DK0394819T3 - Specifikke antistoffer mod troponin-T, deres fremstilling og anvendelse i et reagens til bestemmelse af hjertemuskelnekroser - Google Patents

Specifikke antistoffer mod troponin-T, deres fremstilling og anvendelse i et reagens til bestemmelse af hjertemuskelnekroser

Info

Publication number
DK0394819T3
DK0394819T3 DK90107323.9T DK90107323T DK0394819T3 DK 0394819 T3 DK0394819 T3 DK 0394819T3 DK 90107323 T DK90107323 T DK 90107323T DK 0394819 T3 DK0394819 T3 DK 0394819T3
Authority
DK
Denmark
Prior art keywords
troponin
determination
determined
reagent
preparation
Prior art date
Application number
DK90107323.9T
Other languages
Danish (da)
English (en)
Inventor
Siegfried Dr Looser
Hugo Prof Dr Katus
Anneliese Borgya
Klaus Dr Hallermayer
Original Assignee
Boehringer Mannheim Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh
Application granted granted Critical
Publication of DK0394819T3 publication Critical patent/DK0394819T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716—Muscle proteins, e.g. myosin, actin
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6887—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids from muscle, cartilage or connective tissue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders
    • G01N2800/324—Coronary artery diseases, e.g. angina pectoris, myocardial infarction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/975—Kit

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DK90107323.9T 1989-04-25 1990-04-18 Specifikke antistoffer mod troponin-T, deres fremstilling og anvendelse i et reagens til bestemmelse af hjertemuskelnekroser DK0394819T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3913568 1989-04-25
DE3922873A DE3922873A1 (de) 1989-04-25 1989-07-12 Spezifische antikoerper gegen troponin t, ihre herstellung und verwendung in einem reagenz zur bestimmung von hermuskelnekrosen

Publications (1)

Publication Number Publication Date
DK0394819T3 true DK0394819T3 (da) 1995-06-19

Family

ID=25880249

Family Applications (1)

Application Number Title Priority Date Filing Date
DK90107323.9T DK0394819T3 (da) 1989-04-25 1990-04-18 Specifikke antistoffer mod troponin-T, deres fremstilling og anvendelse i et reagens til bestemmelse af hjertemuskelnekroser

Country Status (9)

Country Link
US (1) US6376206B1 (ja)
EP (1) EP0394819B1 (ja)
JP (2) JP2564686B2 (ja)
AT (1) ATE117435T1 (ja)
DE (2) DE3922873A1 (ja)
DK (1) DK0394819T3 (ja)
ES (1) ES2068937T3 (ja)
GR (1) GR3015224T3 (ja)
HK (1) HK1002814A1 (ja)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4243648A1 (de) * 1992-12-23 1994-07-07 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von Herzmuskelnekrosen mittels Antikörper gegen das N-terminale Troponin I-Peptid
FR2701954B1 (fr) * 1993-02-23 1995-07-07 Pasteur Sanofi Diagnostics Composition stabilisée de troponine pour immunoessais et procédé de stabilisation de troponine pour immunoessais.
EP0699306B1 (en) * 1993-05-17 1999-09-08 Fortron Bioscience, Inc. Assay for cardiac troponin i
CA2130280C (en) * 1993-08-24 1999-08-31 Lilian Lee Method for purification of cardiac troponin i
DE4420742A1 (de) * 1993-10-20 1995-04-27 Boehringer Mannheim Gmbh Synthetischer Standard für Immunoassays
US5795725A (en) * 1995-04-18 1998-08-18 Biosite Diagnostics Incorporated Methods for the assay of troponin I and T and selection of antibodies for use in immunoassays
US6991907B1 (en) 1995-04-18 2006-01-31 Biosite, Inc. Methods for the assay of troponin I and T and complexes of troponin I and T and selection of antibodies for use in immunoassays
US6627404B1 (en) 1995-04-18 2003-09-30 Biosite, Inc. Methods for improving the recovery of troponin I and T in membranes, filters and vessels
DE69633780T3 (de) 1995-04-18 2011-05-05 Biosite Incorporated, San Diego Verfahren zum assay von troponin i und t und komplexen von troponin i und t und auswahl von antikörpern zur verwendung in immunoassays
US6072040A (en) * 1996-10-15 2000-06-06 Medical Analysis Systems, Inc. Stabilized conjugates of uncomplexed subunits of multimeric proteins
US6156521A (en) * 1997-12-19 2000-12-05 Biosite Diagnostics, Inc. Methods for the recovery and measurement of troponin complexes
US7384751B1 (en) * 1997-07-16 2008-06-10 Queen's University At Kingston Methods of diagnosing muscle damage
US20040005578A1 (en) * 2000-04-27 2004-01-08 Yoji Yamada Myocardial cell proliferation-associated genes
MXPA03004105A (es) 2002-05-14 2004-10-15 Hoffmann La Roche Elaboracion de una prognosis en casos de enfermedad cardiaca usando una combinacion de marcadores.
EP1561116B9 (de) 2002-11-16 2009-04-01 Siemens Healthcare Diagnostics Products GmbH Scd40l, papp-a und plazentaler-wachstumsfaktor (pigf) als biochemische markerkombinationen bei kardiovaskulären erkrankungen
DE10351238A1 (de) * 2003-11-03 2005-06-02 Roche Diagnostics Gmbh Diagnosestellung von akuten myokardialen, ischämischen Erkrankungen durch Kombination von Markern
US7838250B1 (en) 2006-04-04 2010-11-23 Singulex, Inc. Highly sensitive system and methods for analysis of troponin
JP5308328B2 (ja) 2006-04-04 2013-10-09 シングレックス，インコーポレイテッド トロポニンの分析のための高感度のシステムおよび方法
CN106908603B (zh) 2007-01-25 2019-04-02 霍夫曼-拉罗奇有限公司 Igfbp-7在心力衰竭评估中的用途
WO2008107201A1 (en) 2007-03-08 2008-09-12 Roche Diagnostics Gmbh Use of slim-1 in the assessment of heart failure
US8617820B2 (en) * 2007-08-28 2013-12-31 Ortho-Clinical Diagnostics, Inc. Use of glycosaminoglycans to reduce non-specific binding in immunoassays
CA2722485C (en) 2008-04-30 2018-02-13 F. Hoffmann-La Roche Ag Use of sfrp-3 in the assessment of heart failure
EP2133696A1 (en) 2008-06-10 2009-12-16 Eberhardt Spanuth Very low concentrations of troponin I or T for assessing a cardiovascular risk with respect to the administration of anti-inflammatory drugs
CN102187228A (zh) * 2008-10-17 2011-09-14 霍夫曼-拉罗奇有限公司 双糖链蛋白聚糖在心力衰竭评估中的用途
JP5592487B2 (ja) 2009-07-27 2014-09-17 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト 心不全の評価におけるミメカンの使用
US9000769B2 (en) 2009-11-23 2015-04-07 Proxim Diagnostics Controlled electrochemical activation of carbon-based electrodes
US8835120B2 (en) * 2009-12-02 2014-09-16 Abbott Laboratories Assay for cardiac troponin-T (cTnT)
US8652788B2 (en) * 2009-12-02 2014-02-18 Abbott Laboratories Assay for diagnosis of cardiac myocyte damage
JP5813665B2 (ja) 2010-01-29 2015-11-17 メタノミクス ゲーエムベーハー 被験体において心不全を診断するための手段及び方法
CN105044349B (zh) * 2010-08-26 2018-04-06 弗·哈夫曼-拉罗切有限公司 生物标志物在评估从动脉高血压向心力衰竭的早期转变中的用途
EP2737315B1 (en) 2011-07-25 2022-03-16 Proxim Diagnostics Corporation Cartridge for diagnostic testing
CA2841915A1 (en) 2011-07-28 2013-01-31 Metanomics Gmbh Means and methods for diagnosing and monitoring heart failure in a subject
US20160116472A1 (en) * 2013-02-04 2016-04-28 The General Hospital Corporation Biomarkers for stroke diagnosis
EP3069146A4 (en) 2013-11-15 2017-04-05 Otago Innovation Limited Biomarker for cardiac disorders
CN103940986B (zh) * 2014-03-24 2015-10-21 安徽省煦棠医疗科技有限公司 肌钙蛋白i特定位点抗体制备及其检测试剂盒
WO2017134264A1 (en) 2016-02-04 2017-08-10 Metanomics Gmbh Means and methods for differentiating between heart failure and pulmonary disease in a subject
US20170363620A1 (en) 2016-06-17 2017-12-21 Abbott Laboratories BIOMARKERS TO PREDICT NEW ONSET HEART FAILURE WITH PRESERVED EJECTION FRACTION (HFpEF)
EP3279667A1 (en) 2016-08-02 2018-02-07 Abbott Laboratories Cardiac troponin i and copeptin as biomarkers for short-term mortality in acute exacerbation of chronic obstructive pulmonary disease (aecopd)
JP2021515567A (ja) * 2018-03-14 2021-06-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規抗トロポニンｔ抗体
BR112020018235A2 (pt) 2018-03-14 2020-12-29 F. Hoffmann-La Roche Ag Métodos para gerar uma biblioteca de polinucleotídeos, bibliotecas de polinucleotídeos, uso de uma biblioteca, método para gerar uma biblioteca de anticorpos e método de seleção de um anticorpo
WO2020264410A1 (en) * 2019-06-26 2020-12-30 Sensor-Kinesis Corporation Troponin t binding agents and uses thereof
JP2022543863A (ja) * 2019-08-09 2022-10-14 エフ．ホフマン－ラ ロシュ アーゲー 新規抗トロポニンｔ抗体
CN113402608B (zh) * 2021-06-24 2022-02-22 河北省科学院生物研究所 一种杂交瘤细胞株及其分泌的单克隆抗体与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3640412A1 (de) * 1986-11-26 1988-06-09 Boehringer Mannheim Gmbh Verfahren zur bestimmung einer spezifisch bindefaehigen substanz

Also Published As

Publication number Publication date
US6376206B1 (en) 2002-04-23
JP2564686B2 (ja) 1996-12-18
GR3015224T3 (en) 1995-05-31
HK1002814A1 (en) 1998-09-18
ES2068937T3 (es) 1995-05-01
DE59008278D1 (de) 1995-03-02
ATE117435T1 (de) 1995-02-15
EP0394819A2 (de) 1990-10-31
DE3922873A1 (de) 1990-10-31
JPH037597A (ja) 1991-01-14
EP0394819A3 (de) 1991-02-06
JPH07198718A (ja) 1995-08-01
JP2818116B2 (ja) 1998-10-30
EP0394819B1 (de) 1995-01-18

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