HK1009833A1 - Identification of genes - Google Patents

Identification of genes

Info

Publication number
HK1009833A1
HK1009833A1 HK98110640A HK98110640A HK1009833A1 HK 1009833 A1 HK1009833 A1 HK 1009833A1 HK 98110640 A HK98110640 A HK 98110640A HK 98110640 A HK98110640 A HK 98110640A HK 1009833 A1 HK1009833 A1 HK 1009833A1
Authority
HK
Hong Kong
Prior art keywords
nucleic acid
microorganisms
mutant
marker sequence
environment
Prior art date
Application number
HK98110640A
Other languages
English (en)
Inventor
David William Holden
Jacqueline Elizabeth Shea
Michael Hensel
Original Assignee
Imp College Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9424921.6A external-priority patent/GB9424921D0/en
Priority claimed from GBGB9501881.8A external-priority patent/GB9501881D0/en
Priority claimed from GBGB9509239.1A external-priority patent/GB9509239D0/en
Application filed by Imp College Innovations Ltd filed Critical Imp College Innovations Ltd
Publication of HK1009833A1 publication Critical patent/HK1009833A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/255Salmonella (G)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3156Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci from Streptococcus pneumoniae (Pneumococcus)
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/38Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from Aspergillus
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/102Mutagenizing nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1065Preparation or screening of tagged libraries, e.g. tagged microorganisms by STM-mutagenesis, tagged polynucleotides, gene tags
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1082Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1086Preparation or screening of expression libraries, e.g. reporter assays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42Salmonella
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
HK98110640A 1994-12-09 1998-09-15 Identification of genes HK1009833A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9424921.6A GB9424921D0 (en) 1994-12-09 1994-12-09 Identification of genes
GBGB9501881.8A GB9501881D0 (en) 1995-01-31 1995-01-31 Identification of genes
GBGB9509239.1A GB9509239D0 (en) 1995-05-05 1995-05-05 Identification of genes
PCT/GB1995/002875 WO1996017951A2 (en) 1994-12-09 1995-12-11 Identification of genes responsible for in vivo survival of microorganisms

Publications (1)

Publication Number Publication Date
HK1009833A1 true HK1009833A1 (en) 1999-06-11

Family

ID=27267507

Family Applications (2)

Application Number Title Priority Date Filing Date
HK98110640A HK1009833A1 (en) 1994-12-09 1998-09-15 Identification of genes
HK07108847.1A HK1100782A1 (en) 1994-12-09 2004-08-09 Identification of genes

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK07108847.1A HK1100782A1 (en) 1994-12-09 2004-08-09 Identification of genes

Country Status (21)

Country Link
US (7) US5876931A (de)
EP (3) EP0796341B1 (de)
JP (3) JP3522285B2 (de)
KR (4) KR20050052665A (de)
CN (3) CN1510137A (de)
AT (2) ATE215986T1 (de)
AU (1) AU711524C (de)
CA (2) CA2206515C (de)
CZ (1) CZ296981B6 (de)
DE (3) DE889120T1 (de)
DK (2) DK0796341T3 (de)
ES (2) ES2178101T3 (de)
FI (1) FI121601B (de)
HK (2) HK1009833A1 (de)
HU (1) HUT76975A (de)
NO (2) NO320492B1 (de)
NZ (3) NZ296581A (de)
PT (1) PT889120E (de)
RU (1) RU2370541C2 (de)
SG (4) SG56084A1 (de)
WO (1) WO1996017951A2 (de)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2178101T3 (es) 1994-12-09 2002-12-16 Imp College Innovations Ltd Genes de virulencia en la region vgc2 de salmonella.
CA2258547A1 (en) * 1996-06-17 1997-12-24 Microcide Pharmaceuticals, Inc. Screening methods using microbial strain pools
US6455323B1 (en) 1997-07-03 2002-09-24 Pharmacia & Upjohn Company Anti-bacterial methods and materials
NO974299D0 (no) * 1997-09-18 1997-09-18 Forskningsparken I Aas As Metode for stabil merking av mikroorganismer
EP0943681A1 (de) * 1998-01-22 1999-09-22 Vrije Universiteit Brussel Lebender attenuierter Salmonella Impfstoff
WO1999037759A2 (en) * 1998-01-22 1999-07-29 Vrije Universiteit Brussel Live attenuated salmonella vaccine
AU3243199A (en) * 1998-03-05 1999-09-20 University Of British Columbia, The Methods for assaying type iii secretion inhibitors
JP2002506635A (ja) * 1998-03-18 2002-03-05 クアーク バイオテク インコーポレイテッド 遺伝子の同定に対する選択サブトラクションアプローチ
WO1999059630A1 (en) * 1998-05-15 1999-11-25 University Of California Los Angeles Type iii bordetella secretion system
EP1970449B1 (de) * 1998-09-04 2010-11-03 Emergent Product Development UK Limited Abgeschwächte Salmonella SP12 Mutante als Antigen-Träger.
WO2000018964A1 (en) * 1998-09-30 2000-04-06 Boston Medical Center Corporation Identification of virulence determinant activators in prokaryotic pathogens
US6720139B1 (en) 1999-01-27 2004-04-13 Elitra Pharmaceuticals, Inc. Genes identified as required for proliferation in Escherichia coli
US6299850B1 (en) 1999-03-16 2001-10-09 The United States Of America As Represented By The Department Of Energy Carbon activation process for increased surface accessibility in electrochemical capacitors
WO2000061724A2 (en) * 1999-04-09 2000-10-19 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
US6790950B2 (en) * 1999-04-09 2004-09-14 Pharmacia & Upjohn Company Anti-bacterial vaccine compositions
GB9910812D0 (en) * 1999-05-10 1999-07-07 Microscience Ltd Vaccine composition
WO2001002555A1 (en) * 1999-07-06 2001-01-11 Institut Pasteur Method of making and identifying attenuated microorganisms, compositions utilizing the sequences responsible for attenuation, and preparations containing attenuated microorganisms
WO2001034810A2 (en) * 1999-11-09 2001-05-17 Elitra Pharmaceuticals, Inc. Genes essential for microbial proliferation
EP1252180A2 (de) * 2000-02-03 2002-10-30 Microscience Limited Virulenz-gene, proteine und ihre verwendung
US6783985B1 (en) 2000-02-18 2004-08-31 Elitra Pharmaceuticals Inc. Gene disruption methodologies for drug target discovery
ATE300949T1 (de) 2000-03-17 2005-08-15 Pharmacia & Upjohn Co Llc Ssa inaktivierte salmonella impfstoffe
GB0008748D0 (en) * 2000-04-11 2000-05-31 Univ Manchester Mutant bank
GB0011108D0 (en) * 2000-05-08 2000-06-28 Microscience Ltd Virulence gene and protein and their use
US20020076722A1 (en) * 2000-09-13 2002-06-20 Neyfakh Alexander A. Antibiotic hypersusceptibility mutations in bacteria
US20020094536A1 (en) * 2000-12-28 2002-07-18 Cell Therapeutics, Inc. Methods for making polynucleotide libraries, polynucleotide arrays, and cell libraries for high-throughput genomics analysis
US20030180953A1 (en) * 2000-12-29 2003-09-25 Elitra Pharmaceuticals, Inc. Gene disruption methodologies for drug target discovery
US20030119013A1 (en) * 2001-04-23 2003-06-26 Bo Jiang Identification of essential genes of Aspergillus fumigatus and methods of use
ATE345386T1 (de) * 2001-05-17 2006-12-15 Creatogen Ag Methode zum auffinden von abgeschwächten oder virulent-defekten mikroben
CA2450658A1 (en) * 2001-06-15 2002-12-27 Chiron Corporation Essential and important genes of pseudomonas aeruginosa and the use thereof to design or identify antibacterial agents
WO2003089572A2 (en) * 2002-04-15 2003-10-30 Chiron Corporation Essential and important genes of pseudomonas aeroginosa and the use thereof to design or identify antibacterial agents
AU2002317940B9 (en) 2001-06-22 2008-06-05 The Secretary Of State For Health Mycobacterial antigens expressed under low oxygen tension
EP2196473A1 (de) 2001-07-04 2010-06-16 Health Protection Agency Während der Latenz exprimierten Antigene aus Mycobacterium
WO2003008631A2 (en) * 2001-07-20 2003-01-30 Health Protection Agency Tagging of microorganisms
US7026123B1 (en) 2001-08-29 2006-04-11 Pioneer Hi-Bred International, Inc. UTR tag assay for gene function discovery
GB0125535D0 (en) 2001-10-24 2001-12-12 Microbiological Res Authority Mycobacterial genes down-regulated during latency
US20040029129A1 (en) * 2001-10-25 2004-02-12 Liangsu Wang Identification of essential genes in microorganisms
CA2466843A1 (en) * 2001-11-12 2003-05-22 Pharmacia & Upjohn Company Salmonella vaccine
US20030170694A1 (en) * 2001-12-21 2003-09-11 Daniel Wall Stabilized nucleic acids in gene and drug discovery and methods of use
US7449178B2 (en) 2002-04-05 2008-11-11 Merial Limited Attenuated gram negative bacteria
EP1350796B1 (de) * 2002-04-05 2009-01-07 Merial Attenuirte Gram-negative Bakterien
EP1534325A4 (de) * 2002-08-20 2007-10-17 Novartis Vaccines & Diagnostic Willkürliche transposon-insertion in staphylococcus aureus und verwendung zur identifizierung von lebenswichtigen genen
FI116068B (fi) * 2003-09-15 2005-09-15 Fit Biotech Oyj Plc Uusi selektiojärjestelmä, siinä käyttökelpoinen vektori, bakteerisolukantoja sekä menetelmä solujen valikoimiseksi
AU2004291637A1 (en) * 2003-11-21 2005-06-02 Merck Patent Gmbh Method for modifying chiral liquid crystal films with the aid of extracting agents
US20050266447A1 (en) * 2004-04-19 2005-12-01 Pioneer Hi-Bred International, Inc. Method for identifying activators of gene transcription
MXPA06013502A (es) 2004-05-21 2007-03-01 Univ California Metodo para mejorar la produccion de compuestos isoprenoides.
EP1919514B1 (de) 2005-07-05 2012-05-16 The Regents of the University of California Isoprenoid-modifizierende enzyme codierende polynucleotide und anwendungsverfahren dafür
EP1752532A1 (de) * 2005-08-09 2007-02-14 Helmholtz-Zentrum für Infektionsforschung GmbH Extrazelluläre Polyhydroxyalkanoate hergestellt aus gentechnisch veränderten Mikroorganismen
DK2024504T4 (da) 2006-05-26 2023-02-27 Amyris Inc Fremstilling af isoprenoider
US20080124355A1 (en) 2006-09-22 2008-05-29 David Gordon Bermudes Live bacterial vaccines for viral infection prophylaxis or treatment
EP3020799B1 (de) 2006-09-26 2020-08-26 The Regents of The University of California Herstellung von isoprenoiden und isoprenoidvorläufern
WO2008153772A2 (en) * 2007-05-25 2008-12-18 Emergent Product Development Gaithersburg Inc. Chlamydia vaccine comprising htra polypeptides
WO2009158240A1 (en) 2008-06-16 2009-12-30 Emergent Product Development Uk Limited Salmonella vectored vaccines against chlamydia and methods of use
US8383345B2 (en) 2008-09-12 2013-02-26 University Of Washington Sequence tag directed subassembly of short sequencing reads into long sequencing reads
US9051665B2 (en) * 2008-11-20 2015-06-09 Steven L. Zeichner Method for screening biomolecules
US10369772B2 (en) 2012-07-10 2019-08-06 Textron Innovations Inc. Method of making core-stiffened structure
US8986965B2 (en) 2010-03-31 2015-03-24 Codexis, Inc. Production of monoterpenes
MX2012013037A (es) 2010-05-10 2013-07-29 Univ California Composiciones de endorribonucleasa y metodos de uso de las mismas.
US9074251B2 (en) 2011-02-10 2015-07-07 Illumina, Inc. Linking sequence reads using paired code tags
US8829171B2 (en) 2011-02-10 2014-09-09 Illumina, Inc. Linking sequence reads using paired code tags
EP2670894B1 (de) 2011-02-02 2017-11-29 University Of Washington Through Its Center For Commercialization Massiv parallele nachbarschaftsabbildung
US8481052B2 (en) 2011-05-17 2013-07-09 Cj Cheiljedang Corporation Avirulent Salmonella gallinarum variants and pharmaceutical composition using the same
JP6406581B2 (ja) 2011-12-16 2018-10-17 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー オプシンポリペプチドおよびその使用法
CN104582717B (zh) 2012-07-19 2018-03-13 雷德伍德生物科技股份有限公司 对cd22有特异性的抗体及其使用方法
KR102076384B1 (ko) 2012-08-16 2020-02-11 아이피어리언 인코포레이티드 타우병증을 치료하는 방법
EP2912065A4 (de) 2012-10-25 2016-10-19 True North Therapeutics Inc Anti-komplement-c1s-antikörper und verwendungen davon
PT2914291T (pt) 2012-11-02 2022-05-05 Bioverativ Usa Inc Anticorpos anti-complemento c1s e suas utilizações
US9683230B2 (en) 2013-01-09 2017-06-20 Illumina Cambridge Limited Sample preparation on a solid support
CN105142677B (zh) 2013-02-15 2019-08-30 加利福尼亚大学董事会 嵌合抗原受体及其使用方法
DK2970951T3 (da) 2013-03-13 2019-05-13 Illumina Inc Fremgangsmåder til nukleinsyresekventering
US20160060660A1 (en) 2013-04-05 2016-03-03 Université Du Luxembourg Biotechnological production of itaconic acid
EP3007726B1 (de) 2013-06-10 2020-04-08 Ipierian, Inc. Verfahren zur behandlung von tauopathien
JP6366719B2 (ja) 2013-12-20 2018-08-01 イルミナ インコーポレイテッド 断片化したゲノムdna試料におけるゲノム連結性情報の保存
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US11873480B2 (en) 2014-10-17 2024-01-16 Illumina Cambridge Limited Contiguity preserving transposition
HRP20230093T1 (hr) 2015-04-06 2023-03-31 Bioverativ Usa Inc. Humanizirana anti-c1s protutijela i postupci njihove primjene
PT3344654T (pt) 2015-09-02 2021-01-26 Immutep Sas Anticorpos anti-lag-3
WO2020047527A2 (en) 2018-09-02 2020-03-05 F1 Bioventures, Llc Methods and compositions for genetically modifying lymphocytes in blood or in enriched pbmcs
US11111505B2 (en) 2016-03-19 2021-09-07 Exuma Biotech, Corp. Methods and compositions for transducing lymphocytes and regulating the activity thereof
JP7108551B2 (ja) 2016-03-19 2022-07-28 エクスマ バイオテック コーポレイション リンパ球に形質導入を行うための方法及び組成物、並びにその制御された増加
US11325948B2 (en) 2016-03-19 2022-05-10 Exuma Biotech Corp. Methods and compositions for genetically modifying lymphocytes to express polypeptides comprising the intracellular domain of MPL
MX2018012176A (es) 2016-04-04 2019-02-07 Bioverativ Usa Inc Anticuerpos anti-factor bb del complemento y usos de estos.
EP3472318B1 (de) 2016-07-08 2023-09-06 Exuma Biotech Corp. Verfahren und zusammensetzungen zur transduktion von lymphozyten und regulierung der aktivität davon
JP2019521706A (ja) * 2016-07-13 2019-08-08 ユーバイオーム, インコーポレイテッド 微生物ゲノム薬理学のための方法およびシステム
IL308156A (en) 2016-10-12 2023-12-01 Bioverativ Usa Inc Anti-C1S antibodies and methods of using them
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US20190367621A1 (en) 2017-01-18 2019-12-05 F1 Oncology, Inc. Chimeric antigen receptors against axl or ror2 and methods of use thereof
BR112019018288A2 (pt) 2017-03-03 2020-03-31 F1 Oncology, Inc. Métodos e composições para transduzir e expandir linfócitos e regular a atividade dos mesmos
ES2898272T3 (es) 2017-04-27 2022-03-04 Univ California Microorganismos y métodos para producir cannabinoides y derivados de cannabinoides
EP3694874A1 (de) 2017-10-11 2020-08-19 Bioverativ USA Inc. Verfahren zur induktion von komplementaktivität
US11541105B2 (en) 2018-06-01 2023-01-03 The Research Foundation For The State University Of New York Compositions and methods for disrupting biofilm formation and maintenance
US11471497B1 (en) 2019-03-13 2022-10-18 David Gordon Bermudes Copper chelation therapeutics
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
WO2022187289A1 (en) 2021-03-01 2022-09-09 Exuma Biotech Corp. Methods and compositions for the delivery of retroviral particles
WO2023168305A1 (en) 2022-03-01 2023-09-07 Exuma Biotech Corp. Viral particles with membrane-bound hyaluronidase

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4440859A (en) * 1977-05-27 1984-04-03 The Regents Of The University Of California Method for producing recombinant bacterial plasmids containing the coding sequences of higher organisms
US4704362A (en) * 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
YU44186B (en) * 1978-12-22 1990-04-30 Biogen Nv Process for obtaining recombinant dnk molecules
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
US4837151A (en) * 1980-05-19 1989-06-06 The Board Of Trustees Of The Leland Stanford Junior University, Stanford University Live vaccines comprising two mutations and foreign antigen
US4550081A (en) * 1980-05-19 1985-10-29 The Board Of Trustees Of The Leland Stanford Jr. University Non-reverting salmonella
US5210035A (en) * 1980-05-19 1993-05-11 Board Of Trustees Of Leland Stanford Jr. University Non-reventing live vaccines
US4766075A (en) * 1982-07-14 1988-08-23 Genentech, Inc. Human tissue plasminogen activator
US4582800A (en) * 1982-07-12 1986-04-15 Hoffmann-La Roche Inc. Novel vectors and method for controlling interferon expression
US4757006A (en) * 1983-10-28 1988-07-12 Genetics Institute, Inc. Human factor VIII:C gene and recombinant methods for production
US4677063A (en) * 1985-05-02 1987-06-30 Cetus Corporation Human tumor necrosis factor
US5643579A (en) * 1984-11-01 1997-07-01 American Home Products Corporation Oral vaccines
US4810648A (en) * 1986-01-08 1989-03-07 Rhone Poulenc Agrochimie Haloarylnitrile degrading gene, its use, and cells containing the gene
US5397697A (en) * 1989-01-10 1995-03-14 Ciba-Geigy Corporation Identification of plant-responsive genes of bacteria
FR2664614B1 (fr) * 1990-07-11 1992-10-16 Pasteur Institut Sequences nucleiques issues du genome de salmonella typhi, et leurs utilisations notamment pour le diagnostic in vitro de la presence de bacteries du genre salmonella dans les produits alimentaires.
SE9101433D0 (sv) 1991-05-13 1991-05-13 Marianne Hansson Recombinant dna sequence and its use
AU2509592A (en) * 1991-08-22 1993-03-16 Washington University Polynucleotide probes for salmonella
AU2778992A (en) * 1991-10-07 1993-05-03 Idaho Research Foundation Inc., The Genetic construct for selection of homologous recombinants on a single selective medium
US5356797A (en) * 1991-11-15 1994-10-18 Board Of Regents, The University Of Texas Membrane expression of heterologous genes
EP0613500A1 (de) 1991-11-15 1994-09-07 The Board Of Regents, The University Of Texas System Membran-spezifische heterologe Genexpression
CA2148829A1 (en) 1992-11-06 1994-05-26 Keum Hwa Choi Avirulent live vaccine and method for immunizing animals against p. multocida pasteurellosis
WO1994026933A1 (en) * 1993-05-13 1994-11-24 The Board Of Trustees Of The Leland Stanford Junior University Genetic footprinting: insertional mutagenesis and genetic selection
US5700638A (en) 1993-08-26 1997-12-23 Washington University Cell death regulator
DE4405652A1 (de) * 1994-02-22 1995-09-07 Hoechst Ag Verfahren zur Herstellung von nichtoxidischer Keramik mit definierter Wärmeleitfähigkeit
WO1996011708A1 (en) 1994-10-18 1996-04-25 Board Of Regents, The University Of Texas System Membrane expression of heterologous genes
ES2178101T3 (es) * 1994-12-09 2002-12-16 Imp College Innovations Ltd Genes de virulencia en la region vgc2 de salmonella.
US5700683A (en) * 1995-02-17 1997-12-23 Pathogenesis Corporation Virulence-attenuating genetic deletions deleted from mycobacterium BCG
WO1997014800A1 (en) * 1995-10-16 1997-04-24 Smithkline Beecham Plc Novel saliva binding protein
EP0939761A4 (de) 1995-11-14 2002-07-31 Gen Hospital Corp Salmonella sekretierte proteine und verwendung davon
US6030624A (en) 1996-08-16 2000-02-29 Uab Research Foundation Mucosal immunogens for novel vaccines
GB9621091D0 (en) * 1996-10-09 1996-11-27 Fondation Pour Le Perfectionem Attenuated microorganisms strains and their uses
AU722326B2 (en) 1997-02-14 2000-07-27 Merck & Co., Inc. Polynucleotide vaccine formulations
US6455323B1 (en) 1997-07-03 2002-09-24 Pharmacia & Upjohn Company Anti-bacterial methods and materials
GB9804809D0 (en) 1998-03-06 1998-04-29 Wallis Timothy S Attenuated salmonella:materials and methods relating thereto
US6585975B1 (en) * 1998-04-30 2003-07-01 Acambis, Inc. Use of Salmonella vectors for vaccination against helicobacter infection
EP1970449B1 (de) * 1998-09-04 2010-11-03 Emergent Product Development UK Limited Abgeschwächte Salmonella SP12 Mutante als Antigen-Träger.
EP1129196B1 (de) * 1998-11-09 2008-01-09 Microscience Limited Virulenzgene und deren proteine und verwendungen
GB9910812D0 (en) * 1999-05-10 1999-07-07 Microscience Ltd Vaccine composition
WO2001032697A2 (en) 1999-11-05 2001-05-10 L'unite De Recherche En Biologie Moleculaire (Urbm) Des Facultes Universitaires Notre Dame De La Paix (Fundp) Virulence genes and proteins from brucella melitensis, and their use
EP1905834A3 (de) * 1999-12-23 2008-07-23 Vmax Limited Virulenzgene, Proteine und deren Verwendung
GB0011108D0 (en) 2000-05-08 2000-06-28 Microscience Ltd Virulence gene and protein and their use
US6548368B1 (en) * 2000-08-23 2003-04-15 Applied Materials, Inc. Method of forming a MIS capacitor
GB0127657D0 (en) 2001-11-19 2002-01-09 Microscience Ltd Virulence genes and proteins and their use
US7449178B2 (en) * 2002-04-05 2008-11-11 Merial Limited Attenuated gram negative bacteria

Also Published As

Publication number Publication date
CZ296981B6 (cs) 2006-08-16
HUT76975A (hu) 1998-01-28
EP1285960A3 (de) 2003-05-07
JP2003144180A (ja) 2003-05-20
US5876931A (en) 1999-03-02
AU4121996A (en) 1996-06-26
DE69505011T2 (de) 1999-05-06
US7842290B2 (en) 2010-11-30
WO1996017951A2 (en) 1996-06-13
SG173213A1 (en) 2011-08-29
KR20050052665A (ko) 2005-06-03
EP0796341A2 (de) 1997-09-24
EP0889120A1 (de) 1999-01-07
JPH10509872A (ja) 1998-09-29
CA2623339A1 (en) 1996-06-13
NZ502020A (en) 2001-06-29
SG165157A1 (en) 2010-10-28
ES2126332T3 (es) 1999-03-16
DE69526377D1 (de) 2002-05-16
CN1510137A (zh) 2004-07-07
RU2370541C2 (ru) 2009-10-20
ATE215986T1 (de) 2002-04-15
EP0889120B1 (de) 2002-04-10
KR20060099543A (ko) 2006-09-19
US20080175866A1 (en) 2008-07-24
JP4220195B2 (ja) 2009-02-04
ATE171477T1 (de) 1998-10-15
CA2206515A1 (en) 1996-06-13
RU2003135645A (ru) 2005-05-27
NO327361B1 (no) 2009-06-15
DE889120T1 (de) 2001-01-11
DK0889120T3 (da) 2002-07-22
AU711524C (en) 2004-03-18
NO320492B1 (no) 2005-12-12
WO1996017951A3 (en) 1996-10-17
KR100445103B1 (ko) 2004-12-04
DE69505011D1 (de) 1998-10-29
NO972468D0 (no) 1997-05-30
SG56084A1 (en) 2003-03-18
DK0796341T3 (da) 1999-06-14
FI121601B (fi) 2011-01-31
US6984490B1 (en) 2006-01-10
FI972424A0 (fi) 1997-06-06
HK1100782A1 (en) 2007-09-28
ES2178101T3 (es) 2002-12-16
US20110229515A1 (en) 2011-09-22
KR100551104B1 (ko) 2006-02-09
NZ511170A (en) 2005-02-25
NO972468L (no) 1997-08-08
CN1912141A (zh) 2007-02-14
JP3522285B2 (ja) 2004-04-26
NZ296581A (en) 2000-02-28
CN1176662A (zh) 1998-03-18
CA2623339C (en) 2012-05-08
SG119177A1 (en) 2006-02-28
EP1285960A2 (de) 2003-02-26
US20060216309A1 (en) 2006-09-28
US6015669A (en) 2000-01-18
CN1912141B (zh) 2010-10-27
CN1160469C (zh) 2004-08-04
KR20040023806A (ko) 2004-03-19
FI972424A (fi) 1997-08-06
PT889120E (pt) 2002-09-30
CZ175597A3 (en) 1997-10-15
NO20042249L (no) 1997-08-08
US6342215B1 (en) 2002-01-29
CA2206515C (en) 2009-11-17
EP0796341B1 (de) 1998-09-23
AU711524B2 (en) 1999-10-14
JP2009005688A (ja) 2009-01-15
DE69526377T2 (de) 2002-11-07

Similar Documents

Publication Publication Date Title
HK1100782A1 (en) Identification of genes
Pattee Distribution of Tn551 insertion sites responsible for auxotrophy on the Staphylococcus aureus chromosome
Olsen et al. Development of broad-host-range vectors and gene banks: self-cloning of the Pseudomonas aeruginosa PAO chromosome
Barak et al. SpoIIE mutants of Bacillus subtilis comprise two distinct phenotypic classes consistent with a dual functional role for the SpoIIE protein
Timberlake et al. Genetic regulation of development in Aspergillus nidulans
ATE447039T1 (de) Coryneforme bakterien zur herstellung von l-glu
AU4431196A (en) Dna integration by transposition
RU2000122755A (ru) Новые кодирующие нуклеотидные последовательности гена thre и способ ферментативного получения l-треонина с использованием коринебактерий
ATE365806T1 (de) L-lysin produzierende coryneforme bakterien und verfahren zur herstellung von lysin
ATE44766T1 (de) Verfahren zur vergroesserung der expression eines bestimmten gens im bacillus subtilis und erhaltene staemme.
AU3868197A (en) Yeast vectors and process for producing proteins with the use of the same
CA2422752A1 (en) Map-based genome mining method for identifying regulatory loci controlling the level of gene transcripts and products
EP0091723A2 (de) Vektor system
Holden Identification of genes
Zamenhof Nucleic acid and mutability
Saville et al. The molecular biology of pathogenesis in Ustilago maydis
WO2002027025A3 (en) Application of bioinformatics for direct study of unculturable microorganisms
CN1590546B (zh) 含生物素生物合成基因的dna片段及其利用
Kellner et al. Sex and parasitism in mucoraceous fungi (Transfer of genetic information between Parasitella simplex and its host Absidia glauca)
CA2100791A1 (en) Method of Directing Biosynthesis of Specific Polyketides
Amjad A study of the structure of the Bacillus subtilis 168 chromosome
Bainbridge et al. Basic Principles of Microbial Genetics
Vicente et al. A standardized format for handling data on plasmids, viruses and transposons: the PVT database format
AU2057688A (en) Alpha-amidating enzyme compositions and processes for their production and use

Legal Events

Date Code Title Description
CHRG Changes in the register

Free format text: ADDITION OF INVENTOR: JACQUELINE ELIZABETH SHEA; MICHAEL HENSEL

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20121211