CO4940499A1 - Derivados de isoquinolinio sustituidos - Google Patents

Derivados de isoquinolinio sustituidos

Info

Publication number
CO4940499A1
CO4940499A1 CO98016617A CO98016617A CO4940499A1 CO 4940499 A1 CO4940499 A1 CO 4940499A1 CO 98016617 A CO98016617 A CO 98016617A CO 98016617 A CO98016617 A CO 98016617A CO 4940499 A1 CO4940499 A1 CO 4940499A1
Authority
CO
Colombia
Prior art keywords
isoquinoline derivatives
substituted isoquinoline
substituted
derivatives
halogenoh
Prior art date
Application number
CO98016617A
Other languages
English (en)
Inventor
Eric Cleveland Bigham
Evan Boswell Grady
John Joseph Savarese
Archibald Swaringen Roy Jr
Shashikant Patel Sanjay
Eric Eugene Boros
Robert Anthony Mook Jr
Vincente Samano
Original Assignee
Glaxo Group Ltd
Cornell Res Foundation Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9706117.0A external-priority patent/GB9706117D0/en
Priority claimed from GBGB9724987.4A external-priority patent/GB9724987D0/en
Application filed by Glaxo Group Ltd, Cornell Res Foundation Inc filed Critical Glaxo Group Ltd
Publication of CO4940499A1 publication Critical patent/CO4940499A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
    • C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Surgery (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Un compuesto de la Fórmula (I):caracterizado porque :X es un halógenoh es 1 a 2;Y es hidrógeno o metoxi,Z1 y Z2 son metilo; W1 y W2 son átomos de carbono; yA es un anión farmaceúticamente aceptable.
CO98016617A 1997-03-25 1998-03-25 Derivados de isoquinolinio sustituidos CO4940499A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9706117.0A GB9706117D0 (en) 1997-03-25 1997-03-25 Ultra-short acting neuromuscular blockers
GBGB9724987.4A GB9724987D0 (en) 1997-11-27 1997-11-27 Ultra-short acting neuromuscular blockers

Publications (1)

Publication Number Publication Date
CO4940499A1 true CO4940499A1 (es) 2000-07-24

Family

ID=26311255

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98016617A CO4940499A1 (es) 1997-03-25 1998-03-25 Derivados de isoquinolinio sustituidos

Country Status (37)

Country Link
US (2) US6187789B1 (es)
EP (4) EP1526130A1 (es)
JP (3) JP4112016B2 (es)
KR (2) KR100554601B1 (es)
CN (1) CN1203061C (es)
AP (1) AP1797A (es)
AR (1) AR012156A1 (es)
AT (3) ATE430734T1 (es)
AU (2) AU6730598A (es)
BR (1) BR9808422B1 (es)
CA (1) CA2284802C (es)
CO (1) CO4940499A1 (es)
CZ (1) CZ293786B6 (es)
DE (3) DE69840816D1 (es)
DK (2) DK0971898T3 (es)
EA (1) EA002224B1 (es)
EE (1) EE04113B1 (es)
ES (2) ES2242275T3 (es)
HK (1) HK1023342A1 (es)
HR (1) HRP980157B1 (es)
HU (1) HU228230B1 (es)
ID (1) ID22901A (es)
IL (1) IL131918A (es)
IS (2) IS2346B (es)
MA (1) MA26476A1 (es)
MY (1) MY121316A (es)
NO (1) NO314726B1 (es)
NZ (1) NZ337797A (es)
PE (1) PE68399A1 (es)
PL (1) PL190860B1 (es)
PT (2) PT971898E (es)
RS (1) RS49869B (es)
SI (1) SI0975599T1 (es)
TR (1) TR199902330T2 (es)
TW (1) TW505635B (es)
UY (1) UY24933A1 (es)
WO (2) WO1998042675A1 (es)

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EA002224B1 (ru) * 1997-03-25 2002-02-28 Глаксо Груп Лимитед Замещенные изохинолины в качестве нервно-мышечных блокаторов ультракраткосрочного действия
US6911455B2 (en) * 1999-12-22 2005-06-28 Smithkline Beecham Corporation Methods for preparing pharmaceutical formulations
US6844904B2 (en) * 2002-12-07 2005-01-18 Cubic Corporation Fast PDLC device
EP1684753A2 (en) * 2003-10-28 2006-08-02 Cornell Research Foundation, Inc. Neuromuscular blocking agents and antagonists thereof
ATE554769T1 (de) * 2006-12-06 2012-05-15 Cornell Res Foundation Inc Neuromuskuläre blocker mit mittlerer dauer und antagonisten advon
WO2008107887A2 (en) * 2007-03-08 2008-09-12 Chemagis Ltd. (1r,1'r)-atracurium salts separation process
BRPI0808581A2 (pt) * 2007-03-26 2014-09-16 Chemagis Ltd "método para separar cisatracúrio com alta pureza de uma mistura de isômeros de (1r, 1'r) - atracúrio"
US8293912B2 (en) * 2007-05-01 2012-10-23 Chemagis Ltd. Process for producing cisatracurium compounds and associated intermediates
US8357807B2 (en) * 2007-05-01 2013-01-22 Chemagis Ltd. Isoquinolinium compounds useful in the preparation of cisatracurium and associated intermediates
BRPI0811687A2 (pt) 2007-06-18 2015-02-18 Chemagis Ltd MÉTODO PARA SEPARAR O ISÔMETRO 1R-CIS, 1'R-CIS (cisatracúrio) DE UMA MISTURA DE ISÔMEROS DE SAIS DE (1R, 1'R) - ATRACÚRIO
EP2176227A1 (en) * 2007-07-09 2010-04-21 Chemagis Ltd. Process for producing cisatracurium and associated intermediates
BRPI0816519A2 (pt) * 2007-10-29 2015-03-24 Chemagis Ltd Processo para preparar um sal de r, r'-atracúrio isomericamente enriquecido e sal de r, r'-atracúrio
BRPI0907656A2 (pt) * 2008-05-01 2019-08-27 Chemagis Ltd composto para testar a pureza de cisatracúrio, método para testar a pureza de uma amostra de besilato de cisatracúrio, uso de um composto para testar a pureza de cisatracúrio e processo para preparar compostos para testar a pureza de cisatracúrio
WO2010107488A1 (en) * 2009-03-17 2010-09-23 Cornell University Reversible nondepolarizing neuromuscular blockade agents and methods for their use
WO2011022491A1 (en) 2009-08-19 2011-02-24 Cornell University Cysteine for physiological injection
JP6236077B2 (ja) * 2012-06-29 2017-11-22 コーネル・ユニバーシティーＣｏｒｎｅｌｌ Ｕｎｉｖｅｒｓｉｔｙ 持続時間が超短期、短期、または中期の非対称性逆転可能神経筋遮断物質
CN103373959A (zh) * 2013-06-14 2013-10-30 安徽省先锋制药有限公司 顺式苄基异喹啉类化合物的制备方法及其用途
WO2014210369A2 (en) * 2013-06-28 2014-12-31 Cornell University Reversal of cysteine-inactivated neuromuscular blocking drugs with combinations of reversal agents
CN108375644B (zh) * 2016-12-07 2021-11-30 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂中间体的分析方法
CN108938573B (zh) * 2017-05-26 2021-08-10 四川科瑞德制药股份有限公司 一种神经肌肉阻滞剂组合物及其制备方法和用途
CN110776481B (zh) * 2018-07-24 2023-06-16 四川大学华西医院 一类双阳离子化合物及其制备方法和用途
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN111662230A (zh) * 2019-03-06 2020-09-15 四川道珍科技有限公司 一类苄基异喹啉化合物、制备方法和用途
CN110117297A (zh) * 2019-04-10 2019-08-13 珠海市赛纬电子材料股份有限公司 一种2-磷酸盐基硫酸丙烯酯的制备方法
TW202128628A (zh) * 2019-12-11 2021-08-01 大陸商江蘇恆瑞醫藥股份有限公司 神經肌肉阻滯劑及其製備方法
CN111471013B (zh) * 2020-05-26 2021-04-30 朗天药业(湖北)有限公司 一种米库氯铵及其注射液的制备方法
CN111909089B (zh) * 2020-08-14 2023-04-14 广东嘉博制药有限公司 一种米库氯铵对照品的制备方法
CN114057642B (zh) * 2021-12-10 2023-03-28 广东嘉博制药有限公司 一种米库氯铵中间体的合成方法
CN115073373A (zh) * 2022-07-08 2022-09-20 广东嘉博制药有限公司 一种不对称合成（r）-5’-甲氧基劳丹素的方法

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US3004031A (en) 1958-07-03 1961-10-10 Allen & Hauburys Ltd Diquaternary salts of papaverino esters
AU506657B2 (en) * 1975-12-10 1980-01-17 Wellcome Foundation Limited, The Isoquinoline derivatives
DK339078A (da) * 1977-08-01 1979-02-02 Massachusetts Gen Hospital Neuromuskulaere blokeringsmidler og fremgangsmaade til deres fremstilling
US4701460A (en) * 1980-12-17 1987-10-20 Burroughs Wellcome Co. Long duration neuromuscular blocking agents
JPS5899465A (ja) 1981-11-23 1983-06-13 ザ・ウエルカム・フアウンデ−シヨン・リミテツド イソキノリン誘導体
GB8418303D0 (en) * 1984-07-18 1984-08-22 Wellcome Found Compounds
BG41897A1 (en) * 1985-07-19 1987-09-15 Ivanov Dichlormethylate of n, n'- 4, 10- dioxa- 3, 11- bis- tetrahydropapaverine and method for its preparation
GB9015473D0 (en) 1990-07-13 1990-08-29 Wellcome Found Neuromuscular blocking agents
JPH04112016A (ja) * 1990-09-03 1992-04-14 Fuji Electric Co Ltd トランスファ成形金型用プランジャ及びトランスファ成形装置
US5240939A (en) * 1991-10-31 1993-08-31 Anaquest, Inc. Nitrogen bridge tetrahydroisoquinolines
EA002224B1 (ru) * 1997-03-25 2002-02-28 Глаксо Груп Лимитед Замещенные изохинолины в качестве нервно-мышечных блокаторов ультракраткосрочного действия

Also Published As

Publication number Publication date
DK0971898T3 (da) 2005-09-05
IS8717A (is) 2008-03-03
ES2210757T3 (es) 2004-07-01
CN1257483A (zh) 2000-06-21
ATE295351T1 (de) 2005-05-15
EA002224B1 (ru) 2002-02-28
EE9900424A (et) 2000-04-17
PT975599E (pt) 2004-03-31
JP2002517168A (ja) 2002-06-11
YU48399A (sh) 2002-06-19
WO1998042674A1 (en) 1998-10-01
AP9901658A0 (en) 1999-09-30
CZ293786B6 (cs) 2004-07-14
AP1797A (en) 2007-11-15
NO994680D0 (no) 1999-09-24
IS2346B (is) 2008-03-15
MY121316A (en) 2006-01-28
KR20050103984A (ko) 2005-11-01
PT971898E (pt) 2005-07-29
EP1380573A3 (en) 2004-01-21
HUP0001556A2 (hu) 2001-04-28
AU6730598A (en) 1998-10-20
BR9808422B1 (pt) 2010-08-24
CN1203061C (zh) 2005-05-25
PE68399A1 (es) 1999-07-23
TW505635B (en) 2002-10-11
US6187789B1 (en) 2001-02-13
IS5185A (is) 1999-09-17
NZ337797A (en) 2001-03-30
EP0971898B1 (en) 2005-05-11
UY24933A1 (es) 2000-12-29
JP4112016B2 (ja) 2008-07-02
DK0975599T3 (da) 2004-03-15
JP2008019272A (ja) 2008-01-31
NO314726B1 (no) 2003-05-12
PL335885A1 (en) 2000-05-22
HU228230B1 (en) 2013-02-28
TR199902330T2 (xx) 2000-02-21
IL131918A0 (en) 2001-03-19
ES2242275T3 (es) 2005-11-01
DE69830157T2 (de) 2006-05-11
EP1380573A2 (en) 2004-01-14
NO994680L (no) 1999-11-24
EP0975599B1 (en) 2003-11-12
HUP0001556A3 (en) 2002-01-28
DE69819703T2 (de) 2004-09-30
RS49869B (sr) 2008-08-07
DE69830157D1 (de) 2005-06-16
JP4112015B2 (ja) 2008-07-02
PL190860B1 (pl) 2006-02-28
MA26476A1 (fr) 2004-12-20
BR9808422A (pt) 2000-05-23
CA2284802C (en) 2009-06-16
ATE254107T1 (de) 2003-11-15
HK1023342A1 (en) 2000-09-08
DE69819703D1 (de) 2003-12-18
DE69840816D1 (de) 2009-06-18
AR012156A1 (es) 2000-09-27
AU7521098A (en) 1998-10-20
US6177445B1 (en) 2001-01-23
CA2284802A1 (en) 1998-10-01
HRP980157A2 (en) 1999-02-28
SI0975599T1 (en) 2004-04-30
JP2002503220A (ja) 2002-01-29
CZ340499A3 (cs) 2000-04-12
EA199900756A1 (ru) 2000-08-28
EE04113B1 (et) 2003-08-15
EP0975599A1 (en) 2000-02-02
KR100554601B1 (ko) 2006-03-03
EP1380573B1 (en) 2009-05-06
IL131918A (en) 2005-09-25
HRP980157B1 (en) 2004-10-31
ID22901A (id) 1999-12-16
KR100578443B1 (ko) 2006-05-11
EP1526130A1 (en) 2005-04-27
AU745382B2 (en) 2002-03-21
WO1998042675A1 (en) 1998-10-01
EP0971898A1 (en) 2000-01-19
ATE430734T1 (de) 2009-05-15
KR20010005621A (ko) 2001-01-15

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