HK1009968A1 - Novel sphingoglycolipid and use thereof - Google Patents
Novel sphingoglycolipid and use thereofInfo
- Publication number
- HK1009968A1 HK1009968A1 HK98110813A HK98110813A HK1009968A1 HK 1009968 A1 HK1009968 A1 HK 1009968A1 HK 98110813 A HK98110813 A HK 98110813A HK 98110813 A HK98110813 A HK 98110813A HK 1009968 A1 HK1009968 A1 HK 1009968A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- galactosyl
- represent
- aminohexosyl
- glucosyl
- shingoglycolipid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30812492 | 1992-10-22 | ||
PCT/JP1993/001523 WO1994009020A1 (fr) | 1992-10-22 | 1993-10-22 | Nouveau shingoglycolipide et son utilisation |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1009968A1 true HK1009968A1 (en) | 1999-09-17 |
Family
ID=17977176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98110813A HK1009968A1 (en) | 1992-10-22 | 1998-09-22 | Novel sphingoglycolipid and use thereof |
Country Status (10)
Country | Link |
---|---|
US (1) | US5849716A (fr) |
EP (1) | EP0666268B1 (fr) |
JP (1) | JP3717512B2 (fr) |
KR (1) | KR100281264B1 (fr) |
AT (1) | ATE191916T1 (fr) |
AU (1) | AU683026B2 (fr) |
CA (1) | CA2147629C (fr) |
DE (1) | DE69328435T2 (fr) |
HK (1) | HK1009968A1 (fr) |
WO (1) | WO1994009020A1 (fr) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2286482C (fr) * | 1997-04-10 | 2008-08-05 | Kirin Beer Kabushiki Kaisha | Activateurs de cellules nkt contenant des .alpha.-glycosylceramides |
WO1999041266A1 (fr) * | 1998-02-12 | 1999-08-19 | Emory University | Derives de sphingolipides et procedes d'utilisation |
JP4099267B2 (ja) * | 1998-08-07 | 2008-06-11 | 株式会社紀文フードケミファ | 乳化剤および乳化組成物 |
EP1349567A4 (fr) * | 2000-12-08 | 2005-10-12 | Childrens Memorial Hospital | Compositions contenant des gangliosides pour le traitement de pathologies de la peau |
WO2003009812A2 (fr) * | 2001-07-25 | 2003-02-06 | New York University | Utilisation de glycosylceramides comme adjuvants pour des vaccins contre les infections et le cancer |
EP1551228B1 (fr) * | 2002-06-13 | 2012-10-03 | New York University | C-glycolipide de synthese et utilisation de celui-ci pour le traitement du cancer, des maladies infectieuses et des maladies auto-immunes |
US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
HUE037560T2 (hu) * | 2003-02-14 | 2018-09-28 | Japan President Nat Ct Neurology & Psychiatry | Glikolipid-származékok, eljárás elõállításukra, szintézis-köztitermékeik, és eljárás a köztitermékek elõállítására |
US7645873B2 (en) | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
EP1647277A4 (fr) * | 2003-07-17 | 2011-09-21 | Otsuka Pharma Co Ltd | Liposome contenant du glycoside |
US7771726B2 (en) * | 2003-10-08 | 2010-08-10 | New York University | Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases |
CN1964626A (zh) * | 2004-03-31 | 2007-05-16 | 纽约大学 | 新型合成c-糖脂、其合成及其治疗传染病、癌症和自身免疫性疾病的用途 |
CA2577009C (fr) * | 2004-08-27 | 2017-05-02 | Steven A. Porcelli | Derives de ceramides utilises comme modulateur d'immunite et d'auto-immunite |
US8022043B2 (en) * | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
AU2005294150B2 (en) | 2004-10-07 | 2011-06-16 | Coimmune, Inc. | Mature dendritic cell compositions and methods for culturing same |
CA2591232C (fr) * | 2004-12-28 | 2014-10-21 | The Rockefeller University | Glycolipides et analogues associes utilises en tant qu'antigenes des lymphocytes nkt |
US7923013B2 (en) | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
JP5053101B2 (ja) | 2005-01-28 | 2012-10-17 | ブリガム ヤング ユニヴァーシティー | CD1d−拘束NKT細胞の細菌糖脂質による活性化 |
US20070231344A1 (en) * | 2005-10-28 | 2007-10-04 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
JP5392451B2 (ja) * | 2005-12-27 | 2014-01-22 | 国立大学法人 琉球大学 | 抗腫瘍剤及び免疫賦活剤 |
AU2007234753B2 (en) * | 2006-04-07 | 2013-02-21 | Brigham Young University | Modified -galactosyl ceramides for staining and stimulating Natural Killer T cells |
JP5564672B2 (ja) * | 2006-06-30 | 2014-07-30 | ザ スクリプス リサーチ インスティテュート | アジュバント及びその使用方法 |
US9603922B2 (en) | 2007-02-21 | 2017-03-28 | Vaccinex, Inc. | Modulation of NKT cell activity with antigen-loaded CD1d molecules |
US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
US8916164B2 (en) * | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
EP2058011A1 (fr) * | 2007-11-07 | 2009-05-13 | Wittycell | Cellule Nkt activant des antigènes et/ou médicaments à liaison gycolipids covalentyl |
EP2231145B1 (fr) * | 2007-12-05 | 2014-09-17 | Wittycell | Compositions et procédés pour améliorer la réponse immunitaire contre des antigènes |
JP5561700B2 (ja) * | 2008-03-25 | 2014-07-30 | 独立行政法人理化学研究所 | 新規糖脂質及びその用途 |
US8680020B2 (en) | 2008-07-15 | 2014-03-25 | Academia Sinica | Glycan arrays on PTFE-like aluminum coated glass slides and related methods |
EP2336144B1 (fr) | 2008-09-11 | 2015-01-21 | Riken | Alpha-galactosylcéramide estérifié |
WO2010040710A1 (fr) * | 2008-10-08 | 2010-04-15 | Wittycell | Composition vaccinale utilisable contre la grippe |
PT2385980T (pt) * | 2009-01-08 | 2018-06-26 | Albert Einstein College Medicine Inc | Vacinas bacterianas com glicolípidos do tipo ceramida associados à parede celular e utilização dos mesmos |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
WO2011130332A1 (fr) | 2010-04-12 | 2011-10-20 | Academia Sinica | Puces au glycane pour la recherche par criblage haut débit de virus |
WO2012074116A1 (fr) | 2010-12-02 | 2012-06-07 | 独立行政法人理化学研究所 | IMMUNOTHÉRAPIE À L'AIDE DE CELLULES ALLO-NKT, CELLULES POUR IMMUNOTHÉRAPIE DANS LESQUELLES α CHAÎNE DU GÈNE DE RÉCEPTEUR DES LYMPHOCYTES T (TCR) A ÉTÉ RÉARRANGÉE EN UN Vα-Jα UNIFORME ET CONSTITUTION D'UNE BANQUE DE CELLULES NKT ISSUES DESDITES CELLULES |
JP6057300B2 (ja) | 2011-01-05 | 2017-01-11 | ナショナル タイワン ユニバーシティ | グリコスフィンゴ脂質の調製及びその使用の方法 |
WO2012165394A1 (fr) * | 2011-05-27 | 2012-12-06 | 学校法人近畿大学 | Agent anti-tumoral |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
WO2014021464A1 (fr) * | 2012-08-03 | 2014-02-06 | 独立行政法人理化学研究所 | Analogue de krn7000 hydroxylé et son utilisation |
CA2880701A1 (fr) | 2012-08-18 | 2014-02-27 | Academia Sinica | Sondes permeables aux cellules pour l'identification et l'imagerie de sialidases |
EP2889039B1 (fr) | 2012-08-22 | 2017-11-08 | Regimmune Corporation | Préparation pour la prévention ou le traitement du diabète de type 1 |
JP6361004B2 (ja) | 2012-11-05 | 2018-07-25 | 株式会社レグイミューン | 免疫寛容誘導剤 |
US10151745B2 (en) | 2012-11-21 | 2018-12-11 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods for determining the risk of acute graft versus host disease |
US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
US10086054B2 (en) | 2013-06-26 | 2018-10-02 | Academia Sinica | RM2 antigens and use thereof |
US9981030B2 (en) | 2013-06-27 | 2018-05-29 | Academia Sinica | Glycan conjugates and use thereof |
KR102298172B1 (ko) | 2013-09-06 | 2021-09-06 | 아카데미아 시니카 | 변화된 글리코실 그룹을 갖는 당지질을 사용한 인간 iNKT 세포 활성화 |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
WO2015109180A2 (fr) | 2014-01-16 | 2015-07-23 | Academia Sinica | Compositions et méthodes pour traiter et détecter des cancers |
EP3129767B1 (fr) | 2014-03-27 | 2021-09-01 | Academia Sinica | Composés de marquage réactifs et leurs utilisations |
CA2950415A1 (fr) | 2014-05-27 | 2015-12-03 | Academia Sinica | Glycoanticorps anti-cd20 et leurs utilisations |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
WO2015184002A1 (fr) | 2014-05-27 | 2015-12-03 | Academia Sinica | Glycoanticorps anti-her2 et leurs utilisations |
CN107074945B (zh) | 2014-05-27 | 2021-08-24 | 中央研究院 | 增进抗体功效的通用糖型的组合物及方法 |
WO2015184001A1 (fr) | 2014-05-28 | 2015-12-03 | Academia Sinica | Glycoanticorps anti-thf-alpha et leurs utilisations |
WO2016040369A2 (fr) | 2014-09-08 | 2016-03-17 | Academia Sinica | Activation des cellules inkt humaines par des glycolipides |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
JP6779887B2 (ja) | 2015-01-24 | 2020-11-04 | アカデミア シニカAcademia Sinica | 新規なグリカンコンジュゲートおよびその使用方法 |
WO2017156192A1 (fr) | 2016-03-08 | 2017-09-14 | Academia Sinica | Procédés de synthèse modulaire de n-glycanes et de puces à n-glycanes |
JP7213549B2 (ja) | 2016-08-22 | 2023-01-27 | シーエイチオー ファーマ インコーポレイテッド | 抗体、結合性断片、および使用の方法 |
JPWO2022118913A1 (fr) | 2020-12-04 | 2022-06-09 |
Family Cites Families (26)
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US4598051A (en) * | 1980-03-12 | 1986-07-01 | The Regents Of The University Of California | Liposome conjugates and diagnostic methods therewith |
US4806466A (en) * | 1981-10-29 | 1989-02-21 | The Regents Of The University Of California | Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes |
IT1168205B (it) * | 1983-07-21 | 1987-05-20 | Wellcome Italia | Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione |
EP0146810A3 (fr) * | 1983-12-05 | 1987-05-13 | Solco Basel AG | Procédé de préparation de dérivés de la sphingosine |
JPS6157594A (ja) * | 1984-08-30 | 1986-03-24 | Suntory Ltd | ガラクトスフインゴ脂質及びその製造法 |
DK17885D0 (da) * | 1985-01-14 | 1985-01-14 | Karlsson Karl Anders | Antiviralt middel |
JPS6239597A (ja) * | 1985-08-13 | 1987-02-20 | ソルコ バ−ゼル アクチエンゲゼルシヤフト | スフインゴシン誘導体の製造方法 |
DE3683214D1 (de) * | 1985-08-13 | 1992-02-13 | Solco Basel Ag | Neues verfahren zur herstellung von sphingosinderivaten. |
JPH07116209B2 (ja) * | 1986-04-11 | 1995-12-13 | メクト株式会社 | シアロシルセラミド類及びその製造方法 |
US4990603A (en) * | 1986-07-04 | 1991-02-05 | Mect Corporation | Sialic acid derivatives and process therefor |
US4937232A (en) * | 1986-09-15 | 1990-06-26 | Duke University | Inhibition of protein kinase C by long-chain bases |
US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
JPS6495A (en) * | 1986-12-19 | 1989-01-05 | Tosoh Corp | Alpha-glycosyl ceramide derivative |
US5026557A (en) * | 1987-09-09 | 1991-06-25 | The Liposome Company, Inc. | Adjuvant composition |
JP2588729B2 (ja) * | 1987-10-05 | 1997-03-12 | 塩野義製薬株式会社 | スフィンゴシン誘導体 |
US5041441A (en) * | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
DE3840044A1 (de) * | 1988-11-27 | 1990-06-07 | Behringwerke Ag | Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung |
US5028715A (en) * | 1989-02-06 | 1991-07-02 | Southwest Research Institute | Radioprotective agents and their method of manufacture |
US5210073A (en) * | 1989-09-29 | 1993-05-11 | Ajinomoto Co., Inc. | Method for treating cancer therapy radiation damage or arteriosclerosis using human adf |
JP3068910B2 (ja) * | 1990-11-08 | 2000-07-24 | 麒麟麦酒株式会社 | 新規スフィンゴ糖脂質、その製造法および使用 |
JPH06145189A (ja) * | 1991-01-23 | 1994-05-24 | Kitasato Inst:The | スフィンゴ糖脂質 |
JPH0559081A (ja) * | 1991-08-29 | 1993-03-09 | Kirin Brewery Co Ltd | 新規スフインゴ糖脂質、その製造法および使用 |
TW261533B (fr) * | 1992-07-16 | 1995-11-01 | Kirin Brewery | |
JPH06239597A (ja) * | 1993-02-18 | 1994-08-30 | Hitachi Zosen Corp | 箱型ブロック用作業台装置 |
US5567684A (en) * | 1994-09-14 | 1996-10-22 | The Regents Of The University Of California | Synthetic ganglioside derivatives |
-
1993
- 1993-10-22 WO PCT/JP1993/001523 patent/WO1994009020A1/fr active IP Right Grant
- 1993-10-22 KR KR1019950701544A patent/KR100281264B1/ko not_active IP Right Cessation
- 1993-10-22 JP JP50984894A patent/JP3717512B2/ja not_active Expired - Fee Related
- 1993-10-22 US US08/416,917 patent/US5849716A/en not_active Expired - Fee Related
- 1993-10-22 EP EP93923043A patent/EP0666268B1/fr not_active Expired - Lifetime
- 1993-10-22 AT AT93923043T patent/ATE191916T1/de not_active IP Right Cessation
- 1993-10-22 DE DE69328435T patent/DE69328435T2/de not_active Expired - Fee Related
- 1993-10-22 CA CA002147629A patent/CA2147629C/fr not_active Expired - Fee Related
- 1993-10-22 AU AU52860/93A patent/AU683026B2/en not_active Ceased
-
1998
- 1998-09-22 HK HK98110813A patent/HK1009968A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO1994009020A1 (fr) | 1994-04-28 |
CA2147629A1 (fr) | 1994-04-28 |
KR100281264B1 (ko) | 2001-02-01 |
EP0666268A4 (fr) | 1995-06-27 |
EP0666268A1 (fr) | 1995-08-09 |
CA2147629C (fr) | 2005-03-22 |
DE69328435D1 (de) | 2000-05-25 |
EP0666268B1 (fr) | 2000-04-19 |
AU5286093A (en) | 1994-05-09 |
KR950704341A (ko) | 1995-11-20 |
JP3717512B2 (ja) | 2005-11-16 |
DE69328435T2 (de) | 2000-09-14 |
ATE191916T1 (de) | 2000-05-15 |
US5849716A (en) | 1998-12-15 |
AU683026B2 (en) | 1997-10-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20101022 |