HK1005867A1 - Improved process for manufacturing l-(-)-carnitine from waste products having opposite configuration - Google Patents

Improved process for manufacturing l-(-)-carnitine from waste products having opposite configuration Download PDF

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Publication number
HK1005867A1
HK1005867A1 HK98104946A HK98104946A HK1005867A1 HK 1005867 A1 HK1005867 A1 HK 1005867A1 HK 98104946 A HK98104946 A HK 98104946A HK 98104946 A HK98104946 A HK 98104946A HK 1005867 A1 HK1005867 A1 HK 1005867A1
Authority
HK
Hong Kong
Prior art keywords
carnitine
acyl
carnitinamide
carnitinenitrile
lactone
Prior art date
Application number
HK98104946A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1005867B (en
Inventor
Giannessi Fabio
Castagnani Roberto
Ornella Tinti Maria
De Angelis Francesco
De Witt Paolo
Misiti Domenico
Original Assignee
Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. filed Critical Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.
Publication of HK1005867B publication Critical patent/HK1005867B/en
Publication of HK1005867A1 publication Critical patent/HK1005867A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Processing Of Solid Wastes (AREA)
  • Fertilizers (AREA)
  • Switches Operated By Changes In Physical Conditions (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
HK98104946A 1993-04-08 1998-06-05 Improved process for manufacturing l-(-)-carnitine from waste products having opposite configuration HK1005867A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM930226A IT1261230B (it) 1993-04-08 1993-04-08 Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
ITRM930226 1993-04-08

Publications (2)

Publication Number Publication Date
HK1005867B HK1005867B (en) 1999-01-29
HK1005867A1 true HK1005867A1 (en) 1999-01-29

Family

ID=11401703

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98104946A HK1005867A1 (en) 1993-04-08 1998-06-05 Improved process for manufacturing l-(-)-carnitine from waste products having opposite configuration

Country Status (14)

Country Link
US (1) US5491260A (enExample)
EP (1) EP0623588B1 (enExample)
JP (1) JP3502657B2 (enExample)
KR (1) KR100301951B1 (enExample)
AT (1) ATE150003T1 (enExample)
CA (1) CA2120811C (enExample)
DE (1) DE69401979T2 (enExample)
DK (1) DK0623588T3 (enExample)
ES (1) ES2099563T3 (enExample)
GR (1) GR3023594T3 (enExample)
HK (1) HK1005867A1 (enExample)
IT (1) IT1261230B (enExample)
TW (1) TW275613B (enExample)
ZA (1) ZA942428B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276207B1 (it) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone
KR100255039B1 (ko) * 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
IT1297120B1 (it) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina
DE10027391B4 (de) * 2000-06-02 2006-05-04 Wella Ag Oligomere und Polymere aus Crotonbetain oder Crotonbetainderivaten
EP2409972A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine from B-lactones
JP6034287B2 (ja) * 2010-07-21 2016-11-30 ロンザ リミテッドＬｏｎｚａ Ｌｉｍｉｔｅｄ β−ラクトンからのカルニチンの製造のためのプロセス
EP2468739A1 (en) * 2010-12-22 2012-06-27 Lonza Ltd. A process for the production of carnitine from B-lactones
EP2409965A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine by cycloaddition

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE664500A (enExample) *
ES332080A1 (es) * 1965-10-15 1967-10-01 Otsuka Pharma Co Ltd Procedimiento para obtencion de complejos de sales opticamente activas de hidroxido de nitrilo,carnitina y acidos glutamicos n-acilos.
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
JPS59183694A (ja) * 1983-04-05 1984-10-18 Hamari Yakuhin Kogyo Kk 光学活性なカルニチンの生化学的製造法
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
US5200526A (en) * 1987-04-27 1993-04-06 The Governors Of The University Of Alberta Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts
JPH0291049A (ja) * 1988-09-21 1990-03-30 Lonza Ag ｒ―ブチロベタインの製造方法
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
MX170707B (es) * 1989-07-28 1993-09-08 Lonza Ag Procedimiento para la produccion discontinua de l-carnitina por transformacion microbiologica de crotonobetaina y gama-butirobetaina
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
IT1245699B (it) * 1991-05-29 1994-10-14 Sigma Tau Ind Farmaceuti Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Also Published As

Publication number Publication date
EP0623588A1 (en) 1994-11-09
DE69401979T2 (de) 1997-06-26
IT1261230B (it) 1996-05-09
ES2099563T3 (es) 1997-05-16
ITRM930226A0 (it) 1993-04-08
ATE150003T1 (de) 1997-03-15
TW275613B (enExample) 1996-05-11
EP0623588B1 (en) 1997-03-12
DK0623588T3 (da) 1997-07-21
JP3502657B2 (ja) 2004-03-02
US5491260A (en) 1996-02-13
JPH06311888A (ja) 1994-11-08
ITRM930226A1 (it) 1994-10-08
ZA942428B (en) 1994-11-29
KR100301951B1 (ko) 2001-10-22
CA2120811C (en) 2004-10-26
CA2120811A1 (en) 1994-10-09
DE69401979D1 (de) 1997-04-17
GR3023594T3 (en) 1997-08-29

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20130331