HK1023342A1 - Substituted isoquinolines as ultra short acting neuromuscular blockers - Google Patents
Substituted isoquinolines as ultra short acting neuromuscular blockersInfo
- Publication number
- HK1023342A1 HK1023342A1 HK00102447A HK00102447A HK1023342A1 HK 1023342 A1 HK1023342 A1 HK 1023342A1 HK 00102447 A HK00102447 A HK 00102447A HK 00102447 A HK00102447 A HK 00102447A HK 1023342 A1 HK1023342 A1 HK 1023342A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- short acting
- ultra short
- neuromuscular blockers
- substituted isoquinolines
- acting neuromuscular
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9706117.0A GB9706117D0 (en) | 1997-03-25 | 1997-03-25 | Ultra-short acting neuromuscular blockers |
| GBGB9724987.4A GB9724987D0 (en) | 1997-11-27 | 1997-11-27 | Ultra-short acting neuromuscular blockers |
| PCT/EP1998/001651 WO1998042674A1 (en) | 1997-03-25 | 1998-03-23 | Substituted isoquinolines as ultra short acting neuromuscular blockers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1023342A1 true HK1023342A1 (en) | 2000-09-08 |
Family
ID=26311255
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK00102447A HK1023342A1 (en) | 1997-03-25 | 2000-04-25 | Substituted isoquinolines as ultra short acting neuromuscular blockers |
Country Status (37)
| Country | Link |
|---|---|
| US (2) | US6177445B1 (de) |
| EP (4) | EP1526130A1 (de) |
| JP (3) | JP4112016B2 (de) |
| KR (2) | KR100578443B1 (de) |
| CN (1) | CN1203061C (de) |
| AP (1) | AP1797A (de) |
| AR (1) | AR012156A1 (de) |
| AT (3) | ATE254107T1 (de) |
| AU (2) | AU6730598A (de) |
| BR (1) | BR9808422B1 (de) |
| CA (1) | CA2284802C (de) |
| CO (1) | CO4940499A1 (de) |
| CZ (1) | CZ293786B6 (de) |
| DE (3) | DE69840816D1 (de) |
| DK (2) | DK0975599T3 (de) |
| EA (1) | EA002224B1 (de) |
| EE (1) | EE04113B1 (de) |
| ES (2) | ES2242275T3 (de) |
| HK (1) | HK1023342A1 (de) |
| HR (1) | HRP980157B1 (de) |
| HU (1) | HU228230B1 (de) |
| ID (1) | ID22901A (de) |
| IL (1) | IL131918A (de) |
| IS (2) | IS2346B (de) |
| MA (1) | MA26476A1 (de) |
| MY (1) | MY121316A (de) |
| NO (1) | NO314726B1 (de) |
| NZ (1) | NZ337797A (de) |
| PE (1) | PE68399A1 (de) |
| PL (1) | PL190860B1 (de) |
| PT (2) | PT975599E (de) |
| RS (1) | RS49869B (de) |
| SI (1) | SI0975599T1 (de) |
| TR (1) | TR199902330T2 (de) |
| TW (1) | TW505635B (de) |
| UY (1) | UY24933A1 (de) |
| WO (2) | WO1998042674A1 (de) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1203061C (zh) * | 1997-03-25 | 2005-05-25 | 艾弗拉药品公司 | 取代异喹啉类，其制备方法，药物组合物及其制药用途 |
| US6911455B2 (en) | 1999-12-22 | 2005-06-28 | Smithkline Beecham Corporation | Methods for preparing pharmaceutical formulations |
| US6844904B2 (en) * | 2002-12-07 | 2005-01-18 | Cubic Corporation | Fast PDLC device |
| EP1684753A2 (de) * | 2003-10-28 | 2006-08-02 | Cornell Research Foundation, Inc. | Neuromuskuläre blockiermittel und ihre antagonisten |
| WO2008070121A1 (en) | 2006-12-06 | 2008-06-12 | Cornell Research Foundation, Inc. | Intermediate duration neuromuscular blocking agents and antagonists thereof |
| WO2008107887A2 (en) | 2007-03-08 | 2008-09-12 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
| WO2008117271A1 (en) * | 2007-03-26 | 2008-10-02 | Chemagis Ltd. | (1r,1'r)-atracurium salts separation process |
| EP2155684B1 (de) * | 2007-05-01 | 2014-04-09 | Chemagis Ltd. | Verfahren zur herstellung von cisatracuriumverbindungen und damit assoziierte zwischenprodukte |
| EP2142510A1 (de) | 2007-05-01 | 2010-01-13 | Chemagis Ltd. | Neuartige isochinolin-verbindungen zur herstellung von cisatracurium und entsprechenden zwischenprodukten |
| US8357805B2 (en) * | 2007-06-18 | 2013-01-22 | Chemagis Ltd. | (1R,1′R)-atracurium salts separation process |
| EP2176227A1 (de) * | 2007-07-09 | 2010-04-21 | Chemagis Ltd. | Verfahren zur herstellung von cisatracurium und zugehörige zwischenprodukte |
| AU2008320380A1 (en) | 2007-10-29 | 2009-05-07 | Chemagis Ltd. | Novel R,R'-atracurium salts |
| BRPI0907656A2 (pt) * | 2008-05-01 | 2019-08-27 | Chemagis Ltd | composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio |
| US8592451B2 (en) | 2009-03-17 | 2013-11-26 | Cornell University | Reversible nondepolarizing neuromuscular blockade agents and methods for their use |
| CN102573794B (zh) | 2009-08-19 | 2017-03-15 | 康奈尔大学 | 供生理注射用的半胱氨酸 |
| EP2867219B1 (de) * | 2012-06-29 | 2017-02-15 | Cornell University | Asymmetrische reversible neuromuskuläre blockiermittel von sehr kurzen, kurzer oder mittellanger dauer |
| CN103373959A (zh) * | 2013-06-14 | 2013-10-30 | 安徽省先锋制药有限公司 | 顺式苄基异喹啉类化合物的制备方法及其用途 |
| WO2014210369A2 (en) * | 2013-06-28 | 2014-12-31 | Cornell University | Reversal of cysteine-inactivated neuromuscular blocking drugs with combinations of reversal agents |
| CN108375644B (zh) * | 2016-12-07 | 2021-11-30 | 四川科瑞德制药股份有限公司 | 一种神经肌肉阻滞剂中间体的分析方法 |
| CN108938573B (zh) * | 2017-05-26 | 2021-08-10 | 四川科瑞德制药股份有限公司 | 一种神经肌肉阻滞剂组合物及其制备方法和用途 |
| CN110776481B (zh) * | 2018-07-24 | 2023-06-16 | 四川大学华西医院 | 一类双阳离子化合物及其制备方法和用途 |
| CN109776486A (zh) * | 2019-02-26 | 2019-05-21 | 武汉松石科技股份有限公司 | 一种硫酸亚丙酯的制备方法 |
| CN111662230A (zh) * | 2019-03-06 | 2020-09-15 | 四川道珍科技有限公司 | 一类苄基异喹啉化合物、制备方法和用途 |
| CN110117297A (zh) * | 2019-04-10 | 2019-08-13 | 珠海市赛纬电子材料股份有限公司 | 一种2-磷酸盐基硫酸丙烯酯的制备方法 |
| WO2021115413A1 (zh) * | 2019-12-11 | 2021-06-17 | 江苏恒瑞医药股份有限公司 | 神经肌肉阻滞剂及其制备方法 |
| CN111471013B (zh) * | 2020-05-26 | 2021-04-30 | 朗天药业(湖北)有限公司 | 一种米库氯铵及其注射液的制备方法 |
| CN111909089B (zh) * | 2020-08-14 | 2023-04-14 | 广东嘉博制药有限公司 | 一种米库氯铵对照品的制备方法 |
| CN114057642B (zh) * | 2021-12-10 | 2023-03-28 | 广东嘉博制药有限公司 | 一种米库氯铵中间体的合成方法 |
| CN115073373A (zh) * | 2022-07-08 | 2022-09-20 | 广东嘉博制药有限公司 | 一种不对称合成（r）-5’-甲氧基劳丹素的方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3004031A (en) | 1958-07-03 | 1961-10-10 | Allen & Hauburys Ltd | Diquaternary salts of papaverino esters |
| AU506657B2 (en) * | 1975-12-10 | 1980-01-17 | Wellcome Foundation Limited, The | Isoquinoline derivatives |
| IL55254A (en) * | 1977-08-01 | 1983-03-31 | Massachusetts Gen Hospital | Bis-isoquinolinium compounds,their preparation and pharmaceutical compositions containing them |
| US4701460A (en) * | 1980-12-17 | 1987-10-20 | Burroughs Wellcome Co. | Long duration neuromuscular blocking agents |
| JPS5899465A (ja) | 1981-11-23 | 1983-06-13 | ザ・ウエルカム・フアウンデ−シヨン・リミテツド | イソキノリン誘導体 |
| GB8418303D0 (en) * | 1984-07-18 | 1984-08-22 | Wellcome Found | Compounds |
| BG41897A1 (en) | 1985-07-19 | 1987-09-15 | Ivanov | Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation |
| GB9015473D0 (en) | 1990-07-13 | 1990-08-29 | Wellcome Found | Neuromuscular blocking agents |
| JPH04112016A (ja) * | 1990-09-03 | 1992-04-14 | Fuji Electric Co Ltd | トランスファ成形金型用プランジャ及びトランスファ成形装置 |
| US5240939A (en) * | 1991-10-31 | 1993-08-31 | Anaquest, Inc. | Nitrogen bridge tetrahydroisoquinolines |
| CN1203061C (zh) * | 1997-03-25 | 2005-05-25 | 艾弗拉药品公司 | 取代异喹啉类，其制备方法，药物组合物及其制药用途 |
-
1998
- 1998-03-23 CN CNB988053004A patent/CN1203061C/zh not_active Expired - Fee Related
- 1998-03-23 WO PCT/EP1998/001651 patent/WO1998042674A1/en not_active Application Discontinuation
- 1998-03-23 EP EP05001475A patent/EP1526130A1/de not_active Withdrawn
- 1998-03-23 DE DE69840816T patent/DE69840816D1/de not_active Expired - Lifetime
- 1998-03-23 US US09/381,721 patent/US6177445B1/en not_active Expired - Fee Related
- 1998-03-23 PT PT98922626T patent/PT975599E/pt unknown
- 1998-03-23 ID IDW991103A patent/ID22901A/id unknown
- 1998-03-23 KR KR1020057019867A patent/KR100578443B1/ko not_active IP Right Cessation
- 1998-03-23 AU AU67305/98A patent/AU6730598A/en not_active Abandoned
- 1998-03-23 DK DK98922626T patent/DK0975599T3/da active
- 1998-03-23 HU HU0001556A patent/HU228230B1/hu not_active IP Right Cessation
- 1998-03-23 AT AT98922626T patent/ATE254107T1/de active
- 1998-03-23 WO PCT/EP1998/001652 patent/WO1998042675A1/en active IP Right Grant
- 1998-03-23 JP JP54323398A patent/JP4112016B2/ja not_active Expired - Fee Related
- 1998-03-23 EP EP98922626A patent/EP0975599B1/de not_active Expired - Lifetime
- 1998-03-23 AP APAP/P/1999/001658A patent/AP1797A/en active
- 1998-03-23 MA MA25006A patent/MA26476A1/fr unknown
- 1998-03-23 AT AT98912494T patent/ATE295351T1/de not_active IP Right Cessation
- 1998-03-23 EP EP98912494A patent/EP0971898B1/de not_active Expired - Lifetime
- 1998-03-23 US US09/381,719 patent/US6187789B1/en not_active Expired - Lifetime
- 1998-03-23 TR TR1999/02330T patent/TR199902330T2/xx unknown
- 1998-03-23 AT AT03020565T patent/ATE430734T1/de not_active IP Right Cessation
- 1998-03-23 PT PT98912494T patent/PT971898E/pt unknown
- 1998-03-23 MY MYPI98001252A patent/MY121316A/en unknown
- 1998-03-23 ES ES98912494T patent/ES2242275T3/es not_active Expired - Lifetime
- 1998-03-23 PE PE1998000209A patent/PE68399A1/es not_active Application Discontinuation
- 1998-03-23 IL IL13191898A patent/IL131918A/xx not_active IP Right Cessation
- 1998-03-23 BR BRPI9808422-4A patent/BR9808422B1/pt not_active IP Right Cessation
- 1998-03-23 AU AU75210/98A patent/AU745382B2/en not_active Ceased
- 1998-03-23 EP EP03020565A patent/EP1380573B1/de not_active Expired - Lifetime
- 1998-03-23 EE EEP199900424A patent/EE04113B1/xx not_active IP Right Cessation
- 1998-03-23 NZ NZ337797A patent/NZ337797A/xx not_active IP Right Cessation
- 1998-03-23 KR KR1019997008687A patent/KR100554601B1/ko not_active IP Right Cessation
- 1998-03-23 EA EA199900756A patent/EA002224B1/ru not_active IP Right Cessation
- 1998-03-23 DE DE69830157T patent/DE69830157T2/de not_active Expired - Lifetime
- 1998-03-23 RS YUP-483/99A patent/RS49869B/sr unknown
- 1998-03-23 PL PL335885A patent/PL190860B1/pl not_active IP Right Cessation
- 1998-03-23 JP JP54323298A patent/JP4112015B2/ja not_active Expired - Fee Related
- 1998-03-23 SI SI9830593T patent/SI0975599T1/xx unknown
- 1998-03-23 DK DK98912494T patent/DK0971898T3/da active
- 1998-03-23 CA CA002284802A patent/CA2284802C/en not_active Expired - Fee Related
- 1998-03-23 DE DE69819703T patent/DE69819703T2/de not_active Expired - Lifetime
- 1998-03-23 CZ CZ19993404A patent/CZ293786B6/cs not_active IP Right Cessation
- 1998-03-23 ES ES98922626T patent/ES2210757T3/es not_active Expired - Lifetime
- 1998-03-24 HR HR980157A patent/HRP980157B1/xx not_active IP Right Cessation
- 1998-03-24 UY UY24933A patent/UY24933A1/es not_active IP Right Cessation
- 1998-03-24 AR ARP980101340A patent/AR012156A1/es active IP Right Grant
- 1998-03-25 CO CO98016617A patent/CO4940499A1/es unknown
- 1998-04-29 TW TW087106631A patent/TW505635B/zh not_active IP Right Cessation
-
1999
- 1999-09-17 IS IS5185A patent/IS2346B/is unknown
- 1999-09-24 NO NO19994680A patent/NO314726B1/no not_active IP Right Cessation
-
2000
- 2000-04-25 HK HK00102447A patent/HK1023342A1/xx not_active IP Right Cessation
-
2007
- 2007-09-25 JP JP2007247928A patent/JP2008019272A/ja active Pending
-
2008
- 2008-03-03 IS IS8717A patent/IS8717A/is unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AS | Change of ownership |
Owner name: CORNELL RESEARCH FOUNDATION INC. Free format text: FORMER OWNER(S): GLAXO GROUP LIMITED, CORNELL RESEARCH FOUNDATION INC Owner name: AVERA PHARMACEUTICALS, INC. Free format text: FORMER OWNER(S): GLAXO GROUP LIMITED, CORNELL RESEARCH FOUNDATION INC |
|
| PF | Patent in force | ||
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20140323 |