GR3018506T3 - Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated - Google Patents

Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Info

Publication number
GR3018506T3
GR3018506T3 GR950403587T GR950403587T GR3018506T3 GR 3018506 T3 GR3018506 T3 GR 3018506T3 GR 950403587 T GR950403587 T GR 950403587T GR 950403587 T GR950403587 T GR 950403587T GR 3018506 T3 GR3018506 T3 GR 3018506T3
Authority
GR
Greece
Prior art keywords
pct
encapsulated
enhanced
foreign substances
making liposomes
Prior art date
Application number
GR950403587T
Other languages
Greek (el)
English (en)
Inventor
Michel Schneider
Herve Tournier
Roland Hyacinthe
Christian Guillot
Bernard Lamy
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of GR3018506T3 publication Critical patent/GR3018506T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR950403587T 1990-12-11 1995-12-21 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated GR3018506T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90810969 1990-12-11
PCT/EP1991/002377 WO1992010166A1 (en) 1990-12-11 1991-12-09 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Publications (1)

Publication Number Publication Date
GR3018506T3 true GR3018506T3 (en) 1996-03-31

Family

ID=8205973

Family Applications (1)

Application Number Title Priority Date Filing Date
GR950403587T GR3018506T3 (en) 1990-12-11 1995-12-21 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Country Status (20)

Country Link
US (1) US5393530A (OSRAM)
EP (1) EP0514523B1 (OSRAM)
JP (1) JP3241720B2 (OSRAM)
KR (1) KR0137783B1 (OSRAM)
AT (1) ATE131724T1 (OSRAM)
AU (1) AU635456B2 (OSRAM)
CA (1) CA2072559C (OSRAM)
DE (1) DE69115682T2 (OSRAM)
DK (1) DK0514523T3 (OSRAM)
ES (1) ES2081605T3 (OSRAM)
GR (1) GR3018506T3 (OSRAM)
HU (1) HUT62458A (OSRAM)
IE (1) IE72163B1 (OSRAM)
IL (1) IL99835A (OSRAM)
IN (1) IN172269B (OSRAM)
IS (1) IS1685B (OSRAM)
MX (1) MX9102516A (OSRAM)
NZ (1) NZ240817A (OSRAM)
WO (1) WO1992010166A1 (OSRAM)
ZA (1) ZA918489B (OSRAM)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
EP0665756A1 (de) * 1992-10-16 1995-08-09 SACHSE, Andreas Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme
US5869305A (en) * 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
US6217849B1 (en) 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
CA2185810A1 (en) * 1994-03-28 1995-10-05 Jo Klaveness Liposomes
JPH10500999A (ja) * 1995-02-24 1998-01-27 ブラッコ リサーチ ソシエテ アノニム 血液プール画像形成造影剤としてのリポソーム懸濁液
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US6447800B2 (en) 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
AU736301B2 (en) 1996-05-01 2001-07-26 Imarx Therapeutics, Inc. Methods for delivering compounds into a cell
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US20010051131A1 (en) * 1996-06-19 2001-12-13 Evan C. Unger Methods for delivering bioactive agents
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
GB9624918D0 (en) * 1996-11-29 1997-01-15 Nycomed Imaging As Particulate components
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
WO1998044910A1 (en) 1997-04-09 1998-10-15 Philipp Lang NEW TECHNIQUE TO MONITOR DRUG DELIVERY NONINVASIVELY $i(IN VIVO)
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
US6306432B1 (en) * 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
US6106858A (en) * 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
IL135060A (en) 1997-09-18 2005-12-18 Skyepharma Inc Sustained release liposomal anesthetic compositions and methods for the preparation thereof
AU752802C (en) 1997-11-14 2006-04-13 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19813773A1 (de) * 1998-03-27 1999-09-30 Clemens Unger Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen
IL140899A0 (en) 1998-07-17 2002-02-10 Skyepharma Inc Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof
US6511676B1 (en) 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
DE10121903A1 (de) * 2001-04-27 2002-10-31 Nimbus Biotechnologie Gmbh System für die Membranpermeationsmessung
AU2002322024B2 (en) * 2001-05-31 2008-05-08 Pacira Pharmaceuticals, Inc. Encapsulation of nanosuspensions in liposomes and microspheres
EP1275378B1 (en) * 2001-07-10 2009-04-15 Canon Kabushiki Kaisha Particulate construct comprising polyhydroxyalkanoate and method for producing it
JP3990880B2 (ja) * 2001-07-10 2007-10-17 キヤノン株式会社 ポリヒドロキシアルカノエート被覆リポソームの製造方法
US20050118249A1 (en) * 2001-11-13 2005-06-02 Murray Webb Lipid carrier compositions and methods for improved drug retention
EP1443900B1 (en) * 2001-11-13 2012-05-23 Celator Pharmaceuticals, Inc. Lipid carrier compositions with enhanced blood stability
US20030129224A1 (en) * 2001-11-13 2003-07-10 Paul Tardi Lipid carrier compositions and methods for improved drug retention
US20050129750A1 (en) * 2003-12-15 2005-06-16 Yu-Fang Hu Process for producing liposome suspension and product containing liposome suspension produced thereby
EP1547582A1 (en) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Method of producing lipid complexed camptothecin-carboxylate
EP1547580A1 (en) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Loading of a camptothecin drug into colloidal nanoparticles
CN1960707B (zh) 2004-06-03 2012-11-14 博莱科瑞士股份有限公司 用于治疗和/或诊断用途的脂质集合体
AU2005295072A1 (en) * 2004-10-08 2006-04-20 Alza Corporation Method of insertion of a lipid-linked moiety into a pre-formed lipid assembly using microwaves
EP1848404A2 (en) * 2005-01-26 2007-10-31 Celator Pharmaceuticals, Inc. Lipid carrier compositions with reduced polydispersity
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
ES2275443B1 (es) 2005-11-30 2008-06-01 Italfarmaco, S.A. Procedimiento de preparacion de liposomas.
JP5080779B2 (ja) * 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
WO2008141230A1 (en) * 2007-05-09 2008-11-20 Lawrence Livermore National Security, Llc Methods and systems for monitoring production of a target protein in a nanolipoprotein particle
EP2224963A1 (en) * 2007-11-19 2010-09-08 CeramOptec GmbH Pegylated compounds for age-related macular degeneration
US9688718B2 (en) * 2008-01-11 2017-06-27 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising hydrogenases and related products, methods and systems
US8883729B2 (en) * 2008-05-22 2014-11-11 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions, methods and systems
US9303273B2 (en) 2008-05-09 2016-04-05 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
WO2010040772A2 (en) 2008-10-07 2010-04-15 Bracco Research Sa Targeting construct comprising anti-polymer antibody and liposomes or microvesicles binding to the same
EP2184054A1 (en) * 2008-11-08 2010-05-12 Lipoxen Technologies Limited Small Interfering RNA Delivery
US10151037B2 (en) 2009-01-12 2018-12-11 Lawrence Livermore National Security, Llc Electrochemical flow-cell for hydrogen production and nicotinamide dependent target reduction, and related methods and systems
US20110070293A1 (en) 2009-09-23 2011-03-24 Javeri Indu Methods for the Preparation of Liposomes Comprising Docetaxel
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
CA2862864C (en) 2011-01-13 2018-12-11 Variation Biotechnologies Inc. Compositions and methods for treating viral infections
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
CA2894442C (en) 2012-01-12 2020-01-21 Variation Biotechnologies Inc. Compositions and methods for treating viral infections
US20150079077A1 (en) * 2012-01-27 2015-03-19 Variation Biotechnologies, Inc. Methods and compositions for therapeutic agents
MX364310B (es) 2013-11-05 2019-04-22 Gustavo A Garcia Sanchez Método para preparar una formulación inmunosupresora.
SMT202000687T1 (it) 2014-04-30 2021-01-05 Fujifilm Corp Composizione di liposomi e metodo per la sua produzione
WO2015166987A1 (ja) * 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
EP3240579B1 (en) 2014-12-31 2022-07-27 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
PT3291797T (pt) 2015-05-04 2020-10-19 Versantis AG Método para preparar vesículas de gradiente de ph transmembranar
WO2017035326A1 (en) 2015-08-25 2017-03-02 Lawrence Livermore National Security, Llc Stable nanolipoprotein particles and related compositions methods and systems
US11279749B2 (en) 2015-09-11 2022-03-22 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
MA43184A (fr) * 2015-11-02 2021-04-14 Fujifilm Corp Composition liposomale et son procédé de production
AU2017260532B2 (en) 2016-05-04 2024-08-22 Lantheus Medical Imaging, Inc. Methods and devices for preparation of ultrasound contrast agents
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
WO2018026794A1 (en) 2016-08-02 2018-02-08 Curirx Inc. Methods for the preparation of liposomes
WO2018204421A2 (en) 2017-05-02 2018-11-08 Lawrence Livermore National Security, Llc Momp telonanoparticles, and related compositions, methods and systems
WO2018204495A1 (en) 2017-05-02 2018-11-08 Synthetic Genomics, Inc. Nanolipoprotein particles and related compositions methods and systems for loading rna
CN112334140A (zh) 2018-06-20 2021-02-05 富士胶片株式会社 包含内含吉西他滨的脂质体组合物及免疫检查点抑制剂的组合医药
CN116785242A (zh) * 2019-06-28 2023-09-22 德州大学系统董事会 重构脂质体安那霉素的方法以及应用
US11980636B2 (en) 2020-11-18 2024-05-14 Jazz Pharmaceuticals Ireland Limited Treatment of hematological disorders
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12285419B2 (en) 2021-10-14 2025-04-29 Pacira Pharmaceuticals, Inc. Bupivacaine multivesicular liposome formulations and uses thereof
US12246092B1 (en) 2024-05-20 2025-03-11 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12280149B1 (en) 2024-05-20 2025-04-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
CA1270198A (en) * 1984-08-08 1990-06-12 Marcel B. Bally Encapsulation of antineoplastic agents in liposomes
JPS6150912A (ja) * 1984-08-16 1986-03-13 Shionogi & Co Ltd リポソ−ム製剤の製造法
JPS63211222A (ja) * 1987-02-27 1988-09-02 Terumo Corp リポソ−ムの製法
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
CH672733A5 (OSRAM) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
US4870160A (en) * 1987-08-19 1989-09-26 Regents Of The University Of Minnesota Polypeptides with laminin activity
IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
EP0393145A4 (en) * 1987-12-22 1991-09-11 The Liposome Company, Inc. Spontaneous vesiculation of multilamellar liposomes
ATE108651T1 (de) * 1988-05-20 1994-08-15 Liposome Co Inc Aktives mittel: lipid-komplex mit hohem verhältnis.
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release

Also Published As

Publication number Publication date
KR920703014A (ko) 1992-12-17
US5393530A (en) 1995-02-28
MX9102516A (es) 1992-06-01
CA2072559C (en) 1997-03-18
JPH05504150A (ja) 1993-07-01
EP0514523A1 (en) 1992-11-25
HUT62458A (en) 1993-05-28
DE69115682D1 (de) 1996-02-01
IL99835A0 (en) 1992-08-18
ZA918489B (en) 1992-07-29
AU635456B2 (en) 1993-03-18
ES2081605T3 (es) 1996-03-16
EP0514523B1 (en) 1995-12-20
IS1685B (is) 1998-02-24
CA2072559A1 (en) 1992-06-12
ATE131724T1 (de) 1996-01-15
JP3241720B2 (ja) 2001-12-25
IE914289A1 (en) 1992-06-17
IN172269B (OSRAM) 1993-05-29
WO1992010166A1 (en) 1992-06-25
IL99835A (en) 1995-11-27
IE72163B1 (en) 1997-03-26
DE69115682T2 (de) 1996-05-15
NZ240817A (en) 1993-01-27
AU9062991A (en) 1992-07-08
KR0137783B1 (ko) 1998-05-15
DK0514523T3 (da) 1996-01-29
IS3773A7 (is) 1992-06-12

Similar Documents

Publication Publication Date Title
ZA918489B (en) Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated
PL339768A1 (en) Method of encapsulating aromatic and taste giving substances by controllable delivery of water into microcapsules
CA2177695A1 (en) Method of transmitting a biologically active material to a cell
EP0140085A3 (en) Drug-containing lipid vesicle preparation and method for preparing them
NO901852L (no) Fremgangsmaate for fremstilling av liposomer.
AU7134200A (en) Method of encapsulating flavors and fragrances by controlled water transport into microcapsules
GR3015813T3 (en) Multiple encapsulated flavor delivery system and method of preparation.
IE830690L (en) Stable plurilamellar vesicles
EP0179745A3 (en) Drug release device
NZ503293A (en) Liposomal camptothecin formulations also comprising at least one phospholipid
DE3476338D1 (en) Preparation of unilamellar large diameter liposomes, their pharmaceutical application in view of the encapsulation of the active principle for sustained release, and device therefor
SK62395A3 (en) Advertising carrier and method of its manufacture
EP0800822A3 (en) Method for preparing closed vesicles by rehydration of dehydrated vesicles
SI0948319T1 (en) Encapsulated cells producing antibodies
Kallenbach Fine structure of the stratum intermedium, stellate reticulum, and outer enamel epithelium in the enamel organ of the kitten
HUT71909A (en) Method of encapsulating substances in biocapsules
DE69018258D1 (de) Aktive Bestandteile enthaltende phospholipidische Liposome und Verfahren zu ihrer Herstellung.
Kasatkin State of Yb impurities in InP crystals.
US4389209A (en) Method of providing systemic protection from bloodsucking insects and other parasites using encapsulated additives in resealed erythrocytes
GB9225588D0 (en) Improving effectiveness of drugs
Utz Avignon Days
FR2579589B1 (fr) Produit du type suspension contenant notamment du petit lait concentre, pour regler la croissance et le developpement des plantes
龚淑玲 et al. Linear Polysiloxane with Dibenzo-18-Crown-6 Moieties as Liquid Membrane Carrier
Ku et al. Microencapsulation of Indomethacin by Pectin-Gelatin Complex Coacervation Method
HU885490D0 (en) Process for producing plasminogeous activator from cells bred in lactine containing fodder medium