IL112242A - Monohydrate of (E)-2'-deoxy-2'-(fluoromethylene)cytidine - Google Patents

Monohydrate of (E)-2'-deoxy-2'-(fluoromethylene)cytidine

Info

Publication number
IL112242A
IL112242A IL11224295A IL11224295A IL112242A IL 112242 A IL112242 A IL 112242A IL 11224295 A IL11224295 A IL 11224295A IL 11224295 A IL11224295 A IL 11224295A IL 112242 A IL112242 A IL 112242A
Authority
IL
Israel
Prior art keywords
fluoromethylene
cytidine
deoxy
monohydrate
neoplastic
Prior art date
Application number
IL11224295A
Other languages
English (en)
Other versions
IL112242A0 (en
Original Assignee
Hoechst Marion Roussel Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst Marion Roussel Inc filed Critical Hoechst Marion Roussel Inc
Publication of IL112242A0 publication Critical patent/IL112242A0/xx
Publication of IL112242A publication Critical patent/IL112242A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IL11224295A 1994-01-07 1995-01-04 Monohydrate of (E)-2'-deoxy-2'-(fluoromethylene)cytidine IL112242A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17895294A 1994-01-07 1994-01-07

Publications (2)

Publication Number Publication Date
IL112242A0 IL112242A0 (en) 1995-03-30
IL112242A true IL112242A (en) 2000-08-31

Family

ID=22654587

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11224295A IL112242A (en) 1994-01-07 1995-01-04 Monohydrate of (E)-2'-deoxy-2'-(fluoromethylene)cytidine

Country Status (20)

Country Link
EP (1) EP0738273B1 (xx)
JP (1) JPH09511227A (xx)
KR (1) KR100330328B1 (xx)
CN (1) CN1043231C (xx)
AT (1) ATE186732T1 (xx)
AU (1) AU684604B2 (xx)
CA (1) CA2179987C (xx)
DE (1) DE69421721T2 (xx)
DK (1) DK0738273T3 (xx)
ES (1) ES2141330T3 (xx)
FI (1) FI114396B (xx)
GR (1) GR3032614T3 (xx)
HU (1) HU217849B (xx)
IL (1) IL112242A (xx)
MX (1) MX9500363A (xx)
NO (1) NO306409B1 (xx)
NZ (1) NZ279030A (xx)
TW (1) TW397838B (xx)
WO (1) WO1995018815A1 (xx)
ZA (1) ZA9512B (xx)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1043324B1 (en) 1997-11-12 2004-06-16 Mitsubishi Chemical Corporation Purine derivatives and medicine containing the same as the active ingredient
KR100747106B1 (ko) 1999-05-11 2007-08-08 미쯔비시 가가꾸 가부시끼가이샤 퓨린 유도체 이수화물, 이를 유효성분으로 함유하는 의약및 이의 제조 중간체

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2002648C (en) * 1988-11-15 2000-02-29 James R. Mccarthy 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives
FI95269C (fi) * 1989-05-15 1996-01-10 Squibb Bristol Myers Co 2',3'-dideoksi-inosiinimonohydraatin, 2',3'-dideoksi-2',3'-didehydrot ymidiinimonohydraatin ja 2',3'-dideoksi-2'-fluori-inosiinihemihydraatin antiviraalisia, hyvin vesiliukoisia, stabiileja, kiteisiä suoloja
JPH0615557B2 (ja) * 1990-02-19 1994-03-02 ヤマサ醤油株式会社 ２’―デオキシ―２’―メチリデンシチジンの２水和物結晶
JP3265548B2 (ja) * 1992-05-12 2002-03-11 メレルファーマス−ティカルズ インコーポレイテッド リボヌクレオチド還元酵素阻害剤の製法

Also Published As

Publication number Publication date
GR3032614T3 (en) 2000-05-31
TW397838B (en) 2000-07-11
NZ279030A (en) 1997-05-26
DE69421721D1 (de) 1999-12-23
HUT75055A (en) 1997-03-28
WO1995018815A1 (en) 1995-07-13
CA2179987C (en) 1999-01-19
DE69421721T2 (de) 2000-04-27
AU684604B2 (en) 1997-12-18
NO306409B1 (no) 1999-11-01
IL112242A0 (en) 1995-03-30
FI114396B (fi) 2004-10-15
JPH09511227A (ja) 1997-11-11
NO962848D0 (no) 1996-07-05
HU9601848D0 (en) 1996-09-30
ES2141330T3 (es) 2000-03-16
NO962848L (no) 1996-09-06
CN1043231C (zh) 1999-05-05
FI962769A0 (fi) 1996-07-05
CN1141045A (zh) 1997-01-22
AU1553295A (en) 1995-08-01
ATE186732T1 (de) 1999-12-15
MX9500363A (es) 1998-04-30
HU217849B (hu) 2000-04-28
FI962769A (fi) 1996-07-05
DK0738273T3 (da) 2000-04-17
EP0738273B1 (en) 1999-11-17
EP0738273A1 (en) 1996-10-23
ZA9512B (en) 1995-09-11
KR100330328B1 (ko) 2002-12-05
CA2179987A1 (en) 1995-07-13

Similar Documents

Publication Publication Date Title
GB2288732B (en) Pharmaceutical compositions
NO952228L (no) Anvendelse av lamotrigin ved behandling av neurologiske lesjoner relatert til traumatiske skader
IL112539A (en) Chloropyrimidine intermediates for preparing-2-aminopurine nucleoside analogues and their preparation
CA2002648A1 (en) 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl cytidine, uridine and guanosine derivatives
SE9500566D0 (sv) L-plate
BR9811121A (pt) Produto, composição farmacêutica, e uso de um produto
TR199701212T1 (xx) �drar� tutamama halinin tedavisi i�in alfa IL- agonistlerinin kullan�lmas�.
EP0736600A3 (en) Use of an immunodeficiency suppressing virus which suppresses lymphokines (ISL) to prevent viral replicas, in particular those of retroviruses
IE893080L (en) Novel 2'-halomethylidene,2'-ethenylidene and¹2'-ethynyl adenosine derivatives
ZA9512B (en) Monohydrate of (E)-2'-deoxy-2'-(fluoromethylene)cytidine
MY124071A (en) Treatment of viral disease in swine
BR9811643A (pt) Suplementação quìmica de osso
GR3034688T3 (en) Use of 6,7-substituted-2-aminotetralines for preparing pharmaceutical compositions useful for the treatment of septic shock, and antipyretic and antiinflammatory pharmaceutical compositions
GR3017335T3 (en) Oligophosphates with antiviral activity.
WO1998044913A3 (en) Compositions containing mkc-442 in combination with other antiviral agents
BR0012380A (pt) 2-amino-benzoxazinonas para o tratamento de vìrus do herpes simples
LTIP1943A (en) Arylating agents, used in the treatment of cancerand disease caused by viral infection
IT1271291B (it) La melatonina quale riequilibratore fisiologico del rapporto linfocitario th1/th2
UA23352A (uk) beta- D- ГЛЮКОЗАМОHІЙHА СІЛЬ alРha-БРОМІЗОВАЛЕРІАHОВОЇ КИСЛОТИ, ЯКА МАЄ ПРОТИВІРУСHУ АКТИВHІСТЬ ВІДHОСHО ВІРУСУ ВЕЗИКУЛЯРHОГО СТОМАТИТУ, ВІРУСУ ПРОСТОГО ГЕРПЕСУ ТА КОРОHАВІРУСУ
DE69407180T2 (de) Fluoro-nukleosid-reinigung
ZA899510B (en) 2',3'-dideoxypurine nucleoside/purine nucleoside phosphorylase inhibitor combination therapy and composition

Legal Events

Date Code Title Description
FF Patent granted
KB Patent renewed
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees