-05 2007-12-13 Matrix Laboratories Limited Novel process for the preparation of sildenafil citrate
AR062501A1 (es) 2006-08-29 2008-11-12 Actelion Pharmaceuticals Ltd Composiciones terapeuticas
US20100179131A1 (en) 2006-09-07 2010-07-15 Nycomed Gmbh Combination treatment for diabetes mellitus
US20090270425A1 (en) * 2006-10-20 2009-10-29 Concert Pharmaceuticals Inc. 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use
MX2009003941A (es) * 2006-10-20 2009-04-24 Concert Pharmaceuticals Inc Derivados de 3-(dihidro-1h-pirazolo[4,3-d]pirimidin-5-il)-4-propox ibencenosulfonamida y metodos de uso.
US20090197899A1 (en) * 2006-10-20 2009-08-06 Concert Pharmaceuticals Inc. 3-(Dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide Derivatives and Methods of Use
US20080194529A1 (en) * 2007-02-12 2008-08-14 Auspex Pharmaceuticals, Inc. HIGHLY SELECTIVE and LONG-ACTING PDE5 MODULATORS
CA2689016C (en) 2007-05-25 2014-08-12 Ipsen Pharma S.A.S. Melanocortin receptor ligands modified with hydantoin
CN101742906A (zh) 2007-06-04 2010-06-16 本古里安大学内盖夫研究发展局 三芳基化合物和包含它们的组合物
KR101002490B1 (ko) * 2007-06-09 2010-12-17 동아제약주식회사 유데나필을 유효성분으로 함유하는 만성 심부전증 치료용약학적 조성물
JP2010540621A (ja) * 2007-10-02 2010-12-24 ドン ア ファーマシューティカル カンパニー リミテッド 良性前立腺肥大症および下部尿路症状の治療または予防用組成物、およびその治療または予防方法
KR100920125B1 (ko) * 2007-10-02 2009-10-01 동아제약주식회사 양성 전립선 비대증 치료를 위한 피라졸로피리미디논화합물 및 알파 아드레날린성 수용체 길항제를 함유하는약제학적 배합물
WO2009099620A1 (en) * 2008-02-04 2009-08-13 Concert Pharmaceuticals Inc. 3-(dihydro-1h-pyrazolo[4,3-d]pyrimidin-5-yl)-4-propoxybenzenesulfonamide derivatives and methods of use
KR20090087795A (ko) * 2008-02-13 2009-08-18 한양대학교 산학협력단 혈관 재협착 예방 및 치료를 위한 약학 조성물 및 이를포함하는 스텐트
KR101071877B1 (ko) * 2009-02-18 2011-10-10 동아제약주식회사 유데나필 산부가염, 그의 제조방법 및 이를 포함하는 약학적 조성물
GB0903493D0 (en) 2009-02-27 2009-04-08 Vantia Ltd New compounds
WO2011126250A2 (ko) 2010-04-05 2011-10-13 에스케이케미칼 주식회사 Pde5 억제제를 함유하는 피부 주름 개선용 조성물
CN102952138B (zh) 2011-08-17 2016-07-06 上海特化医药科技有限公司 一种吡唑并嘧啶酮化合物的盐、多晶型物及其药物组合物、制备方法和应用
CN104168895B (zh) 2012-02-28 2020-02-21 首尔制药株式会社 包含西地那非作为活性成分的掩蔽苦味的高含量快速溶解膜
KR101953735B1 (ko) 2012-12-14 2019-03-04 한미약품 주식회사 포스포다이에스터라제-5 억제제를 포함하는 츄정
JP6657101B2 (ja) 2013-11-05 2020-03-04 ベン グリオン ユニバーシティ オブ ザ ネガフ リサーチ アンド ディベロップメント オーソリティ 糖尿病及びそれから生じる疾患合併症の治療のための化合物
KR20240122604A (ko) 2014-08-12 2024-08-12 주식회사 메지온 유데나필 조성물을 이용하여 폰탄 환자에서 심근 성능을 개선시키는 방법
KR101645652B1 (ko) 2014-11-03 2016-08-08 (주)퓨젠바이오농업회사법인 세리포리아 락세라타에 의해 생산되는 세포외다당체를 유효성분으로 함유하는 성기능개선용 조성물
WO2017168174A1 (en) 2016-04-02 2017-10-05 N4 Pharma Uk Limited New pharmaceutical forms of sildenafil
CN107759603B (zh) * 2016-08-18 2020-09-01 四川科伦药物研究院有限公司 一种杂环化合物的制备方法
CN113493459B (zh) * 2020-04-07 2022-12-13 广州白云山医药集团股份有限公司白云山制药总厂 Pde5抑制剂化合物及其制备方法和应用
EP4259634A1 (en) 2020-12-11 2023-10-18 Ildong Pharmaceutical Co., Ltd. Novel compounds as androgen receptor and phosphodiesterase dual inhibitor

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9013750D0 (en) * 1990-06-20 1990-08-08 Pfizer Ltd Therapeutic agents
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9119704D0 (en) * 1991-09-14 1991-10-30 Pfizer Ltd Therapeutic agents
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
GB9423911D0 (en) * 1994-11-26 1995-01-11 Pfizer Ltd Therapeutic agents
GB9612514D0 (en) * 1996-06-14 1996-08-14 Pfizer Ltd Novel process
NZ338075A (en) * 1997-04-25 2000-10-27 Pfizer Ltd Pyrazolopyrimidinones which inhibit type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterase (cGMP PED5) for the treatment of sexual dysfunction
KR100297814B1 (ko) * 1998-12-29 2001-10-26 조민호 피라졸로피리미디논유도체와이의제조방법그리고이의용도

Also Published As

Publication number Publication date
WO2000027848A1 (en) 2000-05-18
NZ511015A (en) 2003-09-26
AU760422B2 (en) 2003-05-15
TR200101335T2 (tr) 2001-09-21
DK1129093T3 (da) 2003-10-20
KR100353014B1 (ko) 2002-09-18
EP1129093B1 (en) 2003-07-23
HK1039328A1 (en) 2002-04-19
DE69909818T2 (de) 2004-05-27
EP1129093A1 (en) 2001-09-05
JP3577630B2 (ja) 2004-10-13
PT1129093E (pt) 2003-12-31
KR20000035324A (ko) 2000-06-26
US6583147B1 (en) 2003-06-24
AU1081700A (en) 2000-05-29
CA2350538C (en) 2005-06-28
ATE245650T1 (de) 2003-08-15
CN1325398A (zh) 2001-12-05
DE69909818D1 (de) 2003-08-28
CA2350538A1 (en) 2000-05-18
JP2002529467A (ja) 2002-09-10
BRPI9915822B8 (pt) 2021-05-25
BR9915822A (pt) 2001-08-14
BR9915822B1 (pt) 2013-08-27
ES2204169T3 (es) 2004-04-16
CN1136219C (zh) 2004-01-28

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Effective date: 20191109