GEP20043257B - Aerosol Particles Resistant to Hygrosscopic Growth, Method for Their Production and Use Thereof for Delivering an Active Agent to the Lung of A Human Patient by Inhalation - Google Patents

Aerosol Particles Resistant to Hygrosscopic Growth, Method for Their Production and Use Thereof for Delivering an Active Agent to the Lung of A Human Patient by Inhalation

Info

Publication number
GEP20043257B
GEP20043257B GEAP19995857A GEAP1999005857A GEP20043257B GE P20043257 B GEP20043257 B GE P20043257B GE AP19995857 A GEAP19995857 A GE AP19995857A GE AP1999005857 A GEAP1999005857 A GE AP1999005857A GE P20043257 B GEP20043257 B GE P20043257B
Authority
GE
Georgia
Prior art keywords
active agent
lung
delivering
human patient
growth
Prior art date
Application number
GEAP19995857A
Other languages
English (en)
Inventor
Lalor
Clark
Aldous
Kuo
Original Assignee
Nektar Therapeutic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutic filed Critical Nektar Therapeutic
Publication of GEP20043257B publication Critical patent/GEP20043257B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Otolaryngology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
GEAP19995857A 1998-09-14 1999-09-13 Aerosol Particles Resistant to Hygrosscopic Growth, Method for Their Production and Use Thereof for Delivering an Active Agent to the Lung of A Human Patient by Inhalation GEP20043257B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10016398P 1998-09-14 1998-09-14

Publications (1)

Publication Number Publication Date
GEP20043257B true GEP20043257B (en) 2004-06-25

Family

ID=22278404

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19995857A GEP20043257B (en) 1998-09-14 1999-09-13 Aerosol Particles Resistant to Hygrosscopic Growth, Method for Their Production and Use Thereof for Delivering an Active Agent to the Lung of A Human Patient by Inhalation

Country Status (44)

Country Link
EP (1) EP1117442A1 (xx)
JP (1) JP2002524535A (xx)
KR (1) KR20010075063A (xx)
CN (1) CN1317977A (xx)
AP (1) AP1374A (xx)
AR (1) AR022090A1 (xx)
AU (1) AU753014B2 (xx)
BG (1) BG105430A (xx)
BR (1) BR9913722A (xx)
CA (1) CA2343920A1 (xx)
CO (1) CO5130023A1 (xx)
CZ (1) CZ2001829A3 (xx)
DZ (1) DZ2892A1 (xx)
EA (1) EA003476B1 (xx)
EE (1) EE200100151A (xx)
GE (1) GEP20043257B (xx)
GT (1) GT199900156A (xx)
HK (1) HK1042231A1 (xx)
HN (1) HN1999000159A (xx)
HR (1) HRP20010189A2 (xx)
HU (1) HUP0103837A3 (xx)
ID (1) ID28845A (xx)
IL (2) IL141562A0 (xx)
IS (1) IS5878A (xx)
LT (1) LT4897B (xx)
LV (1) LV12658B (xx)
MA (1) MA25590A1 (xx)
MY (1) MY129282A (xx)
NO (1) NO20011251L (xx)
NZ (1) NZ510168A (xx)
OA (1) OA11781A (xx)
PA (1) PA8481901A1 (xx)
PE (1) PE20001061A1 (xx)
PL (1) PL195574B1 (xx)
SA (1) SA99200718B1 (xx)
SK (1) SK3442001A3 (xx)
TN (1) TNSN99173A1 (xx)
TR (1) TR200101182T2 (xx)
TW (1) TWI226248B (xx)
UA (1) UA76085C2 (xx)
UY (1) UY25711A1 (xx)
WO (1) WO2000015262A1 (xx)
YU (1) YU24201A (xx)
ZA (1) ZA200101995B (xx)

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EP1185248B1 (en) 1999-06-09 2012-05-02 Robert E. Sievers Supercritical fluid-assisted nebulization and bubble drying
US6475468B2 (en) * 2001-02-15 2002-11-05 Aeropharm Technology Incorporated Modulated release particles for aerosol delivery
CA2446904A1 (en) * 2001-05-24 2003-04-03 Alexza Molecular Delivery Corporation Delivery of drug esters through an inhalation route
EG24184A (en) * 2001-06-15 2008-10-08 Otsuka Pharma Co Ltd Dry powder inhalation system for transpulmonary
IL163685A0 (en) 2002-02-25 2005-12-18 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
US7759506B2 (en) 2002-02-25 2010-07-20 Diffusion Pharmaceuticals Llc Bipolar trans carotenoid salts and their uses
JP2006513139A (ja) * 2002-07-03 2006-04-20 ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド 治療薬の全身性送達のための中央部気道投与
CA2511385A1 (en) * 2002-12-19 2004-07-22 Pharmacia Corporation Non-hygroscopic formulation comprising a hydroscopic drug
DE10338403A1 (de) * 2003-08-18 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulverformulierung, enthaltend den CGRP-Antagonisten 1-[N2-[3,5-Dibrom-N-[[4-(3,4-dihydro-2(1H)-oxochinazolin-3-yl]-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyrindinyl)-piperazin, Verfahren zu dessen Herstellung sowie dessen Verwendung als Inhalativum
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
RU2006141358A (ru) * 2004-04-23 2008-05-27 Сайдекс, Инк. (Us) Препаративная форма для ингалятора сухого порошка, содержащая простой сульфоалкиловый эфир циклодекстрина
EA017982B1 (ru) 2005-02-24 2013-04-30 ДИФФЬЮЖН ФАРМАСЬЮТИКАЛЗ ЭлЭлСи Фармацевтическая композиция на основе транскаротиноидов и способы лечения опухоли
KR20070110418A (ko) * 2005-03-09 2007-11-16 오노 야꾸힝 고교 가부시키가이샤 입자 및 그 입자를 함유하는 제제
DK2581078T3 (en) 2005-10-26 2015-03-02 Cydex Pharmaceuticals Inc Sulfoalkylætercyclodekstrinsammensætninger and processes for the preparation thereof
US7629331B2 (en) 2005-10-26 2009-12-08 Cydex Pharmaceuticals, Inc. Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof
WO2008021451A2 (en) * 2006-08-14 2008-02-21 Aktiv-Dry Llc Human-powered dry powder inhaler and dry powder inhaler compositions
JP5315056B2 (ja) * 2006-10-25 2013-10-16 大日本住友製薬株式会社 固結抑制粒状製剤
EP1925295A1 (de) * 2006-11-22 2008-05-28 Boehringer Ingelheim Pharma GmbH & Co. KG Stabile Pulverformulierung enthaltend ein Anticholinergikum
EP2146948A4 (en) 2007-04-13 2010-08-04 Diffusion Pharmaceuticals Llc USE OF BIPOLAR TRANS-CAROTINOIDES AS PRE-TREATMENT AND TREATMENT OF PERIPHERAL VASCULAR DISEASE
AU2008319225B2 (en) 2007-10-31 2016-09-29 Diffusion Pharmaceuticals Llc A new class of therapeutics that enhance small molecule diffusion
ES2661215T3 (es) 2009-05-20 2018-03-28 Aeras Composiciones víricas; inmunógenas; secadas por pulverización; estables
US10130689B2 (en) 2009-06-22 2018-11-20 Diffusion Pharmaceuticals Llc Diffusion enhancing compounds and their use alone or with thrombolytics
EP2575487B1 (en) 2010-06-02 2017-10-18 Diffusion Pharmaceuticals Llc Oral formulations of bipolar trans carotenoids
WO2013164380A1 (en) 2012-05-03 2013-11-07 Janssen R&D Ireland Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections
BR112015010601B1 (pt) * 2012-11-09 2022-07-19 Civitas Therapeutics, Inc. Composição farmacêutica e uso da composição
US20180043585A9 (en) * 2013-09-20 2018-02-15 Virginia Commonwealth University Delivery of particles using hygroscopic excipients
CN107106641B (zh) 2014-10-31 2021-12-21 葛兰素史密斯克莱知识产权发展有限公司 粉末制剂
EP3432929A4 (en) 2016-03-24 2019-11-27 Diffusion Pharmaceuticals LLC USE OF BIPOLAR TRANSCAROTINOIDS WITH CHEMOTHERAPY AND RADIOTHERAPY FOR THE TREATMENT OF CANCER
US20220378727A1 (en) * 2021-05-14 2022-12-01 The University Of Hong Kong Dry powder formulations of tamibarotene for pulmonary and intranasal delivery

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3155573A (en) * 1958-05-06 1964-11-03 Benger Lab Ltd Inhalant composition and method of making same
ES2177544T3 (es) * 1992-06-12 2002-12-16 Teijin Ltd Polvo ultrafinno para inhalar y metodo para su preparacion.
US6524557B1 (en) * 1994-12-22 2003-02-25 Astrazeneca Ab Aerosol formulations of peptides and proteins
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
ATE287257T1 (de) * 1997-01-16 2005-02-15 Massachusetts Inst Technology Zubereitung von partikelhaltigen arzneimitteln zur inhalation
US6086376A (en) * 1998-01-30 2000-07-11 Rtp Pharma Inc. Dry aerosol suspension of phospholipid-stabilized drug microparticles in a hydrofluoroalkane propellant

Also Published As

Publication number Publication date
AR022090A1 (es) 2002-09-04
CN1317977A (zh) 2001-10-17
CO5130023A1 (es) 2002-02-27
PE20001061A1 (es) 2000-10-08
NZ510168A (en) 2003-09-26
IS5878A (is) 2001-03-05
SK3442001A3 (en) 2001-11-06
HN1999000159A (es) 1999-11-11
UY25711A1 (es) 1999-11-17
ZA200101995B (en) 2002-03-11
EE200100151A (et) 2002-06-17
SA99200718B1 (ar) 2006-11-04
YU24201A (sh) 2003-08-29
LV12658B (lv) 2001-09-20
UA76085C2 (en) 2006-07-17
TNSN99173A1 (fr) 2005-11-10
AU753014B2 (en) 2002-10-03
BG105430A (en) 2001-12-29
LT4897B (lt) 2002-02-25
BR9913722A (pt) 2001-05-29
HK1042231A1 (zh) 2002-08-09
MY129282A (en) 2007-03-30
LT2001021A (en) 2001-11-26
WO2000015262A1 (en) 2000-03-23
KR20010075063A (ko) 2001-08-09
IL141562A (en) 2007-07-24
OA11781A (en) 2005-07-26
PL195574B1 (pl) 2007-10-31
NO20011251L (no) 2001-04-17
AU6039799A (en) 2000-04-03
PL346768A1 (en) 2002-02-25
NO20011251D0 (no) 2001-03-13
AP1374A (en) 2005-02-28
TWI226248B (en) 2005-01-11
CA2343920A1 (en) 2000-03-23
HRP20010189A2 (en) 2005-04-30
AP2001002093A0 (en) 2001-03-31
PA8481901A1 (es) 2002-04-25
ID28845A (id) 2001-07-05
JP2002524535A (ja) 2002-08-06
DZ2892A1 (fr) 2003-12-15
CZ2001829A3 (cs) 2001-09-12
LV12658A (lv) 2001-05-20
MA25590A1 (fr) 2002-12-31
EP1117442A1 (en) 2001-07-25
EA200100300A1 (ru) 2001-10-22
HUP0103837A3 (en) 2002-11-28
HUP0103837A2 (hu) 2002-05-29
IL141562A0 (en) 2002-03-10
GT199900156A (es) 2001-03-07
TR200101182T2 (tr) 2001-09-21
EA003476B1 (ru) 2003-06-26

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