KR100281264B1 - 신규한 스핀고당 지질 및 그의 사용 - Google Patents
신규한 스핀고당 지질 및 그의 사용 Download PDFInfo
- Publication number
- KR100281264B1 KR100281264B1 KR1019950701544A KR19950701544A KR100281264B1 KR 100281264 B1 KR100281264 B1 KR 100281264B1 KR 1019950701544 A KR1019950701544 A KR 1019950701544A KR 19950701544 A KR19950701544 A KR 19950701544A KR 100281264 B1 KR100281264 B1 KR 100281264B1
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- added
- synthesis
- reaction
- route
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP30812492 | 1992-10-22 | ||
JP308124/1992 | 1992-10-22 | ||
PCT/JP1993/001523 WO1994009020A1 (fr) | 1992-10-22 | 1993-10-22 | Nouveau shingoglycolipide et son utilisation |
Publications (2)
Publication Number | Publication Date |
---|---|
KR950704341A KR950704341A (ko) | 1995-11-20 |
KR100281264B1 true KR100281264B1 (ko) | 2001-02-01 |
Family
ID=17977176
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019950701544A KR100281264B1 (ko) | 1992-10-22 | 1993-10-22 | 신규한 스핀고당 지질 및 그의 사용 |
Country Status (10)
Country | Link |
---|---|
US (1) | US5849716A (fr) |
EP (1) | EP0666268B1 (fr) |
JP (1) | JP3717512B2 (fr) |
KR (1) | KR100281264B1 (fr) |
AT (1) | ATE191916T1 (fr) |
AU (1) | AU683026B2 (fr) |
CA (1) | CA2147629C (fr) |
DE (1) | DE69328435T2 (fr) |
HK (1) | HK1009968A1 (fr) |
WO (1) | WO1994009020A1 (fr) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998044928A1 (fr) * | 1997-04-10 | 1998-10-15 | Kirin Beer Kabushiki Kaisha | ACTIVATEURS DE CELLULES NKT, CONTENANT DES α-GLYCOSYLCERAMIDES |
EP1053243B1 (fr) * | 1998-02-12 | 2011-03-30 | Emory University | Derives de sphingolipides et procedes d'utilisation |
JP4099267B2 (ja) * | 1998-08-07 | 2008-06-11 | 株式会社紀文フードケミファ | 乳化剤および乳化組成物 |
EP1349567A4 (fr) * | 2000-12-08 | 2005-10-12 | Childrens Memorial Hospital | Compositions contenant des gangliosides pour le traitement de pathologies de la peau |
WO2003009812A2 (fr) * | 2001-07-25 | 2003-02-06 | New York University | Utilisation de glycosylceramides comme adjuvants pour des vaccins contre les infections et le cancer |
US7273852B2 (en) * | 2002-06-13 | 2007-09-25 | The Research Foundation Of The City University Of New York | Synthetic C-glycolipid and its use for treating cancer, infectious diseases and autoimmune diseases |
US9809654B2 (en) | 2002-09-27 | 2017-11-07 | Vaccinex, Inc. | Targeted CD1d molecules |
HUE037560T2 (hu) | 2003-02-14 | 2018-09-28 | Japan President Nat Ct Neurology & Psychiatry | Glikolipid-származékok, eljárás elõállításukra, szintézis-köztitermékeik, és eljárás a köztitermékek elõállítására |
US7645873B2 (en) * | 2003-03-20 | 2010-01-12 | The Scripps Research Institute | 6″-amino-6″-deoxygalactosylceramides |
CN1822844B (zh) * | 2003-07-17 | 2012-05-09 | 大塚制药株式会社 | 含配糖物的脂质体 |
US7771726B2 (en) * | 2003-10-08 | 2010-08-10 | New York University | Use of synthetic glycolipids as universal adjuvants for vaccines against cancer and infectious diseases |
CN1964626A (zh) * | 2004-03-31 | 2007-05-16 | 纽约大学 | 新型合成c-糖脂、其合成及其治疗传染病、癌症和自身免疫性疾病的用途 |
WO2006026389A2 (fr) * | 2004-08-27 | 2006-03-09 | Albert Einstein College Of Medicine Of Yeshiva University | Derives de ceramides utilises comme modulateur d'immunite et d'auto-immunite |
US8022043B2 (en) * | 2004-08-27 | 2011-09-20 | Albert Einstein College Of Medicine Of Yeshiva University | Ceramide derivatives as modulators of immunity and autoimmunity |
US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
US20080145931A1 (en) | 2004-10-07 | 2008-06-19 | Argos Therapeutics, Inc. | Mature Dendritic Cell Compositions and Methods of Culturing Same |
JP5090928B2 (ja) * | 2004-12-28 | 2012-12-05 | ザ ロックフェラー ユニバーシティ | Nkt細胞に対する抗原としての糖脂質及びその類似体 |
US7923013B2 (en) * | 2004-12-28 | 2011-04-12 | The Rockefeller University | Glycolipids and analogues thereof as antigens for NKT cells |
WO2006083671A2 (fr) | 2005-01-28 | 2006-08-10 | Brigham Young University | Activation de glycolipides bacteriens de cellules nkt appauvries en cd1d |
US20070231344A1 (en) * | 2005-10-28 | 2007-10-04 | The Brigham And Women's Hospital, Inc. | Conjugate vaccines for non-proteinaceous antigens |
US20100256346A1 (en) * | 2005-12-27 | 2010-10-07 | Hirosuke Oku | Anti-Tumor Agent and Immunostimulating Agent |
PT2056842E (pt) * | 2006-04-07 | 2013-01-24 | Univ Chicago | Galactosil-ceramidas modificadas para coloração e estimulação de células t assassinas naturais |
CA2655947C (fr) * | 2006-06-30 | 2016-08-02 | The Scripps Research Institute | Compositions comprenant des composes agonistes des cellules nkt et procedes d'utilisation |
CA2678618C (fr) | 2007-02-21 | 2019-03-12 | Vaccinex, Inc. | Modulation d'activite de cellule nkt avec des molecules cd1d chargees en antigene |
US7960139B2 (en) | 2007-03-23 | 2011-06-14 | Academia Sinica | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells |
US8916164B2 (en) * | 2007-08-29 | 2014-12-23 | Abivax | Methods of enhancing adjuvaticity of vaccine compositions |
EP2058011A1 (fr) * | 2007-11-07 | 2009-05-13 | Wittycell | Cellule Nkt activant des antigènes et/ou médicaments à liaison gycolipids covalentyl |
US8211861B2 (en) * | 2007-12-05 | 2012-07-03 | Wittycell | Compositions for and methods of enhancing the immune response to antigens |
JP5561700B2 (ja) * | 2008-03-25 | 2014-07-30 | 独立行政法人理化学研究所 | 新規糖脂質及びその用途 |
ES2442024T3 (es) | 2008-07-15 | 2014-02-07 | Academia Sinica | Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados |
EP2336144B1 (fr) * | 2008-09-11 | 2015-01-21 | Riken | Alpha-galactosylcéramide estérifié |
CA2739765A1 (fr) * | 2008-10-08 | 2010-04-15 | Vincent Serra | Composition vaccinale utilisable contre la grippe |
DK2385980T3 (en) * | 2009-01-08 | 2018-07-30 | Albert Einstein College Medicine Inc | BACTERIA VACCINES WITH CELL-WALL-ASSOCIATED CERAMIDE-LIKE GLYCOLIPIDS AND APPLICATIONS THEREOF |
US11377485B2 (en) | 2009-12-02 | 2022-07-05 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
US10087236B2 (en) | 2009-12-02 | 2018-10-02 | Academia Sinica | Methods for modifying human antibodies by glycan engineering |
WO2011130332A1 (fr) | 2010-04-12 | 2011-10-20 | Academia Sinica | Puces au glycane pour la recherche par criblage haut débit de virus |
JPWO2012074116A1 (ja) | 2010-12-02 | 2014-05-19 | 独立行政法人理化学研究所 | アロNKT細胞を用いた免疫療法およびそのためのT細胞抗原受容体(TCR)遺伝子のα鎖領域が均一なVα−Jαに再構成されている細胞および該細胞由来NKT細胞のバンキング |
CA2854725C (fr) | 2011-01-05 | 2019-10-22 | National Taiwan University | Procedes pour la preparation de glycosphingolipides et utilisations de ceux-ci |
EP2716293B1 (fr) * | 2011-05-27 | 2017-09-06 | Kinki University | Agent anti-tumoral |
US10130714B2 (en) | 2012-04-14 | 2018-11-20 | Academia Sinica | Enhanced anti-influenza agents conjugated with anti-inflammatory activity |
JP6233890B2 (ja) * | 2012-08-03 | 2017-11-22 | 国立研究開発法人理化学研究所 | 水酸化krn7000類縁体及びその用途 |
WO2014031498A1 (fr) | 2012-08-18 | 2014-02-27 | Academia Sinica | Sondes perméables aux cellules pour l'identification et l'imagerie de sialidases |
EP2889039B1 (fr) | 2012-08-22 | 2017-11-08 | Regimmune Corporation | Préparation pour la prévention ou le traitement du diabète de type 1 |
CN105120877A (zh) | 2012-11-05 | 2015-12-02 | 株式会社雷吉姆恩 | 免疫耐受诱导物 |
CA2892482C (fr) | 2012-11-21 | 2022-11-08 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Procedes pour determiner le risque d'une maladie aigue du greffon contre l'hote |
US9371352B2 (en) | 2013-02-08 | 2016-06-21 | Vaccinex, Inc. | Modified glycolipids and methods of making and using the same |
EP3013365B1 (fr) | 2013-06-26 | 2019-06-05 | Academia Sinica | Antigènes rm2 et leur utilisation |
WO2014210564A1 (fr) | 2013-06-27 | 2014-12-31 | Academia Sinica | Conjugués de glycane et leur utilisation |
JP6486368B2 (ja) * | 2013-09-06 | 2019-03-20 | アカデミア シニカAcademia Sinica | 改変されたグリコシル基を含む糖脂質を用いたヒトiNKT細胞の活性化 |
US10150818B2 (en) | 2014-01-16 | 2018-12-11 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
AU2015206370A1 (en) | 2014-01-16 | 2016-07-07 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
TWI797430B (zh) | 2014-03-27 | 2023-04-01 | 中央研究院 | 反應性標記化合物及其用途 |
TWI679020B (zh) | 2014-05-27 | 2019-12-11 | 中央研究院 | 抗her2醣抗體及其用途 |
US10118969B2 (en) | 2014-05-27 | 2018-11-06 | Academia Sinica | Compositions and methods relating to universal glycoforms for enhanced antibody efficacy |
CN107074945B (zh) | 2014-05-27 | 2021-08-24 | 中央研究院 | 增进抗体功效的通用糖型的组合物及方法 |
JP2017518989A (ja) | 2014-05-27 | 2017-07-13 | アカデミア シニカAcademia Sinica | 抗cd20糖操作抗体群およびその使用 |
TWI732738B (zh) | 2014-05-28 | 2021-07-11 | 中央研究院 | 抗TNF-α醣抗體及其用途 |
US9879042B2 (en) * | 2014-09-08 | 2018-01-30 | Academia Sinica | Human iNKT cell activation using glycolipids |
US9975965B2 (en) | 2015-01-16 | 2018-05-22 | Academia Sinica | Compositions and methods for treatment and detection of cancers |
US10495645B2 (en) | 2015-01-16 | 2019-12-03 | Academia Sinica | Cancer markers and methods of use thereof |
EP3789766A1 (fr) | 2015-01-24 | 2021-03-10 | Academia Sinica | Nouveaux conjugués de glycane et leurs procédés d'utilisation |
JP2019515876A (ja) | 2016-03-08 | 2019-06-13 | アカデミア シニカAcademia Sinica | N−グリカンおよびそのアレイのモジュール合成のための方法 |
CA3034057A1 (fr) | 2016-08-22 | 2018-03-01 | CHO Pharma Inc. | Anticorps, fragments de liaison, et procedes d'utilisation |
CN116528839A (zh) | 2020-12-04 | 2023-08-01 | 瑞格国际生技股份有限公司 | 药代动力学被改善的含CD1d配体化合物的脂质体制剂 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6495A (en) * | 1986-12-19 | 1989-01-05 | Tosoh Corp | Alpha-glycosyl ceramide derivative |
US4952683A (en) * | 1983-12-05 | 1990-08-28 | Solco Basel Ag | Process for the preparation of sphingosine derivatives |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4598051A (en) * | 1980-03-12 | 1986-07-01 | The Regents Of The University Of California | Liposome conjugates and diagnostic methods therewith |
US4806466A (en) * | 1981-10-29 | 1989-02-21 | The Regents Of The University Of California | Cell agglutination reagent comprising conjugates of antibody covalently bound to liposomes |
IT1168205B (it) * | 1983-07-21 | 1987-05-20 | Wellcome Italia | Derivato di monsialo ganglioside dotato di attivita' antibatterica, antifungina ed antitumorale, composizioni che lo contengono e procedimento per la loro preparazione |
JPS6157594A (ja) * | 1984-08-30 | 1986-03-24 | Suntory Ltd | ガラクトスフインゴ脂質及びその製造法 |
DK17885D0 (da) * | 1985-01-14 | 1985-01-14 | Karlsson Karl Anders | Antiviralt middel |
JPS6239597A (ja) * | 1985-08-13 | 1987-02-20 | ソルコ バ−ゼル アクチエンゲゼルシヤフト | スフインゴシン誘導体の製造方法 |
EP0212400B1 (fr) * | 1985-08-13 | 1992-01-02 | Solco Basel AG | Méthode de préparation de dérivés de la sphingosine |
JPH07116209B2 (ja) * | 1986-04-11 | 1995-12-13 | メクト株式会社 | シアロシルセラミド類及びその製造方法 |
US4990603A (en) * | 1986-07-04 | 1991-02-05 | Mect Corporation | Sialic acid derivatives and process therefor |
US4937232A (en) * | 1986-09-15 | 1990-06-26 | Duke University | Inhibition of protein kinase C by long-chain bases |
US4816450A (en) * | 1986-09-15 | 1989-03-28 | Duke University | Inhibition of protein kinase C by long-chain bases |
US5026557A (en) * | 1987-09-09 | 1991-06-25 | The Liposome Company, Inc. | Adjuvant composition |
JP2588729B2 (ja) * | 1987-10-05 | 1997-03-12 | 塩野義製薬株式会社 | スフィンゴシン誘導体 |
US5041441A (en) * | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
US5073543A (en) * | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
DE3840044A1 (de) * | 1988-11-27 | 1990-06-07 | Behringwerke Ag | Glykosphingolipide mit kopplungsfaehiger gruppe im sphingoidanteil, ihre herstellung und verwendung |
US5028715A (en) * | 1989-02-06 | 1991-07-02 | Southwest Research Institute | Radioprotective agents and their method of manufacture |
EP0425821B1 (fr) * | 1989-09-29 | 1994-08-10 | Ajinomoto Co., Inc. | L'utilisation d'ADF humain (=Adult T-cell leukemia-derived factor) pour la fabrication de médicaments |
JP3068910B2 (ja) * | 1990-11-08 | 2000-07-24 | 麒麟麦酒株式会社 | 新規スフィンゴ糖脂質、その製造法および使用 |
JPH06145189A (ja) * | 1991-01-23 | 1994-05-24 | Kitasato Inst:The | スフィンゴ糖脂質 |
JPH0559081A (ja) * | 1991-08-29 | 1993-03-09 | Kirin Brewery Co Ltd | 新規スフインゴ糖脂質、その製造法および使用 |
TW261533B (fr) * | 1992-07-16 | 1995-11-01 | Kirin Brewery | |
JPH06239597A (ja) * | 1993-02-18 | 1994-08-30 | Hitachi Zosen Corp | 箱型ブロック用作業台装置 |
US5567684A (en) * | 1994-09-14 | 1996-10-22 | The Regents Of The University Of California | Synthetic ganglioside derivatives |
-
1993
- 1993-10-22 US US08/416,917 patent/US5849716A/en not_active Expired - Fee Related
- 1993-10-22 EP EP93923043A patent/EP0666268B1/fr not_active Expired - Lifetime
- 1993-10-22 WO PCT/JP1993/001523 patent/WO1994009020A1/fr active IP Right Grant
- 1993-10-22 CA CA002147629A patent/CA2147629C/fr not_active Expired - Fee Related
- 1993-10-22 AU AU52860/93A patent/AU683026B2/en not_active Ceased
- 1993-10-22 DE DE69328435T patent/DE69328435T2/de not_active Expired - Fee Related
- 1993-10-22 AT AT93923043T patent/ATE191916T1/de not_active IP Right Cessation
- 1993-10-22 KR KR1019950701544A patent/KR100281264B1/ko not_active IP Right Cessation
- 1993-10-22 JP JP50984894A patent/JP3717512B2/ja not_active Expired - Fee Related
-
1998
- 1998-09-22 HK HK98110813A patent/HK1009968A1/xx not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4952683A (en) * | 1983-12-05 | 1990-08-28 | Solco Basel Ag | Process for the preparation of sphingosine derivatives |
JPS6495A (en) * | 1986-12-19 | 1989-01-05 | Tosoh Corp | Alpha-glycosyl ceramide derivative |
Also Published As
Publication number | Publication date |
---|---|
US5849716A (en) | 1998-12-15 |
HK1009968A1 (en) | 1999-09-17 |
DE69328435T2 (de) | 2000-09-14 |
AU5286093A (en) | 1994-05-09 |
EP0666268B1 (fr) | 2000-04-19 |
ATE191916T1 (de) | 2000-05-15 |
JP3717512B2 (ja) | 2005-11-16 |
AU683026B2 (en) | 1997-10-30 |
DE69328435D1 (de) | 2000-05-25 |
CA2147629C (fr) | 2005-03-22 |
CA2147629A1 (fr) | 1994-04-28 |
EP0666268A1 (fr) | 1995-08-09 |
KR950704341A (ko) | 1995-11-20 |
WO1994009020A1 (fr) | 1994-04-28 |
EP0666268A4 (fr) | 1995-06-27 |
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Payment date: 20081014 Year of fee payment: 9 |
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