HK1018910A1 - Modulators of the receptor associated factor(traf), their preparation and use. - Google Patents

Modulators of the receptor associated factor(traf), their preparation and use.

Info

Publication number
HK1018910A1
HK1018910A1 HK99104000A HK99104000A HK1018910A1 HK 1018910 A1 HK1018910 A1 HK 1018910A1 HK 99104000 A HK99104000 A HK 99104000A HK 99104000 A HK99104000 A HK 99104000A HK 1018910 A1 HK1018910 A1 HK 1018910A1
Authority
HK
Hong Kong
Prior art keywords
traf
modulators
preparation
associated factor
receptor associated
Prior art date
Application number
HK99104000A
Other languages
English (en)
Inventor
David Wallach
Nikolai Malinin
Mark Boldin
Andrei Kovalenko
Igor Mett
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL11780096A external-priority patent/IL117800A0/xx
Priority claimed from IL11913396A external-priority patent/IL119133A0/xx
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Publication of HK1018910A1 publication Critical patent/HK1018910A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
HK99104000A 1996-04-02 1999-09-15 Modulators of the receptor associated factor(traf), their preparation and use. HK1018910A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL11780096A IL117800A0 (en) 1996-04-02 1996-04-02 Modulators of TNF receptor associated factor (TRAF) their preparation and use
IL11913396A IL119133A0 (en) 1996-08-26 1996-08-26 Modulators of TNF receptor associated factor (TRAF) their preparation and use

Publications (1)

Publication Number Publication Date
HK1018910A1 true HK1018910A1 (en) 2000-01-07

Family

ID=26323248

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99104000A HK1018910A1 (en) 1996-04-02 1999-09-15 Modulators of the receptor associated factor(traf), their preparation and use.

Country Status (23)

Country Link
US (2) US7485456B1 (ru)
EP (1) EP0894130B1 (ru)
JP (1) JP4180114B2 (ru)
CN (1) CN1197966C (ru)
AT (1) ATE380866T1 (ru)
AU (1) AU732793B2 (ru)
BG (1) BG64755B1 (ru)
BR (1) BR9708518A (ru)
CA (1) CA2250085C (ru)
CZ (3) CZ299682B6 (ru)
DE (1) DE69738370T2 (ru)
DK (1) DK0894130T3 (ru)
EA (1) EA004309B1 (ru)
EE (1) EE04783B1 (ru)
ES (1) ES2294796T3 (ru)
HK (1) HK1018910A1 (ru)
HU (1) HU226328B1 (ru)
NO (1) NO327054B1 (ru)
NZ (1) NZ331902A (ru)
PT (1) PT894130E (ru)
SK (3) SK287085B6 (ru)
UA (1) UA71889C2 (ru)
WO (1) WO1997037016A1 (ru)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA71889C2 (ru) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Translated By PlajМОДУЛЯТОРЫ СВЯЗАННОГО С РЕЦЕПТОРОМ TNF ФАКТОРА (TRAF), ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein
AU1390299A (en) * 1997-11-07 1999-05-31 Genetics Institute Inc. Secreted proteins and polynucleotides encoding them
WO1999043704A1 (en) * 1998-02-27 1999-09-02 The Regents Of The University Of California A NOVEL INHIBITOR OF THE INFLAMMATORY RESPONSE INDUCED BY TNFα AND IL-1
ES2251831T3 (es) 1998-05-06 2006-05-01 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Inhibidores de la activacion de nf-kb.
KR20010085407A (ko) * 1998-08-18 2001-09-07 스타르크, 카르크 Ｔｐｌ-２/ｃｏｔ 키나제 및 그의 사용 방법
IL131719A0 (en) 1999-09-02 2001-03-19 Yeda Res & Dev Iren protein its preparation and use
GB9930616D0 (en) * 1999-12-24 2000-02-16 Mathilda & Terence Kennedy Ins Activation and inhibition of the immune system
KR20020069140A (ko) * 2001-02-21 2002-08-29 주식회사 코메드 종양 괴사 인자 수용체 관련 인자 6 억제 단백질
ATE334696T1 (de) 2001-06-22 2006-08-15 Vlaams Interuniv Inst Biotech Abin zum schutz gegen hepatitis
JP4435574B2 (ja) * 2002-04-18 2010-03-17 イエダ リサーチ アンド ディベロップメント カンパニー リミテッド ＩＬ−２レセプターγ鎖の誘導体、その製法および使用
EP1678209B1 (en) * 2003-10-07 2011-05-11 Yeda Research And Development Co., Ltd. Antibodies to nik, their preparation and use
IL158287A0 (en) * 2003-10-07 2004-05-12 Yeda Res & Dev Antibodies to nik, their preparation and use
EP1689786B1 (en) 2003-11-30 2014-05-14 Yeda Research And Development Co., Ltd. Methods and agents for immune modulation and methods for identifying immune modulators
IL173104A0 (en) * 2006-01-12 2006-06-11 Yeda Res & Dev Siva and ubiquintination
EP3629022A1 (en) 2008-07-25 2020-04-01 Richard W. Wagner Protein screening methods
GB201012420D0 (en) 2010-07-23 2010-09-08 Univ Erasmus Medical Ct Foetal heamoglobin inhibitor
AU2011293294B2 (en) 2010-08-25 2016-03-24 Pangu Biopharma Limited Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Tyrosyl-tRNA synthetases
CN102382850A (zh) * 2010-09-01 2012-03-21 山东新时代药业有限公司 新型人肿瘤坏死因子受体-Fc融合基因及其产物蛋白
JP2014508183A (ja) 2011-03-16 2014-04-03 エフ．ホフマン−ラ ロシュ アーゲー ６，５−複素環式プロパルギルアルコール化合物及びこれらの使用
SI2726101T1 (sl) 2011-06-30 2018-12-31 Genzyme Corporation Inhibitorji aktivacije T-celic
ES2657743T3 (es) 2011-07-19 2018-03-06 Philogen S.P.A. Terapia secuencial con anti-CTLA-4 e IL-2 dirigida
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
US10441654B2 (en) 2014-01-24 2019-10-15 Children's Hospital Of Eastern Ontario Research Institute Inc. SMC combination therapy for the treatment of cancer
CN105986001B (zh) * 2015-02-12 2019-12-03 上海交通大学 一种基于膜结合蛋白和荧光互补的高通量猎物拮抗剂筛选方法
CN113939534A (zh) 2019-04-03 2022-01-14 建新公司 具有降低的断裂的抗αβTCR结合多肽
US20240101691A1 (en) 2022-09-21 2024-03-28 Sanofi Biotechnology Humanized anti-il-1r3 antibody and methods of use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641876A (en) * 1990-01-05 1997-06-24 Cornell Research Foundation, Inc. Rice actin gene and promoter
EP0841934A1 (en) * 1995-08-02 1998-05-20 Teresa J. Ingram Composition for administration to patients with chronic fatigue syndrome and acquired immune deficiency syndrome
AU6692996A (en) * 1995-08-08 1997-03-05 Tularik Inc. Inhibitors of apoptosis
US5804412A (en) * 1996-04-01 1998-09-08 The Regents Of The University Of California Nucleic acids encoding sorting nexins and methods of using same
UA71889C2 (ru) * 1996-04-02 2005-01-17 Йєда Рісерч Енд Дівелопмент Ко. Лтд. Translated By PlajМОДУЛЯТОРЫ СВЯЗАННОГО С РЕЦЕПТОРОМ TNF ФАКТОРА (TRAF), ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ
KR20000010805A (ko) 1996-05-08 2000-02-25 웨인 씨. 제쉬크 알킬 폴리글리코시드 에테르 카르복실레이트
US5843721A (en) * 1997-07-03 1998-12-01 Tularik Inc. Nucleic acids encoding human NIK protein

Also Published As

Publication number Publication date
JP4180114B2 (ja) 2008-11-12
SK287889B6 (sk) 2012-03-02
BG64755B1 (bg) 2006-02-28
BR9708518A (pt) 1999-08-03
US20090291888A1 (en) 2009-11-26
EP0894130B1 (en) 2007-12-12
PT894130E (pt) 2008-01-14
NO984551D0 (no) 1998-09-29
US8236507B2 (en) 2012-08-07
EE04783B1 (et) 2007-02-15
DE69738370D1 (de) 2008-01-24
EE9800322A (et) 1999-04-15
HU226328B1 (en) 2008-09-29
EP0894130A1 (en) 1999-02-03
DE69738370T2 (de) 2008-12-04
CN1221449A (zh) 1999-06-30
CZ298866B6 (cs) 2008-02-27
SK287085B6 (sk) 2009-11-05
JP2000507826A (ja) 2000-06-27
CZ299094B6 (cs) 2008-04-23
AU732793B2 (en) 2001-05-03
WO1997037016A1 (en) 1997-10-09
CZ318398A3 (cs) 1999-05-12
NO327054B1 (no) 2009-04-14
ATE380866T1 (de) 2007-12-15
HUP9902429A2 (hu) 1999-10-28
EA199800885A1 (ru) 1999-04-29
CZ299682B6 (cs) 2008-10-15
EA004309B1 (ru) 2004-02-26
CN1197966C (zh) 2005-04-20
UA71889C2 (ru) 2005-01-17
ES2294796T3 (es) 2008-04-01
DK0894130T3 (da) 2008-01-07
US7485456B1 (en) 2009-02-03
SK136198A3 (en) 1999-05-07
NZ331902A (en) 2000-02-28
NO984551L (no) 1998-11-24
CA2250085A1 (en) 1997-10-09
SK287890B6 (sk) 2012-03-02
CA2250085C (en) 2009-10-20
BG102817A (en) 1999-05-31
HUP9902429A3 (en) 2001-11-28
AU2175597A (en) 1997-10-22

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Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20170331