HK1033171A1 - Process for obtaining l-dihydroorotic acid and use thereof - Google Patents

Process for obtaining l-dihydroorotic acid and use thereof Download PDF

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Publication number
HK1033171A1
HK1033171A1 HK01103785A HK01103785A HK1033171A1 HK 1033171 A1 HK1033171 A1 HK 1033171A1 HK 01103785 A HK01103785 A HK 01103785A HK 01103785 A HK01103785 A HK 01103785A HK 1033171 A1 HK1033171 A1 HK 1033171A1
Authority
HK
Hong Kong
Prior art keywords
dho
concentration
divinylbenzene
cells
serum
Prior art date
Application number
HK01103785A
Other languages
English (en)
Chinese (zh)
Other versions
HK1033171B (en
Inventor
U‧米尔伯特
R‧巴特莱特
E‧鲁斯
C‧福达里
Original Assignee
阿文蒂斯药物德国有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 阿文蒂斯药物德国有限公司 filed Critical 阿文蒂斯药物德国有限公司
Publication of HK1033171A1 publication Critical patent/HK1033171A1/xx
Publication of HK1033171B publication Critical patent/HK1033171B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
HK01103785.2A 1997-12-11 1998-12-08 Process for obtaining l-dihydroorotic acid and use thereof HK1033171B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97121848A EP0933633A1 (en) 1997-12-11 1997-12-11 Process for obtaining L-dihydroorotic acid and use thereof
EP97121848.2 1997-12-11
PCT/EP1998/007972 WO1999030146A1 (en) 1997-12-11 1998-12-08 Process for obtaining l-dihydroorotic acid and use thereof

Publications (2)

Publication Number Publication Date
HK1033171A1 true HK1033171A1 (en) 2001-08-17
HK1033171B HK1033171B (en) 2006-07-28

Family

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Also Published As

Publication number Publication date
PL194068B1 (pl) 2007-04-30
CN1237345C (zh) 2006-01-18
DE69831752T2 (de) 2006-06-22
US6545006B1 (en) 2003-04-08
KR100700906B1 (ko) 2007-03-29
EP1036319A1 (en) 2000-09-20
JP4189124B2 (ja) 2008-12-03
CA2315326A1 (en) 1999-06-17
CZ20002134A3 (cs) 2000-10-11
AU1877599A (en) 1999-06-28
ES2248927T3 (es) 2006-03-16
DK1036319T3 (da) 2006-01-16
ID24807A (id) 2000-08-24
CZ299968B6 (cs) 2009-01-07
HUP0004510A3 (en) 2003-05-28
RU2228932C2 (ru) 2004-05-20
PL341205A1 (en) 2001-03-26
EP1036319B1 (en) 2005-09-28
HUP0004510A1 (hu) 2001-04-28
AR016430A1 (es) 2001-07-04
JP2001526387A (ja) 2001-12-18
KR20010032978A (ko) 2001-04-25
AU747993B2 (en) 2002-05-30
DE69831752D1 (de) 2006-02-09
EP0933633A1 (en) 1999-08-04
CN1281550A (zh) 2001-01-24
WO1999030146A1 (en) 1999-06-17
TR200001671T2 (tr) 2000-11-21
BR9813559A (pt) 2000-10-10
ATE305610T1 (de) 2005-10-15

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HK1033171B (en) Process for obtaining l-dihydroorotic acid and use thereof
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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20091208