|
US4879236A
(en)
*
|
1984-05-16 |
1989-11-07 |
The Texas A&M University System |
Method for producing a recombinant baculovirus expression vector
|
|
JPS619288A
(ja)
*
|
1984-06-21 |
1986-01-16 |
Dai Ichi Seiyaku Co Ltd |
ペプチド類の製法
|
|
IL80529A0
(en)
*
|
1985-11-14 |
1987-02-27 |
Daiichi Seiyaku Co |
Method of producing peptides
|
|
AU599348B2
(en)
*
|
1985-12-18 |
1990-07-19 |
Microgenesys, Inc. |
Method for producing selected polypeptides in virally infected insect cells and polypeptides isolated therefrom
|
|
IL83003A
(en)
|
1986-07-01 |
1995-07-31 |
Genetics Inst |
Osteoinductive factors
|
|
US6150328A
(en)
|
1986-07-01 |
2000-11-21 |
Genetics Institute, Inc. |
BMP products
|
|
GR871029B
(en)
|
1986-07-14 |
1987-11-02 |
Genetics Inst |
Novel osteoinductive factors
|
|
EP0260090A3
(en)
*
|
1986-09-08 |
1988-07-27 |
David H.L. Bishop |
Expression of hepatitis b viral antigens from recombinant baculovirus vectors
|
|
US5071748A
(en)
*
|
1986-09-09 |
1991-12-10 |
Genetics Institute, Inc. |
Mixed baculovirus compositions and uses thereof
|
|
ZA876696B
(en)
*
|
1986-09-09 |
1988-05-25 |
Genetics Inst |
Method for producing a heterologous protein in insect cells
|
|
US5041379A
(en)
*
|
1987-03-16 |
1991-08-20 |
American Biogenetic Science, Inc. |
Heliothis expression systems
|
|
US5024947A
(en)
*
|
1987-07-24 |
1991-06-18 |
Cetus Corporation |
Serum free media for the growth on insect cells and expression of products thereby
|
|
US5443964A
(en)
*
|
1987-08-10 |
1995-08-22 |
Duke University |
Poxvirus insertion/expression vector
|
|
US5578468A
(en)
*
|
1987-08-10 |
1996-11-26 |
Duke University |
Site-specific RNA cleavage
|
|
GB8810808D0
(en)
*
|
1988-05-06 |
1988-06-08 |
Wellcome Found |
Vectors
|
|
JP2511494B2
(ja)
*
|
1988-05-12 |
1996-06-26 |
善治 松浦 |
日本脳炎ウイルス表面抗原蛋白質の製造法
|
|
JPH0221955A
(ja)
*
|
1988-07-07 |
1990-01-24 |
Nippon Steel Corp |
流体噴射ノズル
|
|
SE8802939D0
(sv)
*
|
1988-08-19 |
1988-08-19 |
Kabigen Ab |
A method for the production and isolation of a fusion protein in eukaryotic cells
|
|
US5811523A
(en)
|
1988-11-10 |
1998-09-22 |
Trinchieri; Giorgio |
Antibodies to natural killer stimulatory factor
|
|
WO1990005783A1
(en)
*
|
1988-11-18 |
1990-05-31 |
Cetus Corporation |
Insect signal peptide mediated secretion of recombinant proteins
|
|
US5244805A
(en)
*
|
1989-05-17 |
1993-09-14 |
University Of Georgia Research Foundation, Inc. |
Baculovirus expression vectors
|
|
JP3504263B2
(ja)
|
1991-11-04 |
2004-03-08 |
ジェネティックス・インスチチュート・リミテッド・ライアビリティ・カンパニー |
組み換え型骨形態形成蛋白ヘテロダイマー、組成物および使用法
|
|
ATE343635T1
(de)
|
1993-05-12 |
2006-11-15 |
Genetics Inst Llc |
Bmp-11 zusammenstellungen
|
|
US6291206B1
(en)
|
1993-09-17 |
2001-09-18 |
Genetics Institute, Inc. |
BMP receptor proteins
|
|
US6027919A
(en)
|
1993-12-07 |
2000-02-22 |
Genetics Institute, Inc. |
BMP-12 and BMP-13 proteins and DNA encoding them
|
|
CA2176942C
(en)
|
1993-12-07 |
2011-11-01 |
Anthony J. Celeste |
Bmp-12, bmp-13 and tendon-inducing compositions thereof
|
|
AU1377395A
(en)
|
1993-12-23 |
1995-07-10 |
University Technologies International Inc. |
Methods of expressing proteins in insect cells and methods of killing insects
|
|
US5629167A
(en)
|
1994-04-19 |
1997-05-13 |
Biocine S.P.A. |
Detection of antibodies against Chlamydia trachomatis pgp3 antigen in patient sera by enzyme-linked immunosorbent assay
|
|
US6544523B1
(en)
|
1996-11-13 |
2003-04-08 |
Chiron Corporation |
Mutant forms of Fas ligand and uses thereof
|
|
US6165748A
(en)
|
1997-07-11 |
2000-12-26 |
Genetics Institute, Inc. |
Frazzled nucleotide sequences and expression products
|
|
ES2319939T3
(es)
|
1997-08-27 |
2009-05-14 |
Novartis Vaccines And Diagnostics, Inc. |
Mimeticos moleculares de epitopos de meningococos b.
|
|
CA2671261A1
(en)
|
1997-11-06 |
1999-05-20 |
Novartis Vaccines And Diagnostics S.R.L. |
Neisserial antigens
|
|
ES2333071T5
(es)
|
1998-01-14 |
2015-08-17 |
Novartis Vaccines And Diagnostics S.R.L. |
Antígenos de Neisseria meningitidis
|
|
GB9808932D0
(en)
|
1998-04-27 |
1998-06-24 |
Chiron Spa |
Polyepitope carrier protein
|
|
EP2261338A3
(en)
|
1998-05-01 |
2012-01-04 |
Novartis Vaccines and Diagnostics, Inc. |
Neisseria meningitidis antigens and compositions
|
|
AU1316200A
(en)
|
1998-10-15 |
2000-05-01 |
Chiron Corporation |
Metastatic breast and colon cancer regulated genes
|
|
WO2001027150A2
(en)
|
1999-10-14 |
2001-04-19 |
Clontech Laboratories Inc. |
Anthozoa derived chromo/fluoroproteins and methods for using the same
|
|
PT1141331E
(pt)
|
1998-12-16 |
2008-12-22 |
Novartis Vaccines & Diagnostic |
Quinase dependente de ciclina humana (hpnqalre)
|
|
US6727224B1
(en)
|
1999-02-01 |
2004-04-27 |
Genetics Institute, Llc. |
Methods and compositions for healing and repair of articular cartilage
|
|
WO2000066741A2
(en)
|
1999-04-30 |
2000-11-09 |
Chiron S.P.A. |
Conserved neisserial antigens
|
|
GB9911683D0
(en)
|
1999-05-19 |
1999-07-21 |
Chiron Spa |
Antigenic peptides
|
|
GB9916529D0
(en)
|
1999-07-14 |
1999-09-15 |
Chiron Spa |
Antigenic peptides
|
|
ES2225241T3
(es)
|
1999-10-15 |
2005-03-16 |
Genetics Institute, Llc |
Formulaciones de acido hialuronico para suministrar proteinas osteogenicas.
|
|
MXPA02004283A
(es)
|
1999-10-29 |
2002-10-17 |
Chiron Spa |
Peptidos antigenicos neisseriales.
|
|
JP5250168B2
(ja)
|
2000-01-10 |
2013-07-31 |
ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド |
乳癌において差次的に発現される遺伝子
|
|
NZ520466A
(en)
|
2000-01-17 |
2003-09-26 |
Chiron S |
Outer membrane vesicle (OMV) vaccine comprising n. meningitidis serogroup B outer membrane proteins
|
|
US6689599B1
(en)
|
2000-10-20 |
2004-02-10 |
Genetics Institute, Llc |
Aggrecanase molecules
|
|
CA2425303A1
(en)
|
2000-10-27 |
2002-05-02 |
John Telford |
Nucleic acids and proteins from streptococcus groups a & b
|
|
TWI329129B
(en)
|
2001-02-08 |
2010-08-21 |
Wyeth Corp |
Modified and stabilized gdf propeptides and uses thereof
|
|
GB0107661D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Staphylococcus aureus
|
|
GB0107658D0
(en)
|
2001-03-27 |
2001-05-16 |
Chiron Spa |
Streptococcus pneumoniae
|
|
WO2002081642A2
(en)
|
2001-04-06 |
2002-10-17 |
Georgetown University |
Gene brcc-3 and diagnostic and therapeutic uses thereof
|
|
WO2002081641A2
(en)
|
2001-04-06 |
2002-10-17 |
Georgetown University |
Gene scc-112 and diagnostic and therapeutic uses thereof
|
|
WO2002081639A2
(en)
|
2001-04-06 |
2002-10-17 |
Georgetown University |
Gene brcc2 and diagnostic and therapeutic uses thereof
|
|
ATE393573T1
(de)
|
2001-06-01 |
2008-05-15 |
Wyeth Corp |
Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
|
|
TWI267378B
(en)
|
2001-06-08 |
2006-12-01 |
Wyeth Corp |
Calcium phosphate delivery vehicles for osteoinductive proteins
|
|
AU2002319703A1
(en)
|
2001-07-27 |
2003-02-17 |
Wyeth |
Aggrecanase molecules
|
|
ES2386386T3
(es)
|
2001-12-12 |
2012-08-20 |
Novartis Vaccines And Diagnostics S.R.L. |
Inmunización contra Chlamydia trachomatis
|
|
WO2003054158A2
(en)
|
2001-12-19 |
2003-07-03 |
The University Of Chicago |
Rapidly maturing fluorescent proteins and methods for using the same
|
|
JP2005515779A
(ja)
|
2002-01-31 |
2005-06-02 |
ワイス |
アグレカナーゼ分子
|
|
EP1472364A4
(en)
|
2002-02-05 |
2005-12-28 |
Wyeth Corp |
TRUNK AGGRECANASE MOLECULES
|
|
US7138512B2
(en)
|
2002-04-10 |
2006-11-21 |
Georgetown University |
Gene SHINC-2 and diagnostic and therapeutic uses thereof
|
|
US7244565B2
(en)
|
2002-04-10 |
2007-07-17 |
Georgetown University |
Gene shinc-3 and diagnostic and therapeutic uses thereof
|
|
AU2003243316A1
(en)
|
2002-05-24 |
2003-12-12 |
Nps Allelix Corp. |
Method for enzymatic production of glp-2(1-33) and glp-2-(1-34) peptides
|
|
WO2003099848A2
(en)
|
2002-05-24 |
2003-12-04 |
Restoragen Inc. |
Method for universal enzymatic production of bioactive peptides
|
|
US20070059329A1
(en)
|
2002-11-15 |
2007-03-15 |
Nathalie Norais |
Unexpected surface proteins in meningococcus
|
|
GB0308198D0
(en)
|
2003-04-09 |
2003-05-14 |
Chiron Srl |
ADP-ribosylating bacterial toxin
|
|
NZ546438A
(en)
|
2003-09-12 |
2010-07-30 |
Wyeth Corp |
Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins
|
|
SI1704234T1
(sl)
|
2003-11-21 |
2012-08-31 |
Nps Pharma Inc |
Proizvodnja glukagonu podobnih peptidov 2 in analogov
|
|
JP2007519422A
(ja)
|
2004-02-02 |
2007-07-19 |
アンブレツクス・インコーポレイテツド |
修飾されたヒト四螺旋バンドルポリペプチド及びそれらの使用
|
|
DK1736541T3
(da)
|
2004-03-29 |
2013-05-06 |
Galpharma Co Ltd |
Nyt modificeret galectin 9-protein og anvendelse heraf
|
|
US7250298B2
(en)
|
2004-04-07 |
2007-07-31 |
The University Of Chicago |
Monomeric red fluorescent proteins
|
|
BRPI0512235A
(pt)
|
2004-06-18 |
2008-02-19 |
Ambrx Inc |
polipeptìdeos ligadores de antìgenos e seus usos
|
|
CA2569381A1
(en)
|
2004-07-21 |
2006-08-31 |
Ambrx, Inc. |
Biosynthetic polypeptides utilizing non-naturally encoded amino acids
|
|
WO2009100255A2
(en)
|
2008-02-08 |
2009-08-13 |
Ambrx, Inc. |
Modified leptin polypeptides and their uses
|
|
US7332571B2
(en)
|
2004-12-22 |
2008-02-19 |
Ambrx, Inc. |
Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides
|
|
SG160437A1
(en)
|
2004-12-22 |
2010-04-29 |
Ambrx Inc |
Modified human growth hormone
|
|
KR101447897B1
(ko)
|
2005-03-21 |
2014-10-07 |
비로베이, 인코포레이티드 |
시스테인 단백질분해효소 억제제로서의 알파 케토아미드화합물
|
|
EP3214095B1
(en)
|
2005-05-12 |
2019-12-11 |
ZymoGenetics, Inc. |
Compositions and methods for modulating immune responses
|
|
US7749704B2
(en)
|
2005-11-01 |
2010-07-06 |
Mayo Foundation For Medical Education And Research |
Promoter polymorphisms of the BLyS gene and use in diagnostic methods
|
|
WO2007059312A2
(en)
|
2005-11-16 |
2007-05-24 |
Ambrx, Inc. |
Methods and compositions comprising non-natural amino acids
|
|
US20100015168A1
(en)
|
2006-06-09 |
2010-01-21 |
Novartis Ag |
Immunogenic compositions for streptococcus agalactiae
|
|
MX2009002523A
(es)
|
2006-09-08 |
2009-03-20 |
Ambrx Inc |
Polipeptido de plasma humano modificado o andamios fc y sus usos.
|
|
US7985783B2
(en)
|
2006-09-21 |
2011-07-26 |
The Regents Of The University Of California |
Aldehyde tags, uses thereof in site-specific protein modification
|
|
EP2068909B1
(en)
|
2007-03-30 |
2012-04-25 |
Ambrx, Inc. |
Modified fgf-21 polypeptides and their uses
|
|
AU2008308509B2
(en)
|
2007-10-04 |
2014-10-23 |
Zymogenetics, Inc. |
B7 family member zB7H6 and related compositions and methods
|
|
WO2009059305A2
(en)
|
2007-11-01 |
2009-05-07 |
The University Of Chicago |
Red fluorescent proteins with enhanced bacterial expression, increased brightness and reduced aggregation
|
|
EP2930182A1
(en)
|
2007-11-20 |
2015-10-14 |
Ambrx, Inc. |
Modified insulin polypeptides and their uses
|
|
WO2009073511A2
(en)
|
2007-11-30 |
2009-06-11 |
Mayo Foundation For Medical Education And Research |
Polymorphisms of the blys gene and use in diagnostic methods
|
|
ES2963062T3
(es)
|
2008-07-23 |
2024-03-25 |
Ambrx Inc |
Polipéptidos G-CSF bovinos modificados y sus usos
|
|
NZ592249A
(en)
|
2008-09-26 |
2013-03-28 |
Ambrx Inc |
Non-natural amino acid replication-dependent microorganisms and vaccines
|
|
NZ592250A
(en)
|
2008-09-26 |
2012-11-30 |
Lilly Co Eli |
Modified animal erythropoietin polypeptides and their uses
|
|
EP2292781A1
(en)
|
2009-08-17 |
2011-03-09 |
Genethon |
Baculovirus-based production of biopharmaceuticals free of contaminating baculoviral virions
|
|
EP2333074A1
(en)
|
2009-12-14 |
2011-06-15 |
Robert Steinfeld |
Substances and methods for the treatment of lysosmal storage diseases
|
|
BR112012015597A2
(pt)
|
2009-12-21 |
2017-01-31 |
Ambrx Inc |
peptídeos de somatotropina suínos modificados e seus usos
|
|
NZ600361A
(en)
|
2009-12-21 |
2014-06-27 |
Ambrx Inc |
Modified bovine somatotropin polypeptides and their uses
|
|
SI2605789T1
(sl)
|
2010-08-17 |
2019-10-30 |
Ambrx Inc |
Modificirani polipeptidi relaksina in njihova uporaba
|
|
US9567386B2
(en)
|
2010-08-17 |
2017-02-14 |
Ambrx, Inc. |
Therapeutic uses of modified relaxin polypeptides
|
|
TWI480288B
(zh)
|
2010-09-23 |
2015-04-11 |
Lilly Co Eli |
牛顆粒細胞群落刺激因子及其變體之調配物
|
|
US10480010B2
(en)
|
2011-07-27 |
2019-11-19 |
Genethon |
Baculovirus expression systems
|
|
PE20160769A1
(es)
|
2013-09-12 |
2016-08-12 |
Biomarin Pharm Inc |
Vectores del factor viii del virus adeno-asociado
|
|
LT3412302T
(lt)
|
2014-10-24 |
2021-07-26 |
Bristol-Myers Squibb Company |
Modifikuoti fgf-21 polipeptidai ir jų panaudojimai
|
|
IL297353B1
(en)
|
2015-09-24 |
2025-10-01 |
Biomarin Pharm Inc |
Adeno-associated virus factor 8 vectors, associated virus particles and medical formulations comprising them
|
|
AU2016354561B2
(en)
|
2015-11-12 |
2021-12-02 |
Research Institute At Nationwide Children's Hospital |
Methods of treating muscular dystrophy
|
|
SG11201804166YA
(en)
|
2015-11-16 |
2018-06-28 |
Res Inst Nationwide Childrens Hospital |
Materials and methods for treatment of titin-based myopathies and other titinopaties
|
|
US11584780B2
(en)
|
2016-07-26 |
2023-02-21 |
Biomarin Pharmaceutical Inc. |
Adeno-associated virus capsid proteins
|
|
PE20191716A1
(es)
|
2017-02-08 |
2019-12-05 |
Bristol Myers Squibb Co |
Polipeptidos de relaxina modificada que comprenden un mejorador farmacocinetico y sus usos
|
|
EP3688014A4
(en)
|
2017-09-29 |
2020-09-16 |
Massachusetts Eye and Ear Infirmary |
PRODUCTION OF ADENO-ASSOCIATED VIRUSES IN INSECT CELLS
|
|
KR102824021B1
(ko)
|
2018-01-31 |
2025-06-24 |
더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 |
2c형 지대근이영양증에 대한 유전자 치료
|
|
EP3790627A2
(en)
|
2018-05-09 |
2021-03-17 |
BioMarin Pharmaceutical Inc. |
Methods of treating phenylketonuria
|
|
TW202005978A
(zh)
|
2018-05-14 |
2020-02-01 |
美商拜奧馬林製藥公司 |
新穎肝靶向腺相關病毒載體
|
|
CA3100000A1
(en)
|
2018-05-14 |
2019-11-21 |
Biomarin Pharmaceutical Inc. |
Stable expression of aav vectors in juvenile subjects
|
|
SG11202012715UA
(en)
|
2018-06-29 |
2021-01-28 |
Res Inst Nationwide Childrens Hospital |
Recombinant adeno-associated virus products and methods for treating limb girdle muscular dystrophy 2a
|
|
EP3930765A1
(en)
|
2019-02-26 |
2022-01-05 |
Research Institute at Nationwide Children's Hospital |
Adeno-associated virus vector delivery of b-sarcoglycan and the treatment of muscular dystrophy
|
|
US20200362368A1
(en)
|
2019-05-14 |
2020-11-19 |
Biomarin Pharmaceutical Inc. |
Methods of redosing gene therapy vectors
|
|
ES2978666T3
(es)
|
2019-08-21 |
2024-09-17 |
Res Institute At Nationwidechildrens Hospital |
Suministro de alfa-sarcoglicano por vector de virus adenoasociado y tratamiento de la distrofia muscular
|
|
KR20220066164A
(ko)
|
2019-09-27 |
2022-05-23 |
바이오마린 파머수티컬 인크. |
크기 배제 크로마토그래피 및 다각도 광 산란 기술을 사용한 유전자 치료 바이러스 입자의 특성화
|
|
TW202128733A
(zh)
|
2019-11-14 |
2021-08-01 |
美商拜奧馬林製藥公司 |
使用肝特異性基因療法載體之遺傳性血管性水腫的治療
|
|
CN115052974A
(zh)
|
2020-02-10 |
2022-09-13 |
生物马林药物股份有限公司 |
无病毒细胞培养物
|
|
WO2021183895A1
(en)
|
2020-03-13 |
2021-09-16 |
Biomarin Pharmaceutical Inc. |
Treatment of fabry disease with aav gene therapy vectors
|
|
TW202144575A
(zh)
|
2020-04-03 |
2021-12-01 |
美商拜奧馬林製藥公司 |
使用aav及治療調配物之苯酮尿症治療
|
|
WO2021236908A2
(en)
|
2020-05-20 |
2021-11-25 |
Biomarin Pharmaceutical Inc. |
Use of regulatory proteins for the production of adeno-associated virus
|
|
EP4237545A1
(en)
|
2020-11-02 |
2023-09-06 |
BioMarin Pharmaceutical Inc. |
Process for enriching adeno-associated virus
|
|
US20240408240A1
(en)
|
2021-10-01 |
2024-12-12 |
Biomarin Pharmaceutical Inc. |
Treatment of hereditary angioedema with aav gene therapy vectors and therapeutic formulations
|
|
JP2023059858A
(ja)
|
2021-10-15 |
2023-04-27 |
リサーチ インスティチュート アット ネイションワイド チルドレンズ ホスピタル |
自己相補的アデノ随伴ウイルスベクター及び筋ジストロフィーの治療におけるその使用
|
|
TW202421788A
(zh)
|
2022-09-22 |
2024-06-01 |
美商拜奧馬林製藥公司 |
用aav基因療法載體治療致心律不整性心肌病
|
|
WO2024064856A1
(en)
|
2022-09-22 |
2024-03-28 |
Biomarin Pharmaceutical Inc. |
Treatment of cardiomyopathy with aav gene therapy vectors
|
|
TW202444398A
(zh)
|
2023-01-09 |
2024-11-16 |
美商拜奧馬林製藥公司 |
表觀遺傳修飾劑改善aav基因療法之耐久性
|
|
WO2024238591A2
(en)
|
2023-05-15 |
2024-11-21 |
Biomarin Pharmaceutical Inc. |
Methods of treating anti-aav seropositive hemophilia patients
|
|
WO2025214477A1
(en)
|
2024-04-12 |
2025-10-16 |
Skyline Therapeutics (Shanghai) Co., Ltd. |
Treatment of genetic cardiomyopathies with aav gene therapy vectors
|