HK1007500A1 - Liposomal formulations with a high antieoplastic agent/lipid ratio - Google Patents

Liposomal formulations with a high antieoplastic agent/lipid ratio

Info

Publication number
HK1007500A1
HK1007500A1 HK98106751A HK98106751A HK1007500A1 HK 1007500 A1 HK1007500 A1 HK 1007500A1 HK 98106751 A HK98106751 A HK 98106751A HK 98106751 A HK98106751 A HK 98106751A HK 1007500 A1 HK1007500 A1 HK 1007500A1
Authority
HK
Hong Kong
Prior art keywords
drug
liposomes
lipid ratio
antieoplastic
agent
Prior art date
Application number
HK98106751A
Other languages
English (en)
Inventor
Marcel B Bally
Richard S Ginsberg
George N Mitlenes
Pieter R Culis
Lawrence D Mayer
Original Assignee
Liposome Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21808094&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1007500(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Company filed Critical Liposome Company
Publication of HK1007500A1 publication Critical patent/HK1007500A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
HK98106751A 1987-03-05 1998-06-25 Liposomal formulations with a high antieoplastic agent/lipid ratio HK1007500A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2215487A 1987-03-05 1987-03-05

Publications (1)

Publication Number Publication Date
HK1007500A1 true HK1007500A1 (en) 1999-04-16

Family

ID=21808094

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98106751A HK1007500A1 (en) 1987-03-05 1998-06-25 Liposomal formulations with a high antieoplastic agent/lipid ratio

Country Status (17)

Country Link
EP (2) EP0719546B1 (xx)
JP (1) JP2882607B2 (xx)
KR (1) KR960013703B1 (xx)
AT (2) ATE231389T1 (xx)
AU (3) AU620545B2 (xx)
BR (1) BR1100687A (xx)
CA (1) CA1338702C (xx)
DE (3) DE10199004I1 (xx)
DK (1) DK174869B1 (xx)
ES (2) ES2088385T3 (xx)
GR (1) GR3020725T3 (xx)
HK (1) HK1007500A1 (xx)
IE (1) IE75713B1 (xx)
IL (1) IL85608A (xx)
LU (1) LU90717I2 (xx)
NL (1) NL300036I1 (xx)
WO (1) WO1988006442A1 (xx)

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CA1323306C (en) * 1987-03-05 1993-10-19 Mircea C. Popescu Pharmacological agent-lipid solution preparation
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
WO1990014105A1 (en) * 1989-05-15 1990-11-29 The Liposome Company, Inc. Accumulation of drugs into liposomes by a proton gradient
US5227170A (en) * 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
EP0412507A1 (de) * 1989-08-08 1991-02-13 Humboldt-Universität zu Berlin Verfahren zur Grössenfraktionierung hochmolekularer Stoffe mit Hilfe von Hohlträgern
JP3533215B2 (ja) * 1990-07-31 2004-05-31 ザ リポソーム カンパニー，インコーポレイテッド アミノ酸及びペプチドのリポソーム内への蓄積
EP0548210A1 (en) * 1990-09-10 1993-06-30 School Of Pharmacy, University Of London Liposomes
DE4038075C1 (en) * 1990-11-29 1992-03-19 B. Braun Melsungen Ag, 3508 Melsungen, De Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium
EP0661044A1 (en) * 1991-07-03 1995-07-05 NeXstar Pharmaceuticals, Inc. Drug-containing liposomes
EP0546951A1 (en) * 1991-12-13 1993-06-16 The Liposome Company, Inc. Combination of liposome encapsulated antineoplastic agents, such as doxorubicin with colony stimulating factors
US5543152A (en) * 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
DE4430592A1 (de) 1994-08-20 1996-02-22 Max Delbrueck Centrum Liposomale Zubereitung, ihre Herstellung und ihre Verwendung
US5858397A (en) * 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
NZ514133A (en) * 1996-10-15 2001-09-28 Liposome Co Inc N-acyl phosphatidylethanolamine-mediated liposomal drug delivery
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
DE69928805T2 (de) * 1998-06-18 2006-08-31 Hassan, Moustapha, Dr. Liposomale Formulierungen von Busulfan
US7351427B2 (en) 1998-06-18 2008-04-01 Busulipo Ab Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof
JP2003513030A (ja) * 1999-11-05 2003-04-08 シード・キャピタル・インヴェストメンツ−２・（エスシーアイ−２）・ベスローテン・フエンノートシャップ 低い水溶性および脂肪親和性を示す物質のカプセル化方法、およびこの方法により得られる製剤
EP1427393A2 (de) * 2000-05-02 2004-06-16 Pharmacept GmbH Wirkstoffhaltige liposome
AU2002312777B2 (en) * 2001-03-27 2007-07-05 Phares Pharmaceutical Research N.V. Method and composition for solubilising a biologically active compound with low water solubility
JP2005505602A (ja) * 2001-09-06 2005-02-24 イサム・リサーチ・デベロツプメント・カンパニー・オブ・ザ・ヘブルー・ユニバーシテイ・オブ・エルサレム 予め規定された放出プロファイルを有するリポソーム調剤の製造方法
US9186322B2 (en) 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
JP2006502233A (ja) * 2002-08-02 2006-01-19 トランセーブ，インク． 白金凝集物およびその製造方法
AU2003298738A1 (en) * 2002-11-26 2004-06-18 Su-Ming Chiang Liposomal formulations
ES2337563T3 (es) * 2002-12-31 2010-04-27 Zydus Bsv Pharma Private Limited Liposomas no pegilados de circulacion duradera.
WO2005072776A2 (en) * 2004-01-30 2005-08-11 Instytut Farmaceutyczny Liposomal formulations of the antineoplastic agents
EP1731172B1 (en) 2004-03-26 2013-06-05 Terumo Kabushiki Kaisha Liposome preparation
WO2006012502A2 (en) * 2004-07-23 2006-02-02 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
WO2006077857A1 (ja) * 2005-01-18 2006-07-27 National University Corporation Hokkaido University 粒子を脂質膜で被覆する方法
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
WO2007111720A2 (en) 2005-12-06 2007-10-04 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
WO2010034837A1 (en) * 2008-09-26 2010-04-01 Phares Pharmaceutical Research N.V. Method of solubilising biologically active compounds
CN101474155B (zh) * 2009-01-24 2011-03-16 重庆医科大学 注射用肺靶向载药前体脂质体及其使用方法
PL387296A1 (pl) * 2009-02-17 2010-08-30 Instytut Farmaceutyczny Sposób aktywnego zamykania amfifilowych substancji czynnych w strukturach liposomowych
WO2010143970A2 (en) * 2009-06-08 2010-12-16 Epitarget As Acoustically sensitive drug delivery particles comprising non-lamellar forming phosphatidylcholine
PL226015B1 (pl) 2011-03-03 2017-06-30 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
CN105025904A (zh) 2012-09-04 2015-11-04 埃莱森制药有限责任公司 用顺铂脂质复合物预防癌症的肺部复发
TR201908531T4 (tr) 2012-11-20 2019-08-21 Arbutus Biopharma Corp Terapöti̇k kullanim i̇çi̇n li̇pozom kapsüllü vi̇nkri̇sti̇ni̇n preparasyonuna yöneli̇k geli̇şti̇ri̇lmi̇ş yöntem
TWI678213B (zh) 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
IL268099B1 (en) 2017-01-18 2024-01-01 Temasek Life Sciences Laboratory Ltd Hyperstabilized liposomes that increase targeting of mitotic cells
GR20180100082A (el) * 2018-02-28 2019-09-25 ΝΙΚΟΛΑΟΣ Α. ΦΙΚΙΩΡΗΣ ΚΑΙ ΣΙΑ ΕΤΑΙΡΕΙΑ ΠΕΡΙΟΡΙΣΜΕΝΗΣ ΕΥΘΗΝΗΣ με δ.τ. IN TOUCH HEALTH Ε.Π.Ε Μεθοδος για την παραγωγη οχηματων μεταφορας λιπιδιων
WO2021076630A1 (en) * 2019-10-14 2021-04-22 The Regents Of The University Of California Nano-enabled immunotherapy in cancer
CN112023059B (zh) * 2020-06-03 2023-03-24 太原师范学院 一种pH响应型阿霉素无载体纳米药物及其制备方法和应用

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DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4551288A (en) * 1982-08-16 1985-11-05 Sandoz, Inc. Processes for the preparation of liposome drug delivery systems
GB8325496D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
CA1264668A (en) * 1984-06-20 1990-01-23 Pieter R. Cullis Extrusion techniques for producing liposomes
CA1270198C (en) * 1984-08-08 1990-06-12 Marcel B Bally ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES
US4622188A (en) * 1984-12-21 1986-11-11 E. I. Du Pont De Nemours And Company Method for manufacturing liposomes
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents

Also Published As

Publication number Publication date
AU8141891A (en) 1991-10-10
ES2088385T3 (es) 1996-08-16
JP2882607B2 (ja) 1999-04-12
IE960340L (en) 1988-09-05
DE3855265D1 (de) 1996-06-13
EP0719546B1 (en) 2003-01-22
EP0290296B1 (en) 1996-05-08
WO1988006442A1 (en) 1988-09-07
EP0290296A2 (en) 1988-11-09
AU620545B2 (en) 1992-02-20
ES2198429T3 (es) 2004-02-01
NL300036I1 (nl) 2001-03-01
JPH02502458A (ja) 1990-08-09
EP0719546A1 (en) 1996-07-03
IE880599L (en) 1988-09-05
ATE231389T1 (de) 2003-02-15
DE3856550T2 (de) 2003-12-11
DE10199004I1 (de) 2001-03-29
EP0290296A3 (en) 1989-06-28
AU645332B2 (en) 1994-01-13
AU635435B2 (en) 1993-03-18
LU90717I2 (fr) 2001-03-15
IE75713B1 (en) 1997-09-24
DK174869B1 (da) 2004-01-12
KR890700340A (ko) 1989-04-24
DE3855265T2 (de) 1996-12-12
DK98189D0 (da) 1989-03-01
AU1481688A (en) 1988-09-26
IL85608A (en) 1992-07-15
BR1100687A (pt) 2000-02-08
KR960013703B1 (ko) 1996-10-10
GR3020725T3 (en) 1996-11-30
DE3856550D1 (de) 2003-02-27
CA1338702C (en) 1996-11-12
IL85608A0 (en) 1988-08-31
DK98189A (da) 1989-03-01
AU8141791A (en) 1991-11-07
ATE137670T1 (de) 1996-05-15

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Effective date: 20080303