HK1021741A1 - Modulators of beta-amyloid peptide aggregation comprising d-amino acids - Google Patents
Modulators of beta-amyloid peptide aggregation comprising d-amino acidsInfo
- Publication number
- HK1021741A1 HK1021741A1 HK00100377A HK00100377A HK1021741A1 HK 1021741 A1 HK1021741 A1 HK 1021741A1 HK 00100377 A HK00100377 A HK 00100377A HK 00100377 A HK00100377 A HK 00100377A HK 1021741 A1 HK1021741 A1 HK 1021741A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- beta
- peptide
- amyloid peptide
- compounds
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/703,675 US6303567B1 (en) | 1995-03-14 | 1996-08-27 | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
US89734297A | 1997-07-21 | 1997-07-21 | |
PCT/US1997/015166 WO1998008868A1 (en) | 1996-08-27 | 1997-08-27 | MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1021741A1 true HK1021741A1 (en) | 2000-06-30 |
Family
ID=27107183
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK00100377A HK1021741A1 (en) | 1996-08-27 | 2000-01-20 | Modulators of beta-amyloid peptide aggregation comprising d-amino acids |
Country Status (11)
Country | Link |
---|---|
EP (2) | EP1586584A1 (xx) |
JP (1) | JP2001500852A (xx) |
AT (1) | ATE298765T1 (xx) |
AU (1) | AU741199B2 (xx) |
CA (1) | CA2262453A1 (xx) |
DE (1) | DE69733655T2 (xx) |
DK (1) | DK0929574T3 (xx) |
ES (1) | ES2245003T3 (xx) |
HK (1) | HK1021741A1 (xx) |
PT (1) | PT929574E (xx) |
WO (1) | WO1998008868A1 (xx) |
Families Citing this family (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985242A (en) * | 1995-10-27 | 1999-11-16 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
US6277826B1 (en) | 1996-08-27 | 2001-08-21 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
WO1997021728A1 (en) | 1995-12-12 | 1997-06-19 | Karolinska Innovations Ab | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
EP1015013A4 (en) * | 1997-01-10 | 2002-07-24 | Massachusetts Inst Technology | TREATMENT OF NEUROTOXICITY IN ALZHEIMER'S DISEASE BY BETA-AMYLOID PEPTIDES |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
ATE366259T1 (de) | 1999-03-04 | 2007-07-15 | Praecis Pharm Inc | Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren |
EP1870419A3 (en) * | 1999-03-04 | 2008-01-02 | Praecis Pharmaceuticals Incorporated | Modulators of beta-amyloid peptide aggregation comprising d-amino acids |
IL146009A0 (en) * | 1999-05-05 | 2002-07-25 | Neurochem Inc | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
US7060670B1 (en) | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
WO2001034631A2 (en) * | 1999-11-05 | 2001-05-17 | Axonyx, Inc. | PEPTIDE ANALOGS AND MIMETICS SUITABLE FOR IN VIVO USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL PROTEIN FOLDING INTO AMYLOID, AMYLOID-LIKE DEPOSITS OR β-SHEET RICH PATHOLOGICAL PRECURSOR THEREOF |
KR20080059676A (ko) * | 1999-11-29 | 2008-06-30 | 뉴로겜 인터내셔널 리미티드 | 알츠하이머 및 아밀로이드 관련 질병의 예방 및 치료용백신 |
JP2003522152A (ja) * | 2000-02-11 | 2003-07-22 | プラエシス ファーマシューティカルズ インコーポレーテッド | 薬物の生物学的利用能を高める方法 |
GB2363984A (en) * | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 3-hydroxy-7 -hydroxy steroids and 3-oxo-7 -hydroxy steroids |
GB2363983A (en) | 2000-06-29 | 2002-01-16 | Hunter Fleming Ltd | Protection against neuronal damage using 7-hydroxyepiandrosterone |
WO2002035987A2 (en) | 2000-11-03 | 2002-05-10 | Massachusetts Institute Of Technology | METHODS FOR IDENTIFYING TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE CAUSED BY β-AMYLOID PEPTIDES |
US7067550B2 (en) | 2000-11-03 | 2006-06-27 | Massachusetts Institute Of Technology | Treatments for neurotoxicity in Alzheimer's Disease |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
CN101979093B (zh) * | 2001-01-17 | 2013-04-24 | 罗伯特·H·齐默尔 | 含有肽原料药和其它不易吸收的活性成分的组合物及其应用 |
WO2003055521A1 (fr) * | 2001-12-26 | 2003-07-10 | Takeda Chemical Industries, Ltd. | Remedes contre les troubles cognitifs legers |
US20040052928A1 (en) | 2002-09-06 | 2004-03-18 | Ehud Gazit | Peptides and methods using same for diagnosing and treating amyloid-associated diseases |
US20050148650A1 (en) | 2002-03-01 | 2005-07-07 | Shigenori Ohkawa | Antidepressant |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
US6846640B2 (en) | 2002-04-30 | 2005-01-25 | Pharmacia & Upjohn Company | Time-resolved fluorescence assay for the detection of multimeric forms of A-beta 1-40 |
TWI374893B (en) | 2003-05-30 | 2012-10-21 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
EP1638517A4 (en) | 2003-06-30 | 2010-01-06 | Univ Tel Aviv Future Tech Dev | PEPTIDES, ANTIBODIES AGAINST DISEASES ASSOCIATED WITH AMYLOID AND METHODS OF USE FOR THE DIAGNOSIS AND TREATMENT OF THESE DISEASES |
AR052051A1 (es) | 2004-12-15 | 2007-02-28 | Neuralab Ltd | Anticuerpos ab humanizados usados en mejorar la cognicion |
EP1923388A4 (en) | 2005-08-12 | 2011-03-09 | Takeda Pharmaceutical | BRAIN / NERVE CELL PROTECTION AND THERAPEUTIC FOR SLEEP DISORDERS |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
WO2009017467A1 (en) | 2007-07-27 | 2009-02-05 | Elan Pharma International Limited | Treatment of amyloidogenic diseases |
WO2008050133A2 (en) * | 2006-10-27 | 2008-05-02 | Zapaloid Limited | Inhibition of beta-amyloid aggregation |
US8906859B2 (en) | 2006-11-10 | 2014-12-09 | Cera Therapeutics, Inc. | Uses of kappa opioid synthetic peptide amides |
US8236766B2 (en) | 2006-11-10 | 2012-08-07 | Cara Therapeutics, Inc. | Uses of synthetic peptide amides |
US7842662B2 (en) | 2006-11-10 | 2010-11-30 | Cara Therapeutics, Inc. | Synthetic peptide amide dimers |
RU2500685C2 (ru) | 2006-11-10 | 2013-12-10 | Кара Терапеутикс, Инк | Синтетические пептидные амиды |
US7713937B2 (en) | 2006-11-10 | 2010-05-11 | Cara Therapeutics, Inc. | Synthetic peptide amides and dimeric forms thereof |
JP2010518064A (ja) | 2007-02-12 | 2010-05-27 | メルク・シャープ・エンド・ドーム・コーポレイション | Adおよび関連状態の治療のためのピペラジン誘導体 |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
EP2781513A1 (en) | 2009-03-10 | 2014-09-24 | Takeda Pharmaceutical Company Limited | Benzofuran derivatives |
NZ608499A (en) | 2010-10-07 | 2015-03-27 | Takeda Pharmaceutical | 1,4-oxazepane derivatives |
TW201225972A (en) | 2010-11-15 | 2012-07-01 | Univ Ramot | Dipeptide analogs for treating conditions associated with amyloid fibril formation |
US9193709B2 (en) | 2011-10-07 | 2015-11-24 | Takeda Pharmaceutical Company Limited | 1-arylcarbonyl-4-oxy-piperidine compounds useful for the treatment of neurodegenerative diseases |
US9296746B2 (en) | 2012-10-16 | 2016-03-29 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
CN104981457B (zh) | 2012-12-11 | 2017-09-19 | 武田药品工业株式会社 | 杂环化合物 |
US9598398B2 (en) | 2013-04-04 | 2017-03-21 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
JP6272833B2 (ja) | 2013-04-04 | 2018-01-31 | 武田薬品工業株式会社 | 複素環化合物 |
JP6533799B2 (ja) | 2014-06-09 | 2019-06-19 | 武田薬品工業株式会社 | 放射標識された化合物 |
SG11201806429PA (en) | 2016-02-04 | 2018-08-30 | Takeda Pharmaceuticals Co | Substituted piperidine compound and use thereof |
WO2018164191A1 (ja) | 2017-03-08 | 2018-09-13 | 武田薬品工業株式会社 | 置換ピロリジン化合物およびその用途 |
EP3660003B1 (en) | 2017-07-28 | 2024-01-24 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
MY202221A (en) | 2017-08-03 | 2024-04-17 | Takeda Pharmaceuticals Co | Heterocyclic compound and use thereof |
AU2019241765B2 (en) | 2018-03-28 | 2022-07-07 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
JP7339250B2 (ja) | 2018-06-29 | 2023-09-05 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
JPWO2020153414A1 (ja) | 2019-01-24 | 2021-12-02 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
TW202110824A (zh) | 2019-05-24 | 2021-03-16 | 美商賽吉醫療公司 | 化合物、組合物及使用方法 |
CN114980892A (zh) | 2019-09-13 | 2022-08-30 | 武田药品工业株式会社 | 用于治疗发作性睡病的tak-925 |
CA3154320A1 (en) | 2019-09-13 | 2021-03-18 | Takeda Pharmaceutical Company Limited | Use of an orexin 2 receptor agonist for the treatment of excessive sleepiness |
JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
JP2021080177A (ja) | 2019-11-14 | 2021-05-27 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
JP2021183587A (ja) | 2020-05-22 | 2021-12-02 | 武田薬品工業株式会社 | 複素環化合物 |
WO2022115620A1 (en) | 2020-11-25 | 2022-06-02 | Sage Therapeutics, Inc. | 4-fluoro-(4-(4-benzyl)piperidin-1-yl)(2-(pyrimidin-4-yl)pyridin-3-yl)methanone derivatives and similar compounds as cyp46a1 inhibitors for the treatment of neurodegenerative disorders |
WO2022190060A1 (en) | 2021-03-12 | 2022-09-15 | Takeda Pharmaceutical Company Limited | An orexin 2 receptor agonist for the treatment of an orexin-mediated disease or disorder |
BR112023020104A2 (pt) | 2021-04-02 | 2023-11-14 | Takeda Pharmaceuticals Co | Métodos para recuperação pós-operação, para facilitar a recuperação ou reduzir o tempo de recuperação da anestesia, para prevenir ou tratar distúrbios/depressão respiratória pós-operatória ou distúrbios/depressão respiratória induzida por opioides, sedação pós-operatória ou sedação induzida por opioides e para reduzir um efeito colateral de opioides |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5338837A (en) * | 1991-12-13 | 1994-08-16 | The Trustees Of Princeton University | Glycosylated steroid derivatives for transport across biological membranes and process for making same |
WO1994019692A1 (en) * | 1993-02-18 | 1994-09-01 | The General Hospital Corporation | Alzheimer's disease therapeutics |
ES2175083T3 (es) * | 1995-03-14 | 2002-11-16 | Praecis Pharm Inc | Moduladores de la agregacion de amiloides. |
WO1997021728A1 (en) * | 1995-12-12 | 1997-06-19 | Karolinska Innovations Ab | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
-
1997
- 1997-08-27 EP EP05013789A patent/EP1586584A1/en not_active Withdrawn
- 1997-08-27 ES ES97940663T patent/ES2245003T3/es not_active Expired - Lifetime
- 1997-08-27 DK DK97940663T patent/DK0929574T3/da active
- 1997-08-27 AT AT97940663T patent/ATE298765T1/de not_active IP Right Cessation
- 1997-08-27 DE DE69733655T patent/DE69733655T2/de not_active Expired - Fee Related
- 1997-08-27 EP EP97940663A patent/EP0929574B1/en not_active Expired - Lifetime
- 1997-08-27 PT PT97940663T patent/PT929574E/pt unknown
- 1997-08-27 CA CA002262453A patent/CA2262453A1/en not_active Abandoned
- 1997-08-27 AU AU42387/97A patent/AU741199B2/en not_active Ceased
- 1997-08-27 JP JP10511914A patent/JP2001500852A/ja not_active Ceased
- 1997-08-27 WO PCT/US1997/015166 patent/WO1998008868A1/en active IP Right Grant
-
2000
- 2000-01-20 HK HK00100377A patent/HK1021741A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AU4238797A (en) | 1998-03-19 |
EP0929574B1 (en) | 2005-06-29 |
DE69733655T2 (de) | 2006-04-27 |
PT929574E (pt) | 2005-11-30 |
EP1586584A1 (en) | 2005-10-19 |
CA2262453A1 (en) | 1998-03-05 |
DK0929574T3 (da) | 2005-10-31 |
DE69733655D1 (de) | 2005-08-04 |
ES2245003T3 (es) | 2005-12-16 |
AU741199B2 (en) | 2001-11-22 |
WO1998008868A1 (en) | 1998-03-05 |
JP2001500852A (ja) | 2001-01-23 |
EP0929574A1 (en) | 1999-07-21 |
ATE298765T1 (de) | 2005-07-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20090827 |