GR3019321T3 - Process for the preparation of diacetylrhein - Google Patents

Process for the preparation of diacetylrhein

Info

Publication number
GR3019321T3
GR3019321T3 GR960400633T GR960400633T GR3019321T3 GR 3019321 T3 GR3019321 T3 GR 3019321T3 GR 960400633 T GR960400633 T GR 960400633T GR 960400633 T GR960400633 T GR 960400633T GR 3019321 T3 GR3019321 T3 GR 3019321T3
Authority
GR
Greece
Prior art keywords
diacetylrhein
preparation
relates
liquid
aloe emodin
Prior art date
Application number
GR960400633T
Other languages
English (en)
Inventor
Alfons Dr Carcasona
Wolf Dr Grimminger
Pentti Dr Hietala
Klaus Dr Witthohn
Helga Zaeske
Original Assignee
Madaus Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=6434717&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3019321(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Madaus Ag filed Critical Madaus Ag
Publication of GR3019321T3 publication Critical patent/GR3019321T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/56—Separation; Purification; Stabilisation; Use of additives by solid-liquid treatment; by chemisorption
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C07C2603/24—Anthracenes; Hydrogenated anthracenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Electroluminescent Light Sources (AREA)
  • Holo Graphy (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
GR960400633T 1991-06-25 1996-03-14 Process for the preparation of diacetylrhein GR3019321T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4120989A DE4120989C2 (de) 1991-06-25 1991-06-25 Verfahren zur Herstellung von Diacetylrhein

Publications (1)

Publication Number Publication Date
GR3019321T3 true GR3019321T3 (en) 1996-06-30

Family

ID=6434717

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960400633T GR3019321T3 (en) 1991-06-25 1996-03-14 Process for the preparation of diacetylrhein

Country Status (19)

Country Link
US (2) US5391775A (el)
EP (1) EP0520414B1 (el)
JP (1) JPH0825955B2 (el)
AT (1) ATE135341T1 (el)
AU (1) AU645208B2 (el)
CA (1) CA2072283C (el)
CZ (1) CZ194892A3 (el)
DE (2) DE4120989C2 (el)
DK (1) DK0520414T3 (el)
ES (1) ES2084877T3 (el)
FI (1) FI104892B (el)
GR (1) GR3019321T3 (el)
HU (1) HU220390B (el)
IE (1) IE72526B1 (el)
PL (1) PL168847B1 (el)
RU (1) RU2104996C1 (el)
SK (1) SK194892A3 (el)
TW (1) TW400333B (el)
ZA (1) ZA924644B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5710260A (en) * 1991-06-25 1998-01-20 Madaus Ag Method of extracting sennosides A, B and A1
IT1264545B1 (it) * 1993-07-30 1996-10-02 Medidom Lab Procedimento per la preparazione della diacereina
FI96692C (fi) * 1993-12-17 1996-08-12 Leiras Oy Menetelmä sennosidien A ja B valmistamiseksi
CH689279A5 (fr) * 1995-02-07 1999-01-29 Steba Beheer Bv Procédé de purification de la diacétylrhéine.
US5652265A (en) * 1995-03-29 1997-07-29 Wisconsin Alumni Research Foundation Production of rhein and rhein derivatives
WO2003000246A1 (en) * 2001-06-25 2003-01-03 Arakis Ltd. The use of rhein and derivatives thereof in pain treatment
ITMI20022535A1 (it) * 2002-11-29 2004-05-30 Synteco Spa Procedimento per la purificazione della diacereina.
MXPA03008622A (es) * 2003-09-23 2005-03-30 Interquim S A De C V Metodo de purificacion de diacereina cruda por la via del tolueno.
EP2196450A1 (en) 2008-12-09 2010-06-16 Evultis S.A. Process for the preparation of pure diacetylrhein (diacerein)
CN102264683B (zh) * 2008-12-09 2014-07-09 Evultis公司 制备非基因毒性二乙酰大黄酸(双醋瑞因)的方法以及包含非基因毒性二乙酰大黄酸的制剂
EP2218707A1 (en) 2009-02-16 2010-08-18 Evultis S.A. Process for the preparation of non-genotoxic Diacetylrhein (Diacerein)
WO2011099834A2 (es) * 2010-02-15 2011-08-18 Interquim, S.A. De C.V. Procedimiento para la purificación de diacereina cruda vía sal de potasio/dimetil formamida
ITTO20110120A1 (it) 2011-02-11 2012-08-12 Icrom Spa Un nuovo processo di purificazione per derivati antrachinonici
JP2015527322A (ja) * 2012-07-10 2015-09-17 ジョージア ステイト ユニバーシティ リサーチ ファンデーション， インコーポレイテッド アントラキノン類似体ならびにその作製方法および使用方法
CN105985242A (zh) * 2015-01-27 2016-10-05 邵阳学院 双醋瑞因制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA761627B (en) * 1976-03-16 1978-01-25 C Friedmann Improvements in or relating to the treatment of arthritis
DE3200131A1 (de) * 1982-01-05 1983-07-14 Madaus & Co Dr "verfahren zur gewinnung von laxativen verbindungen aus sennadroge"
IT1189097B (it) * 1986-05-02 1988-01-28 Proter Spa Sali di diacetilreina e loro impiego terapeutico nel trattamento dell'artrosi

Also Published As

Publication number Publication date
FI922930A0 (fi) 1992-06-24
DE4120989C2 (de) 1995-07-27
HU220390B (hu) 2002-01-28
DE4120989A1 (de) 1993-01-07
IE922046A1 (en) 1992-12-30
FI104892B (fi) 2000-04-28
JPH05186394A (ja) 1993-07-27
PL168847B1 (pl) 1996-04-30
CA2072283C (en) 2000-10-24
CA2072283A1 (en) 1992-12-26
HU9202108D0 (en) 1992-10-28
HUT61263A (en) 1992-12-28
US6624192B1 (en) 2003-09-23
ES2084877T3 (es) 1996-05-16
PL295006A1 (en) 1993-02-22
EP0520414B1 (de) 1996-03-13
AU645208B2 (en) 1994-01-06
SK194892A3 (en) 1995-02-08
AU1848492A (en) 1993-03-11
FI922930A (fi) 1992-12-26
US5391775A (en) 1995-02-21
JPH0825955B2 (ja) 1996-03-13
IE72526B1 (en) 1997-04-23
DE59205646D1 (de) 1996-04-18
TW400333B (en) 2000-08-01
EP0520414A1 (de) 1992-12-30
RU2104996C1 (ru) 1998-02-20
CZ194892A3 (en) 1993-01-13
ZA924644B (en) 1993-03-31
ATE135341T1 (de) 1996-03-15
DK0520414T3 (da) 1996-04-01

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