GR3032614T3 - Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine - Google Patents

Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine

Info

Publication number
GR3032614T3
GR3032614T3 GR20000400313T GR20000400313T GR3032614T3 GR 3032614 T3 GR3032614 T3 GR 3032614T3 GR 20000400313 T GR20000400313 T GR 20000400313T GR 20000400313 T GR20000400313 T GR 20000400313T GR 3032614 T3 GR3032614 T3 GR 3032614T3
Authority
GR
Greece
Prior art keywords
fluoromethylene
cytidine
deoxy
monohydrate
neoplastic
Prior art date
Application number
GR20000400313T
Other languages
Greek (el)
English (en)
Inventor
Richard E Donaldson
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of GR3032614T3 publication Critical patent/GR3032614T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR20000400313T 1994-01-07 2000-02-09 Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine GR3032614T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US17895294A 1994-01-07 1994-01-07
PCT/US1994/014648 WO1995018815A1 (en) 1994-01-07 1994-12-13 Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine

Publications (1)

Publication Number Publication Date
GR3032614T3 true GR3032614T3 (en) 2000-05-31

Family

ID=22654587

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000400313T GR3032614T3 (en) 1994-01-07 2000-02-09 Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine

Country Status (20)

Country Link
EP (1) EP0738273B1 (ja)
JP (1) JPH09511227A (ja)
KR (1) KR100330328B1 (ja)
CN (1) CN1043231C (ja)
AT (1) ATE186732T1 (ja)
AU (1) AU684604B2 (ja)
CA (1) CA2179987C (ja)
DE (1) DE69421721T2 (ja)
DK (1) DK0738273T3 (ja)
ES (1) ES2141330T3 (ja)
FI (1) FI114396B (ja)
GR (1) GR3032614T3 (ja)
HU (1) HU217849B (ja)
IL (1) IL112242A (ja)
MX (1) MX9500363A (ja)
NO (1) NO306409B1 (ja)
NZ (1) NZ279030A (ja)
TW (1) TW397838B (ja)
WO (1) WO1995018815A1 (ja)
ZA (1) ZA9512B (ja)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100540046B1 (ko) 1997-11-12 2006-01-10 미쓰비시 가가꾸 가부시키가이샤 퓨린유도체 및 이를 유효성분으로 함유하는 의약
ATE254616T1 (de) 1999-05-11 2003-12-15 Mitsubishi Chem Corp Dihydrat eines purinderivates, medikamente die dieses als aktiven wirkstoff enthalten und zwischenprodukte zu dessen herstellung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2002648C (en) * 1988-11-15 2000-02-29 James R. Mccarthy 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
CA2133961C (en) * 1992-05-12 1998-03-31 James R. Mccarthy A process for the preparation of ribonucleotide reductase inhibitors

Also Published As

Publication number Publication date
HU9601848D0 (en) 1996-09-30
FI114396B (fi) 2004-10-15
CN1043231C (zh) 1999-05-05
JPH09511227A (ja) 1997-11-11
IL112242A0 (en) 1995-03-30
CA2179987C (en) 1999-01-19
CA2179987A1 (en) 1995-07-13
DE69421721T2 (de) 2000-04-27
EP0738273B1 (en) 1999-11-17
NO962848L (no) 1996-09-06
FI962769A0 (fi) 1996-07-05
CN1141045A (zh) 1997-01-22
HUT75055A (en) 1997-03-28
TW397838B (en) 2000-07-11
AU1553295A (en) 1995-08-01
NZ279030A (en) 1997-05-26
WO1995018815A1 (en) 1995-07-13
KR100330328B1 (ko) 2002-12-05
EP0738273A1 (en) 1996-10-23
NO962848D0 (no) 1996-07-05
FI962769A (fi) 1996-07-05
AU684604B2 (en) 1997-12-18
DE69421721D1 (de) 1999-12-23
IL112242A (en) 2000-08-31
DK0738273T3 (da) 2000-04-17
HU217849B (hu) 2000-04-28
ZA9512B (en) 1995-09-11
NO306409B1 (no) 1999-11-01
MX9500363A (es) 1998-04-30
ATE186732T1 (de) 1999-12-15
ES2141330T3 (es) 2000-03-16

Similar Documents

Publication Publication Date Title
NO952228D0 (no) Anvendelse av lamotrigin ved behandling av neurologiske lesjoner relatert til traumatiske skader
IL112539A (en) Chloropyrimidine intermediates for preparing-2-aminopurine nucleoside analogues and their preparation
CA2002648A1 (en) 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives
SE9500566D0 (sv) L-plate
PT755249E (pt) Utilizacao de inibidores da reaccao de maillard para o tratamento de doenca com base em amiloidose
HU9503702D0 (en) Use of modafinil for the treatment of sleep apnoea and ventilation problems of central origin
EP0736600A3 (en) Use of an immunodeficiency suppressing virus which suppresses lymphokines (ISL) to prevent viral replicas, in particular those of retroviruses
WO1996032403A3 (de) Neue cytosin- und cytidinderivate
DE69521122D1 (de) 2,3,4,5-tetrahydro-1h-3-benzazepin säure-additions-salze
IL112242A (en) Monohydrate of (E)-2'-deoxy-2'-(fluoromethylene)cytidine
MY124071A (en) Treatment of viral disease in swine
BR9811643A (pt) Suplementação quìmica de osso
DE69836087D1 (de) Kortikalknochenimplantat für wirbelfusion nach smith-robinson
ES8704962A1 (es) Un procedimiento para preparar 1b-d-ribofuranosil, 1-2-4-triazol-3-carboxamida.
GR3034688T3 (en) Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions
EP0459176A3 (en) Oligophosphates with antiviral activity
WO1998044913A3 (en) Compositions containing mkc-442 in combination with other antiviral agents
BR0012380A (pt) 2-amino-benzoxazinonas para o tratamento de vìrus do herpes simples
MY101613A (en) Diabrotica larvicidal agents
IT1271291B (it) La melatonina quale riequilibratore fisiologico del rapporto linfocitario th1/th2
UA23352A (uk) beta- D- ГЛЮКОЗАМОHІЙHА СІЛЬ alРha-БРОМІЗОВАЛЕРІАHОВОЇ КИСЛОТИ, ЯКА МАЄ ПРОТИВІРУСHУ АКТИВHІСТЬ ВІДHОСHО ВІРУСУ ВЕЗИКУЛЯРHОГО СТОМАТИТУ, ВІРУСУ ПРОСТОГО ГЕРПЕСУ ТА КОРОHАВІРУСУ

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees