GEP201606550B - Oral formulations and lipophilic salts of methylnaltrexone - Google Patents

Oral formulations and lipophilic salts of methylnaltrexone

Info

Publication number
GEP201606550B
GEP201606550B GEAP201112868A GEAP2011012868A GEP201606550B GE P201606550 B GEP201606550 B GE P201606550B GE AP201112868 A GEAP201112868 A GE AP201112868A GE AP2011012868 A GEAP2011012868 A GE AP2011012868A GE P201606550 B GEP201606550 B GE P201606550B
Authority
GE
Georgia
Prior art keywords
methylnaltrexone
oral formulations
lipophilic salts
salts
lipophilic
Prior art date
Application number
GEAP201112868A
Other languages
English (en)
Inventor
Syed M Shah
Christopher Richard Diorio
Eric C Ehrnsperger
Xu Meng
Al Shareffi Kadum A A
Jonathan Marc Cohen
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44148539&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GEP201606550(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of GEP201606550B publication Critical patent/GEP201606550B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Emergency Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GEAP201112868A 2010-03-11 2011-03-10 Oral formulations and lipophilic salts of methylnaltrexone GEP201606550B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US31301810P 2010-03-11 2010-03-11

Publications (1)

Publication Number Publication Date
GEP201606550B true GEP201606550B (en) 2016-10-10

Family

ID=44148539

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP201112868A GEP201606550B (en) 2010-03-11 2011-03-10 Oral formulations and lipophilic salts of methylnaltrexone

Country Status (32)

Country Link
US (8) US8524276B2 (cg-RX-API-DMAC7.html)
EP (2) EP3178472B1 (cg-RX-API-DMAC7.html)
JP (4) JP6143409B2 (cg-RX-API-DMAC7.html)
KR (2) KR101913102B1 (cg-RX-API-DMAC7.html)
CN (2) CN102918039B (cg-RX-API-DMAC7.html)
AR (1) AR080491A1 (cg-RX-API-DMAC7.html)
AU (1) AU2011224275B2 (cg-RX-API-DMAC7.html)
BR (1) BR112012022873B1 (cg-RX-API-DMAC7.html)
CA (1) CA2789798C (cg-RX-API-DMAC7.html)
CL (1) CL2012002192A1 (cg-RX-API-DMAC7.html)
CO (1) CO6630134A2 (cg-RX-API-DMAC7.html)
CR (1) CR20120476A (cg-RX-API-DMAC7.html)
EA (1) EA029096B1 (cg-RX-API-DMAC7.html)
EC (1) ECSP12012208A (cg-RX-API-DMAC7.html)
ES (1) ES2623926T3 (cg-RX-API-DMAC7.html)
GE (1) GEP201606550B (cg-RX-API-DMAC7.html)
GT (1) GT201200247A (cg-RX-API-DMAC7.html)
HU (1) HUE033133T2 (cg-RX-API-DMAC7.html)
IL (1) IL221452A (cg-RX-API-DMAC7.html)
MA (1) MA34146B1 (cg-RX-API-DMAC7.html)
MX (2) MX368805B (cg-RX-API-DMAC7.html)
MY (1) MY160727A (cg-RX-API-DMAC7.html)
NZ (3) NZ601595A (cg-RX-API-DMAC7.html)
PE (1) PE20130063A1 (cg-RX-API-DMAC7.html)
PH (1) PH12012501622A1 (cg-RX-API-DMAC7.html)
PL (2) PL3178472T3 (cg-RX-API-DMAC7.html)
SG (3) SG10201606618PA (cg-RX-API-DMAC7.html)
TN (1) TN2012000392A1 (cg-RX-API-DMAC7.html)
TW (2) TWI589293B (cg-RX-API-DMAC7.html)
UA (2) UA123856C2 (cg-RX-API-DMAC7.html)
WO (1) WO2011112816A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201808498B (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
US20140249171A1 (en) 2014-09-04
KR101913102B1 (ko) 2018-10-31
US20190117646A1 (en) 2019-04-25
IL221452A (en) 2017-07-31
WO2011112816A1 (en) 2011-09-15
AU2011224275B2 (en) 2015-10-01
CA2789798A1 (en) 2011-09-15
EA201270741A1 (ru) 2013-02-28
PL2371357T3 (pl) 2017-09-29
SG183133A1 (en) 2012-09-27
UA111717C2 (uk) 2016-06-10
US20190314365A1 (en) 2019-10-17
US20130330407A1 (en) 2013-12-12
JP2016029054A (ja) 2016-03-03
CN107308125A (zh) 2017-11-03
HK1245673A1 (zh) 2018-08-31
MX349145B (es) 2017-07-14
JP2011190259A (ja) 2011-09-29
TN2012000392A1 (en) 2014-01-30
MX368805B (es) 2019-10-17
TW201622724A (zh) 2016-07-01
ES2623926T3 (es) 2017-07-12
US20120070495A1 (en) 2012-03-22
CN102918039A (zh) 2013-02-06
CN107308125B (zh) 2021-07-16
SG10201606618PA (en) 2016-09-29
US20190117645A1 (en) 2019-04-25
EP3178472A1 (en) 2017-06-14
TWI589293B (zh) 2017-07-01
ZA201808498B (en) 2019-08-28
KR101982482B1 (ko) 2019-05-27
US8956651B2 (en) 2015-02-17
AU2011224275A1 (en) 2012-08-23
MX2012009125A (es) 2012-09-07
NZ703564A (en) 2016-08-26
US20200121673A1 (en) 2020-04-23
TWI605814B (zh) 2017-11-21
KR20130010900A (ko) 2013-01-29
CN102918039B (zh) 2017-06-09
TW201141479A (en) 2011-12-01
NZ601595A (en) 2015-01-30
CR20120476A (es) 2012-11-30
CA2789798C (en) 2020-09-22
UA123856C2 (uk) 2021-06-16
BR112012022873B1 (pt) 2021-09-14
US20160206612A1 (en) 2016-07-21
JP6429955B2 (ja) 2018-11-28
JP2017206553A (ja) 2017-11-24
US10507206B2 (en) 2019-12-17
ECSP12012208A (es) 2015-03-31
EP2371357B1 (en) 2017-02-01
EP3178472B1 (en) 2021-10-27
MA34146B1 (fr) 2013-04-03
US10376505B2 (en) 2019-08-13
JP6143409B2 (ja) 2017-06-07
EP2371357A1 (en) 2011-10-05
CL2012002192A1 (es) 2012-09-28
US9314461B2 (en) 2016-04-19
PE20130063A1 (es) 2013-02-11
EA029096B1 (ru) 2018-02-28
HUE033133T2 (en) 2017-11-28
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US10307417B2 (en) 2019-06-04
CO6630134A2 (es) 2013-03-01
US8524276B2 (en) 2013-09-03
MY160727A (en) 2017-03-15
BR112012022873A2 (pt) 2016-08-30
IL221452A0 (en) 2012-10-31
AR080491A1 (es) 2012-04-11
GT201200247A (es) 2013-09-11
JP2019034958A (ja) 2019-03-07
PH12012501622A1 (en) 2012-11-05
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PL3178472T3 (pl) 2022-02-14
JP6647368B2 (ja) 2020-02-14

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