DK98189A - Formuleringer af liposomale antineoplastiske midler med hoeje medikament-lipid-forhold - Google Patents

Formuleringer af liposomale antineoplastiske midler med hoeje medikament-lipid-forhold

Info

Publication number
DK98189A
DK98189A DK098189A DK98189A DK98189A DK 98189 A DK98189 A DK 98189A DK 098189 A DK098189 A DK 098189A DK 98189 A DK98189 A DK 98189A DK 98189 A DK98189 A DK 98189A
Authority
DK
Denmark
Prior art keywords
drug
liposomes
antineoplastic agents
formulations
lipid
Prior art date
Application number
DK098189A
Other languages
English (en)
Other versions
DK174869B1 (da
DK98189D0 (da
Inventor
Lawrence Mayer
Marcel B Bally
Pieter R Cullis
Richard S Ginsberg
George N Mitilenes
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21808094&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK98189(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of DK98189A publication Critical patent/DK98189A/da
Publication of DK98189D0 publication Critical patent/DK98189D0/da
Application granted granted Critical
Publication of DK174869B1 publication Critical patent/DK174869B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
DK198900981A 1987-03-05 1989-03-01 Liposomale formuleringer med et høj antineoplastisk middel/lipid forhold DK174869B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2215487A 1987-03-05 1987-03-05
US2215487 1987-03-05
PCT/US1988/000646 WO1988006442A1 (en) 1987-03-05 1988-03-03 High drug:lipid formulations of liposomal-antineoplastic agents
US8800646 1988-03-03

Publications (3)

Publication Number Publication Date
DK98189A true DK98189A (da) 1989-03-01
DK98189D0 DK98189D0 (da) 1989-03-01
DK174869B1 DK174869B1 (da) 2004-01-12

Family

ID=21808094

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198900981A DK174869B1 (da) 1987-03-05 1989-03-01 Liposomale formuleringer med et høj antineoplastisk middel/lipid forhold

Country Status (17)

Country Link
EP (2) EP0290296B1 (da)
JP (1) JP2882607B2 (da)
KR (1) KR960013703B1 (da)
AT (2) ATE231389T1 (da)
AU (3) AU620545B2 (da)
BR (1) BR1100687A (da)
CA (1) CA1338702C (da)
DE (3) DE3855265T2 (da)
DK (1) DK174869B1 (da)
ES (2) ES2198429T3 (da)
GR (1) GR3020725T3 (da)
HK (1) HK1007500A1 (da)
IE (1) IE75713B1 (da)
IL (1) IL85608A (da)
LU (1) LU90717I2 (da)
NL (1) NL300036I1 (da)
WO (1) WO1988006442A1 (da)

Families Citing this family (49)

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CA1323306C (en) * 1987-03-05 1993-10-19 Mircea C. Popescu Pharmacological agent-lipid solution preparation
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
US4946683A (en) * 1987-11-18 1990-08-07 Vestar, Inc. Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
EP0472639A4 (en) * 1989-05-15 1992-07-01 The Liposome Company, Inc. Accumulation of drugs into liposomes by a proton gradient
US5227170A (en) * 1989-06-22 1993-07-13 Vestar, Inc. Encapsulation process
EP0412507A1 (de) * 1989-08-08 1991-02-13 Humboldt-Universität zu Berlin Verfahren zur Grössenfraktionierung hochmolekularer Stoffe mit Hilfe von Hohlträgern
CA2087965A1 (en) * 1990-07-30 1992-02-01 Ajoy Chakrabarti Accumulation of amino acids and peptides into liposomes
WO1992004009A1 (en) * 1990-09-10 1992-03-19 School Of Pharmacy, University Of London Liposomes
DE4038075C1 (en) * 1990-11-29 1992-03-19 B. Braun Melsungen Ag, 3508 Melsungen, De Encapsulating solid or liq. lipophilic agents - comprises mixing hydration medium with phospholipid increasing temp. to above soln. phase change temp. and adding remaining medium
EP0661044A1 (en) * 1991-07-03 1995-07-05 NeXstar Pharmaceuticals, Inc. Drug-containing liposomes
EP0546951A1 (en) * 1991-12-13 1993-06-16 The Liposome Company, Inc. Combination of liposome encapsulated antineoplastic agents, such as doxorubicin with colony stimulating factors
US5741516A (en) * 1994-06-20 1998-04-21 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
US5543152A (en) * 1994-06-20 1996-08-06 Inex Pharmaceuticals Corporation Sphingosomes for enhanced drug delivery
DE4430592A1 (de) * 1994-08-20 1996-02-22 Max Delbrueck Centrum Liposomale Zubereitung, ihre Herstellung und ihre Verwendung
US5858397A (en) * 1995-10-11 1999-01-12 University Of British Columbia Liposomal formulations of mitoxantrone
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
AU725257B2 (en) * 1996-10-15 2000-10-12 Transave, Inc. N-acyl phosphatidylethanolamine-mediated liposomal drug delivery
US6458373B1 (en) 1997-01-07 2002-10-01 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US7030155B2 (en) 1998-06-05 2006-04-18 Sonus Pharmaceuticals, Inc. Emulsion vehicle for poorly soluble drugs
US7351427B2 (en) 1998-06-18 2008-04-01 Busulipo Ab Pharmaceutical composition, a method of preparing it and a method of treatment by use thereof
DE69928805T2 (de) * 1998-06-18 2006-08-31 Hassan, Moustapha, Dr. Liposomale Formulierungen von Busulfan
AU2158401A (en) * 1999-11-05 2001-05-14 Seed Capital Investments-2 (Sci-2) B.V. Method for the formulation of substances having a low water-solubility and lipophilicity and formulation thus obtained
EP1427393A2 (de) * 2000-05-02 2004-06-16 Pharmacept GmbH Wirkstoffhaltige liposome
ES2332584T3 (es) * 2001-03-27 2010-02-09 Phares Pharmaceutical Research N.V. Metodo y composicion para solubilizar un compuesto biologicamente activo con baja solubilidad en agua.
EP1429726A2 (en) * 2001-09-06 2004-06-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem A method for preparing liposome formulations with a predefined release profile
CA2494673A1 (en) * 2002-08-02 2004-07-01 Transave, Inc. Platinum aggregates and process for producing the same
US9186322B2 (en) 2002-08-02 2015-11-17 Insmed Incorporated Platinum aggregates and process for producing the same
WO2004047800A2 (en) * 2002-11-26 2004-06-10 Gilead Sciences, Inc. Method of drug loading in liposomes by gradient
JP5355842B2 (ja) * 2002-12-31 2013-11-27 ザイダス ビーエスヴィ ファーマ プライベート リミテッド 非ペギレート化長循環性リポソーム
WO2005072776A2 (en) * 2004-01-30 2005-08-11 Instytut Farmaceutyczny Liposomal formulations of the antineoplastic agents
WO2005092388A1 (ja) * 2004-03-26 2005-10-06 Terumo Kabushiki Kaisha リポソーム製剤
WO2006012502A2 (en) * 2004-07-23 2006-02-02 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
KR20070106703A (ko) * 2005-01-18 2007-11-05 국립대학법인 홋가이도 다이가쿠 입자를 지질막으로 피복하는 방법
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally
EP1959961A2 (en) 2005-12-06 2008-08-27 Rigel Pharmaceuticals, Inc. Formulation of insoluble small molecule therapeutics in lipid-based carriers
WO2010034837A1 (en) * 2008-09-26 2010-04-01 Phares Pharmaceutical Research N.V. Method of solubilising biologically active compounds
CN101474155B (zh) * 2009-01-24 2011-03-16 重庆医科大学 注射用肺靶向载药前体脂质体及其使用方法
PL387296A1 (pl) * 2009-02-17 2010-08-30 Instytut Farmaceutyczny Sposób aktywnego zamykania amfifilowych substancji czynnych w strukturach liposomowych
US8906409B2 (en) * 2009-06-08 2014-12-09 Epitarget As Acoustically sensitive drug delivery particles comprising non-lamellar forming phosphatidylcholine
PL226015B1 (pl) 2011-03-03 2017-06-30 Wrocławskie Centrum Badań Eit + Spółka Z Ograniczoną Liposomowy preparat zawierajacy przeciwnowotworowa substancje aktywna, sposob jego wytwarzania i zawierajaca go kompozycja farmaceutyczna
CN105025904A (zh) 2012-09-04 2015-11-04 埃莱森制药有限责任公司 用顺铂脂质复合物预防癌症的肺部复发
EP2922529B1 (en) 2012-11-20 2019-03-13 Spectrum Pharmaceuticals, Inc. Improved method for the preparation of liposome encapsulated vincristine for therapeutic use
TWI678213B (zh) 2015-07-22 2019-12-01 美商史倍壯製藥公司 用於長春新鹼硫酸鹽脂質體注射之即可使用的調配物
KR20190122676A (ko) 2017-01-18 2019-10-30 테마섹 라이프 사이언스 래보러토리 리미티드 유사분열기세포의 표적화를 증가시키는 고안정화된 리포좀
GR20180100082A (el) * 2018-02-28 2019-09-25 ΝΙΚΟΛΑΟΣ Α. ΦΙΚΙΩΡΗΣ ΚΑΙ ΣΙΑ ΕΤΑΙΡΕΙΑ ΠΕΡΙΟΡΙΣΜΕΝΗΣ ΕΥΘΗΝΗΣ με δ.τ. IN TOUCH HEALTH Ε.Π.Ε Μεθοδος για την παραγωγη οχηματων μεταφορας λιπιδιων
EP4045054A4 (en) * 2019-10-14 2023-11-29 The Regents of the University of California NANO-ACTIVATED IMMUNOTHERAPY FOR CANCER
CN112023059B (zh) * 2020-06-03 2023-03-24 太原师范学院 一种pH响应型阿霉素无载体纳米药物及其制备方法和应用

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DE3374837D1 (en) * 1982-02-17 1988-01-21 Ciba Geigy Ag Lipids in the aqueous phase
US4551288A (en) * 1982-08-16 1985-11-05 Sandoz, Inc. Processes for the preparation of liposome drug delivery systems
GB8325496D0 (en) * 1983-09-23 1983-10-26 Hider R C Pharmaceutical compositions
CA1264668C (en) * 1984-06-20 1990-01-23 EXTRUSION TECHNIQUES FOR THE PRODUCTION OF LIPOSOMES
CA1270198A (en) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation of antineoplastic agents in liposomes
US4622188A (en) * 1984-12-21 1986-11-11 E. I. Du Pont De Nemours And Company Method for manufacturing liposomes
US4737323A (en) * 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
IE60901B1 (en) * 1986-08-21 1994-08-24 Vestar Inc Improved treatment of systemic fungal infections with phospholipid particles encapsulating polyene antifungal antibiotics
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents

Also Published As

Publication number Publication date
EP0290296B1 (en) 1996-05-08
ES2088385T3 (es) 1996-08-16
KR890700340A (ko) 1989-04-24
KR960013703B1 (ko) 1996-10-10
GR3020725T3 (en) 1996-11-30
AU635435B2 (en) 1993-03-18
AU8141791A (en) 1991-11-07
DE3855265D1 (de) 1996-06-13
DE3855265T2 (de) 1996-12-12
DE3856550T2 (de) 2003-12-11
AU620545B2 (en) 1992-02-20
ES2198429T3 (es) 2004-02-01
DK174869B1 (da) 2004-01-12
AU1481688A (en) 1988-09-26
WO1988006442A1 (en) 1988-09-07
ATE137670T1 (de) 1996-05-15
DK98189D0 (da) 1989-03-01
BR1100687A (pt) 2000-02-08
ATE231389T1 (de) 2003-02-15
DE3856550D1 (de) 2003-02-27
EP0290296A2 (en) 1988-11-09
EP0719546A1 (en) 1996-07-03
IL85608A0 (en) 1988-08-31
AU8141891A (en) 1991-10-10
LU90717I2 (fr) 2001-03-15
IE960340L (en) 1988-09-05
CA1338702C (en) 1996-11-12
AU645332B2 (en) 1994-01-13
DE10199004I1 (de) 2001-03-29
IE75713B1 (en) 1997-09-24
IL85608A (en) 1992-07-15
HK1007500A1 (en) 1999-04-16
IE880599L (en) 1988-09-05
JP2882607B2 (ja) 1999-04-12
EP0719546B1 (en) 2003-01-22
NL300036I1 (nl) 2001-03-01
JPH02502458A (ja) 1990-08-09
EP0290296A3 (en) 1989-06-28

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Legal Events

Date Code Title Description
AGE Re-establishment of rights: approved
CTFW Supplementary protection certificate (spc) withdrawn, refused or deemed withdrawn

Spc suppl protection certif: CA 2004 00031

Filing date: 20041008

CTFF Application for supplementary protection certificate (spc) filed

Spc suppl protection certif: CA 2004 00031

Filing date: 20041008

Expiry date: 20130303

PUP Patent expired