HK1005776A1 - Isoquinolines - Google Patents
IsoquinolinesInfo
- Publication number
- HK1005776A1 HK1005776A1 HK98104801A HK98104801A HK1005776A1 HK 1005776 A1 HK1005776 A1 HK 1005776A1 HK 98104801 A HK98104801 A HK 98104801A HK 98104801 A HK98104801 A HK 98104801A HK 1005776 A1 HK1005776 A1 HK 1005776A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- isoquinolines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals
- C07D217/16—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals substituted by oxygen atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939322828A GB9322828D0 (en) | 1993-11-05 | 1993-11-05 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1005776A1 true HK1005776A1 (en) | 1999-01-22 |
Family
ID=10744697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98104801A HK1005776A1 (en) | 1993-11-05 | 1998-06-03 | Isoquinolines |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US5747506A (fr) |
| EP (1) | EP0664289A3 (fr) |
| JP (1) | JPH07188176A (fr) |
| KR (1) | KR950014073A (fr) |
| CN (1) | CN1051998C (fr) |
| AT (1) | AT404940B (fr) |
| AU (1) | AU685852B2 (fr) |
| CA (1) | CA2135000A1 (fr) |
| CH (1) | CH688478A5 (fr) |
| CZ (1) | CZ282329B6 (fr) |
| DE (1) | DE4438737A1 (fr) |
| FI (1) | FI945191A (fr) |
| FR (1) | FR2711989B1 (fr) |
| GB (2) | GB9322828D0 (fr) |
| HK (1) | HK1005776A1 (fr) |
| HU (1) | HU217120B (fr) |
| IL (1) | IL111518A (fr) |
| IT (1) | IT1273993B (fr) |
| NO (1) | NO302293B1 (fr) |
| NZ (1) | NZ264851A (fr) |
| PE (1) | PE30395A1 (fr) |
| PL (1) | PL178210B1 (fr) |
| RU (1) | RU2144027C1 (fr) |
| SK (1) | SK280298B6 (fr) |
| TW (1) | TW353067B (fr) |
| ZA (1) | ZA948738B (fr) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
| US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
| ID19155A (id) * | 1996-12-13 | 1998-06-18 | Tanabe Seiyaku Co | Turunan-turunan piridin, pembuatannya dan intermediet untuk pembuatannya |
| US5919794A (en) * | 1998-05-11 | 1999-07-06 | Virginia Commonwealth University | Methods of using pharmaceutical tetrahydroisoquinolines |
| US6200771B1 (en) * | 1998-10-15 | 2001-03-13 | Cell Pathways, Inc. | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia |
| IL132407A0 (en) * | 1998-10-21 | 2001-03-19 | Pfizer Prod Inc | Method for treating congestive heart failure |
| DE19930614A1 (de) * | 1999-07-02 | 2001-01-04 | Mann & Hummel Filter | Filtereinsatz |
| PT1212089E (pt) | 1999-08-21 | 2006-08-31 | Altana Pharma Ag | Combinacao sinergica de roflumilast e salmeterol |
| CA2402413A1 (fr) * | 2000-03-14 | 2001-09-20 | The University Of Western Ontario | Compositions et procedes exercant un effet sur l'osteogenese |
| WO2002040449A1 (fr) * | 2000-11-14 | 2002-05-23 | Altana Pharma Ag | Dihydroisoquinolines comme nouveaux inhibiteurs de phosphodiesterase |
| BR0115318A (pt) | 2000-11-14 | 2004-02-03 | Altana Pharma Ag | Derivados de (diidro)isoquinolina como inibidores da fosfodiesterase |
| DE10229762A1 (de) * | 2002-07-03 | 2004-01-22 | Aventis Pharma Deutschland Gmbh | Pyrazoloisoquinolinenderivaten zur Inhibierung von NFkappaB-induzierende Kinase |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2006522151A (ja) | 2003-04-01 | 2006-09-28 | アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ | 不妊症におけるホスホジエステラーゼ阻害剤 |
| US7795385B2 (en) * | 2004-12-17 | 2010-09-14 | Bexar Global, Inc. | Use of bombesin/gastrin-releasing peptide antagonists for the treatment of inflammatory conditions, acute lung injury and bipolar disorder |
| CA3089569C (fr) | 2007-06-04 | 2023-12-05 | Synergy Pharmaceuticals Inc. | Agonistes de guanylase cyclase utiles pour le traitement de troubles gastro-intestinaux, d'inflammation, de cancer et d'autres troubles |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US20100120694A1 (en) | 2008-06-04 | 2010-05-13 | Synergy Pharmaceuticals, Inc. | Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders |
| EP2321341B1 (fr) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Agonistes de guanylate cyclase utiles pour le traitement de troubles gastro-intestinaux, inflammatoires, cancéreux et autres |
| WO2010038465A1 (fr) * | 2008-10-02 | 2010-04-08 | 旭化成ファーマ株式会社 | Dérivé d'isoquinoléine substitué en position 8 et son utilisation |
| JP6265583B2 (ja) | 2008-10-17 | 2018-01-24 | ウィスコンシン アルムニ リサーチ ファンデイション | 生理活性アルファベータペプチドを作製する方法 |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| CN108676076A (zh) | 2011-03-01 | 2018-10-19 | 辛纳吉制药公司 | 制备鸟苷酸环化酶c激动剂的方法 |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
| EP2970384A1 (fr) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonistes de la guanylate cyclase et leurs utilisations |
| RS65632B1 (sr) | 2013-06-05 | 2024-07-31 | Bausch Health Ireland Ltd | Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe |
| WO2015021358A2 (fr) | 2013-08-09 | 2015-02-12 | Dominique Charmot | Composés et procédés d'inhibition du transport de phosphate |
| JP2022533251A (ja) | 2019-05-21 | 2022-07-21 | アルデリックス， インコーポレイテッド | 患者において血清リン酸塩を低下させるための組み合わせ |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB645139A (en) * | 1946-10-22 | 1950-10-25 | Servita Gyogyszeryar Es Vegyip | Improved process for the production of isoquinoline derivatives |
| GB1400425A (en) * | 1971-09-22 | 1975-07-16 | Rolland Sa A | Substituted 3-hydroxymethyl-isoquinolines and derivatives |
| US3878215A (en) * | 1971-12-01 | 1975-04-15 | Sandoz Ag | 2-Alkyl-3-substituted-4-aryl isoquinolines |
| US4018927A (en) * | 1973-12-17 | 1977-04-19 | The Regents Of The University Of Michigan | Treatment of proliferating skin diseases with papaverine alkaloids |
| KR840002104B1 (ko) * | 1980-08-08 | 1984-11-15 | 부자 앙드레 | 신규 이소퀴놀린 유도체의 제법 |
| HU183479B (en) * | 1981-06-16 | 1984-05-28 | Chinoin Gyogyszer Es Vegyeszet | Process for producing new 6,7-diethoxy-1-aracket-4-ethoxy-3-hydroxy-benzyl-bracket closed-3,4-dihydroisoquinolin |
| DE3244594A1 (de) * | 1982-12-02 | 1984-06-07 | Hoechst Ag, 6230 Frankfurt | 1-phenylisochinolinderivate und verfahren zu ihrer herstellung, diese verbindung enthaltende pharmazeutische praeparate und deren anwendung |
| GB8328052D0 (en) * | 1983-10-20 | 1983-11-23 | Beecham Group Plc | Compounds |
| US4761403A (en) * | 1986-04-09 | 1988-08-02 | Abbott Laboratories | Lipoxygenase inhibiting compounds |
| CA1330560C (fr) * | 1986-05-21 | 1994-07-05 | Maurits E. A. Vandewalle | Derives di- et tetrahydroisoquinoline |
| HU196758B (en) * | 1986-05-21 | 1989-01-30 | Gyogyszerkutato Intezet | Process for production of 3-hidroxi-methil-quinolines and medical compositions containing them |
| GB8800397D0 (en) * | 1988-01-08 | 1988-02-10 | Sandoz Ltd | Improvements in/relating to organic compounds |
| GB9027055D0 (en) * | 1990-12-13 | 1991-02-06 | Sandoz Ltd | Organic compounds |
-
1993
- 1993-11-05 GB GB939322828A patent/GB9322828D0/en active Pending
-
1994
- 1994-10-28 FR FR9413108A patent/FR2711989B1/fr not_active Expired - Fee Related
- 1994-10-28 CH CH03226/94A patent/CH688478A5/de not_active IP Right Cessation
- 1994-10-29 DE DE4438737A patent/DE4438737A1/de not_active Withdrawn
- 1994-11-01 GB GB9421985A patent/GB2283488B/en not_active Expired - Fee Related
- 1994-11-01 EP EP94810628A patent/EP0664289A3/fr not_active Withdrawn
- 1994-11-03 CZ CZ942698A patent/CZ282329B6/cs not_active IP Right Cessation
- 1994-11-03 IL IL11151894A patent/IL111518A/xx active IP Right Grant
- 1994-11-03 NO NO944187A patent/NO302293B1/no not_active IP Right Cessation
- 1994-11-03 NZ NZ264851A patent/NZ264851A/en unknown
- 1994-11-03 CA CA002135000A patent/CA2135000A1/fr not_active Abandoned
- 1994-11-03 SK SK1319-94A patent/SK280298B6/sk unknown
- 1994-11-03 PE PE1994254101A patent/PE30395A1/es not_active Application Discontinuation
- 1994-11-03 KR KR1019940028732A patent/KR950014073A/ko not_active Application Discontinuation
- 1994-11-03 AU AU77610/94A patent/AU685852B2/en not_active Ceased
- 1994-11-03 FI FI945191A patent/FI945191A/fi unknown
- 1994-11-03 IT ITRM940706A patent/IT1273993B/it active IP Right Grant
- 1994-11-04 ZA ZA948738A patent/ZA948738B/xx unknown
- 1994-11-04 PL PL94305705A patent/PL178210B1/pl unknown
- 1994-11-04 CN CN94118199A patent/CN1051998C/zh not_active Expired - Fee Related
- 1994-11-04 RU RU94040170A patent/RU2144027C1/ru active
- 1994-11-04 HU HU9403184A patent/HU217120B/hu not_active IP Right Cessation
- 1994-11-04 AT AT0204894A patent/AT404940B/de not_active IP Right Cessation
- 1994-11-04 JP JP6271172A patent/JPH07188176A/ja active Pending
- 1994-11-16 TW TW083110617A patent/TW353067B/zh active
-
1996
- 1996-12-20 US US08/771,556 patent/US5747506A/en not_active Expired - Lifetime
-
1998
- 1998-06-03 HK HK98104801A patent/HK1005776A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |