DK98189D0 - Formuleringer af liposomale antineoplastiske midler med hoeje medikament-lipid-forhold - Google Patents

Formuleringer af liposomale antineoplastiske midler med hoeje medikament-lipid-forhold

Info

Publication number
DK98189D0
DK98189D0 DK098189A DK98189A DK98189D0 DK 98189 D0 DK98189 D0 DK 98189D0 DK 098189 A DK098189 A DK 098189A DK 98189 A DK98189 A DK 98189A DK 98189 D0 DK98189 D0 DK 98189D0
Authority
DK
Denmark
Prior art keywords
drug
liposomes
antineoplastic agents
formulations
lipid
Prior art date
Application number
DK098189A
Other languages
English (en)
Other versions
DK98189A (da
DK174869B1 (da
Inventor
Lawrence Mayer
Marcel B Bally
Pieter R Cullis
Richard S Ginsberg
George N Mitilenes
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21808094&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK98189(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of DK98189D0 publication Critical patent/DK98189D0/da
Publication of DK98189A publication Critical patent/DK98189A/da
Application granted granted Critical
Publication of DK174869B1 publication Critical patent/DK174869B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
DK198900981A 1987-03-05 1989-03-01 Liposomale formuleringer med et høj antineoplastisk middel/lipid forhold DK174869B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2215487A 1987-03-05 1987-03-05
US2215487 1987-03-05
PCT/US1988/000646 WO1988006442A1 (en) 1987-03-05 1988-03-03 High drug:lipid formulations of liposomal-antineoplastic agents
US8800646 1988-03-03

Publications (3)

Publication Number Publication Date
DK98189D0 true DK98189D0 (da) 1989-03-01
DK98189A DK98189A (da) 1989-03-01
DK174869B1 DK174869B1 (da) 2004-01-12

Family

ID=21808094

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198900981A DK174869B1 (da) 1987-03-05 1989-03-01 Liposomale formuleringer med et høj antineoplastisk middel/lipid forhold

Country Status (17)

Country Link
EP (2) EP0290296B1 (da)
JP (1) JP2882607B2 (da)
KR (1) KR960013703B1 (da)
AT (2) ATE137670T1 (da)
AU (3) AU620545B2 (da)
BR (1) BR1100687A (da)
CA (1) CA1338702C (da)
DE (3) DE10199004I1 (da)
DK (1) DK174869B1 (da)
ES (2) ES2088385T3 (da)
GR (1) GR3020725T3 (da)
HK (1) HK1007500A1 (da)
IE (1) IE75713B1 (da)
IL (1) IL85608A (da)
LU (1) LU90717I2 (da)
NL (1) NL300036I1 (da)
WO (1) WO1988006442A1 (da)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
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CA1323306C (en) * 1987-03-05 1993-10-19 Mircea C. Popescu Pharmacological agent-lipid solution preparation
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
WO1990014105A1 (en) * 1989-05-15 1990-11-29 The Liposome Company, Inc. Accumulation of drugs into liposomes by a proton gradient
US5227170A (en) * 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
EP0412507A1 (de) * 1989-08-08 1991-02-13 Humboldt-Universität zu Berlin Verfahren zur Grössenfraktionierung hochmolekularer Stoffe mit Hilfe von Hohlträgern
JP3533215B2 (ja) * 1990-07-31 2004-05-31 ザ リポソーム カンパニー，インコーポレイテッド アミノ酸及びペプチドのリポソーム内への蓄積
EP0548210A1 (en) * 1990-09-10 1993-06-30 School Of Pharmacy, University Of London Liposomes
DE4038075C1 (en) * 1990-11-29 1992-03-19 B. Braun Melsungen Ag, 3508 Melsungen, De Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium
EP0661044A1 (en) * 1991-07-03 1995-07-05 NeXstar Pharmaceuticals, Inc. Drug-containing liposomes
EP0546951A1 (en) * 1991-12-13 1993-06-16 The Liposome Company, Inc. Combination of liposome encapsulated antineoplastic agents, such as doxorubicin with colony stimulating factors
US5543152A (en) * 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
DE4430592A1 (de) * 1994-08-20 1996-02-22 Max Delbrueck Centrum Liposomale Zubereitung, ihre Herstellung und ihre Verwendung
US5858397A (en) * 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
EP0966267B1 (en) * 1996-10-15 2009-02-25 Transave, Inc. N-acyl phosphatidylethanolamine-mediated liposomal drug delivery
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US7351427B2 (en) 1998-06-18 2008-04-01 Busulipo Ab Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof
WO1999065481A1 (en) * 1998-06-18 1999-12-23 Karolinska Innovations Ab Liposomal formulations of busulphan
CA2389147A1 (en) * 1999-11-05 2001-05-10 Seed Capital Investment-2 (Sci-2) B.V. Method for the formulation of substances having a low water-solubility and lipophilicity and formulation thus obtained
WO2001082892A2 (de) * 2000-05-02 2001-11-08 Pharmacept Gmbh Wirkstoffhaltige liposome
PT1389089E (pt) * 2001-03-27 2009-11-30 Phares Pharm Res Nv Processo e composição para solubilizar um composto biologicamente activo com uma baixa solubilidade em água
US20060165766A1 (en) * 2001-09-06 2006-07-27 Yechezkel Barenholz Method for preparing liposome formulations with a predefined release profile
KR20050038011A (ko) * 2002-08-02 2005-04-25 트랜세이브, 인코포레이티드 백금 응집체 및 이의 제조 방법
US9186322B2 (en) 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
AU2003298738A1 (en) * 2002-11-26 2004-06-18 Su-Ming Chiang Liposomal formulations
EP1435231B8 (en) * 2002-12-31 2010-03-03 Zydus BSV Pharma Private Limited Non-pegylated long-circulating liposomes
WO2005072776A2 (en) * 2004-01-30 2005-08-11 Instytut Farmaceutyczny Liposomal formulations of the antineoplastic agents
WO2005092388A1 (ja) * 2004-03-26 2005-10-06 Terumo Kabushiki Kaisha リポソーム製剤
WO2006012502A2 (en) * 2004-07-23 2006-02-02 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
CN100566810C (zh) 2005-01-18 2009-12-09 国立大学法人北海道大学 用脂质膜被覆粒子的方法
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
JP2009518443A (ja) 2005-12-06 2009-05-07 リゲル ファーマシューティカルズ インコーポレーティッド 脂質を主材料とする担体に内封された、不溶性小分子治療剤の製剤
EP2331070A1 (en) * 2008-09-26 2011-06-15 Phares Pharmaceutical Research N.V. Method of solubilising biologically active compounds
CN101474155B (zh) * 2009-01-24 2011-03-16 重庆医科大学 注射用肺靶向载药前体脂质体及其使用方法
PL387296A1 (pl) * 2009-02-17 2010-08-30 Instytut Farmaceutyczny Sposób aktywnego zamykania amfifilowych substancji czynnych w strukturach liposomowych
US8906409B2 (en) * 2009-06-08 2014-12-09 Epitarget As Acoustically sensitive drug delivery particles comprising non-lamellar forming phosphatidylcholine
PL226015B1 (pl) 2011-03-03 2017-06-30 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
CN115414384A (zh) 2012-09-04 2022-12-02 埃莱森制药有限责任公司 用顺铂脂质复合物预防癌症的肺部复发
US9801874B2 (en) 2012-11-20 2017-10-31 Spectrum Pharmaceuticals Method for the preparation of liposome encapsulated vincristine for therapeutic use
TWI678213B (zh) 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
AU2018210748B2 (en) 2017-01-18 2023-09-28 Temasek Life Sciences Laboratory Limited Hyperstabilized liposomes increase targeting of mitotic cells
GR20180100082A (el) * 2018-02-28 2019-09-25 ΝΙΚΟΛΑΟΣ Α. ΦΙΚΙΩΡΗΣ ΚΑΙ ΣΙΑ ΕΤΑΙΡΕΙΑ ΠΕΡΙΟΡΙΣΜΕΝΗΣ ΕΥΘΗΝΗΣ με δ.τ. IN TOUCH HEALTH Ε.Π.Ε Μεθοδος για την παραγωγη οχηματων μεταφορας λιπιδιων
EP4045054A4 (en) * 2019-10-14 2023-11-29 The Regents of the University of California NANO-ACTIVATED IMMUNOTHERAPY FOR CANCER
CN112023059B (zh) * 2020-06-03 2023-03-24 太原师范学院 一种pH响应型阿霉素无载体纳米药物及其制备方法和应用
CN116407548A (zh) * 2021-12-31 2023-07-11 南京绿叶制药有限公司 一种蒽环类抗肿瘤药和铂类抗肿瘤药的组合物及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4551288A (en) * 1982-08-16 1985-11-05 Sandoz, Inc. Processes for the preparation of liposome drug delivery systems
GB8325496D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
CA1264668C (en) * 1984-06-20 1990-01-23 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES
CA1270198C (en) * 1984-08-08 1990-06-12 Marcel B Bally ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES
US4622188A (en) * 1984-12-21 1986-11-11 E. I. Du Pont De Nemours And Company Method for manufacturing liposomes
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents

Also Published As

Publication number Publication date
NL300036I1 (nl) 2001-03-01
LU90717I2 (fr) 2001-03-15
KR890700340A (ko) 1989-04-24
ES2088385T3 (es) 1996-08-16
AU635435B2 (en) 1993-03-18
IE880599L (en) 1988-09-05
EP0290296A2 (en) 1988-11-09
DE3856550D1 (de) 2003-02-27
AU620545B2 (en) 1992-02-20
DE3855265D1 (de) 1996-06-13
JPH02502458A (ja) 1990-08-09
IL85608A (en) 1992-07-15
EP0290296A3 (en) 1989-06-28
DE10199004I1 (de) 2001-03-29
JP2882607B2 (ja) 1999-04-12
ES2198429T3 (es) 2004-02-01
KR960013703B1 (ko) 1996-10-10
ATE231389T1 (de) 2003-02-15
AU8141791A (en) 1991-11-07
CA1338702C (en) 1996-11-12
IE75713B1 (en) 1997-09-24
GR3020725T3 (en) 1996-11-30
AU645332B2 (en) 1994-01-13
HK1007500A1 (en) 1999-04-16
DK98189A (da) 1989-03-01
BR1100687A (pt) 2000-02-08
EP0719546B1 (en) 2003-01-22
DE3856550T2 (de) 2003-12-11
AU1481688A (en) 1988-09-26
IE960340L (en) 1988-09-05
WO1988006442A1 (en) 1988-09-07
IL85608A0 (en) 1988-08-31
AU8141891A (en) 1991-10-10
EP0719546A1 (en) 1996-07-03
DK174869B1 (da) 2004-01-12
EP0290296B1 (en) 1996-05-08
ATE137670T1 (de) 1996-05-15
DE3855265T2 (de) 1996-12-12

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Legal Events

Date Code Title Description
AGE Re-establishment of rights: approved
CTFW Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn

Spc suppl protection certif: CA 2004 00031

Filing date: 20041008

CTFF Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2004 00031

Filing date: 20041008

Expiry date: 20130303

PUP Patent expired