HK1021741A1 - Modulators of beta-amyloid peptide aggregation comprising d-amino acids - Google Patents

Modulators of beta-amyloid peptide aggregation comprising d-amino acids

Info

Publication number
HK1021741A1
HK1021741A1 HK00100377A HK00100377A HK1021741A1 HK 1021741 A1 HK1021741 A1 HK 1021741A1 HK 00100377 A HK00100377 A HK 00100377A HK 00100377 A HK00100377 A HK 00100377A HK 1021741 A1 HK1021741 A1 HK 1021741A1
Authority
HK
Hong Kong
Prior art keywords
beta
peptide
amyloid peptide
compounds
amino
Prior art date
Application number
HK00100377A
Other languages
English (en)
Inventor
Mark A Findeis
Malcolm L Gefter
Ethan R Signer
James Wakefield
Susan Molineaux
Joseph Chin
Jung-Ja Lee
Michael Kelley
Sonja Komar-Panicucci
Christopher C Arico-Muendel
Kathryn Phillips
Neil J Hayward
Gary Musso
Original Assignee
Praecis Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/703,675 external-priority patent/US6303567B1/en
Application filed by Praecis Pharm Inc filed Critical Praecis Pharm Inc
Publication of HK1021741A1 publication Critical patent/HK1021741A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK00100377A 1996-08-27 2000-01-20 Modulators of beta-amyloid peptide aggregation comprising d-amino acids HK1021741A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/703,675 US6303567B1 (en) 1995-03-14 1996-08-27 Modulators of β-amyloid peptide aggregation comprising D-amino acids
US89734297A 1997-07-21 1997-07-21
PCT/US1997/015166 WO1998008868A1 (fr) 1996-08-27 1997-08-27 Modulateurs de l'agregation de peptides beta-amyloides, comprenant des d-aminoacides

Publications (1)

Publication Number Publication Date
HK1021741A1 true HK1021741A1 (en) 2000-06-30

Family

ID=27107183

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00100377A HK1021741A1 (en) 1996-08-27 2000-01-20 Modulators of beta-amyloid peptide aggregation comprising d-amino acids

Country Status (11)

Country Link
EP (2) EP1586584A1 (fr)
JP (1) JP2001500852A (fr)
AT (1) ATE298765T1 (fr)
AU (1) AU741199B2 (fr)
CA (1) CA2262453A1 (fr)
DE (1) DE69733655T2 (fr)
DK (1) DK0929574T3 (fr)
ES (1) ES2245003T3 (fr)
HK (1) HK1021741A1 (fr)
PT (1) PT929574E (fr)
WO (1) WO1998008868A1 (fr)

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US6277826B1 (en) 1996-08-27 2001-08-21 Praecis Pharmaceuticals, Inc. Modulators of β-amyloid peptide aggregation comprising D-amino acids
WO1997021728A1 (fr) 1995-12-12 1997-06-19 Karolinska Innovations Ab PEPTIDE FIXANT LA SEQUENCE KLVFF DE L'AMYLOIDE $g(b)
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US20080050367A1 (en) 1998-04-07 2008-02-28 Guriq Basi Humanized antibodies that recognize beta amyloid peptide
US7790856B2 (en) 1998-04-07 2010-09-07 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize beta amyloid peptide
ATE366259T1 (de) 1999-03-04 2007-07-15 Praecis Pharm Inc Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren
EP1870419A3 (fr) * 1999-03-04 2008-01-02 Praecis Pharmaceuticals Incorporated Modulateurs d'agrégation de peptide d'amyloïde béta comportant des acides D-amino
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US7060670B1 (en) 1999-05-05 2006-06-13 Neurochem (International) Limited Stereoselective antifibrillogenic peptides and peptidomimetics thereof
WO2001034631A2 (fr) * 1999-11-05 2001-05-17 Axonyx, Inc. ANALOGUES ET MIMETIQUES PEPTIDIQUES POUVANT ETRE UTILISES IN VIVO POUR TRAITER DES MALADIES ASSOCIEES AU REPLI ANORMAL PROTEIQUE EN DEPOTS AMYLOIDES OU PSEUDO-AMYLOIDES OU LEUR PRECURSEUR PATHOLOGIQUE RICHE EN β-FEUILLE
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WO2002035987A2 (fr) 2000-11-03 2002-05-10 Massachusetts Institute Of Technology Methodes d'identification de traitements de la neurotoxicite dans la maladie d'alzheimer engendree par des peptides $g(b)-amyloides
US7067550B2 (en) 2000-11-03 2006-06-27 Massachusetts Institute Of Technology Treatments for neurotoxicity in Alzheimer's Disease
US7700751B2 (en) 2000-12-06 2010-04-20 Janssen Alzheimer Immunotherapy Humanized antibodies that recognize β-amyloid peptide
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US8236766B2 (en) 2006-11-10 2012-08-07 Cara Therapeutics, Inc. Uses of synthetic peptide amides
US7842662B2 (en) 2006-11-10 2010-11-30 Cara Therapeutics, Inc. Synthetic peptide amide dimers
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US7713937B2 (en) 2006-11-10 2010-05-11 Cara Therapeutics, Inc. Synthetic peptide amides and dimeric forms thereof
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US9193709B2 (en) 2011-10-07 2015-11-24 Takeda Pharmaceutical Company Limited 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases
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AU2019241765B2 (en) 2018-03-28 2022-07-07 Takeda Pharmaceutical Company Limited Heterocyclic compound and use thereof
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JPWO2020153414A1 (ja) 2019-01-24 2021-12-02 武田薬品工業株式会社 複素環化合物及びその用途
TW202110824A (zh) 2019-05-24 2021-03-16 美商賽吉醫療公司 化合物、組合物及使用方法
CN114980892A (zh) 2019-09-13 2022-08-30 武田药品工业株式会社 用于治疗发作性睡病的tak-925
CA3154320A1 (fr) 2019-09-13 2021-03-18 Takeda Pharmaceutical Company Limited Utilisation d'un agoniste du recepteur de l'orexine 2 pour le traitement d'une somnolence excessive
JP2021050161A (ja) 2019-09-25 2021-04-01 武田薬品工業株式会社 複素環化合物及びその用途
JP2021080177A (ja) 2019-11-14 2021-05-27 武田薬品工業株式会社 複素環化合物及びその用途
JP2021183587A (ja) 2020-05-22 2021-12-02 武田薬品工業株式会社 複素環化合物
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Also Published As

Publication number Publication date
AU4238797A (en) 1998-03-19
EP0929574B1 (fr) 2005-06-29
DE69733655T2 (de) 2006-04-27
PT929574E (pt) 2005-11-30
EP1586584A1 (fr) 2005-10-19
CA2262453A1 (fr) 1998-03-05
DK0929574T3 (da) 2005-10-31
DE69733655D1 (de) 2005-08-04
ES2245003T3 (es) 2005-12-16
AU741199B2 (en) 2001-11-22
WO1998008868A1 (fr) 1998-03-05
JP2001500852A (ja) 2001-01-23
EP0929574A1 (fr) 1999-07-21
ATE298765T1 (de) 2005-07-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20090827