HK1002814A1 - Specific antibodies to troponin t their production and their use in a reagent for the determination of heart muscle necroses - Google Patents
Specific antibodies to troponin t their production and their use in a reagent for the determination of heart muscle necrosesInfo
- Publication number
- HK1002814A1 HK1002814A1 HK98100683A HK98100683A HK1002814A1 HK 1002814 A1 HK1002814 A1 HK 1002814A1 HK 98100683 A HK98100683 A HK 98100683A HK 98100683 A HK98100683 A HK 98100683A HK 1002814 A1 HK1002814 A1 HK 1002814A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- troponin
- necroses
- determination
- determined
- heart muscle
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4716—Muscle proteins, e.g. myosin, actin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/32—Cardiovascular disorders
- G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Food Science & Technology (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE3913568 | 1989-04-25 | ||
DE3922873A DE3922873A1 (de) | 1989-04-25 | 1989-07-12 | Spezifische antikoerper gegen troponin t, ihre herstellung und verwendung in einem reagenz zur bestimmung von hermuskelnekrosen |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1002814A1 true HK1002814A1 (en) | 1998-09-18 |
Family
ID=25880249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98100683A HK1002814A1 (en) | 1989-04-25 | 1998-01-26 | Specific antibodies to troponin t their production and their use in a reagent for the determination of heart muscle necroses |
Country Status (9)
Country | Link |
---|---|
US (1) | US6376206B1 (ja) |
EP (1) | EP0394819B1 (ja) |
JP (2) | JP2564686B2 (ja) |
AT (1) | ATE117435T1 (ja) |
DE (2) | DE3922873A1 (ja) |
DK (1) | DK0394819T3 (ja) |
ES (1) | ES2068937T3 (ja) |
GR (1) | GR3015224T3 (ja) |
HK (1) | HK1002814A1 (ja) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4243648A1 (de) * | 1992-12-23 | 1994-07-07 | Boehringer Mannheim Gmbh | Verfahren zur Bestimmung von Herzmuskelnekrosen mittels Antikörper gegen das N-terminale Troponin I-Peptid |
FR2701954B1 (fr) * | 1993-02-23 | 1995-07-07 | Pasteur Sanofi Diagnostics | Composition stabilisée de troponine pour immunoessais et procédé de stabilisation de troponine pour immunoessais. |
JPH09503050A (ja) * | 1993-05-17 | 1997-03-25 | フォートロン バイオサイエンス インク. | 心臓トロポニン▲i▼のアッセイ |
CA2130280C (en) * | 1993-08-24 | 1999-08-31 | Lilian Lee | Method for purification of cardiac troponin i |
DE4420742A1 (de) * | 1993-10-20 | 1995-04-27 | Boehringer Mannheim Gmbh | Synthetischer Standard für Immunoassays |
US6627404B1 (en) | 1995-04-18 | 2003-09-30 | Biosite, Inc. | Methods for improving the recovery of troponin I and T in membranes, filters and vessels |
US5795725A (en) * | 1995-04-18 | 1998-08-18 | Biosite Diagnostics Incorporated | Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays |
US6174686B1 (en) | 1995-04-18 | 2001-01-16 | Biosite Diagnostics, Inc. | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays |
US6991907B1 (en) | 1995-04-18 | 2006-01-31 | Biosite, Inc. | Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays |
DE69713517D1 (de) * | 1996-10-15 | 2002-07-25 | Medical Analysis Systems Inc | Verfahren zur Stabilisierung von Troponin I (CTnI) durch Konjugation mit einem activen Polymer |
US6156521A (en) * | 1997-12-19 | 2000-12-05 | Biosite Diagnostics, Inc. | Methods for the recovery and measurement of troponin complexes |
US7384751B1 (en) * | 1997-07-16 | 2008-06-10 | Queen's University At Kingston | Methods of diagnosing muscle damage |
CA2407656A1 (en) * | 2000-04-27 | 2001-11-08 | Kyowa Hakko Kogyo Co. Ltd. | Myocardial cell proliferation-associated genes |
MXPA03004105A (es) | 2002-05-14 | 2004-10-15 | Hoffmann La Roche | Elaboracion de una prognosis en casos de enfermedad cardiaca usando una combinacion de marcadores. |
US8409815B2 (en) | 2002-11-16 | 2013-04-02 | Siemens Healthcare Diagnostics Products Gmbh | sCD40L and placental growth factor (PLGF) used as a biochemical marker combination in cardiovascular diseases |
DE10351238A1 (de) * | 2003-11-03 | 2005-06-02 | Roche Diagnostics Gmbh | Diagnosestellung von akuten myokardialen, ischämischen Erkrankungen durch Kombination von Markern |
EP2016394A4 (en) | 2006-04-04 | 2013-04-24 | Singulex Inc | METHOD AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES |
US7838250B1 (en) | 2006-04-04 | 2010-11-23 | Singulex, Inc. | Highly sensitive system and methods for analysis of troponin |
DK2115477T3 (en) | 2007-01-25 | 2015-08-10 | Hoffmann La Roche | USE OF IGFBP-7 IN THE EVIDENCE OF HEART FAILURE |
JP5081930B2 (ja) | 2007-03-08 | 2012-11-28 | エフ.ホフマン−ラ ロシュ アーゲー | 心不全の評価におけるslim−1の使用 |
US8617820B2 (en) * | 2007-08-28 | 2013-12-31 | Ortho-Clinical Diagnostics, Inc. | Use of glycosaminoglycans to reduce non-specific binding in immunoassays |
ES2526928T3 (es) | 2008-04-30 | 2015-01-16 | The Governing Council Of The University Of Toronto | Uso de SFRP-3 en la evaluación de la insuficiencia cardíaca |
EP2133696A1 (en) | 2008-06-10 | 2009-12-16 | Eberhardt Spanuth | Very low concentrations of troponin I or T for assessing a cardiovascular risk with respect to the administration of anti-inflammatory drugs |
WO2010043393A1 (en) * | 2008-10-17 | 2010-04-22 | Roche Diagnostics Gmbh | Use of biglycan in the assessment of heart failure |
WO2011012268A1 (en) | 2009-07-27 | 2011-02-03 | Roche Diagnostics Gmbh | Use of mimecan in the assessment of heart failure |
WO2011062738A1 (en) | 2009-11-23 | 2011-05-26 | Mikhail Briman | Controlled electrochemical activation of carbon-based electrodes |
US8835120B2 (en) * | 2009-12-02 | 2014-09-16 | Abbott Laboratories | Assay for cardiac troponin-T (cTnT) |
US8652788B2 (en) * | 2009-12-02 | 2014-02-18 | Abbott Laboratories | Assay for diagnosis of cardiac myocyte damage |
EP3502707A1 (en) | 2010-01-29 | 2019-06-26 | metanomics GmbH | Means and methods for diagnosing heart failure in a subject |
CN103080746B (zh) * | 2010-08-26 | 2015-07-15 | 弗·哈夫曼-拉罗切有限公司 | 生物标志物在评估从动脉高血压向心力衰竭的早期转变中的用途 |
JP5833755B2 (ja) | 2011-07-25 | 2015-12-16 | ブリマン、ミカイル | 診断試験用カートリッジ |
EP3527990A1 (en) | 2011-07-28 | 2019-08-21 | metanomics GmbH | Use of sm_sphingomyelin (d18:1, c23:1) as a marker for heart failure |
US20160116472A1 (en) * | 2013-02-04 | 2016-04-28 | The General Hospital Corporation | Biomarkers for stroke diagnosis |
US9784749B2 (en) | 2013-11-15 | 2017-10-10 | Otago Innovation Limited | Biomarker for cardiac disorders |
CN103940986B (zh) * | 2014-03-24 | 2015-10-21 | 安徽省煦棠医疗科技有限公司 | 肌钙蛋白i特定位点抗体制备及其检测试剂盒 |
CN108885219A (zh) | 2016-02-04 | 2018-11-23 | 梅坦诺米克斯有限公司 | 用于在受试者中鉴别心力衰竭和肺部疾病的装置和方法 |
US20170363620A1 (en) | 2016-06-17 | 2017-12-21 | Abbott Laboratories | BIOMARKERS TO PREDICT NEW ONSET HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF) |
EP3279667A1 (en) | 2016-08-02 | 2018-02-07 | Abbott Laboratories | Cardiac troponin i and copeptin as biomarkers for short-term mortality in acute exacerbation of chronic obstructive pulmonary disease (aecopd) |
BR112020017941A2 (pt) * | 2018-03-14 | 2021-02-17 | F. Hoffmann-La Roche Ag | anticorpos, moléculas de ácido nucleico, vetor, composição e método de determinação da troponina t cardíaca humana |
CN111801351A (zh) | 2018-03-14 | 2020-10-20 | 豪夫迈·罗氏有限公司 | 抗体亲和力成熟的方法 |
WO2020264410A1 (en) * | 2019-06-26 | 2020-12-30 | Sensor-Kinesis Corporation | Troponin t binding agents and uses thereof |
EP4010366A1 (en) * | 2019-08-09 | 2022-06-15 | F. Hoffmann-La Roche AG | Novel anti-troponint antibodies |
CN113402608B (zh) * | 2021-06-24 | 2022-02-22 | 河北省科学院生物研究所 | 一种杂交瘤细胞株及其分泌的单克隆抗体与应用 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3640412A1 (de) * | 1986-11-26 | 1988-06-09 | Boehringer Mannheim Gmbh | Verfahren zur bestimmung einer spezifisch bindefaehigen substanz |
-
1989
- 1989-07-12 DE DE3922873A patent/DE3922873A1/de not_active Withdrawn
-
1990
- 1990-04-18 ES ES90107323T patent/ES2068937T3/es not_active Expired - Lifetime
- 1990-04-18 DE DE59008278T patent/DE59008278D1/de not_active Expired - Lifetime
- 1990-04-18 AT AT90107323T patent/ATE117435T1/de not_active IP Right Cessation
- 1990-04-18 EP EP90107323A patent/EP0394819B1/de not_active Expired - Lifetime
- 1990-04-18 DK DK90107323.9T patent/DK0394819T3/da active
- 1990-04-24 JP JP2109946A patent/JP2564686B2/ja not_active Expired - Lifetime
-
1994
- 1994-10-14 JP JP6249289A patent/JP2818116B2/ja not_active Expired - Lifetime
-
1995
- 1995-02-28 GR GR950400428T patent/GR3015224T3/el unknown
- 1995-06-07 US US08/487,540 patent/US6376206B1/en not_active Expired - Lifetime
-
1998
- 1998-01-26 HK HK98100683A patent/HK1002814A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE3922873A1 (de) | 1990-10-31 |
DK0394819T3 (da) | 1995-06-19 |
DE59008278D1 (de) | 1995-03-02 |
EP0394819B1 (de) | 1995-01-18 |
JP2564686B2 (ja) | 1996-12-18 |
JPH07198718A (ja) | 1995-08-01 |
US6376206B1 (en) | 2002-04-23 |
EP0394819A2 (de) | 1990-10-31 |
ATE117435T1 (de) | 1995-02-15 |
JP2818116B2 (ja) | 1998-10-30 |
ES2068937T3 (es) | 1995-05-01 |
JPH037597A (ja) | 1991-01-14 |
EP0394819A3 (de) | 1991-02-06 |
GR3015224T3 (en) | 1995-05-31 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PE | Patent expired |
Effective date: 20100417 |