HK1001768A1 - 2,4-disulfonyl phenyl, butyl nitrone, its salts and their use as pharmaceuticals - Google Patents

2,4-disulfonyl phenyl, butyl nitrone, its salts and their use as pharmaceuticals

Info

Publication number
HK1001768A1
HK1001768A1 HK98100831A HK98100831A HK1001768A1 HK 1001768 A1 HK1001768 A1 HK 1001768A1 HK 98100831 A HK98100831 A HK 98100831A HK 98100831 A HK98100831 A HK 98100831A HK 1001768 A1 HK1001768 A1 HK 1001768A1
Authority
HK
Hong Kong
Prior art keywords
nervous system
central nervous
salts
pharmaceuticals
butyl nitrone
Prior art date
Application number
HK98100831A
Other languages
English (en)
Inventor
John M Carney
Original Assignee
Oklahoma Med Res Found
Univ Kentucky Res Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oklahoma Med Res Found, Univ Kentucky Res Found filed Critical Oklahoma Med Res Found
Publication of HK1001768A1 publication Critical patent/HK1001768A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/46—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton having the sulfo groups bound to carbon atoms of non-condensed six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK98100831A 1993-12-23 1998-02-04 2,4-disulfonyl phenyl, butyl nitrone, its salts and their use as pharmaceuticals HK1001768A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/173,579 US5488145A (en) 1993-12-23 1993-12-23 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
PCT/US1994/014545 WO1995017876A2 (en) 1993-12-23 1994-12-22 2,4-disulphophenyl butylnitrone, its salts, and their use as pharmaceutical spintraps

Publications (1)

Publication Number Publication Date
HK1001768A1 true HK1001768A1 (en) 1998-07-10

Family

ID=22632663

Family Applications (2)

Application Number Title Priority Date Filing Date
HK98100831A HK1001768A1 (en) 1993-12-23 1998-02-04 2,4-disulfonyl phenyl, butyl nitrone, its salts and their use as pharmaceuticals
HK98109078A HK1008294A1 (en) 1993-12-23 1998-07-11 (2-4-Disulfophenyl) n-tertiary butyl nitrone its salts and their use as pharmaceutical radical trapping agents

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK98109078A HK1008294A1 (en) 1993-12-23 1998-07-11 (2-4-Disulfophenyl) n-tertiary butyl nitrone its salts and their use as pharmaceutical radical trapping agents

Country Status (29)

Country Link
US (4) US5488145A (de)
EP (1) EP0736004B1 (de)
JP (3) JP3412821B2 (de)
KR (1) KR100370522B1 (de)
CN (1) CN1070176C (de)
AT (1) ATE192736T1 (de)
AU (1) AU679835B2 (de)
BR (2) BR9408378A (de)
CA (1) CA2179521C (de)
CZ (1) CZ289629B6 (de)
DE (1) DE69424441T2 (de)
DK (1) DK0736004T3 (de)
ES (1) ES2145264T3 (de)
FI (1) FI111718B (de)
GR (1) GR3034134T3 (de)
HK (2) HK1001768A1 (de)
HR (1) HRP950358B1 (de)
HU (1) HU221167B1 (de)
MY (1) MY114178A (de)
NO (1) NO306457B1 (de)
NZ (1) NZ279025A (de)
PL (1) PL185189B1 (de)
PT (1) PT736004E (de)
RU (1) RU2159231C2 (de)
SG (1) SG64903A1 (de)
SK (1) SK282403B6 (de)
TW (1) TW299315B (de)
UA (1) UA45964C2 (de)
WO (1) WO1995017876A2 (de)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723502A (en) * 1985-07-18 1998-03-03 Proctor; Peter H. Topical spin trap composition and method
US5622994A (en) * 1989-10-17 1997-04-22 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
ATE110565T1 (de) * 1989-10-17 1994-09-15 Oklahoma Med Res Found Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten.
US20050107366A1 (en) * 1991-06-18 2005-05-19 Carney John M. Spin trapping pharmaceutical compositions and methods for use thereof
US6002001A (en) * 1991-06-18 1999-12-14 Oklahoma Medical Research Foundation Spin trapping pharmaceutical compositions and methods for use thereof
US20040208875A1 (en) * 1995-03-15 2004-10-21 Queen's University At Kingston Method for treating amyloidosis
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps
IL123345A (en) * 1995-09-11 2003-07-31 Aventis Pharma Inc Cyclic nitrones and pharmaceutical compositions containing them
EP0888290B1 (de) 1995-11-17 2006-12-27 Florida International University Azulenylnitrone als radikal fanger (spin trapping agents), verfahren zu ihrer herstellung und ihre anwendung
WO1997038683A1 (en) * 1996-04-17 1997-10-23 Oklahoma Medical Research Foundation Nitrone free radical trap treatment of dementia associated with aids virus (hiv-1) infection
IL128070A0 (en) * 1996-07-19 1999-11-30 Centaur Pharmaceuticals Inc Furan nitrone compounds
TW429241B (en) * 1996-09-26 2001-04-11 Sumitomo Pharma Nitrone derivatives
US6046232A (en) 1997-10-17 2000-04-04 Centaur Pharmaceuticals, Inc. α-aryl-N-alkylnitrones and pharmaceutical compositions containing the same
CN1291980A (zh) * 1998-01-16 2001-04-18 桑道药品有限公司 硫醚呋喃硝酮化合物
JP2002509147A (ja) * 1998-01-16 2002-03-26 センター ファーマシューティカルズ， インコーポレイテッド チオフェンニトロン化合物
US6255353B1 (en) * 1998-03-13 2001-07-03 Centaur Pharmaceuticals, Inc. Inhibition of angiogenesis
AU3985799A (en) * 1998-05-19 1999-12-06 Centaur Pharmaceuticals, Inc. Furan nitrone therapeutics for the treatment of inflammatory bowel disease
US6083989A (en) * 1999-05-18 2000-07-04 Centaur Pharmaceuticals, Inc. Aryl nitrone therapeutics for the treatment of inflammatory bowel disease
UA66401C2 (en) 1998-12-02 2004-05-17 Sentor Pharmaceuticals Inc 3,4,5-trisubstituted aryl nitrone compounds and pharmaceutical composition containing the same
US6730700B2 (en) 1998-12-02 2004-05-04 Renovis, Inc. 3,4,5,-trisubstituted aryl nitrone compounds and pharmaceutical compositions containing the same
CN1156478C (zh) 1999-01-25 2004-07-07 国家犹太医疗及研究中心 取代的卟啉
ATE441421T1 (de) * 1999-04-28 2009-09-15 Bellus Health Int Ltd Zusammensetzungen und verfahren zur behandlung von amyloidosis mit sulphonatderivaten
BR9904931A (pt) * 1999-10-18 2001-06-12 Sergio Teixeira Ferreira Inibição de amiloidoses
US6815425B1 (en) 1999-10-22 2004-11-09 The United States Of America As Represented By The Secretary Of The Army Pharmaceutical composition containing pGLU-GLU-PRO-NH2 and method for treating diseases and injuries to the brain, spinal cord and retina using same
WO2001028578A2 (en) * 1999-10-22 2001-04-26 Wrair A PHARMACEUTICAL COMPOSITION CONTAINING pGLU-GLU-PRO-NH2 AND METHOD FOR TREATING DISEASES AND INJURIES TO THE BRAIN, SPINAL CORD AND RETINA USING SAME
SE0000056D0 (sv) * 2000-01-10 2000-01-10 Astrazeneca Ab Novel process
AU2001236442A1 (en) * 2000-01-10 2001-07-24 Centaur Phamaceuticals, Inc. Method for the purification of aryl sulfonic acids and salts
SE0000055D0 (sv) * 2000-01-10 2000-01-10 Centaur Pharmaceuticals Inc Novel process
SE0001916D0 (sv) * 2000-05-23 2000-05-23 Astrazeneca Ab Novel formulation
US6664297B1 (en) 2000-10-18 2003-12-16 Universidade Federal Do Rio De Janeiro Methods for inhibition and dissolution of amyloidoses by administration of compositions comprising 2,4-dinitrophenol
AU2002253857A1 (en) 2001-01-08 2002-09-04 Centaur Pharmaceuticals, Inc. Use of aryl nitrone compounds in methods for treating neuropathic pain
WO2003010154A1 (en) * 2001-07-26 2003-02-06 Samsung Electronics Co. Ltd. Seleno compounds containing nitrone moiety, their preparation and their therapeutic uses
US20030045461A1 (en) * 2001-09-06 2003-03-06 Jen-Chang Hsia Composition and methods of esterified nitroxides gated with carboxylic acids
FR2846968B1 (fr) * 2002-11-08 2005-02-04 Salles Jean Pierre Nouveaux derives amphiphiles de l'alpha-c-phenyl-n-tert- butyl nitrone
US7414076B2 (en) * 2003-06-23 2008-08-19 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US7244764B2 (en) * 2003-06-23 2007-07-17 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20070010573A1 (en) * 2003-06-23 2007-01-11 Xianqi Kong Methods and compositions for treating amyloid-related diseases
US20050059638A1 (en) * 2003-08-04 2005-03-17 Kelly Michael G. Aryl, heteroaromatic and bicyclic aryl nitrone compounds, prodrugs and pharmaceutical compositions of the same to treat human disorders
US20050182060A1 (en) * 2004-02-13 2005-08-18 Kelly Michael G. 2-Substituted and 4-substituted aryl nitrone compounds
US20060183800A1 (en) * 2004-11-12 2006-08-17 Xianqi Kong Methods and fluorinated compositions for treating amyloid-related diseases
CN101103018A (zh) * 2004-11-16 2008-01-09 神经化学（国际）有限公司 治疗cns和淀粉样蛋白-相关疾病的化合物
CA2592320C (en) 2004-12-22 2015-11-24 Neurochem (International) Limited Methods and compositions for treating amyloid-related diseases
US20060235370A1 (en) * 2005-04-04 2006-10-19 Oblong John E Method of regulating mammalian keratinous tissue
TW200716088A (en) * 2005-04-15 2007-05-01 Neurochem Int Ltd Formulations and methods for treating amyloidosis
WO2007013842A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimino)methyl) benzene-1,3-disulfonate n-oxide against maemorrhagic changes in the brain
WO2007013844A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)benzene-1,3-disulfonate n-oxide against nausea
WO2007013843A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-[(tert-butylimino)methyl]benzene-1,3-disulfonate n-oxide against myocardial ischaemia
WO2007013841A1 (en) * 2005-07-26 2007-02-01 Astrazeneca Ab Use of 4-((tert-butylimine)methyl) benzene-1,3-disulfonate n-oxide against cerebral oedema
MX2008008213A (es) * 2005-12-22 2008-09-03 Neurochem Int Ltd Tratamiento de trastornos renales, nefropatia diabetica y dislipidemias.
US8420595B2 (en) * 2006-07-25 2013-04-16 Oklahoma Medical Research Foundation Methods for treating acute acoustic trauma
EP2089417B1 (de) 2006-10-12 2014-12-31 BHI Limited Partnership Verfahren, verbindungen, zusammensetzungen und vehikel zur verabreichung von 3-amino-1-propansulfonsäure
JP2010529947A (ja) * 2006-12-22 2010-09-02 ベラス ヘルス（インターナショナル）リミテッド 代謝性疾患および糖尿病を治療するための方法、化合物、および組成物
US20090082454A1 (en) * 2007-09-25 2009-03-26 Protia, Llc Deuterium-enriched disufenton
EP3028671A1 (de) 2007-09-26 2016-06-08 St. Jude Medical, Inc. Faltbare herzklappenprothesen
EP2242360B1 (de) 2008-02-12 2015-04-08 Tosk, Inc. Doxorubicin-hilfsstoffe zur toxizitätsminderung und anwendungsverfahren dafür
CA2725012C (en) 2008-05-23 2019-05-07 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
WO2010028058A1 (en) * 2008-09-02 2010-03-11 Oklahoma Medical Research Foundation 2, 4-disulfonyl pheny tert-butyl nitrone for the treatment of gliomas
AU2010289838C1 (en) * 2009-08-24 2014-03-06 Hough Ear Institute Methods for treating acute acoustic trauma
AU2012211989B2 (en) * 2011-02-04 2017-03-02 Hough Ear Institute Methods for treating brain injury
US10576125B2 (en) 2016-10-31 2020-03-03 Hough Ear Institute Methods for enhancing synaptogenesis and neuritogenesis
EP3570826A4 (de) 2017-01-19 2020-09-23 Otologic Pharmaceutics, Inc. Formulierungen von n-acetylcystein und deren verwendungen
CN111132672A (zh) 2017-09-20 2020-05-08 俄克拉荷马医学研究基金会 抗药性胶质瘤的治疗
US10829441B2 (en) 2017-11-14 2020-11-10 The University Of Toledo Reactive oxygen species-sensitive nitric oxide synthase inhibitors for the treatment of ischemic stroke
WO2019213245A1 (en) 2018-05-03 2019-11-07 Hough Ear Institute Methods for reducing accumulated pathologic tau protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5036097A (en) * 1989-10-17 1991-07-30 Oklahoma Medical Research Foundation Phenylbutyl nitrone compositions and methods for prevention of gastric ulceration
ATE110565T1 (de) * 1989-10-17 1994-09-15 Oklahoma Med Res Found Verfahren und zubereitungen zur hemmung von mit oxidativer schädigung assoziierten krankheiten.
US5025032A (en) * 1989-10-17 1991-06-18 Oklahoma Medical Research Foundation Phenyl butyl nitrone compositions and methods for treatment of oxidative tissue damage
ATE209908T1 (de) * 1991-06-18 2001-12-15 Oklahoma Med Res Found RADIKALFÄNGER (ßSPIN TRAPSß) ZUR BEHANDLUNG VON MIT OXIDATION VON LIPIDEN UND PROTEINEN VERBUNDENEN ERKRANKUNGEN
US5488145A (en) * 1993-12-23 1996-01-30 Oklahoma Medical Research Foundation 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceutical free radical traps

Also Published As

Publication number Publication date
SK78896A3 (en) 1997-09-10
CZ289629B6 (cs) 2002-03-13
EP0736004A1 (de) 1996-10-09
ATE192736T1 (de) 2000-05-15
FI962589A0 (fi) 1996-06-20
JPH09507232A (ja) 1997-07-22
JP2001010953A (ja) 2001-01-16
CA2179521A1 (en) 1995-07-06
CN1070176C (zh) 2001-08-29
US5475032A (en) 1995-12-12
HU9601739D0 (en) 1996-08-28
DE69424441T2 (de) 2000-10-12
PT736004E (pt) 2000-09-29
NO962637L (no) 1996-08-13
WO1995017876A2 (en) 1995-07-06
BR9408378A (pt) 1997-08-19
PL185189B1 (pl) 2003-03-31
WO1995017876A3 (en) 1995-08-10
PL315154A1 (en) 1996-10-14
CN1156447A (zh) 1997-08-06
JP2004075696A (ja) 2004-03-11
BR1100626A (pt) 1999-11-23
MY114178A (en) 2002-08-30
AU1552795A (en) 1995-07-17
SK282403B6 (sk) 2002-01-07
CA2179521C (en) 2002-03-19
CZ177596A3 (en) 1996-12-11
NO962637D0 (no) 1996-06-20
HRP950358B1 (en) 2001-04-30
RU2159231C2 (ru) 2000-11-20
KR100370522B1 (ko) 2003-05-16
HRP950358A2 (en) 1997-08-31
ES2145264T3 (es) 2000-07-01
US5780510A (en) 1998-07-14
TW299315B (de) 1997-03-01
UA45964C2 (uk) 2002-05-15
US5488145A (en) 1996-01-30
NO306457B1 (no) 1999-11-08
EP0736004B1 (de) 2000-05-10
NZ279025A (en) 1998-02-26
HUT76788A (en) 1997-11-28
DK0736004T3 (da) 2000-10-09
HK1008294A1 (en) 1999-05-07
GR3034134T3 (en) 2000-11-30
HU221167B1 (en) 2002-08-28
FI111718B (fi) 2003-09-15
US5508305A (en) 1996-04-16
FI962589A (fi) 1996-08-20
SG64903A1 (en) 1999-05-25
JP3412821B2 (ja) 2003-06-03
AU679835B2 (en) 1997-07-10
DE69424441D1 (de) 2000-06-15

Similar Documents

Publication Publication Date Title
GR3034134T3 (en) 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as pharmaceuticals
MX9602683A (es) Compuestos de 6-dimetilaminometil-1-fenil-ciclohexano como substancias farmaceuticamente activas.
AU6060896A (en) Oral 1alpha-hydroxyprevitamin D
UA29469C2 (uk) Ліпосомальна фармацевтична композиція для внутрішньовенного введення
NZ334124A (en) Use of the chelating agent clioquinol, with vitamin B12 for the manufacture of a pharmaceutical composition for the treatment of alzheimer's disease
HK1048986A1 (en) 2'-Substituted 1,1'-iphenyl-2-carbonamides, methodfor the production thereof, use thereof as medicament and pharmaceutical preparations containing said compounds.
GR3034186T3 (en) 3,4-diarylchromans for treatment of dermatitis
LTIP1958A (en) New use of ropivacaine
DK0742716T3 (da) Farmaceutisk sammensætning til systemisk transdermal indgivelse med det aktive middel morphin-6-glucuronid
CA2154485A1 (en) Pharmaceutical composition containing 5-morpholinomethyl-3-(4-chlorobenzylideneamine)-2-oxazolidinone and its use for the treatment of cns disorders
YU42395A (sh) 2,4-disulfonil fenil butil nitron, njegove soli i njihova primena kao farmaceutskih preparata
IL112129A (en) 2,4-disulfo alpha-phenyl tertiary butyl nitrone its pharmaceutically acceptable salts and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20061222