HK1033831A1 - Method for producing fludarabin phosphate lithium, sodium, potassium, calcium and magnesium salts, purification method for producing fludarabin phosphate and fludarabin phosphate which is at least 99.5% pure - Google Patents

Method for producing fludarabin phosphate lithium, sodium, potassium, calcium and magnesium salts, purification method for producing fludarabin phosphate and fludarabin phosphate which is at least 99.5% pure

Info

Publication number
HK1033831A1
HK1033831A1 HK01103119A HK01103119A HK1033831A1 HK 1033831 A1 HK1033831 A1 HK 1033831A1 HK 01103119 A HK01103119 A HK 01103119A HK 01103119 A HK01103119 A HK 01103119A HK 1033831 A1 HK1033831 A1 HK 1033831A1
Authority
HK
Hong Kong
Prior art keywords
producing
fludarabin phosphate
fludarabin
phosphate
potassium
Prior art date
Application number
HK01103119A
Other languages
English (en)
Inventor
Ulf Tilstam
Thomas Schmitz
Klaus Nickisch
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7852365&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1033831(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Schering Ag filed Critical Schering Ag
Publication of HK1033831A1 publication Critical patent/HK1033831A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/19—Purine radicals with arabinosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK01103119A 1997-12-11 2001-05-02 Method for producing fludarabin phosphate lithium, sodium, potassium, calcium and magnesium salts, purification method for producing fludarabin phosphate and fludarabin phosphate which is at least 99.5% pure HK1033831A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19756289 1997-12-11
PCT/EP1998/007651 WO1999029710A2 (fr) 1997-12-11 1998-11-30 Procede de purification utilise pour preparer du phosphate de fludarabine

Publications (1)

Publication Number Publication Date
HK1033831A1 true HK1033831A1 (en) 2001-09-28

Family

ID=7852365

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01103119A HK1033831A1 (en) 1997-12-11 2001-05-02 Method for producing fludarabin phosphate lithium, sodium, potassium, calcium and magnesium salts, purification method for producing fludarabin phosphate and fludarabin phosphate which is at least 99.5% pure

Country Status (21)

Country Link
US (2) US6046322A (fr)
EP (1) EP1047704B2 (fr)
JP (2) JP4261051B2 (fr)
KR (2) KR100532898B1 (fr)
AT (2) ATE231880T1 (fr)
AU (1) AU739574B2 (fr)
CA (1) CA2313486A1 (fr)
CZ (1) CZ296366B6 (fr)
DE (2) DE59807096D1 (fr)
DK (1) DK1047704T4 (fr)
ES (1) ES2190136T5 (fr)
HK (1) HK1033831A1 (fr)
HU (1) HU226997B1 (fr)
IL (1) IL136283A (fr)
NO (1) NO315324B1 (fr)
PL (1) PL195712B1 (fr)
SI (1) SI1047704T2 (fr)
SK (1) SK283475B6 (fr)
TW (1) TW424093B (fr)
WO (1) WO1999029710A2 (fr)
ZA (1) ZA9811338B (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE59807096D1 (de) 1997-12-11 2003-03-06 Schering Ag Verfahren zur herstellung von fludarabin-phosphat-lithium-, natrium-, kalium-, calcium- und magnesium-salzen, reinigungsverfahren zur herstellung von fludarabin-phosphat und fludarabin-phosphat mit mindestens 99,5 %iger reinheit
KR100381930B1 (ko) * 2000-03-16 2003-04-26 (주)바이오니아 유전자 변형 농산물 검출방법 및 검출용 프라이머
WO2003049764A1 (fr) 2001-12-12 2003-06-19 Fh Faulding & Co Limited Composition de preservation virale
DE10164510A1 (de) * 2001-12-20 2003-07-10 Schering Ag Orale Fludara reinst Formulierung mit schneller Freisetzung des Wirkstoffes
CA2487070A1 (fr) * 2002-05-24 2003-12-04 Sicor Inc. Composition aqueuse a base de phosphate de fludarabine
EP1464708A1 (fr) * 2003-04-03 2004-10-06 Pro. Bio. Sint. S.p.A. Procédé de préparation de fludarabine phosphate à partir de 2-fluoroadénine
US7698201B2 (en) * 2006-09-14 2010-04-13 The Prudential Insurance Company Of America Financial instrument utilizing an optional benefit election
CN103040855B (zh) * 2012-12-28 2014-05-14 海南锦瑞制药股份有限公司 一种磷酸氟达拉滨的药物组合物及其制备方法
EP3342778B1 (fr) * 2015-08-28 2022-01-12 Zhejiang Hisun Pharmaceutical Co., Ltd. Forme cristalline de phosphate de fludarabine, procédé de préparation de celle-ci, et application de celle-ci
CN109265505A (zh) * 2018-09-12 2019-01-25 连云港杰瑞药业有限公司 一种磷酸氟达拉滨异构体杂质的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE756704A (fr) 1969-09-26 1971-03-01 Parke Davis & Co Procede de production du 5'-phosphate de 9-(beta-d- arabinofuranosyl) adenine et de ses sels
US4188378A (en) * 1978-01-04 1980-02-12 The United States Of America As Represented By The Department Of Health, Education And Welfare Anticancer and antiviral activity of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4210745A (en) * 1978-01-04 1980-07-01 The United States Of America As Represented By The Department Of Health, Education And Welfare Procedure for the preparation of 9-β-D-arabinofuranosyl-2-fluoroadenine
US4357324A (en) * 1981-02-24 1982-11-02 The United States Of America As Represented By The Department Of Health And Human Services Prodrug derivatives of 9β-D-arabinofuranosyl-2-fluoroadenine
DE3323621A1 (de) 1982-07-08 1984-03-01 Yamasa Shoyu K.K., Choshi, Chiba Pharmazeutisches praeparat mit die antitumor-wirkung verstaerkender wirkung, ein solches praeparat enthaltende chemotherapeutische zusammensetzung und verwendung des praeparates zur unterstuetzung der antitumor-behandlung beim menschen und tier
US5110919A (en) * 1989-12-04 1992-05-05 Ash Stevens, Inc. Process for the preparation of 2-amino-9-(2,3,5-tri-o-benzyl-beta-d-arabinofuranosyl) adenine and novel intermediates
ATE169631T1 (de) * 1990-06-27 1998-08-15 Ash Stevens Inc Verfahren zur herstellung von 9-beta-d- arabinofuranosyl-2-fluoroadenin 5'-phosphaten
US5602246A (en) 1992-11-25 1997-02-11 Schering Aktiengesellschaft Process for the preparation of fludarabine or fludarabine phosphate from guanosine
FR2701027B1 (fr) * 1993-02-01 1997-07-18 Warner Lambert Co Procede de synthese ameliore du 9-(beta-d-arabinofuranosyl)adenine 5'-phosphate.
DE19543052A1 (de) * 1995-11-06 1997-05-07 Schering Ag Verfahren zur Herstellung und Reinigung von Fludarabin-Phosphat und die Verwendung von sauren Ionenaustauschern im Verfahren
IT1276126B1 (it) 1995-11-14 1997-10-27 Archimica Spa Procedimento per la preparazine di 9-((2-idrossietossi)metil) guanina
DE59807096D1 (de) 1997-12-11 2003-03-06 Schering Ag Verfahren zur herstellung von fludarabin-phosphat-lithium-, natrium-, kalium-, calcium- und magnesium-salzen, reinigungsverfahren zur herstellung von fludarabin-phosphat und fludarabin-phosphat mit mindestens 99,5 %iger reinheit
US6174873B1 (en) 1998-11-04 2001-01-16 Supergen, Inc. Oral administration of adenosine analogs

Also Published As

Publication number Publication date
AU739574B2 (en) 2001-10-18
WO1999029710A3 (fr) 1999-09-10
ATE231880T1 (de) 2003-02-15
EP1047704B1 (fr) 2003-01-29
ES2190136T3 (es) 2003-07-16
PL341659A1 (en) 2001-04-23
SK8872000A3 (en) 2001-03-12
AU2155099A (en) 1999-06-28
IL136283A0 (en) 2001-05-20
CZ296366B6 (cs) 2006-02-15
HU226997B1 (en) 2010-04-28
JP2009040797A (ja) 2009-02-26
JP4261051B2 (ja) 2009-04-30
JP2001525418A (ja) 2001-12-11
DE59807096D1 (de) 2003-03-06
SK283475B6 (sk) 2003-08-05
CA2313486A1 (fr) 1999-06-17
DK1047704T3 (da) 2003-06-23
ES2190136T5 (es) 2008-03-01
HUP0100169A3 (en) 2002-04-29
AT8617U1 (de) 2006-10-15
KR100532898B1 (ko) 2005-12-05
EP1047704A2 (fr) 2000-11-02
SI1047704T1 (en) 2004-02-29
EP1047704B2 (fr) 2007-11-07
WO1999029710A2 (fr) 1999-06-17
DE29825173U1 (de) 2005-12-22
NO20002962D0 (no) 2000-06-09
ZA9811338B (en) 1999-06-10
IL136283A (en) 2006-10-31
PL195712B1 (pl) 2007-10-31
HUP0100169A1 (hu) 2001-11-28
KR20050085937A (ko) 2005-08-29
US7547776B1 (en) 2009-06-16
CZ20002159A3 (cs) 2000-09-13
NO315324B1 (no) 2003-08-18
SI1047704T2 (sl) 2008-02-29
KR20010032919A (ko) 2001-04-25
DK1047704T4 (da) 2008-03-25
US6046322A (en) 2000-04-04
NO20002962L (no) 2000-06-09
TW424093B (en) 2001-03-01

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Legal Events

Date Code Title Description
PF Patent in force
AM Amended specification (according sect 146 of patent law)

Free format text: METHOD FOR PRODUCING FLUDARABIN PHOSPHATE LITHIUM, SODIUM, POTASSIUM CALCIUM AND MAGNESIUM SALTS, PURIFICATION METHOD FOR PRODUCING FLUDARABIN PHOSPHATE AND FLUDARABIN PHOSPHATE WHICH IS AT LEAST 99,5% PURE

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171130