PT755249E - Utilizacao de inibidores da reaccao de maillard para o tratamento de doenca com base em amiloidose - Google Patents
Utilizacao de inibidores da reaccao de maillard para o tratamento de doenca com base em amiloidoseInfo
- Publication number
- PT755249E PT755249E PT95915254T PT95915254T PT755249E PT 755249 E PT755249 E PT 755249E PT 95915254 T PT95915254 T PT 95915254T PT 95915254 T PT95915254 T PT 95915254T PT 755249 E PT755249 E PT 755249E
- Authority
- PT
- Portugal
- Prior art keywords
- amiloidose
- maillard reaction
- disease treatment
- based disease
- reaction inhibitors
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 238000011282 treatment Methods 0.000 title abstract 2
- 239000002683 reaction inhibitor Substances 0.000 title 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- HAMNKKUPIHEESI-UHFFFAOYSA-N aminoguanidine Chemical compound NNC(N)=N HAMNKKUPIHEESI-UHFFFAOYSA-N 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 206010002022 amyloidosis Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9407305A GB2288732B (en) | 1994-04-13 | 1994-04-13 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT755249E true PT755249E (pt) | 2004-08-31 |
Family
ID=10753465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95915254T PT755249E (pt) | 1994-04-13 | 1995-04-13 | Utilizacao de inibidores da reaccao de maillard para o tratamento de doenca com base em amiloidose |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US5891873A (pt) |
| EP (1) | EP0755249B1 (pt) |
| JP (1) | JPH09512005A (pt) |
| AT (1) | ATE262895T1 (pt) |
| AU (1) | AU2219795A (pt) |
| DE (1) | DE69532804T2 (pt) |
| DK (1) | DK0755249T3 (pt) |
| ES (1) | ES2216012T3 (pt) |
| GB (1) | GB2288732B (pt) |
| PT (1) | PT755249E (pt) |
| WO (1) | WO1995028151A1 (pt) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6673335B1 (en) * | 1992-07-08 | 2004-01-06 | Nektar Therapeutics | Compositions and methods for the pulmonary delivery of aerosolized medicaments |
| US6582728B1 (en) * | 1992-07-08 | 2003-06-24 | Inhale Therapeutic Systems, Inc. | Spray drying of macromolecules to produce inhaleable dry powders |
| DE69332105T2 (de) * | 1992-09-29 | 2003-03-06 | Inhale Therapeutic Systems, San Carlos | Pulmonale abgabe von aktiven fragmenten des parathormons |
| US20030113273A1 (en) * | 1996-06-17 | 2003-06-19 | Patton John S. | Methods and compositions for pulmonary delivery of insulin |
| EP0748213B1 (en) * | 1994-03-07 | 2004-04-14 | Nektar Therapeutics | Methods and compositions for pulmonary delivery of insulin |
| GB2288732B (en) * | 1994-04-13 | 1998-04-29 | Quadrant Holdings Cambridge | Pharmaceutical compositions |
| WO1995031479A1 (en) * | 1994-05-18 | 1995-11-23 | Inhale Therapeutic Systems, Inc. | Methods and compositions for the dry powder formulation of interferons |
| US6290991B1 (en) * | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US6512010B1 (en) | 1996-07-15 | 2003-01-28 | Alza Corporation | Formulations for the administration of fluoxetine |
| US5780513A (en) * | 1996-08-22 | 1998-07-14 | Washington University | Method of inhibiting the release of bioactive IL-1 |
| US6203817B1 (en) | 1997-02-19 | 2001-03-20 | Alza Corporation | Reduction of skin reactions caused by transdermal drug delivery |
| US20030035778A1 (en) * | 1997-07-14 | 2003-02-20 | Robert Platz | Methods and compositions for the dry powder formulation of interferon |
| JPH1143432A (ja) * | 1997-07-25 | 1999-02-16 | Biremo Sci:Kk | 脳の老化抑制及び治療剤 |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| US20060165606A1 (en) | 1997-09-29 | 2006-07-27 | Nektar Therapeutics | Pulmonary delivery particles comprising water insoluble or crystalline active agents |
| US6565885B1 (en) | 1997-09-29 | 2003-05-20 | Inhale Therapeutic Systems, Inc. | Methods of spray drying pharmaceutical compositions |
| EP1053749A4 (en) * | 1998-02-03 | 2003-01-15 | Senju Pharma Co | PREVENTION AND MEDICINE FOR NEURODEGENERATIVE DISEASES |
| GB9916316D0 (en) | 1999-07-12 | 1999-09-15 | Quadrant Holdings Cambridge | Dry powder compositions |
| AU6234700A (en) * | 1999-07-27 | 2001-02-13 | Abgenix, Inc. | Methods and compositions for inhibiting polypeptide accumulation associated with neurological disorders |
| US7871598B1 (en) | 2000-05-10 | 2011-01-18 | Novartis Ag | Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use |
| WO2001085136A2 (en) | 2000-05-10 | 2001-11-15 | Alliance Pharmaceutical Corporation | Phospholipid-based powders for drug delivery |
| US8404217B2 (en) | 2000-05-10 | 2013-03-26 | Novartis Ag | Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use |
| WO2002009674A2 (en) * | 2000-07-28 | 2002-02-07 | Inhale Therapeutic Systems, Inc. | Methods and compositions to upregulate, redirect or limit immune responses to bioactive compounds |
| JP2005514393A (ja) | 2001-12-19 | 2005-05-19 | ネクター セラピューティクス | アミノグリコシドの肺への供給 |
| AU2006247039B2 (en) * | 2005-05-19 | 2011-03-03 | Amgen Inc. | Compositions and methods for increasing the stability of antibodies |
| AU2006251832A1 (en) * | 2005-05-27 | 2006-11-30 | Queen's University At Kingston | Treatment of protein folding disorders |
| US20070031342A1 (en) * | 2005-06-22 | 2007-02-08 | Nektar Therapeutics | Sustained release microparticles for pulmonary delivery |
| CA2665567C (en) * | 2006-10-06 | 2012-07-03 | Amgen Inc. | Stable formulations |
| CA2666492C (en) * | 2006-10-20 | 2012-07-17 | Douglas Rehder | Stable polypeptide formulations |
| US11517613B2 (en) | 2017-06-07 | 2022-12-06 | Amano Enzyme Inc. | Lactase bulk powder and lactase preparation |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0325936A3 (en) * | 1988-01-16 | 1990-01-17 | Ono Pharmaceutical Co., Ltd. | Aminoguanidine derivatives and inhibitory agents on maillard reaction containing them as active ingredients |
| JPH03161441A (ja) * | 1989-11-20 | 1991-07-11 | Senjiyu Seiyaku Kk | メイラード反応阻害剤 |
| JP2854631B2 (ja) * | 1989-11-21 | 1999-02-03 | 千寿製薬株式会社 | 糖尿病合併症および老化によって引き起こされる疾患の予防・治療剤 |
| CA2030718C (en) * | 1989-11-28 | 1998-05-12 | Jacob Berger | Tricyclic compounds |
| KR920700632A (ko) * | 1990-02-19 | 1992-08-10 | 요시다 쇼오지 | 메일라드 반응저해제 |
| JP3298875B2 (ja) * | 1990-03-02 | 2002-07-08 | オレゴン州 | 三置換―および四置換グアニジン類およびそれらの興奮性アミノ酸アンタゴニストとしての用途 |
| US5112596A (en) * | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
| DE69233479T2 (de) * | 1991-02-08 | 2006-03-16 | Scion Pharmaceuticals, Inc., Medford | Substituierte Guanidine und Derivate hiervon als Modulatoren der Freisetzung von Neurotransmittern und neue Methode zur Identifizierung von Inhibitoren der Neurotransmitter-Freisetzung |
| TW221689B (pt) * | 1991-08-27 | 1994-03-11 | Otsuka Pharma Co Ltd | |
| US5453514A (en) * | 1992-12-25 | 1995-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Pyrazole derivatives and compositions and methods of use as maillard reaction inhibitors |
| JPH09511492A (ja) * | 1994-02-03 | 1997-11-18 | ザ ピコワー インスティテュート フォア メディカル リサーチ | アミロイドーシスの前進性グリコシル化終末産物仲介モジュレーション用組成物及び方法 |
| GB2288732B (en) * | 1994-04-13 | 1998-04-29 | Quadrant Holdings Cambridge | Pharmaceutical compositions |
-
1994
- 1994-04-13 GB GB9407305A patent/GB2288732B/en not_active Revoked
-
1995
- 1995-04-13 US US08/727,597 patent/US5891873A/en not_active Expired - Lifetime
- 1995-04-13 DE DE69532804T patent/DE69532804T2/de not_active Expired - Fee Related
- 1995-04-13 JP JP7526804A patent/JPH09512005A/ja not_active Ceased
- 1995-04-13 EP EP95915254A patent/EP0755249B1/en not_active Expired - Lifetime
- 1995-04-13 DK DK95915254T patent/DK0755249T3/da active
- 1995-04-13 AU AU22197/95A patent/AU2219795A/en not_active Abandoned
- 1995-04-13 PT PT95915254T patent/PT755249E/pt unknown
- 1995-04-13 WO PCT/GB1995/000843 patent/WO1995028151A1/en not_active Ceased
- 1995-04-13 ES ES95915254T patent/ES2216012T3/es not_active Expired - Lifetime
- 1995-04-13 AT AT95915254T patent/ATE262895T1/de not_active IP Right Cessation
-
1998
- 1998-12-04 US US09/205,329 patent/US6034080A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB2288732B (en) | 1998-04-29 |
| WO1995028151A1 (en) | 1995-10-26 |
| DK0755249T3 (da) | 2004-07-26 |
| US5891873A (en) | 1999-04-06 |
| DE69532804D1 (de) | 2004-05-06 |
| ES2216012T3 (es) | 2004-10-16 |
| US6034080A (en) | 2000-03-07 |
| GB9407305D0 (en) | 1994-06-08 |
| JPH09512005A (ja) | 1997-12-02 |
| GB2288732A (en) | 1995-11-01 |
| AU2219795A (en) | 1995-11-10 |
| EP0755249A1 (en) | 1997-01-29 |
| EP0755249B1 (en) | 2004-03-31 |
| ATE262895T1 (de) | 2004-04-15 |
| DE69532804T2 (de) | 2005-02-10 |
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